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OPENSEQ.org
NTRC - Nitrogen regulation protein NR(I)
UniProt: P0AFB8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10385
Length: 469 (454)
Sequences: 5258
Seq/Len: 11.58
NTRC
Paralog alert: 0.76 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
287_R 292_K 4.057 1.00
213_E 223_I 3.911 1.00
169_E 312_R 3.827 1.00
441_T 451_L 3.275 1.00
198_A 250_T 3.246 1.00
229_E 263_R 3.071 1.00
286_Q 290_E 3.034 1.00
227_R 262_Y 2.966 1.00
283_N 286_Q 2.842 1.00
31_T 48_P 2.838 1.00
154_I 177_V 2.731 1.00
261_F 272_V 2.602 1.00
260_Q 269_P 2.491 1.00
260_Q 271_K 2.481 1.00
61_D 64_A 2.475 1.00
202_K 247_D 2.403 1.00
433_L 437_A 2.371 1.00
447_E 450_R 2.355 1.00
35_N 38_E 2.342 1.00
328_V 361_E 2.333 1.00
431_R 435_T 2.323 1.00
441_T 448_A 2.314 1.00
319_P 345_E 2.313 1.00
228_F 255_V 2.311 1.00
36_G 60_M 2.295 1.00
16_R 34_E 2.29 1.00
282_Q 287_R 2.283 1.00
340_L 364_C 2.267 1.00
322_A 340_L 2.198 1.00
7_W 33_F 2.153 1.00
9_V 39_V 2.153 1.00
341_H 377_L 2.135 1.00
213_E 266_G 2.114 1.00
237_F 279_A 2.09 1.00
16_R 32_T 2.089 1.00
256_L 276_I 2.062 1.00
319_P 349_T 2.046 1.00
353_W 363_T 2.035 1.00
287_R 290_E 2.034 1.00
99_F 118_A 2.024 1.00
213_E 263_R 2.018 1.00
257_A 361_E 1.992 1.00
286_Q 289_Q 1.984 1.00
177_V 308_L 1.933 1.00
262_Y 269_P 1.932 1.00
67_K 96_Q 1.925 1.00
34_E 38_E 1.917 1.00
440_H 451_L 1.885 1.00
128_P 131_V 1.875 1.00
243_D 282_Q 1.844 1.00
156_R 372_A 1.83 1.00
232_D 272_V 1.818 1.00
187_R 273_D 1.79 1.00
233_G 273_D 1.752 1.00
351_L 354_P 1.749 1.00
150_V 306_V 1.749 1.00
37_A 59_G 1.721 1.00
167_N 307_H 1.721 1.00
341_H 344_T 1.694 1.00
437_A 441_T 1.692 1.00
255_V 261_F 1.688 1.00
232_D 273_D 1.662 1.00
278_A 301_L 1.656 1.00
224_R 267_Y 1.65 1.00
376_V 381_L 1.648 1.00
50_V 115_V 1.636 1.00
20_E 32_T 1.62 1.00
315_R 352_A 1.614 1.00
212_H 217_F 1.613 1.00
143_E 320_R 1.606 1.00
457_N 461_R 1.604 1.00
68_Q 71_Q 1.595 1.00
5_I 29_T 1.591 1.00
343_E 378_I 1.587 1.00
52_L 115_V 1.585 1.00
53_S 65_L 1.571 1.00
323_R 345_E 1.567 1.00
175_E 254_R 1.564 1.00
324_H 328_V 1.562 1.00
322_A 364_C 1.552 1.00
266_G 270_V 1.552 1.00
150_V 308_L 1.542 1.00
315_R 319_P 1.541 1.00
124_E 128_P 1.538 1.00
344_T 348_L 1.525 1.00
144_A 316_E 1.521 1.00
345_E 349_T 1.52 1.00
172_T 308_L 1.515 1.00
307_H 313_E 1.512 1.00
44_A 72_R 1.497 1.00
51_L 69_I 1.488 1.00
430_E 462_K 1.485 1.00
43_L 69_I 1.473 1.00
437_A 452_L 1.468 1.00
127_Q 131_V 1.467 1.00
344_T 378_I 1.466 1.00
40_L 68_Q 1.465 1.00
57_M 60_M 1.462 1.00
242_G 280_T 1.462 1.00
206_E 251_R 1.461 1.00
31_T 42_A 1.452 1.00
151_F 154_I 1.452 1.00
79_I 114_L 1.443 1.00
155_G 184_H 1.44 1.00
243_D 281_H 1.44 1.00
167_N 305_R 1.437 1.00
33_F 39_V 1.431 1.00
228_F 236_L 1.431 1.00
437_A 451_L 1.429 1.00
33_F 42_A 1.413 1.00
20_E 24_A 1.413 1.00
225_Q 229_E 1.407 0.99
53_S 80_I 1.406 0.99
339_L 375_E 1.404 0.99
212_H 264_V 1.4 0.99
169_E 310_P 1.384 0.99
87_L 91_V 1.383 0.99
321_L 325_F 1.381 0.99
284_L 293_F 1.378 0.99
351_L 359_Q 1.371 0.99
315_R 318_I 1.364 0.99
6_V 28_L 1.359 0.99
124_E 127_Q 1.357 0.99
212_H 216_A 1.355 0.99
35_N 59_G 1.352 0.99
162_I 333_L 1.341 0.99
347_A 378_I 1.337 0.99
68_Q 72_R 1.333 0.99
205_I 248_V 1.331 0.99
458_T 462_K 1.33 0.99
149_D 152_R 1.328 0.99
329_A 368_T 1.324 0.99
147_M 151_F 1.323 0.99
73_H 76_L 1.323 0.99
162_I 365_R 1.306 0.99
142_G 151_F 1.302 0.99
42_A 48_P 1.293 0.99
261_F 271_K 1.293 0.99
332_E 365_R 1.291 0.99
26_A 112_V 1.288 0.99
202_K 245_P 1.27 0.99
461_R 465_E 1.269 0.99
127_Q 132_Q 1.269 0.99
344_T 376_V 1.268 0.99
276_I 301_L 1.265 0.99
124_E 131_V 1.264 0.99
444_H 447_E 1.252 0.99
217_F 220_A 1.245 0.98
435_T 439_R 1.241 0.98
446_Q 450_R 1.237 0.98
166_I 277_I 1.236 0.98
457_N 460_T 1.236 0.98
326_L 340_L 1.235 0.98
36_G 65_L 1.229 0.98
10_D 57_M 1.225 0.98
263_R 266_G 1.22 0.98
340_L 345_E 1.22 0.98
89_A 101_Y 1.22 0.98
152_R 155_G 1.211 0.98
8_V 30_C 1.209 0.98
140_I 177_V 1.203 0.98
51_L 76_L 1.2 0.98
154_I 180_A 1.199 0.98
69_I 78_V 1.198 0.98
377_L 380_D 1.195 0.98
140_I 151_F 1.195 0.98
63_L 93_A 1.193 0.98
455_G 458_T 1.19 0.98
157_L 304_I 1.184 0.98
326_L 368_T 1.183 0.98
341_H 375_E 1.177 0.98
434_L 452_L 1.172 0.98
36_G 57_M 1.168 0.97
316_E 349_T 1.168 0.97
445_K 460_T 1.167 0.97
434_L 459_L 1.166 0.97
56_R 84_H 1.164 0.97
190_A 233_G 1.163 0.97
448_A 451_L 1.162 0.97
436_T 440_H 1.156 0.97
22_A 108_I 1.156 0.97
52_L 111_A 1.155 0.97
447_E 451_L 1.154 0.97
140_I 176_L 1.152 0.97
229_E 270_V 1.149 0.97
142_G 154_I 1.146 0.97
455_G 461_R 1.143 0.97
426_Q 465_E 1.141 0.97
325_F 329_A 1.141 0.97
228_F 274_V 1.139 0.97
366_W 370_M 1.139 0.97
319_P 322_A 1.136 0.97
66_L 78_V 1.133 0.97
459_L 462_K 1.131 0.97
92_S 96_Q 1.123 0.97
142_G 177_V 1.122 0.97
161_S 187_R 1.121 0.97
236_L 276_I 1.119 0.96
40_L 60_M 1.113 0.96
325_F 364_C 1.111 0.96
153_I 370_M 1.11 0.96
259_G 271_K 1.109 0.96
9_V 65_L 1.109 0.96
10_D 16_R 1.107 0.96
5_I 31_T 1.099 0.96
165_L 278_A 1.098 0.96
444_H 456_R 1.094 0.96
207_S 212_H 1.092 0.96
142_G 320_R 1.085 0.96
142_G 147_M 1.083 0.96
36_G 40_L 1.082 0.96
446_Q 456_R 1.08 0.95
208_E 224_R 1.08 0.95
315_R 349_T 1.066 0.95
216_A 264_V 1.063 0.95
207_S 217_F 1.062 0.95
53_S 78_V 1.06 0.95
166_I 177_V 1.058 0.95
175_E 194_A 1.056 0.95
66_L 80_I 1.056 0.95
263_R 270_V 1.055 0.95
180_A 184_H 1.053 0.95
26_A 116_E 1.049 0.94
50_V 119_I 1.047 0.94
205_I 209_L 1.046 0.94
31_T 46_K 1.044 0.94
285_E 289_Q 1.038 0.94
242_G 284_L 1.038 0.94
433_L 452_L 1.038 0.94
371_A 380_D 1.03 0.94
196_N 243_D 1.029 0.94
28_L 116_E 1.028 0.94
429_L 433_L 1.027 0.94
346_A 350_R 1.027 0.94
154_I 306_V 1.024 0.93
340_L 376_V 1.024 0.93
289_Q 295_E 1.023 0.93
10_D 15_I 1.014 0.93
141_I 324_H 1.014 0.93
154_I 181_L 1.012 0.93
198_A 243_D 1.009 0.93
196_N 244_M 1.008 0.93
169_E 172_T 1.008 0.93
95_Q 100_D 1.006 0.93
212_H 224_R 1.006 0.93
329_A 364_C 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.93821000.106Contact Map0.736
1ny5A20.82091000.234Contact Map0.792
3dzdA20.78461000.274Contact Map0.782
1ojlA60.64821000.441Contact Map0.77
4fwgA10.92751000.649Contact Map0.376
1r6bX10.83371000.664Contact Map0.342
2bjvA10.56291000.669Contact Map0.665
1qvrA30.83581000.677Contact Map0.308
1hqcA20.581000.706Contact Map0.477
3pxiA30.81241000.711Contact Map0.377
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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