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OPENSEQ.org
YCAK - Uncharacterized NAD(P)H oxidoreductase YcaK
UniProt: P43340 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12702
Length: 196 (191)
Sequences: 3434
Seq/Len: 17.98
YCAK
Paralog alert: 0.67 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: AZOR KEFF KEFG MDAB NQOR YCAK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_T 76_E 4.288 1.00
5_R 36_Q 3.801 1.00
38_T 79_E 3.046 1.00
40_L 76_E 2.996 1.00
75_S 79_E 2.667 1.00
99_K 103_D 2.431 1.00
8_L 27_H 2.384 1.00
25_A 28_Q 2.37 1.00
41_D 44_R 2.359 1.00
26_I 126_V 2.141 1.00
50_V 96_A 2.012 1.00
27_H 31_M 2.003 1.00
38_T 80_H 1.964 1.00
24_D 28_Q 1.955 1.00
25_A 186_L 1.934 1.00
5_R 79_E 1.897 1.00
78_L 110_L 1.873 1.00
6_I 35_I 1.836 1.00
24_D 39_E 1.812 1.00
96_A 100_G 1.748 1.00
19_T 86_V 1.748 1.00
83_L 123_V 1.743 1.00
70_V 74_Y 1.723 1.00
75_S 78_L 1.703 1.00
8_L 23_A 1.65 1.00
29_R 33_R 1.629 1.00
123_V 153_C 1.628 1.00
87_F 95_P 1.626 1.00
71_H 75_S 1.619 1.00
122_K 159_E 1.598 1.00
28_Q 32_E 1.581 1.00
123_V 158_I 1.577 1.00
45_R 72_Q 1.577 1.00
83_L 158_I 1.488 1.00
29_R 32_E 1.477 1.00
102_I 152_M 1.476 1.00
80_H 83_L 1.458 1.00
94_F 148_Y 1.455 1.00
85_V 98_L 1.435 1.00
100_G 104_R 1.432 1.00
29_R 189_V 1.43 1.00
179_A 183_Q 1.418 1.00
6_I 82_T 1.413 1.00
10_W 23_A 1.411 1.00
23_A 86_V 1.398 0.99
183_Q 187_S 1.395 0.99
92_Y 155_Y 1.392 0.99
11_A 97_M 1.376 0.99
28_Q 31_M 1.375 0.99
125_W 163_V 1.372 0.99
5_R 38_T 1.371 0.99
26_I 84_V 1.368 0.99
30_A 35_I 1.357 0.99
73_L 101_Y 1.352 0.99
187_S 190_R 1.347 0.99
77_L 83_L 1.335 0.99
187_S 191_D 1.307 0.99
10_W 39_E 1.297 0.99
69_E 72_Q 1.295 0.99
181_Y 184_S 1.255 0.99
72_Q 76_E 1.251 0.99
10_W 20_A 1.25 0.99
74_Y 110_L 1.248 0.99
82_T 124_R 1.237 0.98
183_Q 186_L 1.236 0.98
50_V 100_G 1.233 0.98
72_Q 75_S 1.225 0.98
48_N 52_T 1.186 0.98
11_A 98_L 1.182 0.98
40_L 45_R 1.167 0.97
4_E 35_I 1.166 0.97
25_A 29_R 1.162 0.97
13_P 90_W 1.157 0.97
175_E 179_A 1.155 0.97
180_S 184_S 1.153 0.97
45_R 69_E 1.128 0.97
177_L 180_S 1.126 0.97
27_H 39_E 1.124 0.97
144_N 147_D 1.123 0.97
31_M 36_Q 1.117 0.96
129_V 167_C 1.109 0.96
30_A 34_K 1.108 0.96
82_T 122_K 1.103 0.96
49_P 100_G 1.102 0.96
186_L 190_R 1.101 0.96
20_A 41_D 1.099 0.96
26_I 30_A 1.09 0.96
22_I 185_L 1.068 0.95
42_L 97_M 1.059 0.95
15_H 44_R 1.052 0.95
8_L 39_E 1.052 0.95
85_V 153_C 1.05 0.94
106_W 156_L 1.049 0.94
120_F 159_E 1.043 0.94
6_I 30_A 1.024 0.93
19_T 128_L 1.012 0.93
71_H 107_N 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1d4aA40.98981000.22Contact Map0.74
4gi5A20.99491000.222Contact Map0.75
4fglA40.99491000.26Contact Map0.729
3lcmA40.95411000.262Contact Map0.801
3p0rA10.97961000.28Contact Map0.655
2hpvA40.94391000.29Contact Map0.731
1t5bA20.9491000.308Contact Map0.738
3u7iA40.97451000.308Contact Map0.745
4c0xA10.95921000.323Contact Map0.665
3r6wA20.96941000.332Contact Map0.654
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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