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OPENSEQ.org
YCJQ - Uncharacterized zinc-type alcohol dehydrogenase-like protein YcjQ
UniProt: P76043 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13914
Length: 350 (332)
Sequences: 22202
Seq/Len: 66.87
YCJQ
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
327_N 330_E 3.528 1.00
32_R 134_W 3.334 1.00
30_R 90_I 3.202 1.00
32_R 88_D 3.012 1.00
27_V 125_L 3.003 1.00
7_T 15_V 2.914 1.00
28_K 90_I 2.891 1.00
178_K 204_D 2.84 1.00
133_S 136_N 2.81 1.00
103_D 127_K 2.75 1.00
323_V 334_Q 2.597 1.00
196_D 200_R 2.582 1.00
195_C 199_R 2.571 1.00
217_E 220_T 2.563 1.00
100_A 103_D 2.527 1.00
135_K 322_V 2.504 1.00
25_N 95_D 2.5 1.00
24_A 94_S 2.475 1.00
30_R 88_D 2.459 1.00
104_S 128_M 2.397 1.00
30_R 114_T 2.385 1.00
324_T 327_N 2.345 1.00
306_E 310_N 2.313 1.00
24_A 95_D 2.27 1.00
5_V 15_V 2.257 1.00
161_V 177_A 2.25 1.00
160_F 183_S 2.231 1.00
7_T 13_A 2.204 1.00
156_R 159_D 2.176 1.00
19_D 114_T 2.167 1.00
192_A 196_D 2.165 1.00
131_G 309_M 2.164 1.00
162_V 227_A 2.15 1.00
21_A 91_E 2.12 1.00
98_D 119_A 2.112 1.00
104_S 134_W 2.098 1.00
321_P 334_Q 2.073 1.00
247_L 253_I 2.037 1.00
174_I 203_A 2.03 1.00
159_D 252_T 2.028 1.00
330_E 333_M 2.004 1.00
23_L 26_E 2.003 1.00
85_V 110_P 2.001 1.00
196_D 199_R 1.992 1.00
323_V 331_S 1.969 1.00
86_V 134_W 1.95 1.00
192_A 208_N 1.939 1.00
28_K 116_I 1.934 1.00
162_V 188_V 1.884 1.00
90_I 114_T 1.856 1.00
195_C 206_C 1.816 1.00
333_M 337_D 1.806 1.00
252_T 278_K 1.785 1.00
143_A 172_I 1.774 1.00
128_M 137_A 1.759 1.00
91_E 101_V 1.751 1.00
2_K 16_E 1.749 1.00
228_D 248_A 1.739 1.00
212_T 217_E 1.737 1.00
104_S 130_Q 1.736 1.00
99_Y 127_K 1.726 1.00
92_C 101_V 1.718 1.00
153_A 229_V 1.717 1.00
330_E 334_Q 1.702 1.00
252_T 280_V 1.698 1.00
4_L 328_S 1.689 1.00
93_G 96_V 1.683 1.00
189_D 195_C 1.68 1.00
213_D 216_K 1.68 1.00
208_N 211_G 1.675 1.00
186_I 227_A 1.662 1.00
179_R 312_Y 1.659 1.00
22_I 116_I 1.651 1.00
322_V 349_T 1.644 1.00
197_I 200_R 1.634 1.00
128_M 134_W 1.618 1.00
26_E 118_N 1.603 1.00
85_V 107_G 1.603 1.00
247_L 251_G 1.595 1.00
46_R 336_V 1.594 1.00
89_I 99_Y 1.591 1.00
247_L 277_A 1.583 1.00
205_F 221_L 1.576 1.00
164_V 243_A 1.57 1.00
183_S 205_F 1.554 1.00
88_D 104_S 1.545 1.00
192_A 211_G 1.539 1.00
230_I 243_A 1.539 1.00
31_V 85_V 1.51 1.00
174_I 187_G 1.507 1.00
26_E 116_I 1.497 1.00
28_K 91_E 1.483 1.00
2_K 326_A 1.479 1.00
28_K 114_T 1.468 1.00
27_V 99_Y 1.458 1.00
2_K 113_E 1.454 1.00
99_Y 103_D 1.45 1.00
25_N 118_N 1.45 1.00
166_L 187_G 1.448 1.00
33_F 135_K 1.442 1.00
22_I 28_K 1.401 0.99
111_L 332_Y 1.4 0.99
306_E 309_M 1.4 0.99
22_I 26_E 1.389 0.99
88_D 134_W 1.382 0.99
230_I 247_L 1.377 0.99
160_F 184_V 1.376 0.99
3_K 17_Y 1.366 0.99
329_P 333_M 1.365 0.99
184_V 205_F 1.36 0.99
160_F 186_I 1.354 0.99
29_I 87_G 1.344 0.99
4_L 14_L 1.343 0.99
173_A 231_I 1.336 0.99
99_Y 125_L 1.321 0.99
216_K 220_T 1.296 0.99
32_R 104_S 1.279 0.99
155_V 182_A 1.258 0.99
187_G 203_A 1.256 0.99
136_N 316_E 1.254 0.99
190_P 209_P 1.254 0.99
33_F 134_W 1.236 0.98
33_F 349_T 1.227 0.98
140_Y 308_L 1.226 0.98
135_K 349_T 1.22 0.98
192_A 195_C 1.218 0.98
151_R 303_T 1.207 0.98
320_D 334_Q 1.201 0.98
199_R 206_C 1.198 0.98
307_L 312_Y 1.195 0.98
164_V 188_V 1.181 0.98
179_R 307_L 1.173 0.98
117_I 125_L 1.171 0.98
200_R 317_D 1.17 0.97
183_S 204_D 1.167 0.97
160_F 228_D 1.166 0.97
217_E 221_L 1.166 0.97
136_N 314_N 1.164 0.97
19_D 28_K 1.133 0.97
163_V 173_A 1.129 0.97
8_A 11_V 1.123 0.97
314_N 317_D 1.119 0.96
153_A 254_S 1.118 0.96
132_S 137_A 1.113 0.96
25_N 119_A 1.106 0.96
14_L 326_A 1.098 0.96
45_F 332_Y 1.089 0.96
190_P 210_I 1.075 0.95
92_C 96_V 1.074 0.95
32_R 86_V 1.073 0.95
31_V 115_V 1.071 0.95
29_I 105_V 1.062 0.95
337_D 341_E 1.061 0.95
195_C 208_N 1.06 0.95
199_R 205_F 1.059 0.95
35_A 84_M 1.055 0.95
159_D 228_D 1.049 0.94
232_E 235_G 1.048 0.94
90_I 101_V 1.044 0.94
175_Q 314_N 1.039 0.94
193_H 196_D 1.037 0.94
146_A 176_L 1.026 0.94
4_L 325_F 1.017 0.93
30_R 113_E 1.01 0.93
190_P 195_C 1.009 0.93
303_T 306_E 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1cdoA20.88291000.154Contact Map0.788
1e3iA20.87711000.155Contact Map0.803
3ukoA20.88291000.156Contact Map0.734
1f8fA10.881000.156Contact Map0.815
4ej6A10.87141000.156Contact Map0.778
4a2cA20.89141000.157Contact Map0.749
3uogA20.87141000.162Contact Map0.825
1p0fA20.87431000.163Contact Map0.779
2jhfA20.881000.163Contact Map0.77
3fpcA40.88861000.164Contact Map0.832
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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