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OPENSEQ.org
YIHV - Uncharacterized sugar kinase YihV
UniProt: P32143 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11848
Length: 298 (294)
Sequences: 9776
Seq/Len: 33.25
YIHV
Paralog alert: 0.85 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: FRLD K1PF K6PF2 KDGK PSUK RBSK YDJH YEGV YEII YIHV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_A 252_V 2.891 1.00
259_D 262_E 2.784 1.00
3_R 131_D 2.592 1.00
220_W 264_V 2.566 1.00
71_L 86_R 2.559 1.00
48_A 53_A 2.498 1.00
68_N 86_R 2.448 1.00
63_D 88_N 2.416 1.00
158_V 251_A 2.291 1.00
56_D 80_N 2.268 1.00
218_C 246_F 2.261 1.00
253_A 258_G 2.241 1.00
148_T 174_L 2.224 1.00
3_R 54_Q 2.213 1.00
5_A 130_W 2.213 1.00
50_R 77_W 2.211 1.00
286_D 289_Q 2.145 1.00
213_Q 219_D 2.131 1.00
6_C 45_A 2.058 1.00
147_F 157_T 2.045 1.00
245_V 270_V 1.982 1.00
253_A 266_F 1.971 1.00
258_G 262_E 1.948 1.00
60_R 121_W 1.901 1.00
182_E 213_Q 1.888 1.00
202_Q 221_L 1.872 1.00
134_L 158_V 1.871 1.00
287_C 291_R 1.867 1.00
176_D 207_G 1.837 1.00
47_A 248_G 1.826 1.00
277_R 289_Q 1.821 1.00
261_A 265_R 1.809 1.00
72_A 76_S 1.804 1.00
145_K 148_T 1.78 1.00
249_A 270_V 1.776 1.00
4_V 48_A 1.762 1.00
250_L 263_S 1.721 1.00
227_Q 261_A 1.72 1.00
156_M 176_D 1.707 1.00
63_D 68_N 1.707 1.00
256_T 287_C 1.663 1.00
46_V 77_W 1.66 1.00
75_E 81_T 1.654 1.00
150_A 155_V 1.652 1.00
218_C 268_S 1.615 1.00
179_A 247_H 1.596 1.00
271_A 275_C 1.595 1.00
238_D 279_G 1.593 1.00
193_E 196_S 1.587 1.00
213_Q 228_H 1.584 1.00
73_E 76_S 1.575 1.00
144_K 170_E 1.56 1.00
145_K 149_L 1.557 1.00
71_L 75_E 1.536 1.00
175_S 178_A 1.532 1.00
149_L 153_A 1.532 1.00
68_N 72_A 1.527 1.00
48_A 252_V 1.522 1.00
242_A 275_C 1.52 1.00
210_Y 250_L 1.505 1.00
10_T 59_G 1.498 1.00
37_G 70_L 1.497 1.00
151_R 176_D 1.489 1.00
128_S 153_A 1.484 1.00
250_L 267_A 1.481 1.00
60_R 87_Y 1.456 1.00
200_Q 203_T 1.454 1.00
232_F 269_G 1.448 1.00
132_V 251_A 1.448 1.00
186_A 192_K 1.418 1.00
234_V 276_T 1.411 1.00
229_Q 264_V 1.408 1.00
71_L 84_T 1.401 0.99
35_E 69_S 1.395 0.99
177_H 208_H 1.393 0.99
160_D 212_T 1.383 0.99
198_L 221_L 1.374 0.99
132_V 158_V 1.373 0.99
148_T 152_Q 1.371 0.99
249_A 266_F 1.37 0.99
132_V 156_M 1.363 0.99
250_L 254_L 1.359 0.99
249_A 267_A 1.358 0.99
144_K 148_T 1.358 0.99
222_E 225_G 1.352 0.99
149_L 152_Q 1.352 0.99
161_G 180_F 1.34 0.99
232_F 265_R 1.34 0.99
199_K 203_T 1.337 0.99
218_C 264_V 1.336 0.99
185_L 211_V 1.331 0.99
49_A 79_V 1.326 0.99
14_R 33_Y 1.318 0.99
63_D 86_R 1.314 0.99
220_W 227_Q 1.313 0.99
195_A 199_K 1.305 0.99
213_Q 216_A 1.297 0.99
219_D 228_H 1.287 0.99
156_M 207_G 1.274 0.99
63_D 89_Q 1.254 0.99
262_E 265_R 1.253 0.99
195_A 226_R 1.253 0.99
118_D 121_W 1.244 0.98
10_T 70_L 1.243 0.98
19_E 31_R 1.243 0.98
208_H 250_L 1.236 0.98
46_V 50_R 1.233 0.98
208_H 260_L 1.231 0.98
61_V 67_G 1.229 0.98
208_H 222_E 1.224 0.98
48_A 248_G 1.221 0.98
151_R 174_L 1.197 0.98
42_A 74_L 1.196 0.98
12_M 69_S 1.19 0.98
220_W 260_L 1.186 0.98
268_S 271_A 1.18 0.98
51_L 249_A 1.179 0.98
156_M 177_H 1.177 0.98
182_E 216_A 1.177 0.98
236_V 275_C 1.174 0.98
179_A 212_T 1.174 0.98
253_A 263_S 1.165 0.97
159_L 175_S 1.164 0.97
72_A 75_E 1.159 0.97
202_Q 223_N 1.152 0.97
273_L 277_R 1.14 0.97
213_Q 217_G 1.131 0.97
73_E 77_W 1.129 0.97
48_A 55_V 1.123 0.97
37_G 73_E 1.123 0.97
234_V 275_C 1.12 0.96
45_A 55_V 1.119 0.96
67_G 92_S 1.118 0.96
289_Q 292_S 1.116 0.96
65_D 68_N 1.108 0.96
133_V 150_A 1.108 0.96
252_V 256_T 1.102 0.96
229_Q 268_S 1.101 0.96
5_A 58_I 1.098 0.96
196_S 199_K 1.094 0.96
250_L 260_L 1.091 0.96
212_T 246_F 1.084 0.96
53_A 255_A 1.084 0.96
61_V 84_T 1.078 0.95
3_R 56_D 1.076 0.95
172_V 175_S 1.074 0.95
288_D 292_S 1.062 0.95
54_Q 80_N 1.061 0.95
181_S 184_G 1.061 0.95
271_A 274_K 1.059 0.95
198_L 211_V 1.054 0.95
179_A 250_L 1.054 0.95
177_H 250_L 1.048 0.94
64_D 92_S 1.043 0.94
61_V 71_L 1.041 0.94
208_H 254_L 1.037 0.94
127_F 130_W 1.034 0.94
273_L 276_T 1.031 0.94
191_V 196_S 1.03 0.94
47_A 245_V 1.029 0.94
68_N 71_L 1.026 0.94
231_A 268_S 1.023 0.93
10_T 57_F 1.017 0.93
200_Q 204_L 1.011 0.93
169_S 204_L 1.009 0.93
14_R 35_E 1.006 0.93
7_V 133_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rbcA111000.09Contact Map0.779
3ry7A10.98321000.123Contact Map0.773
2fv7A20.98991000.127Contact Map0.825
1vm7A20.97651000.135Contact Map0.837
1rkdA111000.138Contact Map0.832
3ikhA40.9531000.143Contact Map0.653
3ljsA20.98321000.149Contact Map0.741
4du5A40.97321000.154Contact Map0.813
2c4eA10.97651000.155Contact Map0.736
2v78A30.96981000.156Contact Map0.851
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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