| UniProt: | P17315 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10155 | ||
| Length: | 663 (625) | ||
| Sequences: | 17216 | ||
| Seq/Len: | 27.55 |
| CIRA
Paralog alert: 0.93 [within 20: 0.34] - ratio of genomes with paralogs Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 549_Y | 571_H | 5.639 | 1.00 | |
| 593_G | 613_T | 4.745 | 1.00 | |
| 479_R | 529_Q | 4.535 | 1.00 | |
| 382_V | 394_W | 4.359 | 1.00 | |
| 384_M | 392_E | 4.155 | 1.00 | |
| 615_W | 637_G | 4.087 | 1.00 | |
| 408_V | 459_L | 4.023 | 1.00 | |
| 414_W | 453_E | 3.954 | 1.00 | |
| 330_Q | 368_D | 3.699 | 1.00 | |
| 416_T | 453_E | 3.505 | 1.00 | |
| 588_S | 620_A | 3.31 | 1.00 | |
| 376_L | 402_Y | 3.217 | 1.00 | |
| 56_Q | 60_Q | 3.195 | 1.00 | |
| 630_R | 658_A | 3.187 | 1.00 | |
| 375_P | 402_Y | 3.165 | 1.00 | |
| 132_R | 156_I | 3.086 | 1.00 | |
| 130_I | 155_I | 3.064 | 1.00 | |
| 551_Y | 571_H | 2.993 | 1.00 | |
| 199_L | 243_W | 2.954 | 1.00 | |
| 475_V | 533_T | 2.936 | 1.00 | |
| 335_G | 365_F | 2.85 | 1.00 | |
| 595_Y | 613_T | 2.794 | 1.00 | |
| 593_G | 615_W | 2.723 | 1.00 | |
| 546_S | 576_T | 2.692 | 1.00 | |
| 408_V | 461_Y | 2.648 | 1.00 | |
| 404_A | 410_V | 2.613 | 1.00 | |
| 471_V | 537_I | 2.606 | 1.00 | |
| 527_R | 557_V | 2.595 | 1.00 | |
| 598_Q | 608_T | 2.585 | 1.00 | |
| 384_M | 394_W | 2.511 | 1.00 | |
| 595_Y | 611_G | 2.451 | 1.00 | |
| 55_T | 58_D | 2.442 | 1.00 | |
| 246_N | 249_H | 2.434 | 1.00 | |
| 74_V | 135_V | 2.422 | 1.00 | |
| 592_S | 616_N | 2.414 | 1.00 | |
| 631_A | 655_Y | 2.397 | 1.00 | |
| 590_Y | 618_G | 2.38 | 1.00 | |
| 376_L | 400_L | 2.376 | 1.00 | |
| 340_H | 360_S | 2.376 | 1.00 | |
| 594_H | 616_N | 2.374 | 1.00 | |
| 591_V | 615_W | 2.363 | 1.00 | |
| 473_S | 535_L | 2.361 | 1.00 | |
| 478_F | 552_N | 2.351 | 1.00 | |
| 543_W | 577_L | 2.349 | 1.00 | |
| 627_V | 661_Y | 2.334 | 1.00 | |
| 378_L | 400_L | 2.309 | 1.00 | |
| 632_G | 656_F | 2.28 | 1.00 | |
| 617_T | 636_L | 2.266 | 1.00 | |
| 336_G | 362_Y | 2.216 | 1.00 | |
| 203_A | 239_V | 2.203 | 1.00 | |
| 338_W | 362_Y | 2.201 | 1.00 | |
| 169_T | 660_D | 2.194 | 1.00 | |
| 542_E | 579_W | 2.193 | 1.00 | |
| 380_T | 398_A | 2.181 | 1.00 | |
| 479_R | 527_R | 2.177 | 1.00 | |
| 56_Q | 158_K | 2.176 | 1.00 | |
| 545_L | 577_L | 2.174 | 1.00 | |
| 620_A | 628_K | 2.148 | 1.00 | |
| 330_Q | 370_W | 2.138 | 1.00 | |
| 627_V | 659_V | 2.132 | 1.00 | |
| 529_Q | 553_D | 2.124 | 1.00 | |
| 53_V | 134_E | 2.119 | 1.00 | |
| 629_L | 659_V | 2.115 | 1.00 | |
| 641_L | 650_E | 2.111 | 1.00 | |
| 410_V | 459_L | 2.082 | 1.00 | |
| 166_G | 190_T | 2.072 | 1.00 | |
| 249_H | 285_W | 2.068 | 1.00 | |
| 166_G | 663_F | 2.065 | 1.00 | |
| 377_A | 403_N | 2.06 | 1.00 | |
| 414_W | 455_W | 2.049 | 1.00 | |
| 131_E | 158_K | 2.044 | 1.00 | |
| 171_D | 658_A | 2.02 | 1.00 | |
| 167_T | 662_R | 2.016 | 1.00 | |
| 633_V | 636_L | 2.015 | 1.00 | |
| 457_L | 477_V | 2.005 | 1.00 | |
| 485_R | 526_A | 1.991 | 1.00 | |
| 57_E | 61_R | 1.991 | 1.00 | |
| 205_G | 235_R | 1.976 | 1.00 | |
| 207_L | 235_R | 1.972 | 1.00 | |
| 475_V | 531_V | 1.972 | 1.00 | |
| 633_V | 655_Y | 1.969 | 1.00 | |
| 66_N | 69_D | 1.953 | 1.00 | |
| 336_G | 364_L | 1.952 | 1.00 | |
| 587_W | 621_W | 1.949 | 1.00 | |
| 548_N | 574_N | 1.942 | 1.00 | |
| 134_E | 154_N | 1.937 | 1.00 | |
| 622_Q | 628_K | 1.929 | 1.00 | |
| 451_T | 484_D | 1.918 | 1.00 | |
| 401_V | 409_T | 1.911 | 1.00 | |
| 76_G | 550_T | 1.911 | 1.00 | |
| 405_T | 408_V | 1.897 | 1.00 | |
| 628_K | 660_D | 1.896 | 1.00 | |
| 411_K | 476_T | 1.889 | 1.00 | |
| 478_F | 550_T | 1.875 | 1.00 | |
| 543_W | 579_W | 1.866 | 1.00 | |
| 474_S | 534_E | 1.862 | 1.00 | |
| 623_V | 629_L | 1.855 | 1.00 | |
| 411_K | 458_G | 1.848 | 1.00 | |
| 104_D | 240_E | 1.845 | 1.00 | |
| 201_M | 241_F | 1.84 | 1.00 | |
| 455_W | 481_D | 1.833 | 1.00 | |
| 169_T | 187_Q | 1.831 | 1.00 | |
| 373_F | 376_L | 1.831 | 1.00 | |
| 396_P | 416_T | 1.823 | 1.00 | |
| 412_G | 457_L | 1.817 | 1.00 | |
| 192_G | 201_M | 1.796 | 1.00 | |
| 416_T | 451_T | 1.796 | 1.00 | |
| 448_K | 484_D | 1.795 | 1.00 | |
| 103_V | 157_T | 1.794 | 1.00 | |
| 589_F | 619_A | 1.779 | 1.00 | |
| 631_A | 657_M | 1.778 | 1.00 | |
| 199_L | 241_F | 1.775 | 1.00 | |
| 616_N | 634_L | 1.77 | 1.00 | |
| 337_E | 363_A | 1.769 | 1.00 | |
| 103_V | 108_V | 1.768 | 1.00 | |
| 363_A | 383_R | 1.766 | 1.00 | |
| 385_D | 395_S | 1.766 | 1.00 | |
| 544_K | 578_D | 1.755 | 1.00 | |
| 363_A | 385_D | 1.752 | 1.00 | |
| 131_E | 159_K | 1.751 | 1.00 | |
| 399_Y | 413_G | 1.741 | 1.00 | |
| 92_R | 532_E | 1.73 | 1.00 | |
| 547_I | 575_G | 1.729 | 1.00 | |
| 417_A | 452_S | 1.7 | 1.00 | |
| 633_V | 653_R | 1.683 | 1.00 | |
| 170_V | 186_G | 1.68 | 1.00 | |
| 540_N | 543_W | 1.679 | 1.00 | |
| 198_V | 243_W | 1.679 | 1.00 | |
| 576_T | 592_S | 1.678 | 1.00 | |
| 91_I | 151_G | 1.672 | 1.00 | |
| 591_V | 617_T | 1.656 | 1.00 | |
| 477_V | 529_Q | 1.652 | 1.00 | |
| 43_N | 46_D | 1.646 | 1.00 | |
| 77_V | 91_I | 1.645 | 1.00 | |
| 52_S | 137_R | 1.639 | 1.00 | |
| 404_A | 459_L | 1.635 | 1.00 | |
| 340_H | 358_S | 1.623 | 1.00 | |
| 245_P | 251_F | 1.622 | 1.00 | |
| 331_F | 371_R | 1.621 | 1.00 | |
| 59_L | 70_V | 1.617 | 1.00 | |
| 393_H | 451_T | 1.61 | 1.00 | |
| 371_R | 377_A | 1.597 | 1.00 | |
| 472_E | 536_K | 1.583 | 1.00 | |
| 375_P | 404_A | 1.581 | 1.00 | |
| 481_D | 527_R | 1.577 | 1.00 | |
| 169_T | 658_A | 1.575 | 1.00 | |
| 57_E | 60_Q | 1.565 | 1.00 | |
| 629_L | 657_M | 1.548 | 1.00 | |
| 473_S | 533_T | 1.545 | 1.00 | |
| 200_G | 242_A | 1.539 | 1.00 | |
| 594_H | 614_I | 1.539 | 1.00 | |
| 104_D | 157_T | 1.536 | 1.00 | |
| 167_T | 660_D | 1.532 | 1.00 | |
| 477_V | 531_V | 1.526 | 1.00 | |
| 249_H | 281_H | 1.526 | 1.00 | |
| 539_F | 577_L | 1.523 | 1.00 | |
| 596_T | 612_Y | 1.519 | 1.00 | |
| 62_K | 73_E | 1.519 | 1.00 | |
| 338_W | 360_S | 1.515 | 1.00 | |
| 201_M | 239_V | 1.503 | 1.00 | |
| 334_V | 366_V | 1.498 | 1.00 | |
| 372_I | 400_L | 1.488 | 1.00 | |
| 419_K | 425_Q | 1.486 | 1.00 | |
| 481_D | 525_K | 1.478 | 1.00 | |
| 372_I | 378_L | 1.478 | 1.00 | |
| 471_V | 535_L | 1.464 | 1.00 | |
| 419_K | 450_E | 1.461 | 1.00 | |
| 46_D | 403_N | 1.451 | 1.00 | |
| 188_F | 205_G | 1.445 | 1.00 | |
| 622_Q | 662_R | 1.443 | 1.00 | |
| 396_P | 400_L | 1.443 | 1.00 | |
| 137_R | 532_E | 1.443 | 1.00 | |
| 628_K | 662_R | 1.439 | 1.00 | |
| 203_A | 237_G | 1.434 | 1.00 | |
| 478_F | 530_G | 1.434 | 1.00 | |
| 92_R | 456_E | 1.434 | 1.00 | |
| 549_Y | 573_A | 1.431 | 1.00 | |
| 412_G | 455_W | 1.426 | 1.00 | |
| 578_D | 590_Y | 1.426 | 1.00 | |
| 201_M | 205_G | 1.425 | 1.00 | |
| 459_L | 475_V | 1.411 | 1.00 | |
| 69_D | 72_K | 1.41 | 1.00 | |
| 614_I | 641_L | 1.408 | 1.00 | |
| 242_A | 250_D | 1.408 | 1.00 | |
| 162_Q | 200_G | 1.403 | 0.99 | |
| 587_W | 619_A | 1.397 | 0.99 | |
| 451_T | 483_K | 1.395 | 0.99 | |
| 634_L | 654_R | 1.393 | 0.99 | |
| 552_N | 568_L | 1.391 | 0.99 | |
| 386_D | 392_E | 1.385 | 0.99 | |
| 623_V | 627_V | 1.381 | 0.99 | |
| 331_F | 369_E | 1.378 | 0.99 | |
| 161_G | 191_S | 1.376 | 0.99 | |
| 454_S | 480_N | 1.373 | 0.99 | |
| 135_V | 153_V | 1.367 | 0.99 | |
| 526_A | 565_L | 1.367 | 0.99 | |
| 367_E | 379_T | 1.344 | 0.99 | |
| 461_Y | 473_S | 1.343 | 0.99 | |
| 168_V | 661_Y | 1.333 | 0.99 | |
| 615_W | 636_L | 1.333 | 0.99 | |
| 325_L | 328_I | 1.332 | 0.99 | |
| 332_L | 368_D | 1.328 | 0.99 | |
| 610_G | 639_K | 1.325 | 0.99 | |
| 487_S | 523_V | 1.323 | 0.99 | |
| 142_S | 381_G | 1.317 | 0.99 | |
| 618_G | 630_R | 1.317 | 0.99 | |
| 544_K | 580_K | 1.31 | 0.99 | |
| 404_A | 408_V | 1.298 | 0.99 | |
| 410_V | 457_L | 1.296 | 0.99 | |
| 531_V | 551_Y | 1.293 | 0.99 | |
| 614_I | 650_E | 1.292 | 0.99 | |
| 573_A | 595_Y | 1.291 | 0.99 | |
| 411_K | 460_Y | 1.289 | 0.99 | |
| 571_H | 597_G | 1.289 | 0.99 | |
| 209_K | 233_S | 1.288 | 0.99 | |
| 550_T | 572_T | 1.285 | 0.99 | |
| 164_W | 190_T | 1.279 | 0.99 | |
| 242_A | 252_T | 1.276 | 0.99 | |
| 205_G | 237_G | 1.272 | 0.99 | |
| 369_E | 377_A | 1.27 | 0.99 | |
| 75_P | 548_N | 1.267 | 0.99 | |
| 450_E | 482_V | 1.265 | 0.99 | |
| 551_Y | 570_F | 1.264 | 0.99 | |
| 144_Y | 152_V | 1.258 | 0.99 | |
| 370_W | 380_T | 1.249 | 0.99 | |
| 251_F | 283_G | 1.247 | 0.99 | |
| 378_L | 398_A | 1.245 | 0.98 | |
| 455_W | 479_R | 1.237 | 0.98 | |
| 30_G | 33_M | 1.232 | 0.98 | |
| 58_D | 61_R | 1.231 | 0.98 | |
| 206_S | 236_D | 1.228 | 0.98 | |
| 244_T | 250_D | 1.226 | 0.98 | |
| 578_D | 588_S | 1.225 | 0.98 | |
| 403_N | 409_T | 1.215 | 0.98 | |
| 400_L | 404_A | 1.215 | 0.98 | |
| 362_Y | 386_D | 1.213 | 0.98 | |
| 89_V | 153_V | 1.213 | 0.98 | |
| 165_S | 191_S | 1.213 | 0.98 | |
| 126_P | 129_S | 1.213 | 0.98 | |
| 38_S | 42_Q | 1.209 | 0.98 | |
| 564_P | 570_F | 1.201 | 0.98 | |
| 535_L | 547_I | 1.201 | 0.98 | |
| 159_K | 240_E | 1.2 | 0.98 | |
| 600_R | 608_T | 1.198 | 0.98 | |
| 586_D | 621_W | 1.179 | 0.98 | |
| 528_I | 554_G | 1.175 | 0.98 | |
| 134_E | 156_I | 1.175 | 0.98 | |
| 167_T | 189_F | 1.166 | 0.97 | |
| 619_A | 633_V | 1.164 | 0.97 | |
| 489_S | 521_Y | 1.163 | 0.97 | |
| 617_T | 633_V | 1.16 | 0.97 | |
| 161_G | 165_S | 1.16 | 0.97 | |
| 67_L | 155_I | 1.16 | 0.97 | |
| 249_H | 283_G | 1.156 | 0.97 | |
| 626_D | 661_Y | 1.152 | 0.97 | |
| 259_R | 275_Q | 1.152 | 0.97 | |
| 536_K | 544_K | 1.145 | 0.97 | |
| 591_V | 636_L | 1.137 | 0.97 | |
| 627_V | 631_A | 1.137 | 0.97 | |
| 659_V | 663_F | 1.13 | 0.97 | |
| 630_R | 660_D | 1.13 | 0.97 | |
| 172_T | 657_M | 1.124 | 0.97 | |
| 104_D | 254_G | 1.119 | 0.96 | |
| 164_W | 192_G | 1.111 | 0.96 | |
| 460_Y | 474_S | 1.106 | 0.96 | |
| 377_A | 401_V | 1.105 | 0.96 | |
| 56_Q | 131_E | 1.104 | 0.96 | |
| 447_L | 486_I | 1.102 | 0.96 | |
| 91_I | 135_V | 1.099 | 0.96 | |
| 164_W | 193_P | 1.098 | 0.96 | |
| 638_D | 652_G | 1.093 | 0.96 | |
| 61_R | 578_D | 1.09 | 0.96 | |
| 364_L | 384_M | 1.089 | 0.96 | |
| 538_P | 544_K | 1.088 | 0.96 | |
| 172_T | 176_E | 1.087 | 0.96 | |
| 456_E | 476_T | 1.087 | 0.96 | |
| 94_L | 482_V | 1.083 | 0.96 | |
| 613_T | 639_K | 1.078 | 0.95 | |
| 602_D | 605_T | 1.077 | 0.95 | |
| 478_F | 532_E | 1.077 | 0.95 | |
| 539_F | 545_L | 1.074 | 0.95 | |
| 54_I | 74_V | 1.074 | 0.95 | |
| 328_I | 370_W | 1.073 | 0.95 | |
| 102_L | 152_V | 1.067 | 0.95 | |
| 53_V | 132_R | 1.064 | 0.95 | |
| 105_G | 154_N | 1.063 | 0.95 | |
| 545_L | 575_G | 1.063 | 0.95 | |
| 636_L | 653_R | 1.061 | 0.95 | |
| 149_L | 452_S | 1.059 | 0.95 | |
| 407_T | 461_Y | 1.059 | 0.95 | |
| 581_P | 584_L | 1.055 | 0.95 | |
| 171_D | 185_N | 1.053 | 0.95 | |
| 74_V | 77_V | 1.051 | 0.94 | |
| 450_E | 485_R | 1.049 | 0.94 | |
| 64_V | 70_V | 1.044 | 0.94 | |
| 588_S | 622_Q | 1.039 | 0.94 | |
| 657_M | 661_Y | 1.036 | 0.94 | |
| 547_I | 573_A | 1.035 | 0.94 | |
| 452_S | 480_N | 1.035 | 0.94 | |
| 400_L | 412_G | 1.034 | 0.94 | |
| 52_S | 534_E | 1.032 | 0.94 | |
| 380_T | 400_L | 1.032 | 0.94 | |
| 624_T | 627_V | 1.029 | 0.94 | |
| 245_P | 249_H | 1.026 | 0.94 | |
| 369_E | 379_T | 1.026 | 0.94 | |
| 100_L | 107_R | 1.023 | 0.93 | |
| 166_G | 170_V | 1.02 | 0.93 | |
| 136_V | 152_V | 1.015 | 0.93 | |
| 382_V | 396_P | 1.013 | 0.93 | |
| 408_V | 412_G | 1.008 | 0.93 | |
| 634_L | 656_F | 1.008 | 0.93 | |
| 581_P | 589_F | 1.006 | 0.93 | |
| 237_G | 257_F | 1.004 | 0.93 | |
| 554_G | 568_L | 1.003 | 0.93 | |
| 75_P | 534_E | 1.001 | 0.92 | |
| 563_K | 605_T | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2hdiA | 1 | 0.9608 | 100 | 0.163 | Contact Map | 0.793 |
| 4epaA | 1 | 0.8808 | 100 | 0.245 | Contact Map | 0.737 |
| 2gufA | 1 | 0.8582 | 100 | 0.253 | Contact Map | 0.771 |
| 3efmA | 1 | 0.8974 | 100 | 0.263 | Contact Map | 0.806 |
| 1xkwA | 1 | 0.8643 | 100 | 0.264 | Contact Map | 0.784 |
| 3qlbA | 2 | 0.8929 | 100 | 0.265 | Contact Map | 0.79 |
| 3fhhA | 1 | 0.8884 | 100 | 0.266 | Contact Map | 0.724 |
| 1qfgA | 1 | 0.8824 | 100 | 0.267 | Contact Map | 0.748 |
| 4b7oA | 1 | 0.9246 | 100 | 0.269 | Contact Map | 0.737 |
| 1fepA | 1 | 0.9231 | 100 | 0.271 | Contact Map | 0.778 |
Sequence Conservation (Image Generated using WebLogo v3)