May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YGEV - Uncharacterized sigma-54-dependent transcriptional regulator YgeV
UniProt: Q46802 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13052
Length: 592 (532)
Sequences: 957
Seq/Len: 1.80
YGEV
Paralog alert: 0.65 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
346_K 355_N 3.702 1.00
477_V 481_L 3.686 1.00
362_Q 396_P 3.421 1.00
330_A 383_A 3.313 1.00
575_I 580_L 3.259 1.00
419_Q 423_E 3.11 1.00
563_H 572_E 3.065 1.00
301_E 445_R 3.031 1.00
346_K 353_S 2.967 1.00
552_E 583_K 2.961 1.00
416_N 419_Q 2.952 1.00
420_F 425_K 2.928 1.00
319_R 406_D 2.846 1.00
345_V 399_A 2.746 1.00
559_A 569_V 2.46 1.00
307_E 387_R 2.456 1.00
366_T 406_D 2.41 1.00
477_V 510_I 2.277 1.00
282_L 309_V 2.224 0.99
474_A 511_D 2.2 0.99
393_E 402_P 2.182 0.99
282_L 439_I 2.133 0.99
553_K 557_R 2.111 0.99
177_D 181_R 2.095 0.99
452_E 482_R 2.044 0.99
338_E 384_K 2.013 0.99
563_H 569_V 1.98 0.99
294_S 502_N 1.979 0.99
334_E 380_M 1.971 0.99
461_L 494_S 1.963 0.98
562_R 572_E 1.937 0.98
480_I 512_S 1.933 0.98
389_I 409_I 1.911 0.98
370_F 412_A 1.895 0.98
451_I 455_V 1.875 0.98
369_L 409_I 1.839 0.97
269_I 312_A 1.83 0.97
330_A 376_D 1.814 0.97
286_I 309_V 1.803 0.97
549_E 586_K 1.766 0.96
334_E 338_E 1.761 0.96
390_E 494_S 1.761 0.96
458_F 497_M 1.746 0.96
344_Y 356_G 1.736 0.96
474_A 477_V 1.715 0.96
393_E 404_Q 1.711 0.96
70_K 104_I 1.708 0.95
360_L 363_A 1.686 0.95
395_L 402_P 1.686 0.95
455_V 473_I 1.673 0.95
269_I 286_I 1.672 0.95
496_L 500_L 1.657 0.94
348_A 397_I 1.612 0.93
296_V 313_I 1.606 0.93
477_V 512_S 1.594 0.93
361_I 369_L 1.593 0.93
577_I 581_Y 1.592 0.93
70_K 109_C 1.586 0.93
272_L 279_M 1.571 0.92
415_Q 420_F 1.568 0.92
101_T 137_V 1.567 0.92
361_I 407_I 1.54 0.91
422_A 428_E 1.534 0.91
456_H 478_V 1.529 0.91
452_E 478_V 1.526 0.90
473_I 478_V 1.513 0.90
311_R 315_K 1.511 0.90
441_L 490_L 1.509 0.90
556_I 569_V 1.497 0.89
375_G 413_T 1.495 0.89
560_L 566_K 1.493 0.89
92_N 117_A 1.484 0.89
435_N 495_N 1.48 0.89
125_H 135_D 1.464 0.88
294_S 498_E 1.455 0.87
565_S 577_I 1.454 0.87
409_I 434_L 1.448 0.87
459_L 501_V 1.444 0.87
555_M 559_A 1.441 0.87
548_L 555_M 1.44 0.87
319_R 407_I 1.438 0.87
310_A 324_F 1.431 0.86
394_I 405_V 1.422 0.86
500_L 510_I 1.41 0.85
365_N 406_D 1.407 0.85
454_L 458_F 1.407 0.85
346_K 354_A 1.395 0.84
361_I 405_V 1.394 0.84
307_E 390_E 1.391 0.84
411_S 434_L 1.375 0.83
368_T 500_L 1.359 0.82
556_I 580_L 1.35 0.82
466_L 502_N 1.342 0.81
358_T 399_A 1.341 0.81
429_D 433_R 1.335 0.81
476_D 512_S 1.323 0.80
569_V 578_A 1.314 0.79
105_L 108_R 1.311 0.79
374_I 377_M 1.311 0.79
386_L 429_D 1.311 0.79
75_V 93_C 1.293 0.78
559_A 563_H 1.289 0.77
353_S 357_K 1.286 0.77
365_N 405_V 1.278 0.76
417_L 426_F 1.277 0.76
420_F 423_E 1.274 0.76
337_L 384_K 1.273 0.76
551_M 555_M 1.271 0.76
313_I 410_I 1.267 0.76
104_I 109_C 1.252 0.74
289_I 361_I 1.25 0.74
337_L 381_L 1.246 0.74
360_L 395_L 1.241 0.73
174_L 182_V 1.239 0.73
307_E 391_A 1.235 0.73
292_S 502_N 1.234 0.73
556_I 575_I 1.234 0.73
375_G 415_Q 1.222 0.72
576_G 581_Y 1.221 0.72
272_L 309_V 1.212 0.71
274_G 304_T 1.21 0.71
344_Y 370_F 1.206 0.70
516_P 519_L 1.204 0.70
473_I 497_M 1.202 0.70
448_Q 485_R 1.201 0.70
299_V 413_T 1.2 0.70
444_L 493_L 1.193 0.69
333_P 338_E 1.192 0.69
564_N 584_I 1.192 0.69
479_E 482_R 1.19 0.69
388_A 391_A 1.183 0.68
579_T 582_R 1.18 0.68
298_V 410_I 1.179 0.68
291_P 318_G 1.177 0.68
373_E 398_G 1.176 0.68
410_I 575_I 1.168 0.67
565_S 581_Y 1.166 0.67
567_K 577_I 1.166 0.67
473_I 510_I 1.166 0.67
571_D 585_K 1.165 0.66
429_D 491_R 1.165 0.66
274_G 279_M 1.164 0.66
111_G 421_I 1.159 0.66
427_R 433_R 1.158 0.66
270_E 287_S 1.157 0.66
358_T 363_A 1.156 0.66
335_Q 338_E 1.156 0.66
309_V 441_L 1.148 0.65
560_L 569_V 1.147 0.65
492_E 498_E 1.144 0.64
339_S 412_A 1.144 0.64
369_L 405_V 1.142 0.64
74_V 94_R 1.139 0.64
295_S 411_S 1.136 0.64
478_V 482_R 1.132 0.63
471_P 501_V 1.13 0.63
348_A 352_A 1.129 0.63
566_K 580_L 1.125 0.63
568_Q 571_D 1.122 0.62
462_H 497_M 1.12 0.62
272_L 312_A 1.119 0.62
336_L 350_T 1.109 0.61
398_G 433_R 1.107 0.61
186_N 189_A 1.105 0.60
142_T 145_V 1.103 0.60
189_A 193_L 1.094 0.59
462_H 501_V 1.094 0.59
386_L 427_R 1.091 0.59
500_L 514_L 1.09 0.59
290_A 408_R 1.089 0.59
418_A 518_N 1.086 0.58
451_I 481_L 1.084 0.58
336_L 414_N 1.082 0.58
380_M 392_R 1.082 0.58
352_A 373_E 1.079 0.58
271_Q 315_K 1.078 0.58
301_E 443_P 1.073 0.57
427_R 491_R 1.071 0.57
583_K 587_Y 1.071 0.57
93_C 144_F 1.069 0.57
557_R 561_S 1.064 0.56
436_V 498_E 1.063 0.56
373_E 412_A 1.062 0.56
548_L 552_E 1.059 0.56
436_V 495_N 1.055 0.55
342_F 359_G 1.055 0.55
126_I 135_D 1.051 0.55
336_L 373_E 1.05 0.55
569_V 572_E 1.048 0.54
399_A 403_I 1.048 0.54
358_T 400_S 1.046 0.54
338_E 380_M 1.046 0.54
566_K 581_Y 1.043 0.54
209_P 332_I 1.041 0.54
463_T 469_V 1.04 0.54
575_I 583_K 1.04 0.54
314_H 368_T 1.037 0.53
285_L 503_V 1.037 0.53
294_S 466_L 1.036 0.53
328_N 432_Y 1.034 0.53
292_S 498_E 1.033 0.53
93_C 114_S 1.031 0.53
114_S 145_V 1.031 0.53
349_F 352_A 1.031 0.53
294_S 436_V 1.027 0.52
375_G 414_N 1.025 0.52
548_L 559_A 1.024 0.52
440_T 446_E 1.022 0.52
373_E 429_D 1.021 0.51
103_V 141_S 1.02 0.51
373_E 433_R 1.02 0.51
475_P 479_E 1.019 0.51
298_V 439_I 1.017 0.51
433_R 491_R 1.015 0.51
196_V 199_N 1.014 0.51
362_Q 403_I 1.014 0.51
383_A 409_I 1.013 0.51
172_G 186_N 1.012 0.51
563_H 568_Q 1.01 0.50
135_D 494_S 1.01 0.50
56_L 61_R 1.005 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.68581000.443Contact Map0.529
1ny5A20.64191000.545Contact Map0.593
1ojlA60.51181000.557Contact Map0.649
3dzdA20.58951000.576Contact Map0.585
4fwgA10.56421000.717Contact Map0.329
2bjvA10.44591000.744Contact Map0.523
1hqcA20.46281000.765Contact Map0.426
1in4A10.48311000.773Contact Map0.445
1r6bX10.78721000.773Contact Map0.333
1qvrA30.85981000.788Contact Map0.317
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.8468 seconds.