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OPENSEQ.org

FUCA - L-fuculose phosphate aldolase
UniProt: P0AB87 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10348
Length: 215 (208)
Sequences: 2936
Seq/Len: 14.12

FUCA
Paralog alert: 0.63 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ARAD FUCA RHAD SGBE ULAF YGBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_D 63_K 5.482 1.00
97_H 183_T 3.298 1.00
162_V 166_K 3.146 1.00
179_Q 183_T 2.809 1.00
38_M 78_M 2.618 1.00
106_R 185_L 2.557 1.00
39_L 55_I 2.556 1.00
9_Q 165_E 2.331 1.00
11_I 52_E 2.295 1.00
134_R 138_E 2.213 1.00
8_R 12_D 2.114 1.00
87_A 160_C 2.107 1.00
149_A 174_V 1.979 1.00
6_L 32_V 1.962 1.00
96_V 179_Q 1.911 1.00
97_H 179_Q 1.9 1.00
39_L 57_F 1.896 1.00
195_S 198_E 1.87 1.00
100_A 183_T 1.863 1.00
124_P 147_R 1.856 1.00
91_V 167_A 1.833 1.00
97_H 182_L 1.83 1.00
163_N 166_K 1.82 1.00
89_A 164_L 1.819 1.00
79_A 138_E 1.771 1.00
32_V 164_L 1.77 1.00
88_N 163_N 1.692 1.00
61_N 82_Q 1.665 1.00
196_D 200_A 1.636 1.00
79_A 83_S 1.626 1.00
11_I 15_L 1.623 1.00
8_R 52_E 1.611 1.00
107_S 122_S 1.605 1.00
105_N 153_Q 1.596 1.00
157_L 174_V 1.586 1.00
51_T 54_H 1.577 1.00
34_Y 39_L 1.563 1.00
79_A 82_Q 1.507 1.00
93_N 171_A 1.424 1.00
16_E 20_L 1.406 0.99
159_A 171_A 1.403 0.99
98_C 157_L 1.4 0.99
197_E 201_V 1.4 0.99
10_I 55_I 1.39 0.99
58_I 74_W 1.374 0.99
161_E 166_K 1.366 0.99
78_M 82_Q 1.348 0.99
127_P 153_Q 1.346 0.99
95_A 98_C 1.339 0.99
34_Y 57_F 1.337 0.99
94_H 155_H 1.333 0.99
101_V 185_L 1.322 0.99
38_M 60_G 1.321 0.99
20_L 172_H 1.321 0.99
92_H 155_H 1.321 0.99
157_L 171_A 1.32 0.99
108_I 178_A 1.32 0.99
5_K 9_Q 1.308 0.99
54_H 68_K 1.301 0.99
138_E 142_L 1.294 0.99
10_I 30_V 1.287 0.99
37_G 57_F 1.285 0.99
104_L 187_I 1.281 0.99
204_E 207_K 1.281 0.99
83_S 145_K 1.274 0.99
96_V 100_A 1.26 0.99
127_P 142_L 1.256 0.99
149_A 159_A 1.252 0.99
142_L 145_K 1.247 0.99
99_T 102_S 1.241 0.98
13_T 168_L 1.237 0.98
176_V 179_Q 1.231 0.98
83_S 141_A 1.228 0.98
84_R 87_A 1.227 0.98
15_L 19_R 1.216 0.98
183_T 186_A 1.216 0.98
175_E 179_Q 1.21 0.98
182_L 186_A 1.183 0.98
76_F 158_I 1.182 0.98
80_A 87_A 1.175 0.98
182_L 187_I 1.148 0.97
73_E 136_L 1.144 0.97
32_V 89_A 1.133 0.97
17_M 168_L 1.119 0.96
181_Y 185_L 1.118 0.96
161_E 170_L 1.117 0.96
109_P 181_Y 1.114 0.96
50_L 54_H 1.107 0.96
105_N 190_P 1.104 0.96
38_M 74_W 1.086 0.96
96_V 183_T 1.084 0.96
129_A 139_H 1.08 0.95
16_E 19_R 1.073 0.95
140_V 152_L 1.065 0.95
152_L 158_I 1.056 0.95
17_M 91_V 1.054 0.95
11_I 55_I 1.053 0.95
139_H 142_L 1.038 0.94
14_C 30_V 1.037 0.94
107_S 125_C 1.036 0.94
33_R 88_N 1.035 0.94
42_P 45_I 1.015 0.93
135_E 138_E 1.001 0.92
96_V 176_V 1 0.92
148_K 170_L 1 0.92
41_T 81_Y 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1e4cP111000.046Contact Map0.726
2opiA20.94421000.104Contact Map0.696
3ocrA20.99531000.13Contact Map0.686
1k0wA60.97211000.141Contact Map0.8
2v9lA10.98141000.149Contact Map0.616
2z7bA10.97671000.159Contact Map0.703
2fk5A20.88841000.169Contact Map0.666
1pvtA10.9071000.173Contact Map0.581
2irpA20.87441000.205Contact Map0.718
3m4rA10.82791000.295Contact Map0.613

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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