| UniProt: | P13036 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10286 | ||
| Length: | 774 (683) | ||
| Sequences: | 13122 | ||
| Seq/Len: | 19.21 |
| FECA
Paralog alert: 0.92 [within 20: 0.27] - ratio of genomes with paralogs Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 643_Y | 667_H | 5.452 | 1.00 | |
| 686_S | 715_M | 4.722 | 1.00 | |
| 592_L | 617_T | 4.601 | 1.00 | |
| 328_H | 379_F | 4.478 | 1.00 | |
| 499_M | 524_P | 4.471 | 1.00 | |
| 501_F | 522_N | 4.3 | 1.00 | |
| 717_W | 742_F | 4.238 | 1.00 | |
| 538_W | 577_T | 3.774 | 1.00 | |
| 544_T | 571_R | 3.74 | 1.00 | |
| 681_T | 722_A | 3.396 | 1.00 | |
| 493_W | 532_Y | 3.384 | 1.00 | |
| 224_A | 248_V | 3.353 | 1.00 | |
| 546_G | 571_R | 3.346 | 1.00 | |
| 330_F | 377_Y | 3.235 | 1.00 | |
| 222_M | 247_F | 3.19 | 1.00 | |
| 328_H | 377_Y | 3.132 | 1.00 | |
| 492_N | 532_Y | 3.038 | 1.00 | |
| 435_H | 486_D | 3.008 | 1.00 | |
| 588_M | 621_T | 2.983 | 1.00 | |
| 336_Y | 371_K | 2.946 | 1.00 | |
| 735_A | 769_Q | 2.942 | 1.00 | |
| 645_Y | 667_H | 2.906 | 1.00 | |
| 534_L | 540_L | 2.837 | 1.00 | |
| 615_R | 651_R | 2.74 | 1.00 | |
| 142_R | 146_A | 2.73 | 1.00 | |
| 688_F | 715_M | 2.699 | 1.00 | |
| 291_F | 322_Y | 2.668 | 1.00 | |
| 334_L | 371_K | 2.668 | 1.00 | |
| 389_I | 422_P | 2.642 | 1.00 | |
| 495_I | 530_V | 2.638 | 1.00 | |
| 440_G | 483_Y | 2.612 | 1.00 | |
| 329_T | 378_Q | 2.59 | 1.00 | |
| 299_G | 314_D | 2.579 | 1.00 | |
| 640_Y | 672_G | 2.544 | 1.00 | |
| 686_S | 717_W | 2.538 | 1.00 | |
| 736_F | 766_L | 2.537 | 1.00 | |
| 637_V | 673_V | 2.47 | 1.00 | |
| 719_A | 741_I | 2.459 | 1.00 | |
| 501_F | 524_P | 2.458 | 1.00 | |
| 591_F | 646_V | 2.454 | 1.00 | |
| 732_L | 772_L | 2.454 | 1.00 | |
| 691_S | 710_R | 2.432 | 1.00 | |
| 334_L | 373_A | 2.413 | 1.00 | |
| 586_A | 623_A | 2.396 | 1.00 | |
| 688_F | 713_G | 2.388 | 1.00 | |
| 685_N | 718_G | 2.359 | 1.00 | |
| 684_L | 717_W | 2.358 | 1.00 | |
| 734_L | 770_G | 2.357 | 1.00 | |
| 332_S | 373_A | 2.355 | 1.00 | |
| 627_L | 634_L | 2.326 | 1.00 | |
| 297_Y | 314_D | 2.314 | 1.00 | |
| 493_W | 530_V | 2.301 | 1.00 | |
| 445_N | 478_E | 2.296 | 1.00 | |
| 687_D | 718_G | 2.287 | 1.00 | |
| 332_S | 375_L | 2.285 | 1.00 | |
| 141_R | 144_D | 2.254 | 1.00 | |
| 639_I | 673_V | 2.253 | 1.00 | |
| 385_H | 426_Q | 2.252 | 1.00 | |
| 338_D | 369_R | 2.249 | 1.00 | |
| 575_L | 590_L | 2.243 | 1.00 | |
| 139_V | 226_D | 2.23 | 1.00 | |
| 441_Y | 480_H | 2.229 | 1.00 | |
| 540_L | 577_T | 2.217 | 1.00 | |
| 295_L | 318_L | 2.214 | 1.00 | |
| 584_L | 625_Y | 2.206 | 1.00 | |
| 391_G | 418_R | 2.202 | 1.00 | |
| 389_I | 420_I | 2.192 | 1.00 | |
| 226_D | 246_N | 2.189 | 1.00 | |
| 737_G | 767_Y | 2.184 | 1.00 | |
| 732_L | 770_G | 2.155 | 1.00 | |
| 538_W | 579_Y | 2.144 | 1.00 | |
| 160_I | 227_V | 2.136 | 1.00 | |
| 441_Y | 482_W | 2.132 | 1.00 | |
| 617_T | 647_N | 2.119 | 1.00 | |
| 683_N | 720_R | 2.115 | 1.00 | |
| 325_D | 328_H | 2.113 | 1.00 | |
| 592_L | 615_R | 2.112 | 1.00 | |
| 682_F | 721_V | 2.101 | 1.00 | |
| 393_Y | 418_R | 2.092 | 1.00 | |
| 636_N | 675_Y | 2.081 | 1.00 | |
| 738_V | 741_I | 2.061 | 1.00 | |
| 588_M | 619_L | 2.052 | 1.00 | |
| 746_Y | 761_G | 2.044 | 1.00 | |
| 541_Y | 589_G | 2.044 | 1.00 | |
| 497_P | 528_L | 2.043 | 1.00 | |
| 443_Y | 480_H | 2.01 | 1.00 | |
| 544_T | 573_W | 2.004 | 1.00 | |
| 261_G | 771_S | 2 | 1.00 | |
| 738_V | 766_L | 1.998 | 1.00 | |
| 722_A | 733_N | 1.997 | 1.00 | |
| 494_T | 533_H | 1.989 | 1.00 | |
| 259_E | 773_K | 1.98 | 1.00 | |
| 162_G | 644_A | 1.977 | 1.00 | |
| 435_H | 488_I | 1.971 | 1.00 | |
| 598_Q | 614_T | 1.97 | 1.00 | |
| 223_D | 250_R | 1.966 | 1.00 | |
| 258_I | 283_V | 1.951 | 1.00 | |
| 327_V | 379_F | 1.942 | 1.00 | |
| 285_G | 293_T | 1.939 | 1.00 | |
| 736_F | 768_M | 1.921 | 1.00 | |
| 724_D | 733_N | 1.911 | 1.00 | |
| 330_F | 375_L | 1.891 | 1.00 | |
| 733_N | 771_S | 1.887 | 1.00 | |
| 680_W | 723_Y | 1.883 | 1.00 | |
| 531_L | 539_N | 1.877 | 1.00 | |
| 391_G | 420_I | 1.869 | 1.00 | |
| 262_V | 279_H | 1.861 | 1.00 | |
| 392_F | 419_G | 1.858 | 1.00 | |
| 591_F | 644_A | 1.851 | 1.00 | |
| 385_H | 424_Y | 1.848 | 1.00 | |
| 542_A | 575_L | 1.843 | 1.00 | |
| 293_T | 320_S | 1.841 | 1.00 | |
| 566_E | 597_N | 1.817 | 1.00 | |
| 331_N | 376_G | 1.808 | 1.00 | |
| 301_R | 312_R | 1.807 | 1.00 | |
| 143_E | 147_K | 1.801 | 1.00 | |
| 725_F | 734_L | 1.799 | 1.00 | |
| 183_R | 620_E | 1.787 | 1.00 | |
| 573_W | 594_N | 1.772 | 1.00 | |
| 642_S | 670_T | 1.767 | 1.00 | |
| 295_L | 316_L | 1.765 | 1.00 | |
| 641_A | 671_L | 1.754 | 1.00 | |
| 258_I | 774_F | 1.752 | 1.00 | |
| 327_V | 380_Q | 1.742 | 1.00 | |
| 738_V | 764_R | 1.736 | 1.00 | |
| 197_M | 202_V | 1.732 | 1.00 | |
| 535_T | 538_W | 1.728 | 1.00 | |
| 523_A | 569_K | 1.718 | 1.00 | |
| 546_G | 569_K | 1.714 | 1.00 | |
| 481_A | 502_E | 1.711 | 1.00 | |
| 529_N | 543_N | 1.702 | 1.00 | |
| 152_T | 155_E | 1.686 | 1.00 | |
| 436_E | 489_D | 1.684 | 1.00 | |
| 197_M | 249_T | 1.674 | 1.00 | |
| 672_G | 685_N | 1.664 | 1.00 | |
| 569_K | 597_N | 1.654 | 1.00 | |
| 223_D | 251_A | 1.642 | 1.00 | |
| 182_I | 243_G | 1.642 | 1.00 | |
| 142_R | 250_R | 1.639 | 1.00 | |
| 502_E | 525_L | 1.636 | 1.00 | |
| 198_D | 319_K | 1.633 | 1.00 | |
| 718_G | 739_K | 1.632 | 1.00 | |
| 261_G | 280_N | 1.624 | 1.00 | |
| 534_L | 577_T | 1.623 | 1.00 | |
| 297_Y | 316_L | 1.616 | 1.00 | |
| 587_E | 622_Q | 1.616 | 1.00 | |
| 138_D | 229_R | 1.613 | 1.00 | |
| 198_D | 333_L | 1.611 | 1.00 | |
| 290_G | 322_Y | 1.609 | 1.00 | |
| 541_Y | 576_G | 1.605 | 1.00 | |
| 293_T | 297_Y | 1.602 | 1.00 | |
| 378_Q | 386_K | 1.6 | 1.00 | |
| 637_V | 675_Y | 1.589 | 1.00 | |
| 717_W | 741_I | 1.586 | 1.00 | |
| 145_F | 156_V | 1.583 | 1.00 | |
| 684_L | 719_A | 1.578 | 1.00 | |
| 263_E | 769_Q | 1.57 | 1.00 | |
| 590_L | 619_L | 1.569 | 1.00 | |
| 734_L | 768_M | 1.566 | 1.00 | |
| 492_N | 534_L | 1.566 | 1.00 | |
| 387_F | 422_P | 1.566 | 1.00 | |
| 594_N | 615_R | 1.55 | 1.00 | |
| 526_P | 546_G | 1.55 | 1.00 | |
| 291_F | 320_S | 1.546 | 1.00 | |
| 293_T | 318_L | 1.545 | 1.00 | |
| 198_D | 249_T | 1.537 | 1.00 | |
| 112_E | 115_L | 1.532 | 1.00 | |
| 129_D | 132_E | 1.531 | 1.00 | |
| 395_Q | 416_W | 1.53 | 1.00 | |
| 321_K | 329_T | 1.529 | 1.00 | |
| 490_I | 530_V | 1.528 | 1.00 | |
| 442_R | 481_A | 1.525 | 1.00 | |
| 725_F | 732_L | 1.52 | 1.00 | |
| 627_L | 673_V | 1.511 | 1.00 | |
| 542_A | 573_W | 1.504 | 1.00 | |
| 716_L | 761_G | 1.5 | 1.00 | |
| 481_A | 500_R | 1.5 | 1.00 | |
| 423_R | 483_Y | 1.496 | 1.00 | |
| 638_S | 674_D | 1.489 | 1.00 | |
| 547_S | 570_A | 1.483 | 1.00 | |
| 387_F | 424_Y | 1.472 | 1.00 | |
| 143_E | 146_A | 1.471 | 1.00 | |
| 503_H | 522_N | 1.47 | 1.00 | |
| 594_N | 613_K | 1.466 | 1.00 | |
| 687_D | 716_L | 1.464 | 1.00 | |
| 489_D | 494_T | 1.462 | 1.00 | |
| 490_I | 495_I | 1.455 | 1.00 | |
| 292_G | 321_K | 1.451 | 1.00 | |
| 669_G | 688_F | 1.449 | 1.00 | |
| 323_A | 329_T | 1.439 | 1.00 | |
| 614_T | 661_V | 1.436 | 1.00 | |
| 324_P | 330_F | 1.435 | 1.00 | |
| 445_N | 476_G | 1.413 | 1.00 | |
| 634_L | 637_V | 1.406 | 0.99 | |
| 132_E | 533_H | 1.405 | 0.99 | |
| 378_Q | 388_N | 1.402 | 0.99 | |
| 590_L | 617_T | 1.397 | 0.99 | |
| 577_T | 588_M | 1.385 | 0.99 | |
| 495_I | 528_L | 1.379 | 0.99 | |
| 443_Y | 478_E | 1.379 | 0.99 | |
| 741_I | 764_R | 1.377 | 0.99 | |
| 427_I | 436_E | 1.376 | 0.99 | |
| 643_Y | 669_G | 1.373 | 0.99 | |
| 572_T | 593_I | 1.366 | 0.99 | |
| 674_D | 683_N | 1.365 | 0.99 | |
| 388_N | 423_R | 1.364 | 0.99 | |
| 439_V | 484_L | 1.357 | 0.99 | |
| 689_Q | 714_F | 1.356 | 0.99 | |
| 684_L | 741_I | 1.348 | 0.99 | |
| 163_V | 182_I | 1.344 | 0.99 | |
| 646_V | 664_S | 1.344 | 0.99 | |
| 503_H | 520_S | 1.341 | 0.99 | |
| 148_T | 159_R | 1.339 | 0.99 | |
| 659_N | 698_N | 1.334 | 0.99 | |
| 226_D | 248_V | 1.333 | 0.99 | |
| 733_N | 773_K | 1.325 | 0.99 | |
| 298_S | 315_D | 1.324 | 0.99 | |
| 253_P | 284_G | 1.319 | 0.99 | |
| 436_E | 487_K | 1.318 | 0.99 | |
| 591_F | 618_G | 1.318 | 0.99 | |
| 584_L | 623_A | 1.311 | 0.99 | |
| 680_W | 721_V | 1.311 | 0.99 | |
| 382_D | 385_H | 1.31 | 0.99 | |
| 579_Y | 586_A | 1.309 | 0.99 | |
| 299_G | 312_R | 1.309 | 0.99 | |
| 721_V | 738_V | 1.305 | 0.99 | |
| 619_L | 645_Y | 1.299 | 0.99 | |
| 644_A | 668_K | 1.299 | 0.99 | |
| 724_D | 773_K | 1.297 | 0.99 | |
| 236_Y | 244_V | 1.294 | 0.99 | |
| 719_A | 738_V | 1.29 | 0.99 | |
| 720_R | 735_A | 1.285 | 0.99 | |
| 585_T | 624_R | 1.284 | 0.99 | |
| 530_V | 534_L | 1.284 | 0.99 | |
| 739_K | 765_T | 1.278 | 0.99 | |
| 200_I | 390_Q | 1.275 | 0.99 | |
| 645_Y | 666_K | 1.274 | 0.99 | |
| 251_A | 319_K | 1.274 | 0.99 | |
| 712_P | 744_Q | 1.27 | 0.99 | |
| 583_A | 625_Y | 1.267 | 0.99 | |
| 549_G | 568_E | 1.266 | 0.99 | |
| 112_E | 117_V | 1.261 | 0.99 | |
| 155_E | 158_N | 1.261 | 0.99 | |
| 623_A | 641_A | 1.255 | 0.99 | |
| 586_A | 621_T | 1.247 | 0.99 | |
| 530_V | 542_A | 1.246 | 0.98 | |
| 638_S | 676_K | 1.245 | 0.98 | |
| 124_D | 128_N | 1.243 | 0.98 | |
| 281_L | 297_Y | 1.241 | 0.98 | |
| 329_T | 380_Q | 1.239 | 0.98 | |
| 726_G | 731_D | 1.239 | 0.98 | |
| 180_F | 245_V | 1.233 | 0.98 | |
| 674_D | 681_T | 1.229 | 0.98 | |
| 541_Y | 578_R | 1.227 | 0.98 | |
| 259_E | 771_S | 1.225 | 0.98 | |
| 573_W | 592_L | 1.221 | 0.98 | |
| 716_L | 746_Y | 1.218 | 0.98 | |
| 568_E | 595_F | 1.214 | 0.98 | |
| 526_P | 530_V | 1.212 | 0.98 | |
| 380_Q | 386_K | 1.207 | 0.98 | |
| 316_L | 336_Y | 1.2 | 0.98 | |
| 430_I | 433_S | 1.198 | 0.98 | |
| 270_S | 274_N | 1.195 | 0.98 | |
| 229_R | 620_E | 1.192 | 0.98 | |
| 667_H | 690_S | 1.185 | 0.98 | |
| 321_K | 331_N | 1.184 | 0.98 | |
| 254_Q | 292_G | 1.184 | 0.98 | |
| 569_K | 596_N | 1.177 | 0.98 | |
| 261_G | 769_Q | 1.17 | 0.97 | |
| 487_K | 494_T | 1.169 | 0.97 | |
| 273_N | 303_S | 1.169 | 0.97 | |
| 200_I | 392_F | 1.168 | 0.97 | |
| 144_D | 147_K | 1.167 | 0.97 | |
| 333_L | 374_S | 1.161 | 0.97 | |
| 324_P | 377_Y | 1.159 | 0.97 | |
| 485_D | 496_T | 1.146 | 0.97 | |
| 600_D | 611_R | 1.144 | 0.97 | |
| 138_D | 622_Q | 1.139 | 0.97 | |
| 735_A | 771_S | 1.136 | 0.97 | |
| 381_P | 387_F | 1.135 | 0.97 | |
| 253_P | 257_G | 1.131 | 0.97 | |
| 613_K | 652_E | 1.131 | 0.97 | |
| 534_L | 538_W | 1.13 | 0.97 | |
| 183_R | 574_E | 1.13 | 0.97 | |
| 437_V | 486_D | 1.129 | 0.97 | |
| 494_T | 531_L | 1.126 | 0.97 | |
| 731_D | 772_L | 1.126 | 0.97 | |
| 199_G | 246_N | 1.121 | 0.97 | |
| 257_G | 284_G | 1.118 | 0.96 | |
| 533_H | 539_N | 1.116 | 0.96 | |
| 480_H | 503_H | 1.114 | 0.96 | |
| 292_G | 323_A | 1.114 | 0.96 | |
| 568_E | 598_Q | 1.107 | 0.96 | |
| 196_L | 244_V | 1.104 | 0.96 | |
| 161_P | 642_S | 1.096 | 0.96 | |
| 325_D | 379_F | 1.094 | 0.96 | |
| 429_M | 434_A | 1.09 | 0.96 | |
| 156_V | 225_I | 1.089 | 0.96 | |
| 565_V | 599_Y | 1.087 | 0.96 | |
| 153_M | 247_F | 1.086 | 0.96 | |
| 641_A | 669_G | 1.086 | 0.96 | |
| 112_E | 116_T | 1.084 | 0.96 | |
| 260_A | 772_L | 1.084 | 0.96 | |
| 388_N | 425_S | 1.082 | 0.96 | |
| 229_R | 622_Q | 1.081 | 0.95 | |
| 526_P | 544_T | 1.08 | 0.95 | |
| 335_Q | 372_L | 1.077 | 0.95 | |
| 140_I | 160_I | 1.074 | 0.95 | |
| 430_I | 435_H | 1.07 | 0.95 | |
| 627_L | 639_I | 1.067 | 0.95 | |
| 488_I | 497_P | 1.063 | 0.95 | |
| 660_L | 666_K | 1.059 | 0.95 | |
| 770_G | 774_F | 1.049 | 0.94 | |
| 386_K | 425_S | 1.047 | 0.94 | |
| 145_F | 150_A | 1.045 | 0.94 | |
| 183_R | 618_G | 1.043 | 0.94 | |
| 540_L | 575_L | 1.043 | 0.94 | |
| 695_D | 699_T | 1.04 | 0.94 | |
| 732_L | 736_F | 1.035 | 0.94 | |
| 264_G | 273_N | 1.031 | 0.94 | |
| 381_P | 424_Y | 1.03 | 0.94 | |
| 139_V | 224_A | 1.026 | 0.94 | |
| 726_G | 732_L | 1.026 | 0.94 | |
| 227_V | 245_V | 1.024 | 0.93 | |
| 256_F | 283_V | 1.022 | 0.93 | |
| 667_H | 688_F | 1.02 | 0.93 | |
| 142_R | 223_D | 1.019 | 0.93 | |
| 591_F | 620_E | 1.017 | 0.93 | |
| 263_E | 278_T | 1.014 | 0.93 | |
| 693_F | 698_N | 1.013 | 0.93 | |
| 433_S | 488_I | 1.012 | 0.93 | |
| 639_I | 671_L | 1.012 | 0.93 | |
| 142_R | 145_F | 1.011 | 0.93 | |
| 682_F | 719_A | 1.01 | 0.93 | |
| 385_H | 437_V | 1.009 | 0.93 | |
| 336_Y | 369_R | 1.007 | 0.93 | |
| 330_F | 334_L | 1.007 | 0.93 | |
| 185_L | 595_F | 1.007 | 0.93 | |
| 144_D | 148_T | 1.004 | 0.93 | |
| 722_A | 735_A | 1.003 | 0.93 | |
| 505_E | 518_E | 1.002 | 0.92 | |
| 768_M | 772_L | 1.001 | 0.92 | |
| 616_H | 648_A | 1.001 | 0.92 | |
| 499_M | 526_P | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1kmoA | 1 | 0.9987 | 100 | 0.197 | Contact Map | 0.785 |
| 2w16A | 2 | 0.9018 | 100 | 0.297 | Contact Map | 0.814 |
| 3cslA | 2 | 0.9199 | 100 | 0.326 | Contact Map | 0.703 |
| 1qfgA | 1 | 0.8385 | 100 | 0.361 | Contact Map | 0.75 |
| 3efmA | 1 | 0.8333 | 100 | 0.362 | Contact Map | 0.801 |
| 4epaA | 1 | 0.8023 | 100 | 0.365 | Contact Map | 0.731 |
| 1xkwA | 1 | 0.7946 | 100 | 0.365 | Contact Map | 0.787 |
| 3qlbA | 2 | 0.8734 | 100 | 0.371 | Contact Map | 0.795 |
| 2gufA | 1 | 0.7468 | 100 | 0.377 | Contact Map | 0.768 |
| 2hdiA | 1 | 0.7442 | 100 | 0.387 | Contact Map | 0.781 |
Sequence Conservation (Image Generated using WebLogo v3)