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YBDR - Uncharacterized zinc-type alcohol dehydrogenase-like protein YbdR
UniProt: P77316 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13537
Length: 412 (361)
Sequences: 11940
Seq/Len: 33.07
YBDR
Paralog alert: 0.79 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
366_E 369_R 4.026 1.00
31_R 67_V 3.223 1.00
33_T 65_E 3.206 1.00
26_D 72_D 2.949 1.00
33_T 162_D 2.944 1.00
80_D 155_K 2.908 1.00
224_L 229_D 2.902 1.00
247_S 250_E 2.877 1.00
191_A 258_V 2.859 1.00
25_A 71_K 2.763 1.00
363_P 366_E 2.746 1.00
298_V 304_V 2.702 1.00
7_H 15_E 2.7 1.00
207_R 234_I 2.656 1.00
163_D 361_Y 2.637 1.00
225_H 230_R 2.596 1.00
189_S 213_Q 2.528 1.00
221_P 225_H 2.495 1.00
25_A 72_D 2.483 1.00
362_M 373_I 2.46 1.00
372_E 376_K 2.448 1.00
29_I 67_V 2.444 1.00
161_S 164_K 2.389 1.00
7_H 13_Q 2.366 1.00
62_F 139_G 2.353 1.00
345_P 349_K 2.299 1.00
21_G 68_E 2.27 1.00
303_I 328_S 2.268 1.00
195_A 216_V 2.264 1.00
221_P 237_N 2.255 1.00
31_R 143_Y 2.237 1.00
31_R 65_E 2.234 1.00
185_Q 188_S 2.215 1.00
362_M 370_G 2.18 1.00
81_R 162_D 2.151 1.00
75_N 148_K 2.137 1.00
159_L 348_E 2.134 1.00
46_R 375_E 2.129 1.00
191_A 217_V 2.109 1.00
225_H 229_D 2.101 1.00
156_V 165_A 2.065 1.00
5_T 15_E 1.943 1.00
203_I 233_A 1.939 1.00
361_Y 387_V 1.913 1.00
77_Q 80_D 1.909 1.00
369_R 372_E 1.909 1.00
93_C 96_C 1.898 1.00
190_V 206_A 1.896 1.00
81_R 158_P 1.849 1.00
360_H 373_I 1.844 1.00
243_D 246_Q 1.836 1.00
76_L 155_K 1.832 1.00
69_T 78_K 1.832 1.00
2_K 16_N 1.812 1.00
68_E 78_K 1.807 1.00
303_I 330_K 1.797 1.00
230_R 356_E 1.791 1.00
67_V 143_Y 1.777 1.00
180_K 342_E 1.766 1.00
90_C 93_C 1.758 1.00
353_K 356_E 1.756 1.00
226_F 230_R 1.748 1.00
298_V 327_L 1.731 1.00
28_I 151_V 1.708 1.00
164_K 355_E 1.704 1.00
66_V 76_L 1.704 1.00
28_I 153_P 1.703 1.00
4_L 367_A 1.702 1.00
70_G 73_V 1.696 1.00
29_I 145_R 1.684 1.00
345_P 348_E 1.682 1.00
261_V 298_V 1.676 1.00
90_C 96_C 1.628 1.00
369_R 373_I 1.626 1.00
218_D 224_L 1.605 1.00
259_D 299_R 1.587 1.00
96_C 104_C 1.586 1.00
224_L 235_P 1.576 1.00
93_C 104_C 1.568 1.00
2_K 142_E 1.566 1.00
2_K 365_E 1.563 1.00
298_V 302_G 1.559 1.00
261_V 294_C 1.554 1.00
373_I 378_E 1.545 1.00
32_I 62_F 1.544 1.00
65_E 162_D 1.521 1.00
63_M 162_D 1.52 1.00
203_I 216_V 1.507 1.00
27_D 145_R 1.496 1.00
215_F 258_V 1.493 1.00
188_S 303_I 1.482 1.00
221_P 240_E 1.48 1.00
29_I 68_E 1.478 1.00
246_Q 250_E 1.474 1.00
29_I 143_Y 1.469 1.00
221_P 224_L 1.45 1.00
34_A 387_V 1.45 1.00
219_H 238_F 1.439 1.00
28_I 76_L 1.428 1.00
19_D 143_Y 1.42 1.00
26_D 147_P 1.416 1.00
37_I 370_G 1.415 1.00
191_A 297_A 1.41 1.00
24_Q 27_D 1.407 0.99
92_D 97_R 1.404 0.99
34_A 163_D 1.398 0.99
242_S 247_S 1.39 0.99
65_E 81_R 1.387 0.99
213_Q 234_I 1.377 0.99
17_V 57_I 1.377 0.99
81_R 156_V 1.359 0.99
8_G 11_H 1.358 0.99
62_F 84_I 1.351 0.99
19_D 29_I 1.35 0.99
90_C 104_C 1.346 0.99
368_A 372_E 1.346 0.99
94_F 299_R 1.341 0.99
237_N 240_E 1.336 0.99
202_T 262_I 1.324 0.99
184_I 188_S 1.322 0.99
30_L 64_G 1.292 0.99
322_A 329_F 1.289 0.99
30_L 82_V 1.287 0.99
216_V 233_A 1.284 0.99
178_A 307_P 1.281 0.99
265_V 290_A 1.28 0.99
219_H 224_L 1.28 0.99
160_L 165_A 1.279 0.99
267_F 289_K 1.278 0.99
105_E 300_R 1.275 0.99
7_H 11_H 1.262 0.99
364_F 388_P 1.257 0.99
27_D 147_P 1.254 0.99
3_A 17_V 1.254 0.99
100_Q 301_G 1.228 0.98
247_S 251_Q 1.227 0.98
189_S 215_F 1.226 0.98
184_I 211_A 1.225 0.98
76_L 80_D 1.22 0.98
163_D 387_V 1.22 0.98
296_A 321_D 1.208 0.98
26_D 148_K 1.208 0.98
35_T 139_G 1.205 0.98
195_A 218_D 1.196 0.98
229_D 235_P 1.196 0.98
34_A 162_D 1.191 0.98
164_K 353_K 1.189 0.98
22_V 145_R 1.189 0.98
31_R 142_E 1.189 0.98
33_T 81_R 1.159 0.97
294_C 304_V 1.147 0.97
22_V 27_D 1.138 0.97
292_R 296_A 1.136 0.97
189_S 212_E 1.132 0.97
258_V 261_V 1.129 0.97
38_C 60_H 1.12 0.96
219_H 239_D 1.105 0.96
372_E 375_E 1.105 0.96
33_T 63_M 1.103 0.96
362_M 386_L 1.103 0.96
182_A 305_S 1.093 0.96
67_V 78_K 1.089 0.96
26_D 71_K 1.089 0.96
341_G 345_P 1.081 0.95
4_L 14_V 1.079 0.95
172_L 201_L 1.077 0.95
92_D 106_N 1.077 0.95
222_Y 225_H 1.071 0.95
224_L 237_N 1.068 0.95
205_C 343_L 1.067 0.95
17_V 137_P 1.063 0.95
188_S 260_A 1.062 0.95
181_N 328_S 1.057 0.95
76_L 153_P 1.054 0.95
69_T 77_Q 1.053 0.95
182_A 260_A 1.048 0.94
5_T 57_I 1.047 0.94
204_A 353_K 1.047 0.94
383_K 386_L 1.046 0.94
177_Q 339_W 1.046 0.94
367_A 386_L 1.04 0.94
346_L 351_L 1.039 0.94
192_V 206_A 1.035 0.94
157_P 348_E 1.024 0.93
140_Q 367_A 1.024 0.93
170_D 174_T 1.022 0.93
363_P 387_V 1.021 0.93
189_S 259_D 1.014 0.93
175_A 205_C 1.013 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ej6A10.83011000.291Contact Map0.751
4a2cA20.8181000.293Contact Map0.718
1h2bA20.81071000.295Contact Map0.78
1kolA20.90051000.296Contact Map0.754
4ilkA20.8181000.296Contact Map0.795
3ukoA20.86411000.298Contact Map0.731
1e3iA20.85441000.301Contact Map0.805
1cdoA20.85921000.302Contact Map0.789
1vj0A40.8351000.302Contact Map0.776
1f8fA10.85921000.303Contact Map0.808
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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