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OPENSEQ.org
YGGP - Uncharacterized protein YggP
UniProt: P52048 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12976
Length: 425 (344)
Sequences: 5746
Seq/Len: 16.70
YGGP
Paralog alert: 0.63 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
348_A 351_E 4.693 1.00
179_A 258_F 3.43 1.00
248_M 251_A 3.365 1.00
9_Y 17_R 3.333 1.00
27_N 80_N 3.239 1.00
32_S 75_V 3.109 1.00
216_A 220_K 2.879 1.00
26_D 79_K 2.86 1.00
345_G 348_A 2.844 1.00
23_E 76_E 2.84 1.00
212_D 238_N 2.824 1.00
278_L 284_L 2.801 1.00
212_D 216_A 2.795 1.00
354_L 358_D 2.792 1.00
204_R 235_V 2.77 1.00
34_I 73_V 2.612 1.00
102_G 105_A 2.605 1.00
184_A 207_V 2.575 1.00
215_L 219_Q 2.569 1.00
9_Y 15_R 2.5 1.00
89_Q 131_V 2.439 1.00
335_Q 338_F 2.436 1.00
351_E 354_L 2.399 1.00
327_A 331_T 2.374 1.00
196_I 234_L 2.36 1.00
34_I 139_F 2.356 1.00
132_L 142_A 2.296 1.00
244_D 247_Q 2.265 1.00
216_A 219_Q 2.255 1.00
220_K 338_F 2.174 1.00
344_G 352_T 2.167 1.00
179_A 208_V 2.147 1.00
173_K 176_G 2.143 1.00
26_D 80_N 2.119 1.00
84_K 123_E 2.111 1.00
90_R 135_H 2.099 1.00
344_G 355_N 2.089 1.00
70_C 114_G 2.034 1.00
138_Y 141_A 2.032 1.00
32_S 118_Y 2.031 1.00
32_S 73_V 2.011 1.00
217_Q 220_K 1.997 1.00
177_N 204_R 1.977 1.00
140_A 343_I 1.972 1.00
29_L 126_I 1.967 1.00
77_V 87_K 1.956 1.00
2_K 18_V 1.944 1.00
99_L 102_G 1.918 1.00
261_I 278_L 1.901 1.00
343_I 367_Y 1.899 1.00
247_Q 251_A 1.86 1.00
4_K 18_V 1.852 1.00
283_C 310_H 1.85 1.00
99_L 105_A 1.831 1.00
74_I 85_Y 1.788 1.00
327_A 330_A 1.787 1.00
215_L 236_Y 1.784 1.00
7_A 17_R 1.777 1.00
30_L 75_V 1.763 1.00
178_I 195_A 1.758 1.00
141_A 337_S 1.748 1.00
76_E 87_K 1.745 1.00
90_R 139_F 1.686 1.00
192_I 207_V 1.685 1.00
29_L 85_Y 1.684 1.00
38_V 352_T 1.669 1.00
4_K 117_T 1.661 1.00
30_L 120_I 1.66 1.00
283_C 312_V 1.657 1.00
259_D 279_A 1.657 1.00
136_G 330_A 1.653 1.00
192_I 232_I 1.639 1.00
206_V 258_F 1.637 1.00
6_A 349_V 1.609 1.00
47_L 357_P 1.605 1.00
351_E 355_N 1.586 1.00
24_I 28_E 1.58 1.00
78_G 81_L 1.579 1.00
212_D 241_G 1.568 1.00
2_K 20_E 1.562 1.00
24_I 120_I 1.555 1.00
209_D 215_L 1.548 1.00
243_S 248_M 1.54 1.00
85_Y 126_I 1.532 1.00
75_V 118_Y 1.53 1.00
207_V 232_I 1.528 1.00
4_K 347_D 1.503 1.00
210_I 239_T 1.498 1.00
304_V 311_V 1.49 1.00
238_N 241_G 1.487 1.00
258_F 261_I 1.483 1.00
342_H 355_N 1.474 1.00
9_Y 13_D 1.472 1.00
86_K 135_H 1.467 1.00
19_F 65_I 1.461 1.00
191_A 262_F 1.46 1.00
86_K 89_Q 1.452 1.00
278_L 309_T 1.444 1.00
73_V 139_F 1.38 0.99
27_N 123_E 1.368 0.99
210_I 215_L 1.365 0.99
176_G 260_D 1.358 0.99
85_Y 131_V 1.355 0.99
28_E 120_I 1.341 0.99
355_N 360_P 1.335 0.99
274_A 284_L 1.33 0.99
176_G 283_C 1.327 0.99
219_Q 236_Y 1.325 0.99
235_V 252_L 1.309 0.99
272_E 276_E 1.306 0.99
36_D 114_G 1.302 0.99
75_V 87_K 1.297 0.99
25_T 28_E 1.291 0.99
33_V 70_C 1.289 0.99
179_A 277_L 1.283 0.99
21_L 30_L 1.278 0.99
328_L 333_Q 1.276 0.99
213_K 216_A 1.275 0.99
5_V 19_F 1.272 0.99
157_A 287_F 1.257 0.99
28_E 122_P 1.255 0.99
265_A 270_V 1.25 0.99
21_L 118_Y 1.246 0.98
27_N 79_K 1.242 0.98
248_M 252_L 1.237 0.98
172_V 202_P 1.221 0.98
39_C 68_H 1.219 0.98
249_L 258_F 1.207 0.98
261_I 274_A 1.203 0.98
278_L 282_G 1.2 0.98
35_S 367_Y 1.197 0.98
137_S 142_A 1.195 0.98
6_A 16_L 1.182 0.98
71_A 139_F 1.176 0.98
140_A 367_Y 1.174 0.98
33_V 119_M 1.172 0.98
177_N 203_S 1.172 0.98
192_I 205_V 1.17 0.97
354_L 357_P 1.161 0.97
77_V 86_K 1.157 0.97
3_T 21_L 1.143 0.97
215_L 238_N 1.142 0.97
170_M 285_N 1.14 0.97
261_I 277_L 1.138 0.97
344_G 366_I 1.133 0.97
249_L 277_L 1.13 0.97
70_C 93_L 1.13 0.97
246_V 250_R 1.13 0.97
184_A 192_I 1.129 0.97
30_L 76_E 1.127 0.97
133_P 136_G 1.127 0.97
35_S 140_A 1.123 0.97
170_M 260_D 1.12 0.96
212_D 215_L 1.116 0.96
180_L 207_V 1.112 0.96
10_G 13_D 1.111 0.96
32_S 117_T 1.108 0.96
181_L 270_V 1.094 0.96
176_G 259_D 1.089 0.96
246_V 273_M 1.08 0.95
304_V 313_G 1.072 0.95
284_L 311_V 1.071 0.95
181_L 208_V 1.069 0.95
6_A 350_P 1.059 0.95
206_V 252_L 1.056 0.95
22_P 30_L 1.038 0.94
222_L 232_I 1.031 0.94
115_N 349_V 1.027 0.94
33_V 368_N 1.024 0.93
175_G 203_S 1.023 0.93
174_P 199_G 1.021 0.93
344_G 348_A 1.016 0.93
276_E 303_N 1.015 0.93
210_I 240_K 1.013 0.93
31_V 72_G 1.007 0.93
24_I 30_L 1.004 0.93
172_V 176_G 1.004 0.93
39_C 69_E 1.003 0.93
104_S 280_E 1.002 0.92
186_P 363_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ej6A10.78591000.439Contact Map0.76
4a2cA20.76711000.44Contact Map0.729
1f8fA10.76941000.441Contact Map0.845
4ilkA20.76711000.443Contact Map0.797
1e3iA20.76711000.444Contact Map0.857
3ukoA20.77881000.446Contact Map0.778
1cdoA20.77181000.446Contact Map0.819
3m6iA20.77651000.447Contact Map0.778
1h2bA20.76471000.448Contact Map0.767
2d8aA10.77651000.448Contact Map0.816
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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