| UniProt: | P45541 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12910 | ||
| Length: | 276 (272) | ||
| Sequences: | 6064 | ||
| Seq/Len: | 22.29 |
| FRLC
Paralog alert: 0.70 [within 20: 0.18] - ratio of genomes with paralogs Cluster includes: END4 FRLC HYI SGBU ULAE YCJR YGBM |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 227_P | 230_E | 3.375 | 1.00 | |
| 53_K | 57_Q | 3.324 | 1.00 | |
| 177_F | 204_R | 3.18 | 1.00 | |
| 210_D | 222_G | 3.099 | 1.00 | |
| 97_D | 141_I | 3.067 | 1.00 | |
| 20_R | 59_Y | 2.89 | 1.00 | |
| 93_K | 137_Y | 2.869 | 1.00 | |
| 29_G | 243_Y | 2.809 | 1.00 | |
| 128_A | 170_L | 2.785 | 1.00 | |
| 97_D | 137_Y | 2.657 | 1.00 | |
| 54_A | 58_T | 2.574 | 1.00 | |
| 86_R | 90_D | 2.394 | 1.00 | |
| 166_H | 170_L | 2.363 | 1.00 | |
| 144_D | 177_F | 2.27 | 1.00 | |
| 14_P | 17_H | 2.126 | 1.00 | |
| 136_E | 173_S | 2.126 | 1.00 | |
| 144_D | 204_R | 2.108 | 1.00 | |
| 264_L | 268_R | 2.108 | 1.00 | |
| 16_E | 55_L | 2.077 | 1.00 | |
| 20_R | 24_E | 2.072 | 1.00 | |
| 197_D | 234_D | 2.062 | 1.00 | |
| 55_L | 59_Y | 2.04 | 1.00 | |
| 261_R | 265_E | 1.976 | 1.00 | |
| 146_I | 204_R | 1.962 | 1.00 | |
| 89_L | 133_E | 1.95 | 1.00 | |
| 56_A | 63_I | 1.943 | 1.00 | |
| 100_K | 141_I | 1.893 | 1.00 | |
| 106_Y | 146_I | 1.893 | 1.00 | |
| 197_D | 237_E | 1.86 | 1.00 | |
| 124_W | 166_H | 1.824 | 1.00 | |
| 135_C | 176_L | 1.796 | 1.00 | |
| 125_G | 170_L | 1.792 | 1.00 | |
| 191_P | 194_S | 1.785 | 1.00 | |
| 55_L | 58_T | 1.781 | 1.00 | |
| 85_R | 130_N | 1.714 | 1.00 | |
| 165_L | 169_A | 1.689 | 1.00 | |
| 23_S | 59_Y | 1.646 | 1.00 | |
| 234_D | 237_E | 1.642 | 1.00 | |
| 99_A | 104_A | 1.641 | 1.00 | |
| 96_M | 138_A | 1.629 | 1.00 | |
| 137_Y | 141_I | 1.626 | 1.00 | |
| 233_R | 237_E | 1.625 | 1.00 | |
| 265_E | 269_A | 1.624 | 1.00 | |
| 122_V | 125_G | 1.614 | 1.00 | |
| 96_M | 141_I | 1.602 | 1.00 | |
| 124_W | 170_L | 1.595 | 1.00 | |
| 51_Q | 54_A | 1.593 | 1.00 | |
| 194_S | 198_K | 1.583 | 1.00 | |
| 206_L | 235_I | 1.575 | 1.00 | |
| 94_L | 97_D | 1.56 | 1.00 | |
| 16_E | 51_Q | 1.545 | 1.00 | |
| 49_I | 101_E | 1.543 | 1.00 | |
| 48_G | 51_Q | 1.539 | 1.00 | |
| 90_D | 94_L | 1.538 | 1.00 | |
| 162_N | 198_K | 1.53 | 1.00 | |
| 20_R | 55_L | 1.53 | 1.00 | |
| 136_E | 140_N | 1.528 | 1.00 | |
| 46_A | 101_E | 1.499 | 1.00 | |
| 139_E | 173_S | 1.485 | 1.00 | |
| 146_I | 179_M | 1.48 | 1.00 | |
| 128_A | 132_S | 1.476 | 1.00 | |
| 19_F | 59_Y | 1.465 | 1.00 | |
| 16_E | 58_T | 1.464 | 1.00 | |
| 50_K | 101_E | 1.461 | 1.00 | |
| 149_P | 185_P | 1.455 | 1.00 | |
| 137_Y | 140_N | 1.429 | 1.00 | |
| 139_E | 175_R | 1.42 | 1.00 | |
| 177_F | 202_K | 1.41 | 1.00 | |
| 210_D | 224_G | 1.407 | 0.99 | |
| 135_C | 171_V | 1.405 | 0.99 | |
| 126_R | 129_E | 1.404 | 0.99 | |
| 21_D | 24_E | 1.395 | 0.99 | |
| 125_G | 129_E | 1.386 | 0.99 | |
| 229_R | 233_R | 1.355 | 0.99 | |
| 119_P | 122_V | 1.353 | 0.99 | |
| 255_E | 258_L | 1.349 | 0.99 | |
| 169_A | 202_K | 1.34 | 0.99 | |
| 50_K | 54_A | 1.32 | 0.99 | |
| 165_L | 198_K | 1.317 | 0.99 | |
| 22_A | 27_Y | 1.313 | 0.99 | |
| 106_Y | 144_D | 1.312 | 0.99 | |
| 2_K | 62_P | 1.311 | 0.99 | |
| 27_Y | 246_V | 1.309 | 0.99 | |
| 89_L | 93_K | 1.285 | 0.99 | |
| 234_D | 238_R | 1.279 | 0.99 | |
| 129_E | 132_S | 1.279 | 0.99 | |
| 19_F | 55_L | 1.272 | 0.99 | |
| 96_M | 137_Y | 1.27 | 0.99 | |
| 54_A | 57_Q | 1.269 | 0.99 | |
| 136_E | 139_E | 1.264 | 0.99 | |
| 132_S | 172_P | 1.264 | 0.99 | |
| 193_M | 230_E | 1.259 | 0.99 | |
| 139_E | 174_P | 1.259 | 0.99 | |
| 90_D | 93_K | 1.254 | 0.99 | |
| 51_Q | 55_L | 1.248 | 0.99 | |
| 93_K | 97_D | 1.234 | 0.98 | |
| 266_R | 270_L | 1.227 | 0.98 | |
| 86_R | 133_E | 1.226 | 0.98 | |
| 93_K | 133_E | 1.217 | 0.98 | |
| 17_H | 20_R | 1.213 | 0.98 | |
| 223_E | 262_Q | 1.207 | 0.98 | |
| 194_S | 197_D | 1.205 | 0.98 | |
| 160_N | 163_D | 1.187 | 0.98 | |
| 258_L | 262_Q | 1.177 | 0.98 | |
| 56_A | 61_M | 1.171 | 0.98 | |
| 196_F | 234_D | 1.171 | 0.98 | |
| 92_I | 134_L | 1.171 | 0.98 | |
| 27_Y | 264_L | 1.152 | 0.97 | |
| 82_E | 86_R | 1.151 | 0.97 | |
| 84_M | 87_E | 1.149 | 0.97 | |
| 53_K | 101_E | 1.149 | 0.97 | |
| 93_K | 140_N | 1.145 | 0.97 | |
| 159_C | 163_D | 1.145 | 0.97 | |
| 21_D | 257_R | 1.144 | 0.97 | |
| 22_A | 30_I | 1.143 | 0.97 | |
| 128_A | 171_V | 1.136 | 0.97 | |
| 121_N | 125_G | 1.133 | 0.97 | |
| 182_I | 231_L | 1.131 | 0.97 | |
| 99_A | 107_T | 1.127 | 0.97 | |
| 164_V | 178_S | 1.123 | 0.97 | |
| 96_M | 143_M | 1.123 | 0.97 | |
| 97_D | 100_K | 1.122 | 0.97 | |
| 83_H | 87_E | 1.107 | 0.96 | |
| 165_L | 199_L | 1.105 | 0.96 | |
| 106_Y | 204_R | 1.104 | 0.96 | |
| 196_F | 238_R | 1.102 | 0.96 | |
| 178_S | 199_L | 1.097 | 0.96 | |
| 180_V | 185_P | 1.089 | 0.96 | |
| 62_P | 105_G | 1.089 | 0.96 | |
| 212_D | 219_Y | 1.086 | 0.96 | |
| 230_E | 234_D | 1.086 | 0.96 | |
| 5_M | 22_A | 1.075 | 0.95 | |
| 16_E | 20_R | 1.074 | 0.95 | |
| 23_S | 60_Q | 1.066 | 0.95 | |
| 200_G | 238_R | 1.063 | 0.95 | |
| 193_M | 197_D | 1.061 | 0.95 | |
| 97_D | 101_E | 1.053 | 0.95 | |
| 142_G | 175_R | 1.049 | 0.94 | |
| 85_R | 129_E | 1.047 | 0.94 | |
| 29_G | 64_I | 1.036 | 0.94 | |
| 235_I | 238_R | 1.035 | 0.94 | |
| 132_S | 173_S | 1.034 | 0.94 | |
| 138_A | 145_L | 1.034 | 0.94 | |
| 120_P | 163_D | 1.03 | 0.94 | |
| 56_A | 59_Y | 1.029 | 0.94 | |
| 63_I | 104_A | 1.028 | 0.94 | |
| 166_H | 169_A | 1.027 | 0.94 | |
| 132_S | 171_V | 1.023 | 0.93 | |
| 165_L | 202_K | 1.011 | 0.93 | |
| 45_K | 48_G | 1.003 | 0.93 | |
| 162_N | 166_H | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3cqjA | 2 | 0.9855 | 100 | 0.196 | Contact Map | 0.693 |
| 1i60A | 1 | 0.9674 | 100 | 0.206 | Contact Map | 0.673 |
| 3kwsA | 2 | 0.9312 | 100 | 0.214 | Contact Map | 0.69 |
| 2zdsA | 6 | 0.9855 | 100 | 0.216 | Contact Map | 0.735 |
| 3vniA | 4 | 0.9601 | 100 | 0.217 | Contact Map | 0.783 |
| 2qulA | 4 | 0.9457 | 100 | 0.222 | Contact Map | 0.769 |
| 3vylA | 8 | 0.9457 | 100 | 0.224 | Contact Map | 0.717 |
| 2hk0A | 4 | 0.9493 | 100 | 0.225 | Contact Map | 0.724 |
| 3dx5A | 1 | 0.942 | 100 | 0.229 | Contact Map | 0.68 |
| 3u0hA | 2 | 0.9638 | 100 | 0.234 | Contact Map | 0.639 |
Sequence Conservation (Image Generated using WebLogo v3)