| UniProt: | P06129 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10126 | ||
| Length: | 614 (591) | ||
| Sequences: | 20221 | ||
| Seq/Len: | 34.21 |
| BTUB
Paralog alert: 0.93 [within 20: 0.34] - ratio of genomes with paralogs Cluster includes: BTUB CIRA FECA FEPA FHUA FHUE FIU YDDB YNCD |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 501_Y | 521_Q | 4.976 | 1.00 | |
| 377_A | 389_G | 4.536 | 1.00 | |
| 457_R | 482_K | 4.385 | 1.00 | |
| 540_Y | 565_S | 4.276 | 1.00 | |
| 409_Y | 436_K | 3.85 | 1.00 | |
| 403_Y | 442_F | 3.818 | 1.00 | |
| 379_S | 387_R | 3.809 | 1.00 | |
| 411_T | 436_K | 3.624 | 1.00 | |
| 567_W | 589_F | 3.551 | 1.00 | |
| 234_W | 276_Y | 3.165 | 1.00 | |
| 379_S | 389_G | 3.093 | 1.00 | |
| 535_D | 572_A | 3.06 | 1.00 | |
| 371_F | 397_W | 3.057 | 1.00 | |
| 184_T | 228_H | 3.016 | 1.00 | |
| 51_R | 55_D | 2.977 | 1.00 | |
| 334_G | 361_Y | 2.951 | 1.00 | |
| 124_V | 149_I | 2.876 | 1.00 | |
| 582_R | 609_S | 2.834 | 1.00 | |
| 449_V | 490_F | 2.82 | 1.00 | |
| 480_R | 509_A | 2.818 | 1.00 | |
| 126_R | 150_I | 2.802 | 1.00 | |
| 403_Y | 444_G | 2.781 | 1.00 | |
| 370_D | 397_W | 2.735 | 1.00 | |
| 503_Y | 521_Q | 2.667 | 1.00 | |
| 456_Y | 504_V | 2.613 | 1.00 | |
| 192_Y | 220_K | 2.611 | 1.00 | |
| 453_I | 486_A | 2.593 | 1.00 | |
| 457_R | 480_R | 2.562 | 1.00 | |
| 50_T | 53_D | 2.501 | 1.00 | |
| 540_Y | 567_W | 2.459 | 1.00 | |
| 498_T | 526_Q | 2.434 | 1.00 | |
| 542_Y | 565_S | 2.422 | 1.00 | |
| 451_W | 488_A | 2.412 | 1.00 | |
| 399_F | 405_F | 2.376 | 1.00 | |
| 69_L | 129_Y | 2.373 | 1.00 | |
| 231_T | 234_W | 2.355 | 1.00 | |
| 545_T | 560_K | 2.289 | 1.00 | |
| 371_F | 395_A | 2.222 | 1.00 | |
| 444_G | 451_W | 2.216 | 1.00 | |
| 537_G | 570_A | 2.21 | 1.00 | |
| 495_L | 527_L | 2.204 | 1.00 | |
| 539_T | 568_D | 2.196 | 1.00 | |
| 158_T | 176_T | 2.194 | 1.00 | |
| 583_G | 606_Y | 2.182 | 1.00 | |
| 178_Q | 186_V | 2.17 | 1.00 | |
| 399_F | 403_Y | 2.132 | 1.00 | |
| 190_G | 220_K | 2.123 | 1.00 | |
| 542_Y | 563_G | 2.117 | 1.00 | |
| 409_Y | 438_W | 2.116 | 1.00 | |
| 579_L | 612_Y | 2.116 | 1.00 | |
| 541_Q | 568_D | 2.105 | 1.00 | |
| 396_G | 404_R | 2.076 | 1.00 | |
| 373_F | 395_A | 2.067 | 1.00 | |
| 375_G | 393_T | 2.061 | 1.00 | |
| 411_T | 434_K | 2.05 | 1.00 | |
| 339_K | 356_R | 2.047 | 1.00 | |
| 584_K | 607_T | 2.032 | 1.00 | |
| 538_I | 567_W | 2.026 | 1.00 | |
| 494_P | 529_W | 2.012 | 1.00 | |
| 237_F | 273_G | 2.012 | 1.00 | |
| 569_L | 588_L | 1.995 | 1.00 | |
| 497_H | 527_L | 1.993 | 1.00 | |
| 235_S | 275_R | 1.987 | 1.00 | |
| 452_R | 487_T | 1.979 | 1.00 | |
| 236_G | 274_L | 1.965 | 1.00 | |
| 51_R | 152_T | 1.963 | 1.00 | |
| 572_A | 580_T | 1.961 | 1.00 | |
| 61_S | 64_D | 1.96 | 1.00 | |
| 48_V | 128_E | 1.946 | 1.00 | |
| 453_I | 484_V | 1.933 | 1.00 | |
| 162_A | 172_Y | 1.918 | 1.00 | |
| 52_Q | 56_R | 1.917 | 1.00 | |
| 440_G | 455_G | 1.915 | 1.00 | |
| 463_L | 479_A | 1.908 | 1.00 | |
| 233_A | 276_Y | 1.906 | 1.00 | |
| 579_L | 610_G | 1.905 | 1.00 | |
| 585_I | 588_L | 1.895 | 1.00 | |
| 450_N | 489_N | 1.881 | 1.00 | |
| 128_E | 148_N | 1.877 | 1.00 | |
| 534_F | 573_Y | 1.868 | 1.00 | |
| 434_K | 462_D | 1.866 | 1.00 | |
| 125_Q | 152_T | 1.862 | 1.00 | |
| 482_K | 505_D | 1.859 | 1.00 | |
| 335_V | 358_T | 1.857 | 1.00 | |
| 581_V | 610_G | 1.855 | 1.00 | |
| 459_D | 480_R | 1.85 | 1.00 | |
| 159_E | 613_T | 1.846 | 1.00 | |
| 431_D | 462_D | 1.841 | 1.00 | |
| 405_F | 442_F | 1.835 | 1.00 | |
| 227_E | 235_S | 1.827 | 1.00 | |
| 372_T | 398_E | 1.821 | 1.00 | |
| 161_S | 611_S | 1.82 | 1.00 | |
| 337_W | 358_T | 1.819 | 1.00 | |
| 161_S | 173_D | 1.814 | 1.00 | |
| 593_Y | 601_T | 1.81 | 1.00 | |
| 100_I | 105_L | 1.807 | 1.00 | |
| 234_W | 274_L | 1.796 | 1.00 | |
| 585_I | 606_Y | 1.794 | 1.00 | |
| 38_P | 41_T | 1.792 | 1.00 | |
| 188_L | 224_G | 1.79 | 1.00 | |
| 459_D | 478_K | 1.786 | 1.00 | |
| 391_W | 411_T | 1.785 | 1.00 | |
| 455_G | 482_K | 1.778 | 1.00 | |
| 100_I | 151_T | 1.776 | 1.00 | |
| 574_P | 580_T | 1.773 | 1.00 | |
| 120_P | 123_L | 1.753 | 1.00 | |
| 71_G | 502_D | 1.75 | 1.00 | |
| 186_V | 226_L | 1.729 | 1.00 | |
| 230_F | 236_G | 1.727 | 1.00 | |
| 456_Y | 502_D | 1.725 | 1.00 | |
| 500_S | 524_K | 1.721 | 1.00 | |
| 394_S | 408_S | 1.715 | 1.00 | |
| 495_L | 529_W | 1.71 | 1.00 | |
| 580_T | 611_S | 1.708 | 1.00 | |
| 101_D | 225_A | 1.703 | 1.00 | |
| 359_G | 378_R | 1.689 | 1.00 | |
| 163_G | 609_S | 1.678 | 1.00 | |
| 125_Q | 153_R | 1.668 | 1.00 | |
| 406_I | 441_A | 1.658 | 1.00 | |
| 439_E | 454_S | 1.658 | 1.00 | |
| 438_W | 459_D | 1.649 | 1.00 | |
| 400_I | 403_Y | 1.648 | 1.00 | |
| 158_T | 614_F | 1.648 | 1.00 | |
| 89_R | 485_E | 1.648 | 1.00 | |
| 406_I | 454_S | 1.644 | 1.00 | |
| 229_N | 235_S | 1.637 | 1.00 | |
| 407_A | 440_G | 1.632 | 1.00 | |
| 194_H | 218_L | 1.628 | 1.00 | |
| 329_G | 364_G | 1.626 | 1.00 | |
| 184_T | 226_L | 1.624 | 1.00 | |
| 575_V | 581_V | 1.616 | 1.00 | |
| 335_V | 360_I | 1.614 | 1.00 | |
| 536_W | 571_V | 1.605 | 1.00 | |
| 568_D | 586_A | 1.599 | 1.00 | |
| 57_W | 68_R | 1.597 | 1.00 | |
| 437_Q | 458_N | 1.594 | 1.00 | |
| 496_T | 528_D | 1.585 | 1.00 | |
| 227_E | 237_F | 1.585 | 1.00 | |
| 52_Q | 55_D | 1.582 | 1.00 | |
| 72_V | 88_I | 1.581 | 1.00 | |
| 414_K | 433_E | 1.581 | 1.00 | |
| 391_W | 395_A | 1.579 | 1.00 | |
| 275_R | 282_K | 1.576 | 1.00 | |
| 585_I | 604_R | 1.564 | 1.00 | |
| 456_Y | 483_G | 1.563 | 1.00 | |
| 499_V | 525_Y | 1.554 | 1.00 | |
| 526_Q | 539_T | 1.548 | 1.00 | |
| 583_G | 608_L | 1.543 | 1.00 | |
| 359_G | 380_D | 1.535 | 1.00 | |
| 406_I | 443_E | 1.524 | 1.00 | |
| 88_I | 145_G | 1.522 | 1.00 | |
| 367_Q | 372_T | 1.516 | 1.00 | |
| 380_D | 390_T | 1.508 | 1.00 | |
| 53_D | 56_R | 1.502 | 1.00 | |
| 183_K | 228_H | 1.497 | 1.00 | |
| 101_D | 151_T | 1.496 | 1.00 | |
| 381_D | 387_R | 1.494 | 1.00 | |
| 185_R | 227_E | 1.494 | 1.00 | |
| 484_V | 503_Y | 1.491 | 1.00 | |
| 399_F | 442_F | 1.483 | 1.00 | |
| 41_T | 398_E | 1.482 | 1.00 | |
| 412_S | 435_S | 1.478 | 1.00 | |
| 455_G | 484_V | 1.476 | 1.00 | |
| 448_G | 490_F | 1.476 | 1.00 | |
| 538_I | 569_L | 1.47 | 1.00 | |
| 443_E | 452_R | 1.467 | 1.00 | |
| 388_H | 434_K | 1.461 | 1.00 | |
| 64_D | 67_R | 1.449 | 1.00 | |
| 275_R | 284_Q | 1.447 | 1.00 | |
| 436_K | 461_S | 1.435 | 1.00 | |
| 331_I | 364_G | 1.43 | 1.00 | |
| 89_R | 439_E | 1.428 | 1.00 | |
| 47_T | 131_R | 1.424 | 1.00 | |
| 541_Q | 566_L | 1.423 | 1.00 | |
| 481_I | 506_A | 1.423 | 1.00 | |
| 492_T | 495_L | 1.422 | 1.00 | |
| 543_L | 564_V | 1.421 | 1.00 | |
| 336_D | 359_G | 1.421 | 1.00 | |
| 442_F | 453_I | 1.417 | 1.00 | |
| 188_L | 222_L | 1.413 | 1.00 | |
| 449_V | 488_A | 1.407 | 0.99 | |
| 190_G | 222_L | 1.403 | 0.99 | |
| 407_A | 438_W | 1.401 | 0.99 | |
| 363_T | 374_E | 1.394 | 0.99 | |
| 465_D | 476_E | 1.391 | 0.99 | |
| 339_K | 354_D | 1.383 | 0.99 | |
| 451_W | 486_A | 1.376 | 0.99 | |
| 489_N | 498_T | 1.373 | 0.99 | |
| 186_V | 190_G | 1.363 | 0.99 | |
| 153_R | 225_A | 1.363 | 0.99 | |
| 581_V | 608_L | 1.36 | 0.99 | |
| 131_R | 485_E | 1.357 | 0.99 | |
| 277_N | 282_K | 1.347 | 0.99 | |
| 574_P | 613_T | 1.342 | 0.99 | |
| 186_V | 224_G | 1.331 | 0.99 | |
| 191_D | 221_T | 1.33 | 0.99 | |
| 491_D | 496_T | 1.326 | 0.99 | |
| 370_D | 399_F | 1.318 | 0.99 | |
| 586_A | 605_E | 1.315 | 0.99 | |
| 161_S | 609_S | 1.299 | 0.99 | |
| 575_V | 579_L | 1.29 | 0.99 | |
| 373_F | 393_T | 1.286 | 0.99 | |
| 235_S | 277_N | 1.285 | 0.99 | |
| 438_W | 457_R | 1.278 | 0.99 | |
| 467_D | 474_Y | 1.277 | 0.99 | |
| 479_A | 515_L | 1.276 | 0.99 | |
| 580_T | 613_T | 1.275 | 0.99 | |
| 528_D | 537_G | 1.275 | 0.99 | |
| 54_I | 65_V | 1.271 | 0.99 | |
| 405_F | 440_G | 1.261 | 0.99 | |
| 70_P | 500_S | 1.257 | 0.99 | |
| 70_P | 487_T | 1.254 | 0.99 | |
| 159_E | 611_S | 1.253 | 0.99 | |
| 534_F | 571_V | 1.238 | 0.98 | |
| 489_N | 496_T | 1.238 | 0.98 | |
| 330_S | 367_Q | 1.232 | 0.98 | |
| 240_G | 270_W | 1.231 | 0.98 | |
| 337_W | 356_R | 1.231 | 0.98 | |
| 330_S | 365_L | 1.226 | 0.98 | |
| 372_T | 396_G | 1.224 | 0.98 | |
| 163_G | 171_N | 1.223 | 0.98 | |
| 238_V | 272_A | 1.221 | 0.98 | |
| 101_D | 239_R | 1.219 | 0.98 | |
| 165_G | 169_Y | 1.217 | 0.98 | |
| 242_G | 268_Q | 1.209 | 0.98 | |
| 566_L | 593_Y | 1.205 | 0.98 | |
| 570_A | 582_R | 1.204 | 0.98 | |
| 461_S | 478_K | 1.203 | 0.98 | |
| 395_A | 399_F | 1.201 | 0.98 | |
| 129_Y | 147_V | 1.199 | 0.98 | |
| 368_V | 395_A | 1.195 | 0.98 | |
| 496_T | 530_Q | 1.194 | 0.98 | |
| 504_V | 518_R | 1.194 | 0.98 | |
| 25_P | 28_L | 1.193 | 0.98 | |
| 69_L | 72_V | 1.192 | 0.98 | |
| 414_K | 420_Q | 1.187 | 0.98 | |
| 240_G | 268_Q | 1.186 | 0.98 | |
| 566_L | 601_T | 1.185 | 0.98 | |
| 395_A | 407_A | 1.181 | 0.98 | |
| 523_V | 542_Y | 1.181 | 0.98 | |
| 398_E | 402_G | 1.171 | 0.98 | |
| 562_G | 591_K | 1.158 | 0.97 | |
| 59_S | 65_V | 1.152 | 0.97 | |
| 433_E | 460_V | 1.151 | 0.97 | |
| 567_W | 588_L | 1.149 | 0.97 | |
| 333_A | 362_L | 1.148 | 0.97 | |
| 521_Q | 544_G | 1.143 | 0.97 | |
| 434_K | 461_S | 1.14 | 0.97 | |
| 502_D | 522_Q | 1.139 | 0.97 | |
| 503_Y | 520_K | 1.134 | 0.97 | |
| 571_V | 585_I | 1.134 | 0.97 | |
| 278_G | 283_S | 1.127 | 0.97 | |
| 466_Y | 473_Y | 1.121 | 0.97 | |
| 514_P | 520_K | 1.118 | 0.96 | |
| 230_F | 234_W | 1.117 | 0.96 | |
| 128_E | 150_I | 1.115 | 0.96 | |
| 138_Y | 146_V | 1.114 | 0.96 | |
| 403_Y | 407_A | 1.114 | 0.96 | |
| 488_A | 499_V | 1.113 | 0.96 | |
| 62_V | 149_I | 1.111 | 0.96 | |
| 528_D | 535_D | 1.104 | 0.96 | |
| 547_Y | 560_K | 1.103 | 0.96 | |
| 501_Y | 523_V | 1.102 | 0.96 | |
| 158_T | 162_A | 1.101 | 0.96 | |
| 366_Q | 375_G | 1.098 | 0.96 | |
| 531_L | 536_W | 1.096 | 0.96 | |
| 478_K | 509_A | 1.093 | 0.96 | |
| 103_V | 288_S | 1.092 | 0.96 | |
| 578_H | 612_Y | 1.086 | 0.96 | |
| 365_L | 372_T | 1.084 | 0.96 | |
| 51_R | 125_Q | 1.079 | 0.95 | |
| 368_V | 373_F | 1.079 | 0.95 | |
| 164_W | 170_Q | 1.076 | 0.95 | |
| 398_E | 404_R | 1.075 | 0.95 | |
| 33_N | 37_Q | 1.071 | 0.95 | |
| 158_T | 174_V | 1.063 | 0.95 | |
| 365_L | 374_E | 1.059 | 0.95 | |
| 569_L | 585_I | 1.058 | 0.95 | |
| 98_V | 147_V | 1.053 | 0.95 | |
| 238_V | 270_W | 1.048 | 0.94 | |
| 160_I | 612_Y | 1.048 | 0.94 | |
| 237_F | 275_R | 1.047 | 0.94 | |
| 456_Y | 485_E | 1.046 | 0.94 | |
| 582_R | 611_S | 1.046 | 0.94 | |
| 143_I | 435_S | 1.045 | 0.94 | |
| 136_A | 376_A | 1.043 | 0.94 | |
| 47_T | 487_T | 1.043 | 0.94 | |
| 435_S | 460_V | 1.041 | 0.94 | |
| 192_Y | 218_L | 1.038 | 0.94 | |
| 88_I | 129_Y | 1.034 | 0.94 | |
| 48_V | 126_R | 1.033 | 0.94 | |
| 360_I | 379_S | 1.033 | 0.94 | |
| 43_L | 394_S | 1.026 | 0.94 | |
| 358_T | 381_D | 1.019 | 0.93 | |
| 579_L | 583_G | 1.015 | 0.93 | |
| 430_L | 464_I | 1.014 | 0.93 | |
| 229_N | 232_D | 1.013 | 0.93 | |
| 159_E | 175_S | 1.013 | 0.93 | |
| 435_S | 458_N | 1.012 | 0.93 | |
| 362_L | 377_A | 1.012 | 0.93 | |
| 377_A | 391_W | 1.011 | 0.93 | |
| 99_L | 148_N | 1.006 | 0.93 | |
| 433_E | 463_L | 1.005 | 0.93 | |
| 391_W | 409_Y | 1.003 | 0.93 | |
| 60_T | 64_D | 1.003 | 0.93 | |
| 445_L | 449_V | 1.001 | 0.92 | |
| 185_R | 229_N | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2gufA | 1 | 0.9674 | 100 | 0.154 | Contact Map | 0.797 |
| 4epaA | 1 | 0.943 | 100 | 0.227 | Contact Map | 0.746 |
| 2hdiA | 1 | 0.9283 | 100 | 0.229 | Contact Map | 0.797 |
| 3qlbA | 2 | 0.9544 | 100 | 0.234 | Contact Map | 0.804 |
| 3efmA | 1 | 0.9609 | 100 | 0.236 | Contact Map | 0.818 |
| 1qfgA | 1 | 0.9463 | 100 | 0.239 | Contact Map | 0.748 |
| 1xkwA | 1 | 0.9235 | 100 | 0.241 | Contact Map | 0.807 |
| 3fhhA | 1 | 0.9251 | 100 | 0.242 | Contact Map | 0.737 |
| 1kmoA | 1 | 0.9772 | 100 | 0.245 | Contact Map | 0.798 |
| 4b7oA | 1 | 0.9837 | 100 | 0.256 | Contact Map | 0.757 |
Sequence Conservation (Image Generated using WebLogo v3)