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ULAE - L-ribulose-5-phosphate 3-epimerase UlaE
UniProt: P39305 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12497
Length: 284 (272)
Sequences: 6056
Seq/Len: 22.26
ULAE
Paralog alert: 0.70 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: END4 FRLC HYI SGBU ULAE YCJR YGBM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
231_D 234_R 3.455 1.00
214_D 226_G 3.273 1.00
61_V 65_V 3.251 1.00
181_Q 208_V 3.152 1.00
104_Q 148_A 3.021 1.00
100_R 144_M 2.862 1.00
26_Q 67_T 2.853 1.00
35_F 247_P 2.833 1.00
135_R 174_Y 2.805 1.00
62_N 66_E 2.683 1.00
104_Q 144_M 2.657 1.00
93_A 97_E 2.414 1.00
170_G 174_Y 2.34 1.00
151_T 181_Q 2.27 1.00
268_R 272_K 2.193 1.00
26_Q 30_T 2.108 1.00
20_C 23_E 2.107 1.00
265_A 269_D 2.095 1.00
143_E 177_N 2.09 1.00
22_L 63_A 2.068 1.00
151_T 208_V 2.047 1.00
201_Q 238_T 1.996 1.00
153_A 208_V 1.983 1.00
195_D 198_M 1.965 1.00
63_A 67_T 1.948 1.00
113_V 153_A 1.938 1.00
96_L 140_E 1.932 1.00
131_R 170_G 1.882 1.00
63_A 66_E 1.833 1.00
92_R 137_G 1.798 1.00
201_Q 241_Q 1.798 1.00
107_Q 148_A 1.787 1.00
132_R 174_Y 1.775 1.00
238_T 241_Q 1.747 1.00
142_V 180_F 1.738 1.00
64_I 71_V 1.725 1.00
129_E 132_R 1.699 1.00
106_A 111_I 1.695 1.00
169_L 173_H 1.679 1.00
144_M 148_A 1.678 1.00
131_R 174_Y 1.661 1.00
103_I 148_A 1.638 1.00
237_E 241_Q 1.632 1.00
166_S 202_A 1.628 1.00
97_E 101_K 1.596 1.00
153_A 183_Y 1.594 1.00
210_V 239_L 1.59 1.00
143_E 147_R 1.586 1.00
101_K 104_Q 1.567 1.00
22_L 59_A 1.562 1.00
29_K 67_T 1.559 1.00
26_Q 63_A 1.556 1.00
59_A 62_N 1.548 1.00
214_D 228_G 1.536 1.00
135_R 139_K 1.53 1.00
133_R 136_D 1.525 1.00
22_L 66_E 1.517 1.00
54_R 108_D 1.504 1.00
103_I 145_A 1.499 1.00
57_R 108_D 1.498 1.00
156_I 189_L 1.493 1.00
269_D 273_A 1.472 1.00
56_Q 59_A 1.472 1.00
146_S 177_N 1.458 1.00
142_V 175_L 1.455 1.00
58_L 108_D 1.45 1.00
27_L 30_T 1.441 1.00
136_D 139_K 1.409 1.00
146_S 179_W 1.389 0.99
259_D 262_A 1.387 0.99
233_E 237_E 1.386 0.99
62_N 65_V 1.377 0.99
173_H 206_H 1.373 0.99
25_L 67_T 1.37 0.99
23_E 26_Q 1.36 0.99
33_F 250_I 1.36 0.99
169_L 202_A 1.356 0.99
144_M 147_R 1.356 0.99
181_Q 206_H 1.351 0.99
58_L 62_N 1.347 0.99
96_L 100_R 1.346 0.99
198_M 202_A 1.346 0.99
103_I 144_M 1.343 0.99
227_E 266_K 1.336 0.99
126_A 129_E 1.33 0.99
270_W 274_R 1.323 0.99
146_S 178_P 1.316 0.99
132_R 136_D 1.315 0.99
197_Q 234_R 1.297 0.99
139_K 176_N 1.291 0.99
238_T 242_S 1.291 0.99
33_F 268_R 1.289 0.99
28_A 33_F 1.279 0.99
128_N 132_R 1.252 0.99
143_E 146_S 1.251 0.99
100_R 104_Q 1.246 0.98
89_D 93_A 1.244 0.98
90_A 94_Q 1.242 0.98
198_M 201_Q 1.238 0.98
64_I 69_V 1.229 0.98
59_A 63_A 1.221 0.98
97_E 100_R 1.22 0.98
168_A 182_L 1.218 0.98
113_V 151_T 1.203 0.98
91_V 94_Q 1.199 0.98
100_R 140_E 1.196 0.98
93_A 140_E 1.191 0.98
25_L 63_A 1.179 0.98
61_V 108_D 1.173 0.98
104_Q 107_Q 1.17 0.97
99_M 141_S 1.168 0.97
135_R 175_L 1.165 0.97
74_M 106_A 1.144 0.97
200_L 242_S 1.141 0.97
7_P 70_R 1.14 0.97
184_P 189_L 1.14 0.97
239_L 242_S 1.111 0.96
187_G 213_K 1.11 0.96
164_S 167_K 1.104 0.96
234_R 238_T 1.102 0.96
200_L 238_T 1.099 0.96
170_G 173_H 1.097 0.96
29_K 68_G 1.096 0.96
163_S 167_K 1.092 0.96
266_K 269_D 1.091 0.96
100_R 147_R 1.09 0.96
34_D 272_K 1.09 0.96
28_A 36_V 1.083 0.96
27_L 261_A 1.073 0.95
22_L 26_Q 1.062 0.95
186_I 235_C 1.06 0.95
106_A 114_I 1.058 0.95
113_V 208_V 1.054 0.95
128_N 170_G 1.053 0.95
104_Q 108_D 1.051 0.94
139_K 175_L 1.047 0.94
71_V 111_I 1.041 0.94
136_D 140_E 1.041 0.94
103_I 150_V 1.04 0.94
216_K 223_V 1.04 0.94
139_K 177_N 1.029 0.94
64_I 67_T 1.028 0.94
127_N 167_K 1.028 0.94
70_R 112_R 1.026 0.94
37_E 73_S 1.022 0.93
25_L 64_I 1.012 0.93
169_L 203_G 1.009 0.93
92_R 136_D 1.004 0.93
140_E 143_E 1.003 0.93
262_A 266_K 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cqjA211000.179Contact Map0.679
1i60A10.94011000.254Contact Map0.676
3u0hA20.93661000.264Contact Map0.655
2qulA40.91551000.267Contact Map0.746
2zdsA60.97541000.267Contact Map0.749
3vniA40.93311000.272Contact Map0.774
3vylA80.92961000.279Contact Map0.712
3cnyA20.9121000.28Contact Map0.696
2qw5A20.95421000.28Contact Map0.611
3kwsA20.9121000.28Contact Map0.679
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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