| UniProt: | P16869 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10306 | ||
| Length: | 729 (670) | ||
| Sequences: | 14624 | ||
| Seq/Len: | 21.83 |
| FHUE
Paralog alert: 0.92 [within 20: 0.31] - ratio of genomes with paralogs Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 610_A | 630_T | 5.582 | 1.00 | |
| 558_R | 590_K | 4.698 | 1.00 | |
| 473_A | 492_T | 4.629 | 1.00 | |
| 652_V | 677_A | 4.48 | 1.00 | |
| 475_Y | 490_N | 4.3 | 1.00 | |
| 679_V | 701_F | 4.3 | 1.00 | |
| 512_Y | 535_N | 3.714 | 1.00 | |
| 506_W | 541_L | 3.694 | 1.00 | |
| 257_T | 316_Q | 3.617 | 1.00 | |
| 397_H | 459_T | 3.566 | 1.00 | |
| 514_S | 535_N | 3.451 | 1.00 | |
| 467_L | 500_F | 3.266 | 1.00 | |
| 647_T | 684_R | 3.254 | 1.00 | |
| 87_Q | 91_E | 3.222 | 1.00 | |
| 157_R | 181_V | 3.2 | 1.00 | |
| 220_I | 251_A | 3.17 | 1.00 | |
| 554_L | 594_F | 3.16 | 1.00 | |
| 466_P | 500_F | 3.145 | 1.00 | |
| 694_Q | 724_T | 3.121 | 1.00 | |
| 155_F | 180_M | 3.081 | 1.00 | |
| 228_Y | 243_T | 2.741 | 1.00 | |
| 502_I | 508_T | 2.734 | 1.00 | |
| 612_R | 630_T | 2.644 | 1.00 | |
| 607_T | 635_F | 2.634 | 1.00 | |
| 654_W | 677_A | 2.625 | 1.00 | |
| 604_W | 636_T | 2.617 | 1.00 | |
| 652_V | 679_V | 2.609 | 1.00 | |
| 506_W | 543_S | 2.555 | 1.00 | |
| 469_L | 498_L | 2.539 | 1.00 | |
| 192_G | 210_L | 2.532 | 1.00 | |
| 257_T | 314_L | 2.522 | 1.00 | |
| 475_Y | 492_T | 2.513 | 1.00 | |
| 212_S | 222_A | 2.499 | 1.00 | |
| 265_Y | 308_N | 2.489 | 1.00 | |
| 402_G | 456_Y | 2.488 | 1.00 | |
| 691_F | 727_Y | 2.479 | 1.00 | |
| 552_T | 596_L | 2.478 | 1.00 | |
| 657_R | 672_E | 2.468 | 1.00 | |
| 695_G | 721_F | 2.463 | 1.00 | |
| 681_L | 700_L | 2.459 | 1.00 | |
| 693_L | 725_G | 2.432 | 1.00 | |
| 550_L | 598_G | 2.424 | 1.00 | |
| 467_L | 498_L | 2.366 | 1.00 | |
| 196_A | 206_Y | 2.359 | 1.00 | |
| 606_L | 636_T | 2.355 | 1.00 | |
| 649_G | 682_F | 2.355 | 1.00 | |
| 653_N | 680_D | 2.333 | 1.00 | |
| 696_N | 722_S | 2.321 | 1.00 | |
| 254_G | 257_T | 2.319 | 1.00 | |
| 195_S | 726_T | 2.314 | 1.00 | |
| 654_W | 675_S | 2.308 | 1.00 | |
| 86_S | 89_R | 2.302 | 1.00 | |
| 193_D | 728_Q | 2.299 | 1.00 | |
| 226_G | 243_T | 2.294 | 1.00 | |
| 192_G | 729_F | 2.264 | 1.00 | |
| 651_G | 680_D | 2.261 | 1.00 | |
| 558_R | 588_V | 2.221 | 1.00 | |
| 705_Y | 716_G | 2.221 | 1.00 | |
| 603_N | 638_Y | 2.209 | 1.00 | |
| 407_K | 451_H | 2.204 | 1.00 | |
| 508_T | 541_L | 2.189 | 1.00 | |
| 258_T | 315_K | 2.169 | 1.00 | |
| 650_G | 679_V | 2.168 | 1.00 | |
| 684_R | 692_S | 2.162 | 1.00 | |
| 105_T | 160_V | 2.157 | 1.00 | |
| 263_Y | 308_N | 2.151 | 1.00 | |
| 539_L | 556_I | 2.134 | 1.00 | |
| 267_R | 306_E | 2.13 | 1.00 | |
| 554_L | 592_V | 2.094 | 1.00 | |
| 697_V | 700_L | 2.093 | 1.00 | |
| 84_I | 159_E | 2.092 | 1.00 | |
| 397_H | 461_V | 2.083 | 1.00 | |
| 471_L | 496_A | 2.081 | 1.00 | |
| 259_L | 314_L | 2.066 | 1.00 | |
| 403_G | 455_L | 2.065 | 1.00 | |
| 468_H | 501_D | 2.062 | 1.00 | |
| 509_Y | 555_A | 2.058 | 1.00 | |
| 88_Q | 92_D | 2.056 | 1.00 | |
| 156_E | 183_K | 2.051 | 1.00 | |
| 159_E | 179_N | 2.051 | 1.00 | |
| 224_I | 247_G | 2.042 | 1.00 | |
| 405_Y | 453_K | 2.031 | 1.00 | |
| 692_S | 726_T | 2.027 | 1.00 | |
| 403_G | 453_K | 1.999 | 1.00 | |
| 512_Y | 537_Y | 1.993 | 1.00 | |
| 691_F | 725_G | 1.991 | 1.00 | |
| 557_F | 613_Y | 1.989 | 1.00 | |
| 195_S | 207_V | 1.978 | 1.00 | |
| 322_W | 388_G | 1.971 | 1.00 | |
| 557_F | 611_T | 1.969 | 1.00 | |
| 220_I | 249_V | 1.967 | 1.00 | |
| 697_V | 721_F | 1.961 | 1.00 | |
| 87_Q | 183_K | 1.959 | 1.00 | |
| 494_P | 514_S | 1.941 | 1.00 | |
| 224_I | 245_F | 1.909 | 1.00 | |
| 499_V | 507_S | 1.898 | 1.00 | |
| 686_Q | 692_S | 1.894 | 1.00 | |
| 646_L | 685_Y | 1.888 | 1.00 | |
| 564_V | 587_T | 1.885 | 1.00 | |
| 601_T | 604_W | 1.878 | 1.00 | |
| 464_A | 467_L | 1.859 | 1.00 | |
| 537_Y | 560_E | 1.858 | 1.00 | |
| 107_G | 611_T | 1.856 | 1.00 | |
| 222_A | 249_V | 1.851 | 1.00 | |
| 695_G | 723_I | 1.847 | 1.00 | |
| 609_G | 633_K | 1.844 | 1.00 | |
| 553_T | 595_E | 1.838 | 1.00 | |
| 326_L | 384_L | 1.837 | 1.00 | |
| 608_F | 634_M | 1.832 | 1.00 | |
| 219_K | 251_A | 1.826 | 1.00 | |
| 510_A | 539_L | 1.814 | 1.00 | |
| 476_T | 493_T | 1.795 | 1.00 | |
| 648_V | 683_T | 1.779 | 1.00 | |
| 197_E | 724_T | 1.778 | 1.00 | |
| 226_G | 245_F | 1.774 | 1.00 | |
| 97_T | 100_E | 1.772 | 1.00 | |
| 514_S | 533_T | 1.763 | 1.00 | |
| 497_G | 511_S | 1.756 | 1.00 | |
| 680_D | 698_N | 1.755 | 1.00 | |
| 156_E | 184_H | 1.744 | 1.00 | |
| 123_R | 593_E | 1.739 | 1.00 | |
| 533_T | 563_N | 1.719 | 1.00 | |
| 193_D | 726_T | 1.717 | 1.00 | |
| 604_W | 638_Y | 1.715 | 1.00 | |
| 133_D | 248_I | 1.715 | 1.00 | |
| 83_T | 162_R | 1.71 | 1.00 | |
| 195_S | 724_T | 1.709 | 1.00 | |
| 132_V | 182_R | 1.709 | 1.00 | |
| 697_V | 719_R | 1.708 | 1.00 | |
| 503_N | 506_W | 1.699 | 1.00 | |
| 90_M | 101_V | 1.698 | 1.00 | |
| 515_I | 534_G | 1.685 | 1.00 | |
| 600_I | 636_T | 1.685 | 1.00 | |
| 530_A | 563_N | 1.681 | 1.00 | |
| 509_Y | 540_G | 1.679 | 1.00 | |
| 687_V | 693_L | 1.672 | 1.00 | |
| 398_N | 462_T | 1.672 | 1.00 | |
| 404_S | 454_S | 1.669 | 1.00 | |
| 221_R | 250_D | 1.668 | 1.00 | |
| 454_S | 476_T | 1.662 | 1.00 | |
| 491_H | 533_T | 1.658 | 1.00 | |
| 77_D | 501_D | 1.656 | 1.00 | |
| 466_P | 502_I | 1.654 | 1.00 | |
| 190_F | 210_L | 1.654 | 1.00 | |
| 454_S | 474_R | 1.651 | 1.00 | |
| 635_F | 651_G | 1.649 | 1.00 | |
| 132_V | 137_T | 1.645 | 1.00 | |
| 261_A | 310_V | 1.635 | 1.00 | |
| 407_K | 449_T | 1.634 | 1.00 | |
| 74_T | 77_D | 1.632 | 1.00 | |
| 88_Q | 91_E | 1.628 | 1.00 | |
| 230_N | 241_E | 1.596 | 1.00 | |
| 261_A | 312_M | 1.595 | 1.00 | |
| 590_K | 614_I | 1.588 | 1.00 | |
| 463_L | 498_L | 1.586 | 1.00 | |
| 222_A | 226_G | 1.586 | 1.00 | |
| 222_A | 247_G | 1.585 | 1.00 | |
| 560_E | 588_V | 1.583 | 1.00 | |
| 122_S | 176_A | 1.578 | 1.00 | |
| 463_L | 469_L | 1.578 | 1.00 | |
| 693_L | 723_I | 1.577 | 1.00 | |
| 462_T | 468_H | 1.57 | 1.00 | |
| 215_T | 219_K | 1.566 | 1.00 | |
| 330_H | 380_D | 1.565 | 1.00 | |
| 401_F | 457_A | 1.563 | 1.00 | |
| 502_I | 541_L | 1.561 | 1.00 | |
| 208_A | 226_G | 1.554 | 1.00 | |
| 477_N | 490_N | 1.55 | 1.00 | |
| 605_Q | 637_S | 1.536 | 1.00 | |
| 556_I | 590_K | 1.533 | 1.00 | |
| 653_N | 678_L | 1.52 | 1.00 | |
| 260_S | 313_T | 1.519 | 1.00 | |
| 552_T | 594_F | 1.508 | 1.00 | |
| 263_Y | 310_V | 1.508 | 1.00 | |
| 328_A | 380_D | 1.506 | 1.00 | |
| 133_D | 262_G | 1.503 | 1.00 | |
| 678_L | 716_G | 1.502 | 1.00 | |
| 60_Y | 92_D | 1.493 | 1.00 | |
| 655_Q | 676_Y | 1.491 | 1.00 | |
| 556_I | 592_V | 1.486 | 1.00 | |
| 510_A | 537_Y | 1.486 | 1.00 | |
| 202_N | 232_D | 1.481 | 1.00 | |
| 405_Y | 451_H | 1.48 | 1.00 | |
| 259_L | 312_M | 1.477 | 1.00 | |
| 199_G | 203_K | 1.475 | 1.00 | |
| 678_L | 705_Y | 1.469 | 1.00 | |
| 93_Q | 104_N | 1.467 | 1.00 | |
| 253_L | 259_L | 1.465 | 1.00 | |
| 191_K | 211_Q | 1.463 | 1.00 | |
| 687_V | 691_F | 1.459 | 1.00 | |
| 133_D | 182_R | 1.454 | 1.00 | |
| 605_Q | 639_R | 1.441 | 1.00 | |
| 198_Y | 204_E | 1.431 | 1.00 | |
| 698_N | 720_N | 1.43 | 1.00 | |
| 650_G | 681_L | 1.427 | 1.00 | |
| 108_I | 122_S | 1.426 | 1.00 | |
| 162_R | 593_E | 1.425 | 1.00 | |
| 494_P | 498_L | 1.423 | 1.00 | |
| 543_S | 552_T | 1.42 | 1.00 | |
| 679_V | 700_L | 1.418 | 1.00 | |
| 541_L | 554_L | 1.417 | 1.00 | |
| 469_L | 496_A | 1.416 | 1.00 | |
| 517_Q | 532_I | 1.416 | 1.00 | |
| 100_E | 103_E | 1.413 | 1.00 | |
| 550_L | 596_L | 1.407 | 0.99 | |
| 544_D | 551_T | 1.404 | 0.99 | |
| 686_Q | 728_Q | 1.403 | 0.99 | |
| 250_D | 258_T | 1.399 | 0.99 | |
| 315_K | 323_Q | 1.399 | 0.99 | |
| 398_N | 460_R | 1.397 | 0.99 | |
| 221_R | 252_D | 1.396 | 0.99 | |
| 228_Y | 241_E | 1.394 | 0.99 | |
| 509_Y | 542_K | 1.387 | 0.99 | |
| 549_R | 598_G | 1.377 | 0.99 | |
| 256_L | 317_Q | 1.376 | 0.99 | |
| 674_G | 703_K | 1.374 | 0.99 | |
| 533_T | 562_D | 1.373 | 0.99 | |
| 551_T | 597_N | 1.37 | 0.99 | |
| 566_Q | 584_V | 1.359 | 0.99 | |
| 197_E | 205_R | 1.357 | 0.99 | |
| 536_N | 559_I | 1.355 | 0.99 | |
| 692_S | 728_Q | 1.352 | 0.99 | |
| 458_A | 470_I | 1.351 | 0.99 | |
| 650_G | 700_L | 1.341 | 0.99 | |
| 194_V | 727_Y | 1.338 | 0.99 | |
| 682_F | 694_Q | 1.331 | 0.99 | |
| 557_F | 591_G | 1.326 | 0.99 | |
| 123_R | 538_E | 1.317 | 0.99 | |
| 392_L | 395_R | 1.317 | 0.99 | |
| 611_T | 631_T | 1.316 | 0.99 | |
| 637_S | 649_G | 1.298 | 0.99 | |
| 681_L | 697_V | 1.296 | 0.99 | |
| 630_T | 656_N | 1.295 | 0.99 | |
| 234_W | 718_P | 1.289 | 0.99 | |
| 610_A | 632_V | 1.286 | 0.99 | |
| 596_L | 608_F | 1.28 | 0.99 | |
| 250_D | 260_S | 1.273 | 0.99 | |
| 186_T | 211_Q | 1.273 | 0.99 | |
| 532_I | 561_Q | 1.27 | 0.99 | |
| 169_T | 177_A | 1.268 | 0.99 | |
| 252_D | 258_T | 1.267 | 0.99 | |
| 385_F | 456_Y | 1.265 | 0.99 | |
| 106_L | 609_G | 1.264 | 0.99 | |
| 632_V | 654_W | 1.26 | 0.99 | |
| 159_E | 181_V | 1.26 | 0.99 | |
| 315_K | 325_T | 1.259 | 0.99 | |
| 389_S | 398_N | 1.257 | 0.99 | |
| 245_F | 265_Y | 1.256 | 0.99 | |
| 646_L | 683_T | 1.249 | 0.99 | |
| 193_D | 209_D | 1.247 | 0.99 | |
| 508_T | 539_L | 1.245 | 0.98 | |
| 184_H | 248_I | 1.243 | 0.98 | |
| 461_V | 471_L | 1.23 | 0.98 | |
| 332_E | 378_K | 1.23 | 0.98 | |
| 537_Y | 558_R | 1.225 | 0.98 | |
| 256_L | 316_Q | 1.216 | 0.98 | |
| 219_K | 253_L | 1.206 | 0.98 | |
| 198_Y | 202_N | 1.206 | 0.98 | |
| 477_N | 488_E | 1.205 | 0.98 | |
| 399_L | 459_T | 1.203 | 0.98 | |
| 167_L | 472_G | 1.191 | 0.98 | |
| 501_D | 507_S | 1.189 | 0.98 | |
| 120_Y | 178_I | 1.188 | 0.98 | |
| 498_L | 510_A | 1.185 | 0.98 | |
| 318_F | 324_A | 1.185 | 0.98 | |
| 89_R | 92_D | 1.176 | 0.98 | |
| 395_R | 461_V | 1.175 | 0.98 | |
| 498_L | 502_I | 1.174 | 0.98 | |
| 502_I | 506_W | 1.165 | 0.97 | |
| 700_L | 719_R | 1.165 | 0.97 | |
| 192_G | 208_A | 1.162 | 0.97 | |
| 517_Q | 523_D | 1.159 | 0.97 | |
| 702_D | 718_P | 1.159 | 0.97 | |
| 227_G | 244_F | 1.158 | 0.97 | |
| 69_T | 73_M | 1.156 | 0.97 | |
| 637_S | 647_T | 1.155 | 0.97 | |
| 258_T | 317_Q | 1.151 | 0.97 | |
| 460_R | 468_H | 1.151 | 0.97 | |
| 612_R | 629_R | 1.144 | 0.97 | |
| 529_L | 565_A | 1.141 | 0.97 | |
| 322_W | 386_A | 1.141 | 0.97 | |
| 560_E | 586_G | 1.139 | 0.97 | |
| 592_V | 612_R | 1.138 | 0.97 | |
| 645_E | 685_Y | 1.133 | 0.97 | |
| 694_Q | 726_T | 1.132 | 0.97 | |
| 98_L | 180_M | 1.123 | 0.97 | |
| 600_I | 606_L | 1.122 | 0.97 | |
| 87_Q | 156_E | 1.119 | 0.96 | |
| 160_V | 178_I | 1.114 | 0.96 | |
| 194_V | 208_A | 1.113 | 0.96 | |
| 95_L | 101_V | 1.112 | 0.96 | |
| 468_H | 499_V | 1.108 | 0.96 | |
| 190_F | 212_S | 1.105 | 0.96 | |
| 725_G | 729_F | 1.1 | 0.96 | |
| 690_N | 727_Y | 1.099 | 0.96 | |
| 683_T | 697_V | 1.098 | 0.96 | |
| 453_K | 477_N | 1.096 | 0.96 | |
| 85_V | 105_T | 1.094 | 0.96 | |
| 192_G | 196_A | 1.092 | 0.96 | |
| 84_I | 157_R | 1.09 | 0.96 | |
| 186_T | 191_K | 1.087 | 0.96 | |
| 691_F | 695_G | 1.086 | 0.96 | |
| 89_R | 93_Q | 1.084 | 0.96 | |
| 597_N | 605_Q | 1.084 | 0.96 | |
| 151_D | 154_L | 1.083 | 0.96 | |
| 538_E | 555_A | 1.082 | 0.96 | |
| 92_D | 637_S | 1.082 | 0.96 | |
| 106_L | 595_E | 1.077 | 0.95 | |
| 545_W | 552_T | 1.073 | 0.95 | |
| 640_L | 648_V | 1.071 | 0.95 | |
| 677_A | 703_K | 1.064 | 0.95 | |
| 210_L | 224_I | 1.063 | 0.95 | |
| 198_Y | 723_I | 1.056 | 0.95 | |
| 215_T | 220_I | 1.054 | 0.95 | |
| 83_T | 595_E | 1.051 | 0.94 | |
| 122_S | 160_V | 1.049 | 0.94 | |
| 101_V | 158_V | 1.048 | 0.94 | |
| 135_I | 327_N | 1.044 | 0.94 | |
| 659_Y | 672_E | 1.042 | 0.94 | |
| 392_L | 397_H | 1.041 | 0.94 | |
| 589_S | 615_A | 1.038 | 0.94 | |
| 391_E | 396_Q | 1.038 | 0.94 | |
| 542_K | 553_T | 1.037 | 0.94 | |
| 328_A | 382_L | 1.037 | 0.94 | |
| 90_M | 95_L | 1.036 | 0.94 | |
| 125_F | 561_Q | 1.034 | 0.94 | |
| 326_L | 382_L | 1.032 | 0.94 | |
| 134_G | 179_N | 1.032 | 0.94 | |
| 190_F | 213_P | 1.031 | 0.94 | |
| 248_I | 260_S | 1.03 | 0.94 | |
| 544_D | 548_S | 1.03 | 0.94 | |
| 723_I | 727_Y | 1.029 | 0.94 | |
| 329_T | 381_A | 1.025 | 0.93 | |
| 209_D | 223_R | 1.025 | 0.93 | |
| 494_P | 512_Y | 1.022 | 0.93 | |
| 206_Y | 228_Y | 1.02 | 0.93 | |
| 557_F | 593_E | 1.016 | 0.93 | |
| 91_E | 726_T | 1.008 | 0.93 | |
| 606_L | 634_M | 1.008 | 0.93 | |
| 698_N | 722_S | 1.008 | 0.93 | |
| 470_I | 499_V | 1.004 | 0.93 | |
| 196_A | 204_E | 1.001 | 0.92 | |
| 546_M | 550_L | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3efmA | 1 | 0.9383 | 100 | 0.237 | Contact Map | 0.811 |
| 2w16A | 2 | 0.9781 | 100 | 0.253 | Contact Map | 0.818 |
| 1xkwA | 1 | 0.8903 | 100 | 0.27 | Contact Map | 0.786 |
| 3qlbA | 2 | 0.952 | 100 | 0.285 | Contact Map | 0.787 |
| 1qfgA | 1 | 0.9081 | 100 | 0.289 | Contact Map | 0.752 |
| 4epaA | 1 | 0.8313 | 100 | 0.323 | Contact Map | 0.721 |
| 3fhhA | 1 | 0.8107 | 100 | 0.327 | Contact Map | 0.698 |
| 2hdiA | 1 | 0.7874 | 100 | 0.328 | Contact Map | 0.782 |
| 1kmoA | 1 | 0.9122 | 100 | 0.334 | Contact Map | 0.774 |
| 2gufA | 1 | 0.7833 | 100 | 0.355 | Contact Map | 0.764 |
Sequence Conservation (Image Generated using WebLogo v3)