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NARL - Nitrate/nitrite response regulator protein NarL
UniProt: P0AF28 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10643
Length: 216 (208)
Sequences: 29664
Seq/Len: 142.62

NARL
Paralog alert: 0.94 [within 20: 0.57] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
19_R 37_E 3.584 1.00
19_R 39_S 2.904 1.00
42_E 64_G 2.586 1.00
23_K 37_E 2.583 1.00
159_R 162_D 2.534 1.00
185_S 188_K 2.476 1.00
40_N 64_G 2.439 1.00
92_E 112_E 2.409 1.00
12_I 44_G 2.407 1.00
23_K 27_S 2.342 1.00
65_M 73_K 2.341 1.00
160_E 197_K 2.318 1.00
173_N 188_K 2.299 1.00
36_G 53_P 2.279 1.00
41_G 65_M 2.254 1.00
95_V 115_D 2.175 1.00
40_N 43_Q 2.107 1.00
25_L 113_P 2.073 1.00
49_E 77_K 2.042 1.00
66_N 69_E 1.979 1.00
45_I 73_K 1.976 1.00
190_H 193_H 1.892 1.00
165_K 169_Q 1.859 1.00
39_S 43_Q 1.802 1.00
38_A 47_L 1.785 1.00
84_V 123_A 1.784 1.00
71_L 83_I 1.771 1.00
55_L 120_L 1.741 1.00
100_K 121_H 1.734 1.00
85_V 98_A 1.698 1.00
60_L 85_V 1.683 1.00
26_I 120_L 1.667 1.00
172_P 175_M 1.646 1.00
104_D 126_G 1.639 1.00
61_N 89_S 1.633 1.00
58_L 70_T 1.63 1.00
29_A 117_L 1.615 1.00
8_T 36_G 1.609 1.00
58_L 71_L 1.595 1.00
71_L 85_V 1.571 1.00
73_K 76_E 1.544 1.00
36_G 47_L 1.543 1.00
166_L 176_I 1.539 1.00
85_V 103_A 1.521 1.00
36_G 51_L 1.496 1.00
12_I 62_M 1.471 1.00
89_S 94_D 1.467 1.00
56_I 81_G 1.461 1.00
200_L 209_W 1.454 1.00
65_M 69_E 1.454 1.00
10_L 38_A 1.451 1.00
13_D 19_R 1.424 1.00
31_D 121_H 1.421 1.00
45_I 70_T 1.413 1.00
41_G 70_T 1.407 0.99
139_A 143_R 1.375 0.99
68_L 101_R 1.374 0.99
8_T 34_V 1.363 0.99
171_L 179_R 1.36 0.99
75_R 104_D 1.355 0.99
166_L 179_R 1.347 0.99
144_A 168_A 1.315 0.99
60_L 68_L 1.302 0.99
46_E 50_S 1.292 0.99
42_E 65_M 1.285 0.99
69_E 72_D 1.276 0.99
47_L 51_L 1.275 0.99
8_T 33_T 1.249 0.99
186_T 190_H 1.243 0.98
73_K 77_K 1.235 0.98
164_L 206_A 1.233 0.98
105_G 119_A 1.229 0.98
157_T 197_K 1.229 0.98
45_I 65_M 1.217 0.98
191_V 195_L 1.207 0.98
189_V 192_K 1.205 0.98
47_L 50_S 1.2 0.98
29_A 121_H 1.177 0.98
42_E 46_E 1.177 0.98
72_D 97_T 1.171 0.98
48_A 74_L 1.171 0.98
91_H 94_D 1.168 0.97
16_P 39_S 1.167 0.97
38_A 44_G 1.152 0.97
55_L 124_A 1.142 0.97
14_D 59_D 1.133 0.97
123_A 126_G 1.117 0.96
209_W 213_E 1.112 0.96
93_E 97_T 1.109 0.96
43_Q 46_E 1.102 0.96
22_V 86_F 1.097 0.96
174_K 178_R 1.083 0.96
62_M 70_T 1.072 0.95
44_G 48_A 1.062 0.95
68_L 97_T 1.056 0.95
96_V 114_E 1.048 0.94
12_I 56_I 1.043 0.94
43_Q 47_L 1.041 0.94
173_N 177_A 1.041 0.94
185_S 189_V 1.037 0.94
10_L 44_G 1.032 0.94
174_K 184_E 1.027 0.94
162_D 165_K 1.025 0.93
22_V 116_L 1.024 0.93
61_N 88_V 1.016 0.93
166_L 171_L 1.015 0.93
92_E 96_V 1.015 0.93
56_I 74_L 1.013 0.93
47_L 53_P 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA20.97221000.105Contact Map0.578
1a04A20.99541000.107Contact Map0.67
4gvpA40.95831000.108Contact Map0.778
4hyeA20.94911000.127Contact Map0.811
3kloA40.99541000.138Contact Map0.447
1yioA10.93981000.175Contact Map0.686
1ys7A20.99071000.218Contact Map0.753
3q9sA10.96761000.223Contact Map0.671
4b09A120.98611000.235Contact Map0.658
1kgsA10.97221000.252Contact Map0.681

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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