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OPENSEQ.org
SGBU - Putative L-ribulose-5-phosphate 3-epimerase SgbU
UniProt: P37679 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12286
Length: 286 (277)
Sequences: 6094
Seq/Len: 22.00
SGBU
Paralog alert: 0.70 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: END4 FRLC HYI SGBU ULAE YCJR YGBM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
235_D 238_G 3.482 1.00
59_V 63_I 3.369 1.00
212_D 230_G 3.308 1.00
179_T 206_A 3.153 1.00
102_R 146_S 3.124 1.00
98_S 142_Q 2.94 1.00
24_V 65_T 2.877 1.00
33_F 251_S 2.847 1.00
133_A 172_M 2.836 1.00
60_A 64_E 2.72 1.00
102_R 142_Q 2.685 1.00
91_E 95_E 2.454 1.00
168_K 172_M 2.347 1.00
149_M 179_T 2.303 1.00
141_E 175_S 2.194 1.00
24_V 28_S 2.173 1.00
18_S 21_E 2.153 1.00
272_R 276_E 2.127 1.00
269_I 273_R 2.122 1.00
149_M 206_A 2.08 1.00
20_P 61_A 2.039 1.00
199_K 242_T 2.005 1.00
61_A 65_T 1.966 1.00
193_D 196_A 1.964 1.00
94_R 138_W 1.932 1.00
111_T 151_A 1.93 1.00
61_A 64_E 1.89 1.00
151_A 206_A 1.887 1.00
129_R 168_K 1.884 1.00
130_Q 172_M 1.822 1.00
105_R 146_S 1.808 1.00
62_M 69_I 1.805 1.00
90_R 135_G 1.786 1.00
140_V 178_F 1.778 1.00
104_A 109_I 1.768 1.00
199_K 245_K 1.767 1.00
242_T 245_K 1.739 1.00
129_R 172_M 1.726 1.00
167_K 171_E 1.72 1.00
142_Q 146_S 1.691 1.00
27_K 65_T 1.685 1.00
127_G 130_Q 1.643 1.00
164_S 200_L 1.639 1.00
101_I 146_S 1.638 1.00
241_K 245_K 1.628 1.00
24_V 61_A 1.604 1.00
273_R 277_A 1.602 1.00
95_E 99_K 1.601 1.00
141_E 145_A 1.597 1.00
151_A 181_Y 1.597 1.00
99_K 102_R 1.596 1.00
208_I 243_L 1.593 1.00
101_I 143_A 1.581 1.00
212_D 232_G 1.549 1.00
131_R 134_E 1.539 1.00
133_A 137_A 1.514 1.00
55_R 106_D 1.513 1.00
20_P 57_S 1.503 1.00
56_T 106_D 1.498 1.00
54_Q 57_S 1.496 1.00
20_P 64_E 1.495 1.00
140_V 173_L 1.492 1.00
57_S 60_A 1.489 1.00
154_I 187_L 1.479 1.00
52_A 106_D 1.471 1.00
171_E 204_R 1.469 1.00
144_A 175_S 1.448 1.00
25_L 28_S 1.427 1.00
167_K 200_L 1.421 1.00
23_L 65_T 1.418 1.00
60_A 63_I 1.391 0.99
179_T 204_R 1.389 0.99
142_Q 145_A 1.383 0.99
134_E 137_A 1.383 0.99
231_E 270_Q 1.383 0.99
144_A 177_W 1.378 0.99
144_A 176_P 1.375 0.99
101_I 142_Q 1.373 0.99
124_H 127_G 1.366 0.99
130_Q 134_E 1.352 0.99
237_V 241_K 1.345 0.99
94_R 98_S 1.342 0.99
242_T 246_L 1.337 0.99
196_A 200_L 1.334 0.99
56_T 60_A 1.329 0.99
26_A 31_F 1.326 0.99
137_A 174_A 1.316 0.99
263_E 266_L 1.313 0.99
31_F 254_I 1.308 0.99
21_E 24_V 1.299 0.99
195_P 238_G 1.298 0.99
95_E 98_S 1.294 0.99
274_W 278_R 1.267 0.99
31_F 272_R 1.254 0.99
23_L 61_A 1.254 0.99
141_E 144_A 1.247 0.99
57_S 61_A 1.243 0.98
111_T 149_M 1.239 0.98
126_E 130_Q 1.232 0.98
196_A 199_K 1.226 0.98
198_L 246_L 1.216 0.98
97_M 139_A 1.216 0.98
87_E 91_E 1.207 0.98
88_A 92_R 1.204 0.98
98_S 138_W 1.204 0.98
98_S 102_R 1.192 0.98
62_M 67_V 1.183 0.98
59_V 106_D 1.177 0.98
133_A 173_L 1.172 0.98
89_V 92_R 1.165 0.97
72_M 104_A 1.163 0.97
243_L 246_L 1.158 0.97
91_E 138_W 1.15 0.97
166_W 180_V 1.147 0.97
126_E 168_K 1.144 0.97
102_R 105_R 1.137 0.97
182_P 187_L 1.13 0.97
198_L 242_T 1.122 0.97
25_L 265_V 1.121 0.97
111_T 206_A 1.118 0.96
167_K 201_G 1.112 0.96
162_S 165_K 1.105 0.96
168_K 171_E 1.104 0.96
98_S 145_A 1.104 0.96
5_Q 68_G 1.099 0.96
238_G 242_T 1.095 0.96
27_K 66_G 1.095 0.96
185_G 211_K 1.095 0.96
26_A 34_V 1.093 0.96
20_P 24_V 1.091 0.96
102_R 106_D 1.082 0.96
69_I 109_I 1.079 0.95
68_G 110_R 1.073 0.95
62_M 65_T 1.067 0.95
32_D 276_E 1.066 0.95
214_Q 227_V 1.063 0.95
125_D 165_K 1.062 0.95
104_A 112_I 1.058 0.95
161_N 165_K 1.054 0.95
101_I 148_V 1.052 0.95
184_V 239_I 1.046 0.94
138_W 141_E 1.043 0.94
270_Q 273_R 1.04 0.94
164_S 168_K 1.034 0.94
25_L 29_C 1.03 0.94
27_K 32_D 1.026 0.94
134_E 138_W 1.024 0.93
202_I 246_L 1.021 0.93
28_S 265_V 1.019 0.93
167_K 204_R 1.016 0.93
33_F 68_G 1.015 0.93
137_A 173_L 1.015 0.93
23_L 62_M 1.002 0.92
90_R 134_E 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cqjA20.9791000.189Contact Map0.679
1i60A10.9581000.26Contact Map0.674
2qulA40.90911000.26Contact Map0.741
3qc0A10.91611000.267Contact Map0.663
2zdsA60.98251000.271Contact Map0.738
3vylA80.91611000.272Contact Map0.712
3vniA40.92661000.273Contact Map0.774
3kwsA20.89861000.274Contact Map0.672
2hk0A40.91961000.274Contact Map0.7
4hnoA10.94061000.279Contact Map0.64
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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