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OPENSEQ.org
HYI - Hydroxypyruvate isomerase
UniProt: P30147 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11584
Length: 258 (256)
Sequences: 5894
Seq/Len: 23.02
HYI
Paralog alert: 0.70 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: END4 FRLC HYI SGBU ULAE YCJR YGBM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
220_N 223_Y 3.396 1.00
46_K 50_A 3.307 1.00
174_K 201_G 3.191 1.00
207_D 215_G 3.136 1.00
92_R 136_E 2.993 1.00
88_A 132_M 2.935 1.00
22_E 52_N 2.889 1.00
92_R 132_M 2.787 1.00
123_V 167_D 2.778 1.00
31_G 236_W 2.772 1.00
47_H 51_S 2.568 1.00
81_E 85_D 2.395 1.00
163_K 167_D 2.32 1.00
139_L 174_K 2.252 1.00
18_L 48_V 2.117 1.00
131_N 170_C 2.095 1.00
194_T 227_V 2.083 1.00
16_D 19_A 2.039 1.00
22_E 26_Q 2.038 1.00
188_E 191_N 2.018 1.00
48_V 52_N 2.016 1.00
139_L 201_G 1.979 1.00
141_L 201_G 1.956 1.00
84_R 128_Y 1.925 1.00
119_H 163_K 1.897 1.00
194_T 230_N 1.879 1.00
120_A 167_D 1.869 1.00
130_A 173_L 1.853 1.00
95_R 136_E 1.851 1.00
101_K 141_L 1.824 1.00
80_E 125_N 1.767 1.00
48_V 51_S 1.762 1.00
49_L 56_H 1.76 1.00
117_Q 120_A 1.732 1.00
119_H 167_D 1.71 1.00
94_A 99_N 1.678 1.00
227_V 230_N 1.666 1.00
226_K 230_N 1.64 1.00
162_L 166_D 1.623 1.00
203_L 228_I 1.608 1.00
132_M 136_E 1.607 1.00
91_I 136_E 1.59 1.00
91_I 133_L 1.587 1.00
248_E 252_R 1.587 1.00
44_E 47_H 1.583 1.00
25_A 52_N 1.581 1.00
85_D 89_A 1.576 1.00
18_L 51_S 1.573 1.00
41_D 44_E 1.565 1.00
43_E 96_A 1.557 1.00
3_R 55_E 1.554 1.00
159_R 195_Q 1.538 1.00
18_L 44_E 1.526 1.00
207_D 217_G 1.524 1.00
123_V 127_R 1.492 1.00
89_A 92_R 1.489 1.00
141_L 176_Q 1.489 1.00
121_T 124_E 1.475 1.00
42_I 96_A 1.465 1.00
130_A 168_V 1.461 1.00
22_E 48_V 1.458 1.00
47_H 50_A 1.45 1.00
191_N 195_Q 1.446 1.00
134_M 172_N 1.438 1.00
21_F 52_N 1.425 1.00
131_N 135_K 1.425 1.00
134_M 170_C 1.407 0.99
29_F 239_C 1.39 0.99
43_E 47_H 1.372 0.99
144_P 182_M 1.362 0.99
84_R 88_A 1.348 0.99
127_R 169_G 1.344 0.99
132_M 135_K 1.338 0.99
222_D 226_K 1.328 0.99
124_E 127_R 1.326 0.99
174_K 199_K 1.325 0.99
190_T 223_Y 1.321 0.99
166_D 199_K 1.297 0.99
24_A 29_F 1.294 0.99
23_K 26_Q 1.29 0.99
120_A 124_E 1.282 0.99
49_L 54_L 1.276 0.99
114_S 117_Q 1.276 0.99
101_K 139_L 1.275 0.99
162_L 195_Q 1.27 0.99
91_I 132_M 1.258 0.99
131_N 134_M 1.255 0.99
116_E 120_A 1.253 0.99
227_V 231_S 1.24 0.98
88_A 92_R 1.234 0.98
123_V 168_V 1.232 0.98
85_D 88_A 1.225 0.98
79_R 82_E 1.225 0.98
157_G 160_Q 1.199 0.98
191_N 194_T 1.191 0.98
177_Y 182_M 1.188 0.98
19_A 22_E 1.187 0.98
193_M 227_V 1.185 0.98
252_R 256_P 1.18 0.98
134_M 171_C 1.177 0.98
87_V 129_A 1.151 0.97
161_A 175_I 1.146 0.97
115_S 160_Q 1.141 0.97
44_E 48_V 1.138 0.97
92_R 95_R 1.135 0.97
88_A 128_Y 1.131 0.97
31_G 57_T 1.125 0.97
162_L 196_W 1.125 0.97
253_W 256_P 1.122 0.97
179_I 224_L 1.122 0.97
24_A 32_V 1.117 0.96
223_Y 227_V 1.103 0.96
25_A 53_K 1.103 0.96
78_G 82_E 1.102 0.96
246_T 249_A 1.1 0.96
77_P 81_E 1.092 0.96
156_T 160_Q 1.085 0.96
46_K 96_A 1.084 0.96
88_A 135_K 1.083 0.96
193_M 231_S 1.073 0.95
101_K 201_G 1.072 0.95
92_R 96_A 1.068 0.95
21_F 48_V 1.063 0.95
163_K 166_D 1.061 0.95
81_E 128_Y 1.06 0.95
49_L 52_N 1.058 0.95
91_I 138_I 1.054 0.95
116_E 163_K 1.04 0.94
197_A 231_S 1.04 0.94
46_K 98_G 1.036 0.94
124_E 128_Y 1.031 0.94
94_A 102_I 1.03 0.94
18_L 22_E 1.026 0.94
76_I 79_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1k77A10.99611000.123Contact Map0.697
3ngfA20.99221000.165Contact Map0.642
1i60A10.95351000.211Contact Map0.673
2hk0A40.9691000.219Contact Map0.724
2qulA40.9691000.221Contact Map0.773
3kwsA20.96511000.223Contact Map0.683
3vniA40.9691000.227Contact Map0.794
3vylA80.96511000.228Contact Map0.725
3qc0A10.96121000.232Contact Map0.655
2zvrA20.97291000.234Contact Map0.77
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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