May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
NORR - Anaerobic nitric oxide reductase transcription regulator NorR
UniProt: P37013 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12108
Length: 504 (498)
Sequences: 1312
Seq/Len: 2.63
NORR
Paralog alert: 0.76 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
475_N 485_M 3.73 1.00
333_E 337_A 3.665 1.00
276_E 310_R 3.562 1.00
329_R 334_E 3.494 1.00
375_Q 408_E 3.46 1.00
334_E 339_R 3.355 1.00
274_K 309_Q 3.169 1.00
249_E 294_A 2.953 1.00
197_L 353_L 2.941 1.00
475_N 482_C 2.904 1.00
216_E 359_R 2.785 1.00
260_V 313_D 2.784 1.00
245_A 297_A 2.766 1.00
280_N 320_D 2.726 1.00
465_R 469_R 2.58 1.00
189_G 194_M 2.496 1.00
201_I 224_V 2.493 1.00
372_F 411_I 2.471 1.00
474_Q 485_M 2.459 1.00
468_I 493_L 2.404 1.00
222_E 301_R 2.352 1.00
79_I 115_G 2.326 1.00
330_D 333_E 2.287 1.00
283_L 323_V 2.264 1.00
284_F 326_A 2.25 1.00
369_A 387_L 2.233 1.00
308_I 319_V 2.207 1.00
260_V 270_N 2.176 1.00
259_H 271_R 2.15 1.00
366_I 369_A 2.149 1.00
372_F 376_C 2.146 1.00
170_N 173_P 2.143 1.00
325_A 348_L 2.124 1.00
302_V 308_I 2.073 1.00
391_A 395_L 2.049 1.00
376_C 411_I 2.048 1.00
468_I 497_A 2.016 1.00
366_I 392_R 1.996 0.99
467_T 471_A 1.985 0.99
463_F 467_T 1.98 0.99
219_T 355_V 1.969 0.99
398_Y 401_P 1.932 0.99
489_D 492_N 1.924 0.99
252_A 291_L 1.916 0.99
387_L 411_I 1.903 0.99
260_V 310_R 1.865 0.99
307_D 316_C 1.847 0.99
304_Q 408_E 1.825 0.99
471_A 475_N 1.821 0.99
362_G 365_V 1.806 0.99
271_R 314_D 1.707 0.98
187_M 194_M 1.691 0.98
303_L 323_V 1.69 0.98
212_L 325_A 1.677 0.98
471_A 485_M 1.674 0.98
274_K 277_M 1.672 0.97
208_D 379_R 1.671 0.97
464_Q 496_L 1.66 0.97
275_F 283_L 1.66 0.97
187_M 224_V 1.659 0.97
213_I 224_V 1.655 0.97
373_C 387_L 1.638 0.97
333_E 336_L 1.619 0.97
460_T 463_F 1.612 0.97
261_K 268_I 1.607 0.97
214_S 332_R 1.571 0.96
194_M 198_K 1.567 0.96
307_D 318_R 1.565 0.96
213_I 225_A 1.564 0.96
310_R 317_L 1.562 0.96
478_N 490_V 1.559 0.96
275_F 302_V 1.557 0.96
391_A 431_A 1.527 0.95
471_A 482_C 1.508 0.95
290_E 328_N 1.503 0.95
313_D 317_L 1.503 0.95
289_G 327_T 1.5 0.94
283_L 302_V 1.497 0.94
203_I 419_R 1.49 0.94
213_I 353_L 1.479 0.94
481_A 484_R 1.478 0.94
309_Q 316_C 1.474 0.94
194_M 224_V 1.467 0.94
480_A 484_R 1.46 0.93
365_V 369_A 1.447 0.93
390_G 431_A 1.445 0.93
376_C 415_V 1.439 0.93
41_S 45_R 1.439 0.93
243_N 246_A 1.433 0.92
197_L 224_V 1.432 0.92
290_E 329_R 1.43 0.92
373_C 415_V 1.429 0.92
207_S 416_V 1.423 0.92
201_I 228_I 1.421 0.92
209_L 380_Q 1.418 0.92
239_L 281_G 1.415 0.92
290_E 334_E 1.414 0.92
234_R 320_D 1.409 0.92
366_I 396_Q 1.402 0.91
259_H 264_F 1.402 0.91
255_E 340_F 1.399 0.91
478_N 481_A 1.398 0.91
190_L 367_L 1.392 0.91
369_A 411_I 1.39 0.91
469_R 473_A 1.386 0.91
340_F 344_L 1.38 0.91
469_R 502_L 1.374 0.90
208_D 234_R 1.373 0.90
331_L 340_F 1.372 0.90
187_M 223_L 1.366 0.90
209_L 412_H 1.365 0.90
252_A 295_L 1.365 0.90
241_Y 309_Q 1.363 0.90
169_Q 173_P 1.358 0.90
489_D 495_R 1.346 0.89
176_A 179_F 1.344 0.89
368_L 372_F 1.34 0.89
264_F 267_A 1.336 0.89
456_L 488_T 1.33 0.88
388_S 391_A 1.326 0.88
414_A 433_H 1.321 0.88
491_A 495_R 1.317 0.88
492_N 495_R 1.312 0.87
197_L 201_I 1.307 0.87
191_S 363_D 1.302 0.87
308_I 313_D 1.299 0.87
202_E 231_A 1.288 0.86
459_A 463_F 1.276 0.85
216_E 357_P 1.275 0.85
248_P 311_V 1.274 0.85
388_S 430_E 1.264 0.85
224_V 355_V 1.262 0.84
472_L 497_A 1.252 0.84
289_G 331_L 1.249 0.84
277_M 313_D 1.248 0.84
497_A 500_L 1.246 0.83
234_R 237_N 1.236 0.83
481_A 485_M 1.229 0.82
255_E 331_L 1.226 0.82
310_R 313_D 1.221 0.82
355_V 418_A 1.219 0.82
362_G 366_I 1.218 0.81
261_K 270_N 1.214 0.81
209_L 416_V 1.209 0.81
253_E 298_K 1.207 0.81
400_F 410_A 1.206 0.81
482_C 485_M 1.204 0.80
392_R 396_Q 1.202 0.80
195_T 199_K 1.194 0.80
237_N 280_N 1.189 0.79
115_G 129_T 1.188 0.79
362_G 399_S 1.185 0.79
299_L 302_V 1.179 0.78
430_E 433_H 1.179 0.78
455_N 487_E 1.178 0.78
210_N 325_A 1.172 0.78
338_G 373_C 1.168 0.78
462_A 466_E 1.168 0.78
210_N 306_G 1.164 0.77
472_L 482_C 1.164 0.77
241_Y 307_D 1.163 0.77
204_V 351_F 1.163 0.77
479_W 497_A 1.161 0.77
167_E 171_M 1.152 0.76
222_E 275_F 1.152 0.76
276_E 317_L 1.151 0.76
473_A 477_H 1.148 0.76
490_V 494_H 1.14 0.75
243_N 285_L 1.138 0.75
263_A 267_A 1.138 0.75
382_L 415_V 1.136 0.75
459_A 467_T 1.134 0.75
234_R 321_V 1.134 0.75
201_I 213_I 1.132 0.74
259_H 263_A 1.13 0.74
74_P 77_E 1.129 0.74
286_D 347_R 1.128 0.74
155_G 159_N 1.125 0.74
468_I 486_L 1.124 0.74
334_E 337_A 1.119 0.73
259_H 270_N 1.116 0.73
486_L 493_L 1.115 0.73
255_E 259_H 1.106 0.72
194_M 404_V 1.101 0.71
254_S 259_H 1.101 0.71
490_V 493_L 1.097 0.71
289_G 340_F 1.091 0.70
127_A 417_L 1.087 0.70
254_S 328_N 1.085 0.70
242_L 274_K 1.084 0.70
255_E 289_G 1.08 0.69
478_N 484_R 1.079 0.69
255_E 327_T 1.077 0.69
275_F 308_I 1.075 0.69
308_I 318_R 1.074 0.69
289_G 329_R 1.072 0.69
189_G 227_A 1.072 0.69
242_L 283_L 1.072 0.69
493_L 497_A 1.071 0.68
83_G 127_A 1.067 0.68
14_E 18_G 1.067 0.68
83_G 124_L 1.066 0.68
275_F 321_V 1.065 0.68
115_G 127_A 1.064 0.68
198_K 224_V 1.059 0.67
362_G 396_Q 1.053 0.67
10_N 13_I 1.044 0.66
385_V 415_V 1.043 0.65
259_H 289_G 1.041 0.65
329_R 404_V 1.039 0.65
272_S 310_R 1.034 0.64
479_W 494_H 1.032 0.64
369_A 414_A 1.028 0.64
288_I 392_R 1.027 0.64
241_Y 274_K 1.027 0.64
263_A 311_V 1.022 0.63
189_G 367_L 1.019 0.63
166_L 169_Q 1.013 0.62
223_L 284_F 1.011 0.62
247_L 308_I 1.01 0.62
468_I 500_L 1.01 0.62
279_D 320_D 1.009 0.62
193_G 360_E 1.006 0.61
119_F 124_L 1.003 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.85911000.321Contact Map0.592
1ny5A20.7481000.442Contact Map0.672
1ojlA60.60321000.463Contact Map0.68
3dzdA20.71431000.48Contact Map0.626
4fwgA10.88291000.656Contact Map0.309
2bjvA10.52381000.689Contact Map0.558
1hqcA20.54761000.719Contact Map0.41
1r6bX10.81941000.722Contact Map0.369
1qvrA30.83331000.725Contact Map0.327
1in4A10.57541000.729Contact Map0.428
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.3505 seconds.