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RHAD - Rhamnulose-1-phosphate aldolase
UniProt: P32169 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11866
Length: 274 (266)
Sequences: 395
Seq/Len: 1.48

RHAD
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ARAD FUCA RHAD SGBE ULAF YGBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
199_Q 202_Q 2.772 1.00
206_L 231_A 2.476 1.00
161_F 208_L 1.89 0.97
13_M 33_L 1.782 0.95
96_D 100_A 1.682 0.93
236_Q 240_K 1.671 0.93
35_L 221_L 1.655 0.92
254_E 258_A 1.631 0.91
25_W 218_G 1.559 0.89
18_T 22_L 1.555 0.88
64_L 126_C 1.555 0.88
37_L 92_I 1.551 0.88
17_T 79_F 1.51 0.86
95_V 118_L 1.508 0.86
30_G 233_K 1.497 0.86
147_L 231_A 1.496 0.86
218_G 223_E 1.476 0.85
8_W 192_E 1.458 0.84
146_N 240_K 1.436 0.82
49_F 53_P 1.417 0.81
179_G 209_W 1.414 0.81
25_W 30_G 1.41 0.81
34_T 111_E 1.402 0.80
119_P 123_L 1.397 0.80
160_V 179_G 1.345 0.76
180_V 206_L 1.334 0.75
57_P 101_G 1.333 0.75
133_N 180_V 1.331 0.75
144_A 228_I 1.326 0.75
117_E 212_H 1.319 0.74
51_Q 56_I 1.314 0.74
123_L 195_Q 1.306 0.73
20_A 33_L 1.304 0.73
79_F 194_G 1.304 0.73
59_S 84_L 1.303 0.73
172_C 208_L 1.279 0.71
75_S 115_T 1.262 0.70
51_Q 130_K 1.253 0.69
140_M 221_L 1.252 0.69
146_N 236_Q 1.244 0.68
32_N 73_T 1.243 0.68
142_C 228_I 1.234 0.67
56_I 101_G 1.232 0.67
152_Y 211_F 1.232 0.67
62_M 101_G 1.229 0.67
53_P 60_Q 1.226 0.66
254_E 257_I 1.222 0.66
171_E 230_T 1.218 0.66
46_H 51_Q 1.217 0.65
43_A 46_H 1.211 0.65
257_I 261_K 1.209 0.65
252_S 255_E 1.2 0.64
27_E 226_G 1.198 0.64
52_Q 56_I 1.189 0.63
236_Q 264_G 1.183 0.62
9_F 35_L 1.181 0.62
61_P 64_L 1.18 0.62
93_V 118_L 1.178 0.62
75_S 188_P 1.173 0.61
194_G 228_I 1.162 0.60
52_Q 130_K 1.162 0.60
32_N 75_S 1.161 0.60
72_V 76_G 1.16 0.60
23_K 236_Q 1.152 0.59
47_D 51_Q 1.148 0.59
173_L 259_L 1.146 0.59
70_F 172_C 1.138 0.58
195_Q 254_E 1.135 0.58
51_Q 64_L 1.134 0.57
22_L 256_L 1.132 0.57
53_P 61_P 1.13 0.57
201_M 215_F 1.123 0.56
32_N 188_P 1.122 0.56
27_E 30_G 1.121 0.56
60_Q 126_C 1.12 0.56
181_G 204_H 1.119 0.56
53_P 56_I 1.118 0.56
82_V 214_V 1.117 0.56
75_S 144_A 1.112 0.55
76_G 180_V 1.111 0.55
98_D 109_T 1.104 0.54
196_A 255_E 1.104 0.54
81_N 118_L 1.101 0.54
53_P 128_R 1.101 0.54
144_A 170_T 1.094 0.53
219_P 223_E 1.089 0.53
52_Q 61_P 1.086 0.53
98_D 253_R 1.081 0.52
73_T 221_L 1.078 0.52
58_L 62_M 1.076 0.51
240_K 243_S 1.074 0.51
30_G 225_F 1.074 0.51
31_G 117_E 1.071 0.51
126_C 130_K 1.069 0.51
76_G 212_H 1.069 0.51
172_C 185_W 1.064 0.50
3_N 130_K 1.062 0.50
193_I 197_T 1.062 0.50
239_V 243_S 1.061 0.50
3_N 57_P 1.057 0.50
23_K 80_R 1.052 0.49
80_R 233_K 1.051 0.49
92_I 161_F 1.049 0.49
43_A 84_L 1.049 0.49
153_V 239_V 1.046 0.48
123_L 132_T 1.041 0.48
34_T 129_I 1.041 0.48
114_P 218_G 1.039 0.48
239_V 254_E 1.035 0.47
189_G 194_G 1.034 0.47
58_L 61_P 1.031 0.47
52_Q 60_Q 1.031 0.47
66_A 174_V 1.029 0.47
49_F 128_R 1.029 0.47
70_F 97_S 1.028 0.47
115_T 228_I 1.028 0.47
184_P 196_A 1.027 0.46
32_N 189_G 1.022 0.46
29_N 171_E 1.022 0.46
71_I 92_I 1.021 0.46
197_T 226_G 1.018 0.46
51_Q 57_P 1.016 0.45
91_G 112_A 1.014 0.45
85_D 88_A 1.012 0.45
180_V 218_G 1.012 0.45
192_E 195_Q 1.011 0.45
43_A 47_D 1.01 0.45
48_N 64_L 1.007 0.44
3_N 51_Q 1.007 0.44
77_K 233_K 1.006 0.44
50_H 84_L 1.006 0.44
115_T 189_G 1.005 0.44
125_H 139_I 1.002 0.44
37_L 42_I 1 0.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v9lA10.98181000.239Contact Map0.342
1pvtA10.8541000.377Contact Map0.334
3ocrA20.82121000.431Contact Map0.31
1e4cP10.77371000.434Contact Map0.397
2opiA20.76281000.45Contact Map0.387
1k0wA60.76641000.468Contact Map0.418
2z7bA10.79561000.472Contact Map0.364
2fk5A20.70441000.478Contact Map0.416
2irpA20.7081000.494Contact Map0.403
3m4rA10.7081000.536Contact Map0.297

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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