| UniProt: | P06971 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10302 | ||
| Length: | 747 (685) | ||
| Sequences: | 13999 | ||
| Seq/Len: | 20.44 |
| FHUA
Paralog alert: 0.92 [within 20: 0.30] - ratio of genomes with paralogs Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 621_Y | 645_H | 5.558 | 1.00 | |
| 669_G | 689_T | 4.616 | 1.00 | |
| 575_N | 601_R | 4.582 | 1.00 | |
| 484_G | 509_F | 4.446 | 1.00 | |
| 486_Y | 507_K | 4.343 | 1.00 | |
| 260_T | 321_H | 4.323 | 1.00 | |
| 691_V | 717_F | 4.134 | 1.00 | |
| 529_Y | 552_K | 3.596 | 1.00 | |
| 523_V | 558_V | 3.571 | 1.00 | |
| 531_E | 552_K | 3.254 | 1.00 | |
| 664_T | 696_R | 3.225 | 1.00 | |
| 478_V | 517_Y | 3.215 | 1.00 | |
| 161_R | 185_V | 3.106 | 1.00 | |
| 477_K | 517_Y | 3.084 | 1.00 | |
| 223_Y | 254_W | 3.072 | 1.00 | |
| 159_L | 184_M | 3.064 | 1.00 | |
| 405_H | 471_D | 3.03 | 1.00 | |
| 623_Y | 645_H | 2.998 | 1.00 | |
| 571_G | 605_I | 2.981 | 1.00 | |
| 710_A | 742_T | 2.927 | 1.00 | |
| 268_F | 313_K | 2.923 | 1.00 | |
| 262_F | 319_F | 2.922 | 1.00 | |
| 88_A | 92_A | 2.9 | 1.00 | |
| 260_T | 319_F | 2.869 | 1.00 | |
| 519_F | 525_P | 2.749 | 1.00 | |
| 599_R | 629_T | 2.728 | 1.00 | |
| 671_Y | 689_T | 2.721 | 1.00 | |
| 231_A | 246_Y | 2.644 | 1.00 | |
| 331_Q | 392_T | 2.616 | 1.00 | |
| 270_N | 311_N | 2.608 | 1.00 | |
| 261_N | 320_D | 2.591 | 1.00 | |
| 674_S | 684_K | 2.587 | 1.00 | |
| 615_V | 651_A | 2.564 | 1.00 | |
| 618_V | 650_W | 2.563 | 1.00 | |
| 327_F | 396_S | 2.563 | 1.00 | |
| 480_V | 515_V | 2.549 | 1.00 | |
| 693_A | 716_L | 2.518 | 1.00 | |
| 669_G | 691_V | 2.51 | 1.00 | |
| 711_L | 739_V | 2.508 | 1.00 | |
| 215_D | 225_Y | 2.507 | 1.00 | |
| 266_S | 313_K | 2.502 | 1.00 | |
| 523_V | 560_Y | 2.474 | 1.00 | |
| 486_Y | 509_F | 2.472 | 1.00 | |
| 709_V | 743_A | 2.459 | 1.00 | |
| 567_I | 609_A | 2.443 | 1.00 | |
| 617_V | 651_A | 2.41 | 1.00 | |
| 569_V | 607_A | 2.41 | 1.00 | |
| 199_F | 209_T | 2.384 | 1.00 | |
| 574_Y | 624_T | 2.377 | 1.00 | |
| 410_G | 468_Y | 2.341 | 1.00 | |
| 195_K | 213_F | 2.318 | 1.00 | |
| 478_V | 515_V | 2.301 | 1.00 | |
| 415_R | 463_K | 2.266 | 1.00 | |
| 229_G | 246_Y | 2.264 | 1.00 | |
| 198_Q | 744_T | 2.231 | 1.00 | |
| 667_T | 691_V | 2.225 | 1.00 | |
| 670_R | 692_D | 2.225 | 1.00 | |
| 671_Y | 687_S | 2.219 | 1.00 | |
| 196_E | 746_R | 2.196 | 1.00 | |
| 335_F | 388_F | 2.193 | 1.00 | |
| 668_G | 692_D | 2.185 | 1.00 | |
| 331_Q | 390_V | 2.182 | 1.00 | |
| 712_H | 740_V | 2.181 | 1.00 | |
| 525_P | 558_V | 2.177 | 1.00 | |
| 227_L | 250_P | 2.163 | 1.00 | |
| 721_Y | 734_G | 2.16 | 1.00 | |
| 85_V | 163_E | 2.159 | 1.00 | |
| 614_S | 653_Y | 2.151 | 1.00 | |
| 195_K | 747_F | 2.138 | 1.00 | |
| 333_L | 388_F | 2.134 | 1.00 | |
| 666_G | 694_L | 2.131 | 1.00 | |
| 106_T | 164_I | 2.129 | 1.00 | |
| 556_V | 573_V | 2.111 | 1.00 | |
| 87_T | 90_E | 2.106 | 1.00 | |
| 482_L | 513_G | 2.088 | 1.00 | |
| 571_G | 603_V | 2.085 | 1.00 | |
| 696_R | 708_N | 2.054 | 1.00 | |
| 266_S | 315_V | 2.039 | 1.00 | |
| 108_G | 622_T | 2.037 | 1.00 | |
| 257_D | 260_T | 2.033 | 1.00 | |
| 575_N | 599_R | 2.032 | 1.00 | |
| 411_V | 467_V | 2.023 | 1.00 | |
| 333_L | 390_V | 2.021 | 1.00 | |
| 601_R | 625_D | 2.016 | 1.00 | |
| 163_E | 183_N | 2 | 1.00 | |
| 264_F | 317_Y | 1.988 | 1.00 | |
| 479_L | 518_L | 1.987 | 1.00 | |
| 713_V | 716_L | 1.98 | 1.00 | |
| 581_N | 598_I | 1.969 | 1.00 | |
| 665_L | 695_V | 1.967 | 1.00 | |
| 225_Y | 252_F | 1.966 | 1.00 | |
| 526_Y | 572_A | 1.957 | 1.00 | |
| 327_F | 394_L | 1.953 | 1.00 | |
| 413_F | 465_T | 1.953 | 1.00 | |
| 198_Q | 210_G | 1.948 | 1.00 | |
| 711_L | 741_A | 1.924 | 1.00 | |
| 411_V | 465_T | 1.911 | 1.00 | |
| 160_E | 187_K | 1.904 | 1.00 | |
| 264_F | 315_V | 1.902 | 1.00 | |
| 227_L | 248_I | 1.895 | 1.00 | |
| 259_K | 322_E | 1.893 | 1.00 | |
| 529_Y | 554_Y | 1.891 | 1.00 | |
| 713_V | 739_V | 1.887 | 1.00 | |
| 663_L | 697_Y | 1.879 | 1.00 | |
| 574_Y | 622_T | 1.879 | 1.00 | |
| 698_D | 708_N | 1.876 | 1.00 | |
| 516_N | 524_T | 1.876 | 1.00 | |
| 708_N | 744_T | 1.875 | 1.00 | |
| 223_Y | 252_F | 1.872 | 1.00 | |
| 329_V | 392_T | 1.871 | 1.00 | |
| 89_E | 93_L | 1.832 | 1.00 | |
| 547_A | 580_N | 1.814 | 1.00 | |
| 554_Y | 577_T | 1.789 | 1.00 | |
| 98_S | 101_E | 1.781 | 1.00 | |
| 619_G | 649_L | 1.769 | 1.00 | |
| 259_K | 321_H | 1.755 | 1.00 | |
| 466_G | 487_D | 1.744 | 1.00 | |
| 262_F | 317_Y | 1.743 | 1.00 | |
| 713_V | 737_R | 1.728 | 1.00 | |
| 200_K | 742_T | 1.724 | 1.00 | |
| 692_D | 714_N | 1.723 | 1.00 | |
| 405_H | 473_A | 1.72 | 1.00 | |
| 511_W | 531_E | 1.719 | 1.00 | |
| 263_T | 318_S | 1.711 | 1.00 | |
| 612_S | 615_V | 1.709 | 1.00 | |
| 334_R | 389_S | 1.708 | 1.00 | |
| 702_V | 745_F | 1.69 | 1.00 | |
| 337_E | 386_Q | 1.686 | 1.00 | |
| 531_E | 550_K | 1.676 | 1.00 | |
| 514_G | 528_S | 1.676 | 1.00 | |
| 412_D | 466_G | 1.676 | 1.00 | |
| 393_Q | 468_Y | 1.67 | 1.00 | |
| 191_T | 224_S | 1.67 | 1.00 | |
| 611_L | 651_A | 1.668 | 1.00 | |
| 527_F | 556_V | 1.665 | 1.00 | |
| 229_G | 248_I | 1.665 | 1.00 | |
| 699_L | 709_V | 1.663 | 1.00 | |
| 620_S | 648_S | 1.659 | 1.00 | |
| 520_D | 523_V | 1.659 | 1.00 | |
| 487_D | 510_T | 1.656 | 1.00 | |
| 233_S | 244_Q | 1.652 | 1.00 | |
| 570_T | 606_E | 1.65 | 1.00 | |
| 508_Q | 550_K | 1.649 | 1.00 | |
| 88_A | 187_K | 1.645 | 1.00 | |
| 650_W | 668_G | 1.644 | 1.00 | |
| 126_R | 604_E | 1.639 | 1.00 | |
| 667_T | 693_A | 1.639 | 1.00 | |
| 330_R | 393_Q | 1.627 | 1.00 | |
| 198_Q | 742_T | 1.627 | 1.00 | |
| 477_K | 519_F | 1.618 | 1.00 | |
| 160_E | 188_R | 1.608 | 1.00 | |
| 329_V | 394_L | 1.608 | 1.00 | |
| 550_K | 580_N | 1.606 | 1.00 | |
| 193_P | 213_F | 1.606 | 1.00 | |
| 466_G | 485_R | 1.595 | 1.00 | |
| 139_L | 186_S | 1.595 | 1.00 | |
| 75_P | 78_K | 1.59 | 1.00 | |
| 84_S | 166_R | 1.584 | 1.00 | |
| 475_W | 515_V | 1.583 | 1.00 | |
| 615_V | 653_Y | 1.581 | 1.00 | |
| 573_V | 603_V | 1.579 | 1.00 | |
| 702_V | 743_A | 1.572 | 1.00 | |
| 526_Y | 557_G | 1.567 | 1.00 | |
| 139_L | 144_L | 1.566 | 1.00 | |
| 577_T | 599_R | 1.565 | 1.00 | |
| 225_Y | 250_P | 1.557 | 1.00 | |
| 532_S | 551_G | 1.548 | 1.00 | |
| 224_S | 253_T | 1.547 | 1.00 | |
| 140_N | 251_A | 1.545 | 1.00 | |
| 211_F | 229_G | 1.541 | 1.00 | |
| 196_E | 744_T | 1.532 | 1.00 | |
| 415_R | 461_K | 1.531 | 1.00 | |
| 670_R | 690_V | 1.529 | 1.00 | |
| 91_M | 102_A | 1.525 | 1.00 | |
| 519_F | 558_V | 1.518 | 1.00 | |
| 488_W | 507_K | 1.517 | 1.00 | |
| 140_N | 265_L | 1.509 | 1.00 | |
| 205_S | 235_N | 1.503 | 1.00 | |
| 320_D | 328_T | 1.494 | 1.00 | |
| 690_V | 734_G | 1.494 | 1.00 | |
| 94_H | 105_Y | 1.489 | 1.00 | |
| 691_V | 716_L | 1.487 | 1.00 | |
| 527_F | 554_Y | 1.48 | 1.00 | |
| 190_T | 214_S | 1.479 | 1.00 | |
| 577_T | 597_E | 1.476 | 1.00 | |
| 218_D | 222_V | 1.473 | 1.00 | |
| 616_N | 652_D | 1.472 | 1.00 | |
| 709_V | 741_A | 1.465 | 1.00 | |
| 125_I | 180_G | 1.455 | 1.00 | |
| 406_T | 474_Q | 1.451 | 1.00 | |
| 672_T | 688_Y | 1.451 | 1.00 | |
| 194_L | 214_S | 1.45 | 1.00 | |
| 474_Q | 479_L | 1.447 | 1.00 | |
| 89_E | 92_A | 1.447 | 1.00 | |
| 409_T | 469_V | 1.444 | 1.00 | |
| 101_E | 104_S | 1.438 | 1.00 | |
| 475_W | 480_V | 1.437 | 1.00 | |
| 667_T | 716_L | 1.429 | 1.00 | |
| 253_T | 261_N | 1.425 | 1.00 | |
| 573_V | 601_R | 1.416 | 1.00 | |
| 140_N | 186_S | 1.415 | 1.00 | |
| 109_V | 125_I | 1.394 | 0.99 | |
| 202_G | 206_L | 1.393 | 0.99 | |
| 256_P | 262_F | 1.39 | 0.99 | |
| 598_I | 639_P | 1.387 | 0.99 | |
| 413_F | 463_K | 1.387 | 0.99 | |
| 225_Y | 229_G | 1.384 | 0.99 | |
| 616_N | 654_T | 1.379 | 0.99 | |
| 698_D | 746_R | 1.373 | 0.99 | |
| 400_T | 403_I | 1.37 | 0.99 | |
| 78_K | 518_L | 1.368 | 0.99 | |
| 166_R | 604_E | 1.367 | 0.99 | |
| 222_V | 254_W | 1.363 | 0.99 | |
| 550_K | 579_T | 1.359 | 0.99 | |
| 569_V | 605_I | 1.357 | 0.99 | |
| 647_A | 671_Y | 1.346 | 0.99 | |
| 714_N | 738_Q | 1.346 | 0.99 | |
| 534_E | 549_S | 1.345 | 0.99 | |
| 622_T | 646_M | 1.343 | 0.99 | |
| 397_K | 406_T | 1.341 | 0.99 | |
| 268_F | 311_N | 1.333 | 0.99 | |
| 558_V | 571_G | 1.332 | 0.99 | |
| 123_L | 182_L | 1.331 | 0.99 | |
| 255_R | 261_N | 1.329 | 0.99 | |
| 70_T | 74_T | 1.328 | 0.99 | |
| 230_L | 247_A | 1.323 | 0.99 | |
| 320_D | 330_R | 1.319 | 0.99 | |
| 623_Y | 644_K | 1.317 | 0.99 | |
| 690_V | 721_Y | 1.31 | 0.99 | |
| 645_H | 673_G | 1.31 | 0.99 | |
| 142_L | 332_N | 1.308 | 0.99 | |
| 511_W | 515_V | 1.305 | 0.99 | |
| 603_V | 623_Y | 1.302 | 0.99 | |
| 549_S | 578_K | 1.298 | 0.99 | |
| 663_L | 695_V | 1.294 | 0.99 | |
| 574_Y | 602_G | 1.293 | 0.99 | |
| 693_A | 713_V | 1.293 | 0.99 | |
| 652_D | 666_G | 1.293 | 0.99 | |
| 61_I | 93_L | 1.292 | 0.99 | |
| 621_Y | 647_A | 1.287 | 0.99 | |
| 568_V | 608_K | 1.287 | 0.99 | |
| 256_P | 319_F | 1.286 | 0.99 | |
| 237_Q | 736_E | 1.286 | 0.99 | |
| 231_A | 244_Q | 1.284 | 0.99 | |
| 567_I | 607_A | 1.279 | 0.99 | |
| 708_N | 746_R | 1.278 | 0.99 | |
| 553_Q | 576_L | 1.278 | 0.99 | |
| 624_T | 642_V | 1.277 | 0.99 | |
| 561_V | 568_V | 1.273 | 0.99 | |
| 560_Y | 569_V | 1.27 | 0.99 | |
| 607_A | 619_G | 1.269 | 0.99 | |
| 480_V | 513_G | 1.266 | 0.99 | |
| 406_T | 472_Q | 1.263 | 0.99 | |
| 686_G | 719_R | 1.261 | 0.99 | |
| 716_L | 737_R | 1.259 | 0.99 | |
| 399_A | 404_D | 1.257 | 0.99 | |
| 694_L | 710_A | 1.255 | 0.99 | |
| 566_P | 609_A | 1.25 | 0.99 | |
| 637_N | 681_N | 1.244 | 0.98 | |
| 253_T | 263_T | 1.243 | 0.98 | |
| 515_V | 527_F | 1.238 | 0.98 | |
| 107_P | 620_S | 1.238 | 0.98 | |
| 224_S | 255_R | 1.232 | 0.98 | |
| 201_A | 205_S | 1.231 | 0.98 | |
| 470_Q | 481_T | 1.231 | 0.98 | |
| 526_Y | 559_K | 1.229 | 0.98 | |
| 190_T | 194_L | 1.229 | 0.98 | |
| 323_F | 329_V | 1.218 | 0.98 | |
| 200_K | 208_Q | 1.215 | 0.98 | |
| 515_V | 519_F | 1.214 | 0.98 | |
| 173_Y | 181_L | 1.21 | 0.98 | |
| 328_T | 395_Q | 1.209 | 0.98 | |
| 201_A | 207_F | 1.208 | 0.98 | |
| 163_E | 185_V | 1.2 | 0.98 | |
| 488_W | 505_D | 1.199 | 0.98 | |
| 197_V | 745_F | 1.196 | 0.98 | |
| 188_R | 251_A | 1.196 | 0.98 | |
| 583_M | 595_G | 1.195 | 0.98 | |
| 638_T | 644_K | 1.192 | 0.98 | |
| 518_L | 524_T | 1.191 | 0.98 | |
| 248_I | 268_F | 1.188 | 0.98 | |
| 196_E | 212_D | 1.183 | 0.98 | |
| 324_N | 327_F | 1.18 | 0.98 | |
| 322_E | 328_T | 1.168 | 0.97 | |
| 652_D | 664_T | 1.165 | 0.97 | |
| 472_Q | 479_L | 1.163 | 0.97 | |
| 330_R | 395_Q | 1.155 | 0.97 | |
| 546_F | 582_L | 1.15 | 0.97 | |
| 554_Y | 575_N | 1.149 | 0.97 | |
| 261_N | 322_E | 1.147 | 0.97 | |
| 465_T | 488_W | 1.145 | 0.97 | |
| 394_L | 409_T | 1.144 | 0.97 | |
| 676_Y | 684_K | 1.142 | 0.97 | |
| 600_A | 626_A | 1.141 | 0.97 | |
| 407_L | 471_D | 1.141 | 0.97 | |
| 611_L | 617_V | 1.135 | 0.97 | |
| 391_D | 412_D | 1.134 | 0.97 | |
| 195_K | 199_F | 1.133 | 0.97 | |
| 562_P | 569_V | 1.125 | 0.97 | |
| 525_P | 556_V | 1.125 | 0.97 | |
| 90_E | 93_L | 1.125 | 0.97 | |
| 695_V | 713_V | 1.123 | 0.97 | |
| 718_D | 736_E | 1.113 | 0.96 | |
| 403_I | 473_A | 1.108 | 0.96 | |
| 84_S | 606_E | 1.107 | 0.96 | |
| 619_G | 647_A | 1.105 | 0.96 | |
| 267_Y | 314_M | 1.1 | 0.96 | |
| 743_A | 747_F | 1.084 | 0.96 | |
| 193_P | 216_S | 1.084 | 0.96 | |
| 96_P | 102_A | 1.083 | 0.96 | |
| 213_F | 227_L | 1.08 | 0.95 | |
| 164_I | 182_L | 1.079 | 0.95 | |
| 398_F | 407_L | 1.079 | 0.95 | |
| 193_P | 215_D | 1.077 | 0.95 | |
| 597_E | 630_T | 1.072 | 0.95 | |
| 473_A | 482_L | 1.07 | 0.95 | |
| 710_A | 744_T | 1.069 | 0.95 | |
| 323_F | 394_L | 1.065 | 0.95 | |
| 142_L | 334_R | 1.064 | 0.95 | |
| 126_R | 555_E | 1.064 | 0.95 | |
| 201_A | 741_A | 1.063 | 0.95 | |
| 91_M | 96_P | 1.058 | 0.95 | |
| 141_G | 183_N | 1.058 | 0.95 | |
| 197_V | 211_F | 1.058 | 0.95 | |
| 662_G | 697_Y | 1.056 | 0.95 | |
| 482_L | 515_V | 1.053 | 0.95 | |
| 265_L | 316_G | 1.053 | 0.95 | |
| 125_I | 164_I | 1.052 | 0.95 | |
| 479_L | 516_N | 1.046 | 0.94 | |
| 88_A | 160_E | 1.039 | 0.94 | |
| 126_R | 602_G | 1.039 | 0.94 | |
| 645_H | 671_Y | 1.036 | 0.94 | |
| 90_E | 94_H | 1.033 | 0.94 | |
| 99_V | 184_M | 1.031 | 0.94 | |
| 195_K | 211_F | 1.03 | 0.94 | |
| 400_T | 405_H | 1.029 | 0.94 | |
| 92_A | 744_T | 1.028 | 0.94 | |
| 86_V | 106_T | 1.028 | 0.94 | |
| 699_L | 702_V | 1.026 | 0.94 | |
| 741_A | 745_F | 1.023 | 0.93 | |
| 85_V | 161_R | 1.02 | 0.93 | |
| 519_F | 523_V | 1.018 | 0.93 | |
| 579_T | 597_E | 1.017 | 0.93 | |
| 714_N | 740_V | 1.014 | 0.93 | |
| 617_V | 649_L | 1.011 | 0.93 | |
| 107_P | 606_E | 1.008 | 0.93 | |
| 676_Y | 681_N | 1.008 | 0.93 | |
| 166_R | 606_E | 1.005 | 0.93 | |
| 511_W | 529_Y | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1qfgA | 1 | 0.9518 | 100 | 0.228 | Contact Map | 0.759 |
| 3qlbA | 2 | 0.9572 | 100 | 0.244 | Contact Map | 0.794 |
| 3efmA | 1 | 0.9009 | 100 | 0.275 | Contact Map | 0.806 |
| 2w16A | 2 | 0.9277 | 100 | 0.296 | Contact Map | 0.818 |
| 1xkwA | 1 | 0.8661 | 100 | 0.298 | Contact Map | 0.789 |
| 1kmoA | 1 | 0.905 | 100 | 0.333 | Contact Map | 0.785 |
| 4epaA | 1 | 0.8327 | 100 | 0.339 | Contact Map | 0.723 |
| 3fhhA | 1 | 0.7952 | 100 | 0.347 | Contact Map | 0.708 |
| 2hdiA | 1 | 0.7604 | 100 | 0.357 | Contact Map | 0.774 |
| 4b7oA | 1 | 0.8862 | 100 | 0.367 | Contact Map | 0.739 |
Sequence Conservation (Image Generated using WebLogo v3)