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OPENSEQ.org
RBSK - Ribokinase
UniProt: P0A9J6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10818
Length: 309 (302)
Sequences: 9701
Seq/Len: 32.12
RBSK
Paralog alert: 0.85 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: FRLD K1PF K6PF2 KDGK PSUK RBSK YDJH YEGV YEII YIHV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
270_P 273_E 2.876 1.00
56_A 263_T 2.874 1.00
6_S 136_S 2.751 1.00
231_A 275_I 2.576 1.00
51_A 56_A 2.541 1.00
74_R 89_V 2.498 1.00
71_E 89_V 2.487 1.00
66_D 91_K 2.465 1.00
8_V 135_A 2.447 1.00
229_V 257_F 2.308 1.00
164_A 262_I 2.298 1.00
53_R 80_D 2.241 1.00
59_A 83_D 2.233 1.00
264_A 269_K 2.194 1.00
6_S 57_N 2.189 1.00
154_K 180_L 2.124 1.00
297_W 300_E 2.123 1.00
224_L 230_W 2.082 1.00
153_A 163_V 2.055 1.00
213_H 232_S 2.044 1.00
256_T 281_A 2.013 1.00
9_V 48_A 1.979 1.00
264_A 277_F 1.97 1.00
269_K 273_E 1.947 1.00
182_D 218_R 1.934 1.00
63_C 124_L 1.908 1.00
298_R 302_D 1.863 1.00
75_Q 79_T 1.863 1.00
50_A 259_G 1.849 1.00
272_P 276_R 1.846 1.00
188_E 224_L 1.844 1.00
288_R 300_E 1.842 1.00
151_A 154_K 1.828 1.00
63_C 90_I 1.767 1.00
260_A 281_A 1.763 1.00
7_L 51_A 1.754 1.00
162_I 182_D 1.743 1.00
261_L 274_A 1.728 1.00
238_Q 272_P 1.714 1.00
267_E 298_R 1.699 1.00
156_A 161_T 1.695 1.00
66_D 71_E 1.685 1.00
249_D 290_G 1.634 1.00
49_V 80_D 1.619 1.00
139_L 164_A 1.618 1.00
282_A 286_V 1.614 1.00
229_V 279_H 1.603 1.00
78_A 84_I 1.586 1.00
224_L 239_R 1.581 1.00
76_Q 79_T 1.562 1.00
185_T 258_N 1.561 1.00
201_N 204_D 1.549 1.00
155_I 159_N 1.548 1.00
51_A 263_T 1.542 1.00
211_V 214_E 1.534 1.00
221_L 261_L 1.523 1.00
40_F 73_V 1.522 1.00
13_I 62_A 1.519 1.00
261_L 278_A 1.51 1.00
133_A 159_N 1.504 1.00
157_H 182_D 1.5 1.00
71_E 75_Q 1.495 1.00
253_A 286_V 1.488 1.00
151_A 155_I 1.485 1.00
74_R 78_A 1.484 1.00
150_M 176_E 1.477 1.00
181_V 184_I 1.468 1.00
245_V 287_T 1.462 1.00
137_A 262_I 1.446 1.00
162_I 218_R 1.432 1.00
243_F 280_A 1.41 1.00
150_M 154_K 1.408 1.00
183_I 219_T 1.406 0.99
233_V 236_E 1.395 0.99
209_A 232_S 1.394 0.99
38_V 72_S 1.389 0.99
166_N 223_T 1.388 0.99
154_K 158_Q 1.388 0.99
74_R 87_V 1.378 0.99
210_Q 214_E 1.377 0.99
206_A 237_G 1.376 0.99
121_S 124_L 1.365 0.99
191_A 222_I 1.361 0.99
155_I 158_Q 1.356 0.99
231_A 238_Q 1.356 0.99
243_F 276_R 1.353 0.99
260_A 277_F 1.349 0.99
167_P 186_P 1.348 0.99
261_L 265_L 1.348 0.99
204_D 207_K 1.343 0.99
260_A 278_A 1.343 0.99
137_A 162_I 1.343 0.99
240_V 275_I 1.338 0.99
66_D 92_G 1.326 0.99
229_V 275_I 1.319 0.99
52_G 82_I 1.309 0.99
206_A 210_Q 1.302 0.99
219_T 233_V 1.299 0.99
17_H 36_Y 1.295 0.99
66_D 89_V 1.286 0.99
224_L 227_R 1.274 0.99
230_W 239_R 1.264 0.99
219_T 261_L 1.239 0.98
64_T 70_G 1.238 0.98
273_E 276_R 1.237 0.98
22_Q 34_N 1.23 0.98
49_V 53_R 1.228 0.98
219_T 271_L 1.226 0.98
279_H 282_A 1.224 0.98
54_S 260_A 1.222 0.98
137_A 164_A 1.219 0.98
13_I 73_V 1.216 0.98
162_I 183_I 1.209 0.98
51_A 259_G 1.206 0.98
188_E 227_R 1.203 0.98
165_L 181_V 1.201 0.98
213_H 234_N 1.192 0.98
10_L 138_L 1.191 0.98
15_A 72_S 1.189 0.98
45_A 77_L 1.186 0.98
247_A 286_V 1.185 0.98
231_A 271_L 1.184 0.98
264_A 274_A 1.18 0.98
51_A 58_I 1.173 0.98
284_I 288_R 1.173 0.98
185_T 223_T 1.167 0.97
75_Q 78_A 1.157 0.97
157_H 180_L 1.155 0.97
76_Q 80_D 1.154 0.97
207_K 210_Q 1.153 0.97
300_E 303_A 1.146 0.97
209_A 222_I 1.137 0.97
192_E 198_R 1.135 0.97
93_E 119_A 1.131 0.97
8_V 61_I 1.13 0.97
6_S 59_A 1.124 0.97
245_V 286_V 1.121 0.97
40_F 76_Q 1.119 0.96
224_L 228_G 1.118 0.96
138_L 156_A 1.117 0.96
56_A 266_L 1.109 0.96
70_G 95_T 1.107 0.96
48_A 58_I 1.105 0.96
282_A 285_A 1.103 0.96
223_T 257_F 1.099 0.96
68_S 71_E 1.091 0.96
261_L 271_L 1.087 0.96
263_T 267_E 1.081 0.95
57_N 83_D 1.08 0.95
50_A 256_T 1.074 0.95
140_M 163_V 1.07 0.95
211_V 215_K 1.066 0.95
240_V 279_H 1.065 0.95
143_E 147_E 1.058 0.95
299_E 303_A 1.054 0.95
185_T 261_L 1.051 0.94
67_D 95_T 1.049 0.94
284_I 287_T 1.047 0.94
64_T 74_R 1.037 0.94
64_T 87_V 1.036 0.94
183_I 261_L 1.035 0.94
219_T 265_L 1.017 0.93
72_S 75_Q 1.013 0.93
16_D 41_G 1.012 0.93
187_N 190_E 1.01 0.93
178_L 181_V 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1rkdA111000.116Contact Map0.831
2rbcA10.97411000.132Contact Map0.778
3ry7A10.97731000.137Contact Map0.766
2fv7A20.99031000.139Contact Map0.818
1vm7A20.97091000.164Contact Map0.834
3ikhA40.9321000.165Contact Map0.648
3vasA20.98381000.177Contact Map0.747
3kzhA20.99031000.178Contact Map0.723
3ljsA20.95791000.179Contact Map0.747
4du5A40.95151000.186Contact Map0.809
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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