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OPENSEQ.org
MDAB - Modulator of drug activity B
UniProt: P0AEY5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12656
Length: 193 (182)
Sequences: 2692
Seq/Len: 14.79
MDAB
Paralog alert: 0.64 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: AZOR KEFF KEFG MDAB NQOR YCAK
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_N 38_D 3.765 1.00
40_R 59_W 3.086 1.00
40_R 56_N 3.064 1.00
42_V 56_N 2.643 1.00
119_Y 155_N 2.459 1.00
79_K 83_D 2.332 1.00
58_L 90_H 2.326 1.00
55_Q 59_W 2.26 1.00
93_L 111_G 2.196 1.00
27_V 30_G 2.123 1.00
80_K 84_D 2.044 1.00
63_V 160_M 2.029 1.00
21_N 124_T 1.952 1.00
43_R 46_S 1.931 1.00
27_V 185_R 1.925 1.00
4_I 37_H 1.924 1.00
26_E 30_G 1.847 1.00
3_N 59_W 1.81 1.00
119_Y 160_M 1.799 1.00
28_A 122_S 1.772 1.00
6_I 29_D 1.738 1.00
50_V 54_V 1.722 1.00
118_K 161_E 1.694 1.00
74_A 150_P 1.636 1.00
8_N 25_T 1.624 1.00
21_N 66_Q 1.583 1.00
62_V 120_M 1.577 1.00
4_I 62_V 1.573 1.00
55_Q 58_L 1.555 1.00
121_L 165_T 1.551 1.00
62_V 118_K 1.541 1.00
76_W 80_K 1.521 1.00
9_G 77_T 1.507 1.00
72_M 157_F 1.506 1.00
182_E 185_R 1.49 1.00
63_V 119_Y 1.461 1.00
82_I 154_A 1.456 1.00
50_V 53_E 1.439 1.00
20_L 124_T 1.404 0.99
180_Y 183_E 1.397 0.99
179_R 183_E 1.382 0.99
30_G 34_D 1.368 0.99
29_D 33_R 1.355 0.99
182_E 186_K 1.348 0.99
3_N 40_R 1.342 0.99
51_K 55_Q 1.341 0.99
54_V 90_H 1.332 0.99
6_I 25_T 1.328 0.99
125_W 169_N 1.314 0.99
86_F 158_L 1.291 0.99
52_A 56_N 1.288 0.99
2_S 37_H 1.288 0.99
53_E 81_Y 1.265 0.99
74_A 151_F 1.253 0.99
11_K 70_W 1.247 0.99
122_S 166_F 1.231 0.98
31_T 189_V 1.225 0.98
24_L 124_T 1.201 0.98
8_N 41_I 1.191 0.98
8_N 22_D 1.183 0.98
185_R 189_V 1.182 0.98
25_T 66_Q 1.166 0.97
33_R 38_D 1.157 0.97
27_V 181_T 1.146 0.97
129_M 169_N 1.14 0.97
27_V 31_T 1.135 0.97
9_G 78_V 1.131 0.97
4_I 32_L 1.121 0.97
116_G 161_E 1.121 0.97
186_K 189_V 1.116 0.96
65_W 78_V 1.111 0.96
5_L 56_N 1.104 0.96
51_K 54_V 1.102 0.96
57_F 63_V 1.101 0.96
30_G 185_R 1.101 0.96
65_W 155_N 1.096 0.96
67_M 75_P 1.096 0.96
123_L 167_I 1.093 0.96
66_Q 122_S 1.087 0.96
93_L 96_S 1.087 0.96
118_K 164_P 1.066 0.95
11_K 77_T 1.064 0.95
31_T 185_R 1.061 0.95
61_D 117_K 1.059 0.95
31_T 34_D 1.058 0.95
174_M 178_P 1.053 0.95
85_V 158_L 1.044 0.94
42_V 81_Y 1.029 0.94
69_G 147_V 1.024 0.93
28_A 32_L 1.022 0.93
28_A 184_Y 1.008 0.93
148_Y 165_T 1.007 0.93
35_L 60_A 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2amjA411000.208Contact Map0.768
3rpeA211000.229Contact Map0.771
1d4aA40.90671000.279Contact Map0.753
4gi5A20.94821000.286Contact Map0.8
4fglA40.90671000.33Contact Map0.775
3lcmA40.87051000.355Contact Map0.862
3p0rA10.89641000.356Contact Map0.7
2hpvA40.87051000.359Contact Map0.747
3r6wA20.90161000.363Contact Map0.704
1t5bA20.87561000.364Contact Map0.796
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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