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OPENSEQ.org
FRLD - Fructoselysine kinase
UniProt: P45543 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12912
Length: 261 (260)
Sequences: 9639
Seq/Len: 37.07
FRLD
Paralog alert: 0.85 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: FRLD K1PF K6PF2 KDGK PSUK RBSK YDJH YEGV YEII YIHV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_I 232_C 2.998 1.00
239_T 242_Q 2.674 1.00
200_A 244_I 2.585 1.00
119_H 141_A 2.53 1.00
34_C 39_I 2.425 1.00
54_T 72_T 2.361 1.00
57_K 72_T 2.328 1.00
42_G 66_D 2.314 1.00
198_S 226_F 2.289 1.00
36_R 63_M 2.288 1.00
141_A 231_L 2.253 1.00
233_G 238_M 2.231 1.00
5_A 115_Y 2.208 1.00
131_P 159_H 2.197 1.00
3_T 116_D 2.193 1.00
49_D 74_H 2.147 1.00
193_L 199_I 2.112 1.00
182_V 201_W 2.038 1.00
225_S 250_C 2.024 1.00
233_G 246_Q 1.993 1.00
167_A 193_L 1.95 1.00
130_F 140_T 1.941 1.00
238_M 242_Q 1.939 1.00
33_Y 228_A 1.927 1.00
3_T 40_Q 1.92 1.00
161_D 187_G 1.865 1.00
58_Q 62_R 1.848 1.00
241_P 245_A 1.827 1.00
207_W 241_P 1.815 1.00
230_F 243_A 1.751 1.00
212_E 249_A 1.742 1.00
229_G 250_C 1.734 1.00
32_V 63_M 1.711 1.00
139_L 161_D 1.709 1.00
128_D 131_P 1.675 1.00
218_D 259_G 1.666 1.00
133_L 138_K 1.665 1.00
193_L 208_R 1.662 1.00
164_F 227_I 1.661 1.00
61_A 67_I 1.646 1.00
251_A 255_I 1.625 1.00
6_T 31_A 1.624 1.00
49_D 54_T 1.623 1.00
46_W 73_K 1.611 1.00
59_D 62_R 1.574 1.00
34_C 232_C 1.558 1.00
198_S 248_T 1.555 1.00
10_N 45_T 1.548 1.00
4_L 34_C 1.542 1.00
57_K 61_A 1.533 1.00
190_I 230_F 1.529 1.00
132_Q 136_A 1.529 1.00
117_I 231_L 1.487 1.00
160_L 163_A 1.475 1.00
113_A 136_A 1.474 1.00
222_A 255_I 1.473 1.00
132_Q 135_A 1.467 1.00
173_T 176_L 1.465 1.00
54_T 58_Q 1.459 1.00
23_S 56_L 1.456 1.00
230_F 247_G 1.443 1.00
162_F 188_T 1.443 1.00
134_H 161_D 1.433 1.00
117_I 139_L 1.431 1.00
128_D 132_Q 1.423 1.00
209_Q 244_I 1.421 1.00
180_A 183_A 1.42 1.00
214_V 256_Q 1.404 0.99
229_G 246_Q 1.388 0.99
143_D 192_T 1.382 0.99
212_E 245_A 1.378 0.99
131_P 135_A 1.367 0.99
199_I 208_R 1.364 0.99
178_M 201_W 1.363 0.99
198_S 244_I 1.357 0.99
57_K 70_V 1.348 0.99
117_I 141_A 1.344 0.99
21_A 55_K 1.34 0.99
229_G 247_G 1.34 0.99
193_L 196_N 1.339 0.99
175_R 206_F 1.334 0.99
200_A 207_W 1.327 0.99
188_T 240_L 1.305 0.99
202_D 205_Q 1.305 0.99
139_L 187_G 1.303 0.99
144_F 165_A 1.301 0.99
188_T 202_D 1.297 0.99
35_T 65_V 1.289 0.99
230_F 234_W 1.286 0.99
179_K 183_A 1.28 0.99
34_C 228_A 1.267 0.99
253_K 257_Y 1.26 0.99
28_V 60_L 1.256 0.99
10_N 56_L 1.252 0.99
175_R 179_K 1.24 0.98
216_V 255_I 1.24 0.98
200_A 240_L 1.235 0.98
134_H 159_H 1.232 0.98
32_V 36_R 1.219 0.98
188_T 230_F 1.211 0.98
242_Q 245_A 1.203 0.98
232_C 236_A 1.198 0.98
59_D 63_M 1.192 0.98
118_V 133_L 1.183 0.98
47_V 53_G 1.182 0.98
248_T 251_A 1.178 0.98
37_Y 229_G 1.17 0.97
193_L 197_G 1.168 0.97
166_S 169_Q 1.166 0.97
7_I 118_V 1.165 0.97
233_G 243_A 1.165 0.97
167_A 196_N 1.16 0.97
142_F 160_L 1.141 0.97
164_F 192_T 1.14 0.97
49_D 72_T 1.136 0.97
253_K 256_Q 1.13 0.97
31_A 41_P 1.13 0.97
58_Q 61_A 1.129 0.97
23_S 59_D 1.125 0.97
139_L 162_F 1.12 0.96
40_Q 66_D 1.116 0.96
154_Q 184_R 1.114 0.96
39_I 235_S 1.114 0.96
182_V 203_G 1.107 0.96
209_Q 248_T 1.104 0.96
178_M 191_V 1.104 0.96
47_V 70_V 1.1 0.96
176_L 179_K 1.097 0.96
34_C 41_P 1.087 0.96
180_A 184_R 1.087 0.96
230_F 240_L 1.084 0.96
245_A 249_A 1.083 0.96
10_N 43_C 1.08 0.95
5_A 44_I 1.079 0.95
55_K 58_Q 1.079 0.95
192_T 226_F 1.076 0.95
214_V 255_I 1.074 0.95
164_F 230_F 1.065 0.95
33_Y 225_S 1.056 0.95
157_V 160_L 1.054 0.95
3_T 42_G 1.049 0.94
243_A 247_G 1.031 0.94
120_A 140_T 1.024 0.93
37_Y 250_C 1.021 0.93
50_D 77_T 1.02 0.93
188_T 234_W 1.017 0.93
234_W 243_A 1.011 0.93
47_V 57_K 1.009 0.93
127_E 131_P 1.008 0.93
239_T 243_A 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rbcA10.99231000.138Contact Map0.779
3hj6A20.99621000.159Contact Map0.522
3ljsA211000.165Contact Map0.73
3iq0A211000.165Contact Map0.84
4du5A411000.166Contact Map0.803
2fv7A20.99231000.166Contact Map0.839
1tyyA20.99231000.171Contact Map0.788
4e69A20.99621000.171Contact Map0.714
4k8kA20.99231000.173Contact Map0.807
2v78A30.98471000.173Contact Map0.843
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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