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OPENSEQ.org
YEGV - Uncharacterized sugar kinase YegV
UniProt: P76419 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14065
Length: 321 (295)
Sequences: 9419
Seq/Len: 31.93
YEGV
Paralog alert: 0.85 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: FRLD K1PF K6PF2 KDGK PSUK RBSK YDJH YEGV YEII YIHV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
68_I 277_A 2.959 1.00
284_P 287_D 2.888 1.00
18_S 144_S 2.799 1.00
245_Y 289_V 2.633 1.00
63_L 68_I 2.517 1.00
147_Y 174_F 2.515 1.00
78_Q 101_A 2.476 1.00
86_R 99_D 2.471 1.00
65_R 92_E 2.345 1.00
20_M 143_G 2.342 1.00
243_A 271_H 2.299 1.00
174_F 276_L 2.296 1.00
310_T 313_E 2.279 1.00
166_E 195_C 2.246 1.00
278_G 283_L 2.222 1.00
18_S 69_E 2.183 1.00
238_L 244_W 2.156 1.00
227_Q 246_F 2.105 1.00
270_S 295_V 2.103 1.00
278_G 291_L 2.037 1.00
83_E 99_D 2.015 1.00
75_P 134_W 2.005 1.00
283_L 287_D 1.99 1.00
203_R 238_L 1.982 1.00
197_P 232_A 1.982 1.00
21_V 60_A 1.953 1.00
302_H 313_E 1.934 1.00
62_A 273_G 1.929 1.00
165_L 173_P 1.915 1.00
286_A 290_L 1.886 1.00
87_N 91_K 1.859 1.00
252_G 286_A 1.841 1.00
281_S 311_R 1.841 1.00
274_G 295_V 1.805 1.00
275_V 288_A 1.776 1.00
61_V 92_E 1.749 1.00
19_V 63_L 1.744 1.00
78_Q 83_E 1.707 1.00
172_T 197_P 1.707 1.00
296_A 300_V 1.655 1.00
90_A 95_I 1.653 1.00
162_V 191_R 1.651 1.00
200_S 272_A 1.646 1.00
235_I 275_V 1.646 1.00
257_F 294_A 1.632 1.00
163_E 166_E 1.622 1.00
75_P 100_N 1.62 1.00
88_R 91_K 1.613 1.00
238_L 253_C 1.598 1.00
243_A 293_N 1.587 1.00
145_L 172_T 1.575 1.00
25_A 74_L 1.572 1.00
52_V 85_I 1.561 1.00
263_D 304_G 1.558 1.00
145_L 276_L 1.552 1.00
218_E 221_T 1.536 1.00
196_R 199_V 1.523 1.00
86_R 90_A 1.52 1.00
275_V 292_G 1.516 1.00
224_K 228_E 1.513 1.00
267_A 300_V 1.503 1.00
63_L 277_A 1.501 1.00
50_V 84_M 1.495 1.00
141_A 169_Q 1.492 1.00
259_T 301_G 1.476 1.00
254_I 289_V 1.456 1.00
223_G 246_F 1.447 1.00
83_E 87_N 1.441 1.00
198_L 233_P 1.429 1.00
225_Q 228_E 1.415 1.00
247_S 250_A 1.414 1.00
156_P 159_E 1.412 1.00
172_T 232_A 1.411 1.00
145_L 174_F 1.407 0.99
274_G 291_L 1.403 0.99
245_Y 252_G 1.403 0.99
257_F 290_L 1.396 0.99
244_W 253_C 1.395 0.99
176_D 237_R 1.388 0.99
162_V 166_E 1.387 0.99
220_T 251_S 1.385 0.99
131_N 134_W 1.381 0.99
238_L 241_E 1.373 0.99
275_V 279_L 1.366 0.99
225_Q 229_K 1.354 0.99
274_G 292_G 1.345 0.99
78_Q 102_E 1.331 0.99
210_A 236_V 1.322 0.99
76_L 82_A 1.319 0.99
29_V 48_Q 1.313 0.99
287_D 290_L 1.303 0.99
177_F 201_L 1.295 0.99
64_K 94_L 1.294 0.99
243_A 289_V 1.282 0.99
25_A 85_I 1.281 0.99
34_Y 46_K 1.278 0.99
233_P 247_S 1.278 0.99
220_T 224_K 1.272 0.99
190_A 229_K 1.264 0.99
203_R 241_E 1.261 0.99
233_P 275_V 1.261 0.99
233_P 285_L 1.25 0.99
245_Y 285_L 1.243 0.98
86_R 98_I 1.233 0.98
66_L 274_G 1.232 0.98
61_V 65_R 1.231 0.98
87_N 90_A 1.23 0.98
63_L 70_A 1.227 0.98
278_G 288_A 1.227 0.98
27_I 84_M 1.226 0.98
103_G 129_Q 1.226 0.98
82_A 105_N 1.219 0.98
298_W 302_H 1.217 0.98
168_L 197_P 1.214 0.98
63_L 273_G 1.214 0.98
261_V 300_V 1.212 0.98
172_T 198_L 1.198 0.98
88_R 92_E 1.197 0.98
68_I 280_A 1.194 0.98
22_V 146_L 1.189 0.98
254_I 293_N 1.187 0.98
223_G 236_V 1.179 0.98
221_T 224_K 1.178 0.98
293_N 296_A 1.178 0.98
78_Q 99_D 1.169 0.97
277_A 281_S 1.153 0.97
20_M 73_A 1.151 0.97
57_L 89_M 1.15 0.97
227_Q 248_N 1.148 0.97
80_V 83_E 1.147 0.97
259_T 300_V 1.147 0.97
275_V 285_L 1.141 0.97
132_R 163_E 1.132 0.97
52_V 88_R 1.124 0.97
175_I 196_R 1.12 0.96
238_L 242_G 1.119 0.96
140_V 171_V 1.115 0.96
136_A 163_E 1.113 0.96
76_L 86_R 1.11 0.96
298_W 301_G 1.105 0.96
296_A 299_V 1.105 0.96
148_F 173_P 1.097 0.96
200_S 237_R 1.096 0.96
193_M 196_R 1.095 0.96
146_L 171_V 1.092 0.96
18_S 71_G 1.083 0.96
290_L 294_A 1.071 0.95
198_L 275_V 1.062 0.95
79_G 105_N 1.061 0.95
60_A 70_A 1.059 0.95
76_L 98_I 1.056 0.95
62_A 270_S 1.054 0.95
147_Y 276_L 1.05 0.94
237_R 271_H 1.046 0.94
200_S 275_V 1.043 0.94
163_E 167_E 1.042 0.94
25_A 72_N 1.04 0.94
233_P 279_L 1.039 0.94
257_F 293_N 1.033 0.94
288_A 292_G 1.027 0.94
147_Y 272_A 1.026 0.94
83_E 86_R 1.024 0.93
84_M 87_N 1.024 0.93
279_L 288_A 1.015 0.93
140_V 143_G 1.012 0.93
100_N 103_G 1.008 0.93
26_V 106_G 1.005 0.93
257_F 297_S 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rbcA10.95331000.218Contact Map0.768
3ljsA20.92831000.231Contact Map0.74
3hj6A20.96571000.239Contact Map0.512
3pl2A40.94391000.245Contact Map0.851
4du5A40.96261000.246Contact Map0.808
2fv7A20.95641000.248Contact Map0.821
3iq0A20.93461000.249Contact Map0.845
3ry7A10.90341000.249Contact Map0.763
1rkdA10.92211000.25Contact Map0.829
1vm7A20.9471000.252Contact Map0.851
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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