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OPENSEQ.org
GLRR - Transcriptional regulatory protein GlrR
UniProt: P0AFU4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11285
Length: 444 (432)
Sequences: 5225
Seq/Len: 12.09
GLRR
Paralog alert: 0.77 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: ATOC DHAR FHLA GLRR HYFR NORR NTRC PRPR PSPF RTCR TYRR YGEV ZRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
283_A 288_E 3.945 1.00
209_A 219_N 3.793 1.00
165_Q 308_A 3.739 1.00
410_T 420_M 3.237 1.00
194_G 246_V 3.083 1.00
282_K 286_R 2.979 1.00
225_Q 259_P 2.965 1.00
223_L 258_R 2.876 1.00
33_V 50_V 2.789 1.00
150_A 173_F 2.764 1.00
279_D 282_K 2.639 1.00
257_V 268_I 2.545 1.00
256_K 265_D 2.458 1.00
63_D 66_Q 2.426 1.00
256_K 267_D 2.425 1.00
402_Y 406_L 2.392 1.00
198_E 243_P 2.375 1.00
324_Q 357_V 2.366 1.00
410_T 417_A 2.358 1.00
315_P 341_M 2.354 1.00
400_L 404_R 2.344 1.00
416_H 419_R 2.315 1.00
37_S 40_E 2.313 1.00
18_L 36_E 2.257 1.00
38_G 62_M 2.23 1.00
336_F 360_I 2.226 1.00
278_R 283_A 2.214 1.00
224_F 251_V 2.197 1.00
318_A 336_F 2.18 1.00
337_S 373_S 2.147 1.00
11_V 41_G 2.116 1.00
9_L 35_A 2.07 1.00
209_A 262_S 2.068 1.00
252_L 272_I 2.039 1.00
18_L 34_T 2.03 1.00
233_F 275_A 2.027 1.00
253_Q 357_V 2 1.00
283_A 286_R 1.995 1.00
349_W 359_V 1.99 1.00
282_K 285_A 1.971 1.00
258_R 265_D 1.958 1.00
315_P 345_M 1.925 1.00
101_F 120_A 1.908 1.00
229_G 269_N 1.897 1.00
69_A 98_Q 1.897 1.00
36_E 40_E 1.895 1.00
239_D 278_R 1.88 1.00
173_F 304_I 1.836 1.00
409_I 420_M 1.832 1.00
209_A 259_P 1.826 1.00
152_L 368_S 1.797 1.00
183_R 269_N 1.771 1.00
163_N 303_K 1.759 1.00
347_A 350_P 1.744 1.00
228_E 268_I 1.73 1.00
146_L 302_L 1.723 1.00
39_A 61_E 1.698 1.00
406_L 410_T 1.661 1.00
220_R 263_N 1.657 1.00
337_S 340_A 1.642 1.00
228_E 269_N 1.639 1.00
372_I 377_V 1.628 1.00
139_R 316_L 1.627 1.00
52_L 117_I 1.626 1.00
7_H 31_S 1.609 1.00
22_G 34_T 1.591 1.00
262_S 266_I 1.588 1.00
70_E 73_K 1.582 1.00
171_E 250_R 1.571 1.00
55_S 67_L 1.571 1.00
129_D 133_R 1.57 1.00
311_T 348_S 1.559 1.00
339_D 374_D 1.556 1.00
274_S 297_L 1.554 1.00
251_V 257_V 1.553 1.00
399_E 431_L 1.553 1.00
168_T 304_I 1.549 1.00
426_T 430_K 1.541 1.00
54_I 117_I 1.54 1.00
319_N 341_M 1.528 1.00
208_H 213_F 1.527 1.00
311_T 315_P 1.518 1.00
146_L 304_I 1.51 1.00
340_A 344_L 1.508 1.00
151_R 180_A 1.488 1.00
238_G 276_T 1.486 1.00
320_H 324_Q 1.484 1.00
140_S 312_E 1.483 1.00
163_N 301_S 1.473 1.00
46_N 74_V 1.472 1.00
303_K 309_E 1.467 1.00
318_A 360_I 1.457 1.00
221_E 225_Q 1.453 1.00
280_L 289_F 1.441 1.00
202_E 247_K 1.438 1.00
341_M 345_M 1.438 1.00
45_L 71_I 1.434 1.00
317_L 321_L 1.416 1.00
33_V 44_V 1.415 1.00
406_L 420_M 1.41 1.00
147_L 150_A 1.408 1.00
53_V 71_I 1.402 0.99
224_F 232_L 1.402 0.99
335_A 371_V 1.398 0.99
406_L 421_A 1.397 0.99
55_S 82_I 1.393 0.99
59_M 62_M 1.387 0.99
35_A 44_V 1.384 0.99
208_H 212_A 1.383 0.99
340_A 374_D 1.38 0.99
81_I 116_A 1.375 0.99
42_L 70_E 1.374 0.99
22_G 26_T 1.369 0.99
311_T 314_I 1.365 0.99
35_A 41_G 1.359 0.99
347_A 355_Q 1.351 0.99
158_V 361_E 1.346 0.99
158_V 329_H 1.344 0.99
75_Q 78_M 1.343 0.99
325_A 364_V 1.341 0.99
89_I 93_V 1.341 0.99
37_S 61_E 1.336 0.99
165_Q 306_A 1.326 0.99
70_E 74_V 1.321 0.99
208_H 260_L 1.318 0.99
129_D 132_W 1.315 0.99
257_V 267_D 1.313 0.99
143_M 147_L 1.309 0.99
8_L 30_Y 1.304 0.99
239_D 277_H 1.3 0.99
201_L 244_L 1.3 0.99
138_T 147_L 1.297 0.99
44_V 50_V 1.286 0.99
145_R 148_E 1.285 0.99
340_A 372_I 1.278 0.99
28_E 114_Y 1.251 0.99
328_R 361_E 1.241 0.98
426_T 429_Y 1.238 0.98
403_L 428_F 1.236 0.98
322_L 336_F 1.236 0.98
343_R 374_D 1.234 0.98
427_E 431_L 1.233 0.98
413_N 416_H 1.229 0.98
415_T 419_R 1.228 0.98
272_I 297_L 1.222 0.98
198_E 241_P 1.219 0.98
91_D 103_F 1.219 0.98
404_R 408_Q 1.217 0.98
424_N 427_E 1.217 0.98
71_I 80_V 1.216 0.98
336_F 341_M 1.214 0.98
259_P 262_S 1.213 0.98
53_V 78_M 1.212 0.98
12_D 59_M 1.205 0.98
430_K 434_R 1.204 0.98
136_I 147_L 1.203 0.98
148_E 151_R 1.197 0.98
186_K 229_G 1.188 0.98
213_F 216_A 1.181 0.98
321_L 325_A 1.18 0.98
322_L 364_V 1.179 0.98
373_S 376_L 1.179 0.98
162_I 273_I 1.173 0.98
413_N 425_R 1.169 0.97
54_I 113_L 1.168 0.97
136_I 173_F 1.164 0.97
417_A 420_M 1.163 0.97
10_L 32_V 1.163 0.97
38_G 59_M 1.162 0.97
126_P 130_E 1.161 0.97
424_N 430_K 1.161 0.97
204_E 220_R 1.158 0.97
153_V 300_V 1.157 0.97
362_Q 366_L 1.156 0.97
38_G 67_L 1.149 0.97
225_Q 266_I 1.148 0.97
414_V 429_Y 1.143 0.97
337_S 371_V 1.142 0.97
312_E 345_M 1.139 0.97
161_L 274_S 1.138 0.97
224_F 270_V 1.138 0.97
321_L 360_I 1.128 0.97
396_N 434_R 1.128 0.97
405_K 409_I 1.125 0.97
138_T 173_F 1.124 0.97
415_T 425_R 1.123 0.97
255_R 267_D 1.116 0.96
311_T 345_M 1.115 0.96
150_A 176_A 1.106 0.96
285_A 291_E 1.105 0.96
24_R 110_K 1.101 0.96
138_T 150_A 1.101 0.96
42_L 62_M 1.098 0.96
58_R 86_H 1.094 0.96
65_M 95_A 1.086 0.96
7_H 33_V 1.085 0.96
157_D 183_R 1.083 0.96
315_P 318_A 1.081 0.95
212_A 260_L 1.081 0.95
138_T 143_M 1.079 0.95
33_V 48_E 1.077 0.95
68_F 80_V 1.073 0.95
314_I 344_L 1.069 0.95
238_G 280_L 1.068 0.95
416_H 420_M 1.065 0.95
428_F 431_L 1.061 0.95
11_V 67_L 1.058 0.95
281_P 285_A 1.058 0.95
192_N 239_D 1.056 0.95
259_P 266_I 1.055 0.95
232_L 272_I 1.055 0.95
55_S 80_V 1.052 0.95
138_T 316_L 1.052 0.95
136_I 172_I 1.051 0.94
208_H 220_R 1.041 0.94
38_G 42_L 1.041 0.94
30_Y 118_D 1.038 0.94
176_A 180_A 1.034 0.94
94_A 98_Q 1.034 0.94
203_S 213_F 1.034 0.94
146_L 173_F 1.031 0.94
28_E 118_D 1.028 0.94
141_P 145_R 1.026 0.94
342_K 346_T 1.022 0.93
171_E 190_A 1.022 0.93
150_A 177_I 1.022 0.93
68_F 82_I 1.021 0.93
319_N 323_R 1.021 0.93
403_L 421_A 1.019 0.93
150_A 302_L 1.017 0.93
12_D 18_L 1.016 0.93
367_T 376_L 1.014 0.93
203_S 208_H 1.008 0.93
52_L 121_L 1.007 0.93
201_L 205_L 1.007 0.93
189_I 227_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4l4uA10.9821000.103Contact Map0.735
1ny5A20.85361000.232Contact Map0.79
3dzdA20.82881000.27Contact Map0.782
1ojlA60.68021000.443Contact Map0.771
4fwgA10.88061000.654Contact Map0.381
1r6bX10.87161000.664Contact Map0.342
2bjvA10.59461000.669Contact Map0.675
1qvrA30.86491000.678Contact Map0.306
3pxiA30.84911000.705Contact Map0.367
1hqcA20.62611000.707Contact Map0.465
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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