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OPENSEQ.org
SUPH - Sugar phosphatase YbiV
UniProt: P75792 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13327
Length: 271 (264)
Sequences: 5467
Seq/Len: 20.71
SUPH
Paralog alert: 0.75 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: COF MPGP SUPH YBHA YBJI YIDA YIGL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_D 251_N 4.796 1.00
248_D 257_N 4.201 1.00
249_D 252_H 3.44 1.00
212_A 226_A 3.383 1.00
223_L 229_S 3.242 1.00
25_R 260_Q 2.885 1.00
16_N 20_T 2.862 1.00
4_K 209_N 2.826 1.00
200_L 210_V 2.79 1.00
8_T 40_F 2.77 1.00
44_S 51_L 2.735 1.00
237_E 241_Q 2.705 1.00
25_R 253_E 2.57 1.00
220_A 239_I 2.49 1.00
191_H 221_E 2.343 1.00
248_D 252_H 2.326 1.00
7_V 196_I 2.297 1.00
231_A 243_A 2.229 1.00
32_E 35_K 2.228 1.00
220_A 242_I 2.114 1.00
239_I 242_I 2.108 1.00
5_V 41_V 2.096 1.00
207_P 225_M 2.091 1.00
197_S 225_M 2.081 1.00
206_S 209_N 2.077 1.00
224_K 242_I 2.032 1.00
237_E 240_K 1.994 1.00
217_G 238_N 1.966 1.00
27_M 57_E 1.966 1.00
32_E 260_Q 1.897 1.00
230_F 258_V 1.89 1.00
229_S 244_R 1.887 1.00
217_G 236_A 1.852 1.00
198_R 201_K 1.838 1.00
30_Y 40_F 1.829 1.00
22_N 253_E 1.816 1.00
32_E 36_R 1.773 1.00
197_S 201_K 1.749 1.00
212_A 223_L 1.732 1.00
65_V 195_G 1.713 1.00
3_V 211_V 1.702 1.00
85_T 88_E 1.684 1.00
10_M 15_L 1.633 1.00
7_V 43_A 1.629 1.00
233_G 249_D 1.626 1.00
24_P 28_A 1.621 1.00
194_N 197_S 1.583 1.00
8_T 213_I 1.579 1.00
231_A 235_A 1.577 1.00
196_I 222_M 1.532 1.00
228_Y 245_Y 1.518 1.00
28_A 32_E 1.486 1.00
245_Y 262_V 1.479 1.00
208_Q 227_R 1.474 1.00
255_A 259_I 1.456 1.00
6_I 259_I 1.454 1.00
228_Y 244_R 1.448 1.00
193_A 225_M 1.441 1.00
226_A 229_S 1.441 1.00
33_L 38_I 1.438 1.00
6_I 33_L 1.421 1.00
247_T 254_G 1.419 1.00
5_V 200_L 1.416 1.00
80_F 198_R 1.406 0.99
74_E 77_K 1.4 0.99
44_S 66_A 1.39 0.99
39_K 203_W 1.38 0.99
16_N 251_N 1.378 0.99
200_L 207_P 1.363 0.99
5_V 205_L 1.357 0.99
213_I 255_A 1.355 0.99
29_Q 256_L 1.353 0.99
31_Q 35_K 1.348 0.99
200_L 205_L 1.341 0.99
213_I 258_V 1.319 0.99
3_V 38_I 1.279 0.99
230_F 247_T 1.277 0.99
238_N 241_Q 1.274 0.99
247_T 258_V 1.273 0.99
223_L 239_I 1.263 0.99
245_Y 258_V 1.244 0.98
38_I 211_V 1.238 0.98
70_A 187_I 1.238 0.98
198_R 202_R 1.237 0.98
17_D 250_N 1.236 0.98
91_I 172_I 1.235 0.98
212_A 222_M 1.234 0.98
27_M 31_Q 1.221 0.98
235_A 239_I 1.219 0.98
3_V 228_Y 1.208 0.98
3_V 209_N 1.204 0.98
41_V 199_L 1.203 0.98
187_I 190_L 1.202 0.98
25_R 29_Q 1.2 0.98
235_A 240_K 1.198 0.98
138_D 141_E 1.197 0.98
240_K 246_A 1.194 0.98
220_A 224_K 1.192 0.98
211_V 258_V 1.191 0.98
211_V 230_F 1.185 0.98
234_N 250_N 1.183 0.98
231_A 239_I 1.159 0.97
229_S 239_I 1.158 0.97
207_P 210_V 1.156 0.97
162_I 166_H 1.138 0.97
88_E 91_I 1.133 0.97
7_V 41_V 1.125 0.97
26_F 253_E 1.124 0.97
82_G 198_R 1.121 0.97
5_V 210_V 1.117 0.96
34_K 61_E 1.114 0.96
78_Q 81_H 1.102 0.96
248_D 254_G 1.098 0.96
193_A 221_E 1.091 0.96
232_M 247_T 1.08 0.95
26_F 29_Q 1.079 0.95
216_S 236_A 1.077 0.95
88_E 172_I 1.077 0.95
191_H 194_N 1.071 0.95
70_A 190_L 1.062 0.95
245_Y 257_N 1.054 0.95
211_V 262_V 1.047 0.94
245_Y 261_A 1.045 0.94
47_Q 67_E 1.044 0.94
199_L 203_W 1.043 0.94
174_K 221_E 1.04 0.94
176_V 186_I 1.037 0.94
200_L 225_M 1.035 0.94
227_R 244_R 1.028 0.94
258_V 262_V 1.026 0.94
186_I 191_H 1.022 0.93
7_V 210_V 1.02 0.93
72_V 195_G 1.017 0.93
25_R 257_N 1.009 0.93
210_V 226_A 1.008 0.93
6_I 38_I 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pgvA40.96681000.208Contact Map0.772
1rlmA411000.212Contact Map0.861
3l7yA10.98151000.214Contact Map0.805
1nrwA10.95571000.219Contact Map0.799
2b30A40.97051000.236Contact Map0.771
3daoA20.96311000.238Contact Map0.763
1rkqA20.98891000.247Contact Map0.833
1nf2A30.97421000.256Contact Map0.856
3dnpA10.98891000.259Contact Map0.808
2pq0A20.94831000.263Contact Map0.794
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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