| UniProt: | P76115 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13774 | ||
| Length: | 700 (669) | ||
| Sequences: | 17147 | ||
| Seq/Len: | 25.63 |
| YNCD
Paralog alert: 0.93 [within 20: 0.33] - ratio of genomes with paralogs Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 568_W | 596_N | 5.654 | 1.00 | |
| 616_A | 636_T | 4.674 | 1.00 | |
| 520_Q | 548_Q | 4.495 | 1.00 | |
| 419_Y | 445_H | 4.367 | 1.00 | |
| 417_V | 447_W | 4.298 | 1.00 | |
| 233_S | 287_R | 4.293 | 1.00 | |
| 638_V | 663_F | 4.189 | 1.00 | |
| 461_W | 505_S | 3.955 | 1.00 | |
| 467_A | 499_D | 3.937 | 1.00 | |
| 196_V | 227_V | 3.707 | 1.00 | |
| 350_V | 403_T | 3.653 | 1.00 | |
| 469_R | 499_D | 3.398 | 1.00 | |
| 611_Y | 643_G | 3.314 | 1.00 | |
| 411_L | 455_Y | 3.22 | 1.00 | |
| 52_G | 56_R | 3.204 | 1.00 | |
| 130_V | 154_V | 3.155 | 1.00 | |
| 233_S | 285_Y | 3.154 | 1.00 | |
| 410_K | 455_Y | 3.138 | 1.00 | |
| 132_N | 155_T | 3.017 | 1.00 | |
| 516_L | 552_L | 2.974 | 1.00 | |
| 570_W | 596_N | 2.956 | 1.00 | |
| 241_S | 279_T | 2.926 | 1.00 | |
| 204_R | 219_N | 2.909 | 1.00 | |
| 461_W | 507_T | 2.882 | 1.00 | |
| 235_L | 285_Y | 2.739 | 1.00 | |
| 618_Y | 636_T | 2.712 | 1.00 | |
| 616_A | 638_V | 2.705 | 1.00 | |
| 185_G | 198_Y | 2.704 | 1.00 | |
| 239_F | 279_T | 2.695 | 1.00 | |
| 565_N | 601_S | 2.683 | 1.00 | |
| 355_G | 400_Y | 2.679 | 1.00 | |
| 546_R | 576_R | 2.613 | 1.00 | |
| 202_T | 219_N | 2.591 | 1.00 | |
| 457_M | 463_I | 2.562 | 1.00 | |
| 230_D | 233_S | 2.559 | 1.00 | |
| 656_F | 692_G | 2.548 | 1.00 | |
| 613_G | 641_F | 2.526 | 1.00 | |
| 200_V | 223_A | 2.49 | 1.00 | |
| 165_I | 183_A | 2.487 | 1.00 | |
| 243_D | 277_K | 2.486 | 1.00 | |
| 615_E | 639_G | 2.461 | 1.00 | |
| 419_Y | 447_W | 2.454 | 1.00 | |
| 514_L | 554_W | 2.443 | 1.00 | |
| 51_D | 54_E | 2.433 | 1.00 | |
| 562_F | 602_I | 2.417 | 1.00 | |
| 413_L | 453_L | 2.408 | 1.00 | |
| 234_K | 286_E | 2.378 | 1.00 | |
| 618_Y | 634_S | 2.375 | 1.00 | |
| 617_R | 639_G | 2.362 | 1.00 | |
| 621_D | 631_K | 2.353 | 1.00 | |
| 411_L | 453_L | 2.353 | 1.00 | |
| 614_T | 638_V | 2.349 | 1.00 | |
| 169_S | 179_Y | 2.303 | 1.00 | |
| 71_V | 135_V | 2.295 | 1.00 | |
| 561_D | 604_Y | 2.276 | 1.00 | |
| 564_V | 602_I | 2.251 | 1.00 | |
| 356_L | 397_I | 2.233 | 1.00 | |
| 519_F | 571_L | 2.233 | 1.00 | |
| 168_S | 180_G | 2.227 | 1.00 | |
| 640_L | 662_L | 2.184 | 1.00 | |
| 293_D | 342_H | 2.184 | 1.00 | |
| 52_G | 157_Q | 2.156 | 1.00 | |
| 657_G | 689_Y | 2.142 | 1.00 | |
| 237_L | 281_A | 2.141 | 1.00 | |
| 520_Q | 546_R | 2.139 | 1.00 | |
| 415_A | 451_G | 2.132 | 1.00 | |
| 548_Q | 572_D | 2.109 | 1.00 | |
| 196_V | 225_L | 2.1 | 1.00 | |
| 358_Y | 397_I | 2.089 | 1.00 | |
| 360_N | 395_W | 2.081 | 1.00 | |
| 198_Y | 225_L | 2.079 | 1.00 | |
| 239_F | 281_A | 2.075 | 1.00 | |
| 463_I | 505_S | 2.054 | 1.00 | |
| 134_E | 153_N | 2.047 | 1.00 | |
| 350_V | 405_W | 2.04 | 1.00 | |
| 200_V | 221_A | 2.033 | 1.00 | |
| 49_V | 134_E | 2.029 | 1.00 | |
| 667_Y | 684_S | 2.01 | 1.00 | |
| 503_I | 518_L | 1.985 | 1.00 | |
| 412_S | 456_A | 1.984 | 1.00 | |
| 516_L | 550_A | 1.978 | 1.00 | |
| 109_D | 224_K | 1.969 | 1.00 | |
| 63_N | 66_E | 1.964 | 1.00 | |
| 610_W | 644_Y | 1.963 | 1.00 | |
| 467_A | 501_I | 1.949 | 1.00 | |
| 237_L | 283_L | 1.929 | 1.00 | |
| 562_F | 604_Y | 1.917 | 1.00 | |
| 195_D | 227_V | 1.909 | 1.00 | |
| 131_Q | 157_Q | 1.902 | 1.00 | |
| 236_S | 284_R | 1.9 | 1.00 | |
| 464_Y | 504_G | 1.894 | 1.00 | |
| 515_S | 553_A | 1.892 | 1.00 | |
| 526_E | 545_T | 1.888 | 1.00 | |
| 420_S | 448_L | 1.885 | 1.00 | |
| 356_L | 399_P | 1.879 | 1.00 | |
| 454_K | 462_N | 1.86 | 1.00 | |
| 567_S | 599_F | 1.858 | 1.00 | |
| 235_L | 283_L | 1.858 | 1.00 | |
| 73_G | 569_T | 1.856 | 1.00 | |
| 168_S | 694_N | 1.854 | 1.00 | |
| 166_E | 696_A | 1.852 | 1.00 | |
| 458_T | 461_W | 1.845 | 1.00 | |
| 464_Y | 517_A | 1.842 | 1.00 | |
| 297_V | 338_S | 1.838 | 1.00 | |
| 659_V | 689_Y | 1.826 | 1.00 | |
| 501_I | 522_D | 1.818 | 1.00 | |
| 519_F | 569_T | 1.817 | 1.00 | |
| 449_P | 469_R | 1.813 | 1.00 | |
| 398_D | 420_S | 1.811 | 1.00 | |
| 497_T | 525_D | 1.803 | 1.00 | |
| 612_A | 642_T | 1.803 | 1.00 | |
| 165_I | 697_W | 1.792 | 1.00 | |
| 566_A | 600_A | 1.79 | 1.00 | |
| 206_T | 217_Q | 1.778 | 1.00 | |
| 653_V | 693_M | 1.774 | 1.00 | |
| 494_K | 525_D | 1.766 | 1.00 | |
| 657_G | 691_V | 1.766 | 1.00 | |
| 639_G | 660_D | 1.757 | 1.00 | |
| 197_D | 226_G | 1.752 | 1.00 | |
| 408_S | 411_L | 1.744 | 1.00 | |
| 131_Q | 158_T | 1.738 | 1.00 | |
| 452_S | 466_A | 1.73 | 1.00 | |
| 465_L | 503_I | 1.719 | 1.00 | |
| 601_S | 615_E | 1.718 | 1.00 | |
| 232_A | 288_S | 1.713 | 1.00 | |
| 229_I | 235_L | 1.707 | 1.00 | |
| 563_R | 603_G | 1.696 | 1.00 | |
| 559_A | 562_F | 1.688 | 1.00 | |
| 300_Y | 335_G | 1.688 | 1.00 | |
| 470_G | 498_N | 1.685 | 1.00 | |
| 202_T | 221_A | 1.683 | 1.00 | |
| 357_N | 398_D | 1.678 | 1.00 | |
| 108_V | 113_A | 1.677 | 1.00 | |
| 90_I | 150_G | 1.674 | 1.00 | |
| 469_R | 497_T | 1.673 | 1.00 | |
| 55_M | 67_S | 1.668 | 1.00 | |
| 398_D | 418_R | 1.657 | 1.00 | |
| 232_A | 287_R | 1.628 | 1.00 | |
| 518_L | 548_Q | 1.621 | 1.00 | |
| 39_S | 42_D | 1.618 | 1.00 | |
| 659_V | 662_L | 1.616 | 1.00 | |
| 108_V | 156_T | 1.595 | 1.00 | |
| 614_T | 640_L | 1.595 | 1.00 | |
| 446_K | 497_T | 1.58 | 1.00 | |
| 518_L | 550_A | 1.576 | 1.00 | |
| 91_R | 551_E | 1.575 | 1.00 | |
| 519_F | 549_G | 1.572 | 1.00 | |
| 170_Y | 692_G | 1.568 | 1.00 | |
| 198_Y | 223_A | 1.566 | 1.00 | |
| 522_D | 546_R | 1.565 | 1.00 | |
| 198_Y | 202_T | 1.564 | 1.00 | |
| 514_L | 552_L | 1.556 | 1.00 | |
| 161_Q | 197_D | 1.552 | 1.00 | |
| 558_F | 602_I | 1.546 | 1.00 | |
| 406_Q | 412_S | 1.544 | 1.00 | |
| 410_K | 457_M | 1.541 | 1.00 | |
| 170_Y | 178_R | 1.532 | 1.00 | |
| 358_Y | 395_W | 1.518 | 1.00 | |
| 449_P | 453_L | 1.515 | 1.00 | |
| 351_T | 406_Q | 1.512 | 1.00 | |
| 457_M | 505_S | 1.508 | 1.00 | |
| 48_S | 137_R | 1.508 | 1.00 | |
| 407_L | 413_L | 1.503 | 1.00 | |
| 354_T | 401_L | 1.498 | 1.00 | |
| 603_G | 613_G | 1.497 | 1.00 | |
| 617_R | 637_L | 1.496 | 1.00 | |
| 658_R | 690_G | 1.495 | 1.00 | |
| 172_G | 176_S | 1.494 | 1.00 | |
| 339_R | 400_Y | 1.493 | 1.00 | |
| 109_D | 156_T | 1.492 | 1.00 | |
| 619_M | 635_Y | 1.488 | 1.00 | |
| 507_T | 514_L | 1.487 | 1.00 | |
| 53_E | 56_R | 1.486 | 1.00 | |
| 181_L | 202_T | 1.478 | 1.00 | |
| 163_P | 183_A | 1.478 | 1.00 | |
| 464_Y | 506_K | 1.474 | 1.00 | |
| 203_T | 220_L | 1.469 | 1.00 | |
| 74_L | 90_I | 1.466 | 1.00 | |
| 226_G | 234_K | 1.46 | 1.00 | |
| 66_E | 69_T | 1.458 | 1.00 | |
| 166_E | 694_N | 1.455 | 1.00 | |
| 53_E | 58_A | 1.453 | 1.00 | |
| 42_D | 456_A | 1.439 | 1.00 | |
| 204_R | 217_Q | 1.439 | 1.00 | |
| 360_N | 393_L | 1.437 | 1.00 | |
| 465_L | 501_I | 1.434 | 1.00 | |
| 421_S | 445_H | 1.432 | 1.00 | |
| 188_G | 195_D | 1.427 | 1.00 | |
| 453_L | 465_L | 1.416 | 1.00 | |
| 286_E | 296_S | 1.414 | 1.00 | |
| 407_L | 453_L | 1.402 | 0.99 | |
| 175_G | 208_H | 1.4 | 0.99 | |
| 522_D | 544_K | 1.397 | 0.99 | |
| 109_D | 238_I | 1.388 | 0.99 | |
| 228_R | 234_K | 1.385 | 0.99 | |
| 472_E | 478_E | 1.384 | 0.99 | |
| 637_L | 667_Y | 1.382 | 0.99 | |
| 497_T | 524_D | 1.378 | 0.99 | |
| 568_W | 598_G | 1.377 | 0.99 | |
| 299_M | 334_Q | 1.363 | 0.99 | |
| 571_L | 593_I | 1.36 | 0.99 | |
| 633_P | 665_K | 1.355 | 0.99 | |
| 500_T | 521_T | 1.355 | 0.99 | |
| 168_S | 692_G | 1.345 | 0.99 | |
| 610_W | 642_T | 1.342 | 0.99 | |
| 221_A | 241_S | 1.328 | 0.99 | |
| 91_R | 502_E | 1.327 | 0.99 | |
| 402_Q | 414_D | 1.321 | 0.99 | |
| 609_G | 644_Y | 1.317 | 0.99 | |
| 137_R | 551_E | 1.317 | 0.99 | |
| 160_Q | 184_T | 1.314 | 0.99 | |
| 135_V | 152_M | 1.312 | 0.99 | |
| 563_R | 605_V | 1.312 | 0.99 | |
| 659_V | 687_R | 1.311 | 0.99 | |
| 351_T | 404_Q | 1.31 | 0.99 | |
| 569_T | 597_M | 1.307 | 0.99 | |
| 598_G | 618_Y | 1.305 | 0.99 | |
| 472_E | 496_S | 1.305 | 0.99 | |
| 72_P | 567_S | 1.304 | 0.99 | |
| 505_S | 516_L | 1.301 | 0.99 | |
| 638_V | 662_L | 1.3 | 0.99 | |
| 570_W | 595_R | 1.299 | 0.99 | |
| 171_Y | 175_G | 1.297 | 0.99 | |
| 660_D | 688_N | 1.296 | 0.99 | |
| 301_A | 334_Q | 1.285 | 0.99 | |
| 142_A | 416_G | 1.282 | 0.99 | |
| 528_V | 542_A | 1.278 | 0.99 | |
| 596_N | 620_G | 1.274 | 0.99 | |
| 195_D | 229_I | 1.273 | 0.99 | |
| 637_L | 684_S | 1.267 | 0.99 | |
| 545_T | 590_M | 1.266 | 0.99 | |
| 126_D | 129_S | 1.266 | 0.99 | |
| 643_G | 654_D | 1.264 | 0.99 | |
| 134_E | 155_T | 1.262 | 0.99 | |
| 158_T | 224_K | 1.262 | 0.99 | |
| 645_K | 696_A | 1.261 | 0.99 | |
| 286_E | 294_D | 1.26 | 0.99 | |
| 164_T | 184_T | 1.259 | 0.99 | |
| 550_A | 570_W | 1.256 | 0.99 | |
| 54_E | 58_A | 1.256 | 0.99 | |
| 352_F | 403_T | 1.255 | 0.99 | |
| 654_D | 694_N | 1.251 | 0.99 | |
| 463_I | 503_I | 1.249 | 0.99 | |
| 653_V | 657_G | 1.248 | 0.99 | |
| 226_G | 236_S | 1.248 | 0.99 | |
| 655_L | 693_M | 1.246 | 0.98 | |
| 646_Y | 655_L | 1.246 | 0.98 | |
| 413_L | 451_G | 1.241 | 0.98 | |
| 405_W | 415_A | 1.238 | 0.98 | |
| 197_D | 228_R | 1.235 | 0.98 | |
| 496_S | 523_T | 1.233 | 0.98 | |
| 645_K | 654_D | 1.232 | 0.98 | |
| 166_E | 182_K | 1.226 | 0.98 | |
| 171_Y | 177_W | 1.222 | 0.98 | |
| 297_V | 336_I | 1.212 | 0.98 | |
| 238_I | 282_G | 1.212 | 0.98 | |
| 506_K | 515_S | 1.211 | 0.98 | |
| 299_M | 336_I | 1.208 | 0.98 | |
| 603_G | 611_Y | 1.205 | 0.98 | |
| 343_R | 351_T | 1.202 | 0.98 | |
| 589_R | 595_R | 1.199 | 0.98 | |
| 293_D | 340_W | 1.196 | 0.98 | |
| 295_M | 338_S | 1.196 | 0.98 | |
| 404_Q | 412_S | 1.196 | 0.98 | |
| 512_G | 556_Q | 1.195 | 0.98 | |
| 640_L | 659_V | 1.189 | 0.98 | |
| 234_K | 288_S | 1.186 | 0.98 | |
| 501_I | 520_Q | 1.182 | 0.98 | |
| 588_N | 628_N | 1.174 | 0.98 | |
| 52_G | 131_Q | 1.162 | 0.97 | |
| 513_L | 555_D | 1.162 | 0.97 | |
| 229_I | 285_Y | 1.16 | 0.97 | |
| 502_E | 517_A | 1.16 | 0.97 | |
| 241_S | 277_K | 1.16 | 0.97 | |
| 167_A | 695_I | 1.157 | 0.97 | |
| 167_A | 181_L | 1.154 | 0.97 | |
| 59_T | 70_G | 1.15 | 0.97 | |
| 623_M | 631_K | 1.15 | 0.97 | |
| 453_L | 457_M | 1.147 | 0.97 | |
| 201_S | 222_N | 1.144 | 0.97 | |
| 183_A | 200_V | 1.136 | 0.97 | |
| 457_M | 461_W | 1.136 | 0.97 | |
| 460_A | 507_T | 1.135 | 0.97 | |
| 421_S | 443_S | 1.133 | 0.97 | |
| 163_P | 185_G | 1.131 | 0.97 | |
| 555_D | 563_R | 1.125 | 0.97 | |
| 614_T | 662_L | 1.125 | 0.97 | |
| 90_I | 135_V | 1.123 | 0.97 | |
| 509_I | 514_L | 1.116 | 0.96 | |
| 519_F | 551_E | 1.115 | 0.96 | |
| 34_A | 38_V | 1.115 | 0.96 | |
| 456_A | 462_N | 1.114 | 0.96 | |
| 49_V | 132_N | 1.111 | 0.96 | |
| 144_Y | 151_V | 1.108 | 0.96 | |
| 554_W | 566_A | 1.104 | 0.96 | |
| 664_D | 686_G | 1.102 | 0.96 | |
| 293_D | 354_T | 1.1 | 0.96 | |
| 606_P | 612_A | 1.094 | 0.96 | |
| 397_I | 421_S | 1.086 | 0.96 | |
| 210_Y | 686_G | 1.085 | 0.96 | |
| 229_I | 233_S | 1.082 | 0.96 | |
| 72_P | 553_A | 1.077 | 0.95 | |
| 64_L | 154_V | 1.076 | 0.95 | |
| 611_Y | 645_K | 1.064 | 0.95 | |
| 404_Q | 414_D | 1.062 | 0.95 | |
| 179_Y | 204_R | 1.062 | 0.95 | |
| 564_V | 600_A | 1.061 | 0.95 | |
| 240_N | 280_Q | 1.053 | 0.95 | |
| 182_K | 201_S | 1.052 | 0.95 | |
| 693_M | 697_W | 1.047 | 0.94 | |
| 547_R | 573_A | 1.047 | 0.94 | |
| 558_F | 564_V | 1.047 | 0.94 | |
| 48_S | 553_A | 1.046 | 0.94 | |
| 224_K | 236_S | 1.041 | 0.94 | |
| 182_K | 199_T | 1.039 | 0.94 | |
| 412_S | 454_K | 1.038 | 0.94 | |
| 61_R | 67_S | 1.037 | 0.94 | |
| 642_T | 659_V | 1.036 | 0.94 | |
| 230_D | 287_R | 1.033 | 0.94 | |
| 530_D | 540_K | 1.033 | 0.94 | |
| 165_I | 181_L | 1.032 | 0.94 | |
| 289_L | 295_M | 1.031 | 0.94 | |
| 475_T | 493_L | 1.029 | 0.94 | |
| 160_Q | 164_T | 1.029 | 0.94 | |
| 137_R | 553_A | 1.024 | 0.93 | |
| 691_V | 695_I | 1.02 | 0.93 | |
| 636_T | 665_K | 1.018 | 0.93 | |
| 158_T | 226_G | 1.018 | 0.93 | |
| 566_A | 598_G | 1.016 | 0.93 | |
| 105_R | 112_P | 1.014 | 0.93 | |
| 284_R | 298_M | 1.013 | 0.93 | |
| 188_G | 193_P | 1.011 | 0.93 | |
| 169_S | 177_W | 1.011 | 0.93 | |
| 50_V | 71_V | 1.003 | 0.93 | |
| 647_N | 650_N | 1.002 | 0.92 | |
| 415_A | 453_L | 1.002 | 0.92 | |
| 88_L | 152_M | 1.001 | 0.92 | |
| 348_V | 405_W | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4epaA | 1 | 0.9143 | 100 | 0.255 | Contact Map | 0.727 |
| 1qfgA | 1 | 0.9286 | 100 | 0.258 | Contact Map | 0.761 |
| 3efmA | 1 | 0.9186 | 100 | 0.26 | Contact Map | 0.817 |
| 1xkwA | 1 | 0.9043 | 100 | 0.265 | Contact Map | 0.79 |
| 3qlbA | 2 | 0.9371 | 100 | 0.269 | Contact Map | 0.789 |
| 2hdiA | 1 | 0.8243 | 100 | 0.275 | Contact Map | 0.771 |
| 1kmoA | 1 | 0.9286 | 100 | 0.279 | Contact Map | 0.78 |
| 2gufA | 1 | 0.8186 | 100 | 0.285 | Contact Map | 0.765 |
| 4b7oA | 1 | 0.9229 | 100 | 0.291 | Contact Map | 0.748 |
| 3fhhA | 1 | 0.8586 | 100 | 0.292 | Contact Map | 0.73 |
Sequence Conservation (Image Generated using WebLogo v3)