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OPENSEQ.org
DHAR - PTS-dependent dihydroxyacetone kinase operon regulatory protein
UniProt: P76016 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13902
Length: 639 (621)
Sequences: 1291
Seq/Len: 2.08
DHAR
Paralog alert: 0.66 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
356_E 496_R 3.662 1.00
401_R 406_N 3.416 1.00
470_M 474_Q 3.377 1.00
413_E 447_R 3.369 1.00
527_A 531_L 3.278 1.00
603_T 613_L 3.092 1.00
616_I 621_L 3.092 1.00
385_E 434_S 2.971 1.00
471_L 476_R 2.813 1.00
592_E 624_K 2.761 1.00
467_D 470_M 2.745 1.00
401_R 404_N 2.731 1.00
593_K 597_I 2.549 1.00
512_S 544_Y 2.51 1.00
362_A 438_Q 2.498 1.00
374_R 457_D 2.435 1.00
400_D 450_A 2.407 1.00
524_D 560_R 2.377 1.00
599_A 610_M 2.372 1.00
527_A 559_I 2.344 1.00
603_T 610_M 2.308 1.00
602_V 613_L 2.26 1.00
503_P 532_V 2.22 1.00
220_D 224_N 2.067 0.99
246_R 250_E 2.043 0.99
523_I 528_L 2.039 0.99
337_L 490_I 1.987 0.99
389_D 431_E 1.978 0.99
506_V 523_I 1.971 0.99
444_V 453_L 1.967 0.99
546_V 550_L 1.961 0.99
412_L 420_L 1.943 0.99
337_L 364_L 1.919 0.99
509_K 547_I 1.872 0.98
18_T 124_S 1.832 0.98
16_I 130_T 1.829 0.98
403_D 407_G 1.821 0.98
421_F 463_T 1.798 0.98
343_Q 555_D 1.782 0.98
417_G 457_D 1.782 0.98
527_A 561_V 1.781 0.98
524_D 527_A 1.751 0.97
365_S 379_Y 1.751 0.97
530_R 561_V 1.731 0.97
399_G 407_G 1.729 0.97
618_R 622_W 1.724 0.97
393_A 435_A 1.723 0.97
416_H 457_D 1.719 0.97
510_L 551_A 1.714 0.97
460_V 485_L 1.709 0.97
148_T 178_T 1.709 0.97
466_A 471_L 1.705 0.97
444_V 455_P 1.702 0.96
125_G 151_F 1.667 0.96
399_G 403_D 1.64 0.95
366_Q 370_N 1.639 0.95
385_E 427_Y 1.638 0.95
349_F 552_L 1.616 0.95
606_R 618_R 1.609 0.95
446_T 453_L 1.599 0.94
19_S 115_T 1.59 0.94
596_I 610_M 1.584 0.94
507_N 528_L 1.581 0.94
595_A 599_A 1.576 0.94
426_E 464_T 1.566 0.94
324_F 367_A 1.556 0.93
64_A 181_I 1.556 0.93
550_L 559_I 1.534 0.93
152_D 156_R 1.534 0.93
526_D 561_V 1.528 0.93
412_L 458_V 1.516 0.92
329_Q 334_T 1.511 0.92
374_R 458_V 1.507 0.92
523_I 547_I 1.505 0.92
145_F 162_A 1.504 0.92
502_I 506_V 1.491 0.91
513_L 547_I 1.49 0.91
412_L 456_I 1.489 0.91
389_D 393_A 1.486 0.91
401_R 405_E 1.48 0.91
506_V 547_I 1.47 0.91
341_G 364_L 1.469 0.91
620_T 623_R 1.466 0.90
225_L 251_L 1.46 0.90
159_G 616_I 1.432 0.89
517_F 552_L 1.43 0.89
486_H 545_S 1.428 0.89
404_N 408_R 1.427 0.89
473_E 479_R 1.426 0.89
409_L 450_A 1.414 0.88
76_F 87_R 1.409 0.88
624_K 628_H 1.397 0.87
600_A 610_M 1.395 0.87
605_G 610_M 1.379 0.86
600_A 607_I 1.376 0.86
440_I 460_V 1.371 0.86
423_E 463_T 1.37 0.86
362_A 441_K 1.367 0.86
521_L 551_A 1.366 0.86
468_L 477_F 1.361 0.85
349_F 548_E 1.361 0.85
503_P 528_L 1.36 0.85
596_I 621_L 1.359 0.85
356_E 494_P 1.357 0.85
324_F 341_G 1.355 0.85
526_D 560_R 1.346 0.85
599_A 603_T 1.346 0.85
173_A 176_P 1.344 0.84
588_F 595_A 1.34 0.84
610_M 619_T 1.339 0.84
617_G 622_W 1.339 0.84
445_I 456_I 1.334 0.84
344_A 412_L 1.333 0.84
116_C 120_L 1.328 0.83
394_E 463_T 1.327 0.83
351_V 368_I 1.32 0.83
117_A 147_A 1.317 0.83
392_L 432_L 1.315 0.83
505_L 509_K 1.306 0.82
441_K 544_Y 1.302 0.82
388_G 393_A 1.295 0.81
391_A 465_T 1.289 0.81
437_L 480_Q 1.285 0.81
411_R 414_L 1.283 0.80
396_F 425_I 1.275 0.80
39_Q 42_T 1.274 0.80
217_I 225_L 1.273 0.80
589_A 627_Q 1.266 0.79
145_F 164_A 1.265 0.79
399_G 402_T 1.262 0.79
480_Q 484_A 1.261 0.79
420_L 460_V 1.261 0.79
612_A 626_K 1.248 0.78
327_M 334_T 1.246 0.78
362_A 442_Q 1.245 0.78
502_I 531_L 1.24 0.77
487_A 545_S 1.239 0.77
424_K 449_D 1.239 0.77
616_I 624_K 1.238 0.77
600_A 625_M 1.234 0.77
437_L 478_S 1.233 0.77
416_H 456_I 1.231 0.77
588_F 624_K 1.229 0.76
397_I 410_S 1.228 0.76
391_A 394_E 1.227 0.76
606_R 622_W 1.222 0.76
469_A 567_H 1.221 0.76
513_L 544_Y 1.216 0.75
592_E 596_I 1.216 0.75
119_S 145_F 1.214 0.75
480_Q 541_F 1.213 0.75
42_T 45_S 1.206 0.74
349_F 517_F 1.206 0.74
487_A 509_K 1.204 0.74
608_Q 618_R 1.203 0.74
116_C 119_S 1.202 0.74
151_F 157_L 1.2 0.74
471_L 474_Q 1.195 0.73
383_N 437_L 1.194 0.73
424_K 463_T 1.193 0.73
495_L 543_L 1.19 0.73
587_S 590_E 1.188 0.73
606_R 621_L 1.182 0.72
26_L 29_R 1.179 0.72
478_S 484_A 1.178 0.72
353_L 461_I 1.175 0.72
523_I 559_I 1.174 0.72
425_I 428_L 1.173 0.72
424_K 484_A 1.17 0.71
362_A 381_A 1.17 0.71
478_S 541_F 1.168 0.71
607_I 622_W 1.167 0.71
424_K 480_Q 1.164 0.71
524_D 558_R 1.16 0.70
438_Q 480_Q 1.157 0.70
391_A 423_E 1.156 0.70
503_P 506_V 1.152 0.70
426_E 465_T 1.148 0.69
555_D 563_D 1.147 0.69
550_L 563_D 1.147 0.69
449_D 484_A 1.146 0.69
565_P 568_L 1.145 0.69
105_G 115_T 1.139 0.68
364_L 492_I 1.134 0.68
331_D 500_G 1.134 0.68
381_A 438_Q 1.131 0.67
152_D 467_D 1.13 0.67
503_P 507_N 1.13 0.67
320_V 370_N 1.129 0.67
426_E 438_Q 1.128 0.67
403_D 463_T 1.128 0.67
368_I 461_I 1.127 0.67
144_A 165_C 1.125 0.67
120_L 130_T 1.124 0.67
391_A 463_T 1.123 0.67
525_D 529_A 1.123 0.67
369_H 419_T 1.121 0.66
409_L 414_L 1.12 0.66
413_E 454_I 1.117 0.66
467_D 482_Y 1.116 0.66
28_K 31_T 1.112 0.66
349_F 487_A 1.112 0.66
617_G 621_L 1.111 0.65
607_I 621_L 1.107 0.65
609_E 612_A 1.107 0.65
338_I 451_R 1.106 0.65
391_A 402_T 1.106 0.65
484_A 541_F 1.103 0.65
510_L 559_I 1.102 0.65
402_T 423_E 1.094 0.64
423_E 484_A 1.093 0.64
127_A 353_L 1.093 0.64
108_C 118_L 1.093 0.64
345_A 459_K 1.092 0.64
498_R 501_S 1.091 0.63
114_G 134_Q 1.087 0.63
392_L 435_A 1.086 0.63
347_S 552_L 1.08 0.62
534_C 542_E 1.078 0.62
609_E 613_L 1.076 0.62
110_E 115_T 1.072 0.61
352_L 462_A 1.072 0.61
506_V 531_L 1.071 0.61
399_G 424_K 1.069 0.61
419_T 550_L 1.068 0.61
22_R 110_E 1.068 0.61
38_A 42_T 1.066 0.61
346_R 373_E 1.065 0.61
410_S 424_K 1.064 0.61
330_D 504_A 1.063 0.60
399_G 463_T 1.062 0.60
426_E 466_A 1.062 0.60
354_C 464_T 1.06 0.60
27_M 31_T 1.058 0.60
426_E 484_A 1.054 0.59
418_G 422_L 1.053 0.59
391_A 410_S 1.053 0.59
427_Y 484_A 1.053 0.59
383_N 424_K 1.051 0.59
588_F 592_E 1.05 0.59
399_G 480_Q 1.05 0.59
431_E 443_G 1.048 0.59
437_L 483_Y 1.048 0.59
411_R 446_T 1.047 0.59
409_L 447_R 1.046 0.59
68_M 84_I 1.046 0.59
341_G 490_I 1.044 0.58
600_A 622_W 1.044 0.58
215_G 236_L 1.042 0.58
439_V 442_Q 1.041 0.58
410_S 480_Q 1.037 0.58
420_L 456_I 1.037 0.58
594_E 598_N 1.034 0.57
611_S 614_L 1.034 0.57
427_Y 478_S 1.033 0.57
327_M 367_A 1.031 0.57
597_I 601_Q 1.031 0.57
536_W 546_V 1.03 0.57
399_G 423_E 1.029 0.57
334_T 337_L 1.028 0.57
407_G 463_T 1.028 0.57
117_A 121_A 1.022 0.56
596_I 625_M 1.022 0.56
423_E 480_Q 1.021 0.56
509_K 544_Y 1.021 0.56
426_E 449_D 1.021 0.56
62_E 88_N 1.02 0.56
365_S 419_T 1.02 0.56
118_L 164_A 1.02 0.56
61_L 624_K 1.019 0.56
603_T 609_E 1.018 0.55
402_T 465_T 1.018 0.55
183_R 186_G 1.016 0.55
395_E 410_S 1.013 0.55
618_R 621_L 1.012 0.55
491_T 497_M 1.012 0.55
329_Q 359_V 1.009 0.54
27_M 33_N 1.006 0.54
385_E 431_E 1.004 0.54
150_L 161_I 1.002 0.54
380_I 414_L 1.002 0.54
409_L 451_R 1.001 0.54
119_S 135_H 1 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.63691000.472Contact Map0.533
1ojlA60.46951000.576Contact Map0.618
1ny5A20.59471000.58Contact Map0.578
3dzdA20.55241000.61Contact Map0.568
4fwgA10.52581000.739Contact Map0.305
2bjvA10.40691000.752Contact Map0.498
1hqcA20.43821000.764Contact Map0.426
1in4A10.46011000.772Contact Map0.428
1r6bX10.78251000.793Contact Map0.303
1l8qA10.44911000.794Contact Map0.284
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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