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OPENSEQ.org

ULAF - L-ribulose-5-phosphate 4-epimerase UlaF
UniProt: P39306 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12498
Length: 228 (219)
Sequences: 2881
Seq/Len: 13.16

ULAF
Paralog alert: 0.64 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ARAD FUCA RHAD SGBE ULAF YGBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_D 63_K 5.728 1.00
98_H 195_I 3.323 1.00
174_K 178_D 3.213 1.00
191_K 195_I 2.852 1.00
38_V 79_L 2.638 1.00
39_V 55_M 2.637 1.00
107_L 197_R 2.52 1.00
9_F 52_A 2.446 1.00
7_Q 177_H 2.353 1.00
37_L 57_V 2.293 1.00
6_Q 10_E 2.204 1.00
88_L 172_W 2.151 1.00
37_L 65_V 1.998 1.00
97_T 191_K 1.936 1.00
98_H 194_W 1.896 1.00
161_G 186_M 1.896 1.00
208_S 212_N 1.883 1.00
98_H 191_K 1.866 1.00
101_A 195_I 1.864 1.00
90_G 176_A 1.833 1.00
30_A 176_A 1.824 1.00
207_D 210_L 1.815 1.00
4_L 30_A 1.788 1.00
175_D 178_D 1.778 1.00
92_V 179_A 1.744 1.00
89_G 175_D 1.734 1.00
61_S 83_R 1.654 1.00
169_P 186_M 1.653 1.00
6_Q 52_A 1.644 1.00
80_E 84_R 1.644 1.00
80_E 145_K 1.64 1.00
39_V 57_V 1.622 1.00
51_K 54_D 1.606 1.00
9_F 13_M 1.599 1.00
108_A 123_D 1.534 1.00
32_D 39_V 1.53 1.00
141_L 145_K 1.523 1.00
102_W 197_R 1.512 1.00
106_G 165_Y 1.471 1.00
209_F 213_K 1.458 1.00
195_I 198_G 1.452 1.00
80_E 83_R 1.445 1.00
38_V 60_M 1.412 1.00
99_A 169_P 1.41 1.00
8_V 28_V 1.398 0.99
97_T 101_A 1.396 0.99
173_G 178_D 1.394 0.99
87_S 157_L 1.385 0.99
3_K 7_Q 1.376 0.99
79_L 83_R 1.37 0.99
96_S 99_A 1.369 0.99
14_E 18_Y 1.367 0.99
149_E 152_G 1.364 0.99
169_P 183_A 1.363 0.99
108_A 126_C 1.351 0.99
171_A 183_A 1.35 0.99
94_T 183_A 1.343 0.99
18_Y 184_V 1.332 0.99
125_P 154_A 1.329 0.99
145_K 149_E 1.313 0.99
155_E 158_H 1.301 0.99
161_G 171_A 1.289 0.99
95_H 167_H 1.288 0.99
13_M 17_R 1.274 0.99
8_V 55_M 1.271 0.99
93_H 167_H 1.261 0.99
100_T 103_A 1.253 0.99
109_I 190_A 1.252 0.99
128_R 149_E 1.25 0.99
105_A 199_I 1.236 0.98
194_W 198_G 1.218 0.98
84_R 152_G 1.216 0.98
58_V 75_T 1.205 0.98
11_A 180_V 1.195 0.98
81_L 88_L 1.187 0.98
187_E 191_K 1.184 0.98
30_A 90_G 1.175 0.98
50_M 54_D 1.168 0.97
188_E 191_K 1.162 0.97
206_I 210_L 1.155 0.97
173_G 182_N 1.15 0.97
193_A 197_R 1.148 0.97
85_Y 88_L 1.148 0.97
64_V 67_G 1.138 0.97
194_W 199_I 1.138 0.97
77_T 170_F 1.137 0.97
147_I 164_V 1.135 0.97
132_E 136_Q 1.125 0.97
15_L 180_V 1.118 0.96
110_P 193_A 1.113 0.96
15_L 92_V 1.113 0.96
84_R 148_I 1.093 0.96
1_M 37_L 1.082 0.96
164_V 170_F 1.076 0.95
59_D 65_V 1.076 0.95
158_H 215_F 1.068 0.95
32_D 57_V 1.065 0.95
97_T 195_I 1.065 0.95
116_H 121_F 1.051 0.94
14_E 17_R 1.046 0.94
160_P 182_N 1.038 0.94
54_D 69_Y 1.034 0.94
151_L 172_W 1.034 0.94
42_P 45_V 1.032 0.94
10_E 49_T 1.03 0.94
146_V 149_E 1.023 0.93
38_V 75_T 1.021 0.93
9_F 55_M 1.02 0.93
85_Y 172_W 1.007 0.93
45_V 54_D 1.006 0.93
5_K 66_E 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1k0wA60.99561000.122Contact Map0.81
1e4cP10.91671000.165Contact Map0.712
3ocrA20.95181000.187Contact Map0.673
2opiA20.89041000.192Contact Map0.678
1pvtA10.87281000.221Contact Map0.57
2v9lA10.94741000.221Contact Map0.611
2z7bA10.94741000.224Contact Map0.689
2fk5A20.83771000.237Contact Map0.64
2irpA20.83331000.246Contact Map0.718
3m4rA10.78951000.347Contact Map0.608

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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