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OPENSEQ.org
ADHP - Alcohol dehydrogenase, propanol-preferring
UniProt: P39451 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12622
Length: 336 (333)
Sequences: 22806
Seq/Len: 68.49
ADHP
Paralog alert: 0.83 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
313_D 316_T 3.391 1.00
32_E 137_S 3.194 1.00
30_K 65_A 3.077 1.00
27_A 128_A 2.888 1.00
32_E 63_V 2.875 1.00
7_T 15_T 2.856 1.00
28_L 65_A 2.799 1.00
182_K 208_D 2.729 1.00
136_D 139_A 2.697 1.00
78_D 130_K 2.673 1.00
164_W 188_K 2.614 1.00
200_K 204_E 2.534 1.00
309_R 320_E 2.526 1.00
199_L 203_T 2.494 1.00
75_K 78_D 2.463 1.00
138_A 308_L 2.418 1.00
25_G 70_G 2.393 1.00
24_H 69_P 2.39 1.00
79_R 131_V 2.367 1.00
30_K 63_V 2.363 1.00
30_K 120_E 2.287 1.00
5_V 15_T 2.226 1.00
165_I 181_A 2.224 1.00
295_Q 299_E 2.211 1.00
73_S 125_A 2.206 1.00
310_P 313_D 2.193 1.00
7_T 13_D 2.184 1.00
24_H 70_G 2.156 1.00
19_L 120_E 2.14 1.00
160_R 163_Q 2.1 1.00
170_L 191_A 2.089 1.00
134_G 298_A 2.08 1.00
308_L 333_D 2.062 1.00
196_D 200_K 2.045 1.00
307_A 320_E 2.043 1.00
79_R 137_S 2.037 1.00
163_Q 254_R 2.01 1.00
21_S 66_E 2.007 1.00
178_L 207_A 1.986 1.00
60_G 116_G 1.986 1.00
23_K 26_E 1.956 1.00
221_I 224_E 1.947 1.00
188_K 209_L 1.944 1.00
249_V 255_V 1.917 1.00
319_T 323_E 1.916 1.00
196_D 212_N 1.914 1.00
316_T 319_T 1.911 1.00
61_I 137_S 1.908 1.00
166_A 192_I 1.905 1.00
200_K 203_T 1.897 1.00
309_R 317_I 1.888 1.00
28_L 122_I 1.857 1.00
131_V 140_A 1.822 1.00
65_A 120_E 1.804 1.00
193_D 199_L 1.776 1.00
2_K 16_Y 1.764 1.00
320_E 325_K 1.756 1.00
147_G 176_L 1.754 1.00
199_L 210_A 1.714 1.00
166_A 229_A 1.713 1.00
79_R 133_D 1.709 1.00
68_G 71_V 1.707 1.00
60_G 82_V 1.701 1.00
66_E 76_P 1.689 1.00
254_R 278_E 1.669 1.00
74_L 130_K 1.654 1.00
212_N 215_T 1.651 1.00
67_V 76_P 1.636 1.00
92_C 95_C 1.618 1.00
45_N 322_E 1.617 1.00
316_T 320_E 1.612 1.00
249_V 253_G 1.609 1.00
4_A 314_I 1.609 1.00
201_L 204_E 1.608 1.00
168_Y 245_A 1.59 1.00
131_V 137_S 1.589 1.00
22_L 122_I 1.589 1.00
231_A 234_V 1.588 1.00
26_E 124_V 1.583 1.00
196_D 215_T 1.564 1.00
249_V 277_I 1.552 1.00
254_R 280_V 1.529 1.00
64_V 74_L 1.516 1.00
25_G 124_V 1.48 1.00
63_V 79_R 1.479 1.00
234_V 237_V 1.476 1.00
74_L 78_D 1.464 1.00
31_M 60_G 1.457 1.00
26_E 122_I 1.456 1.00
33_C 333_D 1.453 1.00
2_K 119_E 1.452 1.00
184_V 301_K 1.445 1.00
27_A 74_L 1.436 1.00
117_M 318_F 1.434 1.00
2_K 312_A 1.433 1.00
28_L 120_E 1.424 1.00
178_L 191_A 1.422 1.00
220_K 223_Q 1.422 1.00
28_L 66_E 1.416 1.00
138_A 333_D 1.386 0.99
295_Q 298_A 1.379 0.99
311_L 334_F 1.368 0.99
164_W 190_I 1.362 0.99
3_A 17_K 1.358 0.99
63_V 137_S 1.357 0.99
22_L 26_E 1.349 0.99
33_C 138_A 1.345 0.99
22_L 28_L 1.339 0.99
217_D 220_K 1.336 0.99
315_N 319_T 1.33 0.99
4_A 14_V 1.322 0.99
89_C 92_C 1.32 0.99
74_L 128_A 1.306 0.99
216_E 221_I 1.303 0.99
188_K 208_D 1.295 0.99
155_K 292_E 1.277 0.99
29_L 62_G 1.271 0.99
32_E 79_R 1.249 0.99
44_K 318_F 1.243 0.98
168_Y 192_I 1.237 0.98
95_C 103_C 1.228 0.98
194_V 213_S 1.219 0.98
92_C 103_C 1.216 0.98
159_I 187_A 1.201 0.98
143_I 297_A 1.2 0.98
191_A 207_A 1.192 0.98
306_V 320_E 1.187 0.98
36_V 317_I 1.186 0.98
196_D 199_L 1.186 0.98
296_F 301_K 1.176 0.98
33_C 137_S 1.172 0.98
217_D 221_I 1.165 0.97
123_V 128_A 1.163 0.97
230_H 234_V 1.154 0.97
230_H 250_R 1.151 0.97
203_T 210_A 1.15 0.97
25_G 125_A 1.15 0.97
89_C 95_C 1.149 0.97
139_A 303_V 1.139 0.97
184_V 296_F 1.137 0.97
19_L 28_L 1.118 0.96
135_L 140_A 1.109 0.96
167_I 177_A 1.094 0.96
37_C 58_H 1.091 0.96
221_I 225_K 1.09 0.96
155_K 289_D 1.088 0.96
4_A 311_L 1.086 0.96
157_S 256_V 1.085 0.96
31_M 121_C 1.083 0.96
292_E 295_Q 1.076 0.95
203_T 209_L 1.066 0.95
14_V 312_A 1.058 0.95
319_T 322_E 1.053 0.95
194_V 214_H 1.051 0.94
231_A 235_T 1.048 0.94
67_V 71_V 1.044 0.94
35_G 59_E 1.042 0.94
314_I 332_I 1.036 0.94
220_K 224_E 1.034 0.94
201_L 327_R 1.032 0.94
229_A 234_V 1.027 0.94
150_T 180_Y 1.022 0.93
37_C 59_E 1.021 0.93
157_S 232_A 1.014 0.93
190_I 229_A 1.011 0.93
199_L 212_N 1.01 0.93
75_K 130_K 1.008 0.93
197_E 200_K 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gkvA40.99111000.058Contact Map0.805
4eezA211000.066Contact Map0.814
1rjwA40.9941000.069Contact Map0.866
1h2bA20.98511000.075Contact Map0.803
4ej6A10.98511000.081Contact Map0.764
4a2cA20.98211000.085Contact Map0.733
4ilkA20.98511000.085Contact Map0.774
3s2eA80.9971000.087Contact Map0.846
1e3iA20.98211000.092Contact Map0.799
3jv7A40.98211000.093Contact Map0.812
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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