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OPENSEQ.org

EVGA - Positive transcription regulator EvgA
UniProt: P0ACZ4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11609
Length: 204 (203)
Sequences: 30907
Seq/Len: 152.25

EVGA
Paralog alert: 0.94 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
13_I 30_E 3.601 1.00
13_I 32_T 2.964 1.00
35_G 57_G 2.688 1.00
17_R 30_E 2.666 1.00
6_I 37_A 2.448 1.00
33_E 57_G 2.437 1.00
58_V 66_T 2.372 1.00
147_Q 150_S 2.316 1.00
161_N 176_S 2.249 1.00
85_H 105_G 2.218 1.00
88_G 108_N 2.207 1.00
173_K 176_S 2.201 1.00
34_G 58_V 2.176 1.00
28_L 46_P 2.109 1.00
19_L 106_M 2.088 1.00
148_E 185_K 2.064 1.00
38_V 66_T 2.054 1.00
42_E 70_R 2.049 1.00
33_E 36_S 2.038 1.00
2_N 26_E 1.984 1.00
153_R 157_D 1.871 1.00
32_T 36_S 1.87 1.00
31_L 40_R 1.852 1.00
59_N 62_Q 1.841 1.00
178_Y 181_R 1.775 1.00
17_R 21_I 1.768 1.00
20_L 113_I 1.751 1.00
78_I 91_C 1.72 1.00
2_N 28_L 1.718 1.00
48_I 113_I 1.714 1.00
51_I 63_V 1.7 1.00
64_L 76_I 1.692 1.00
77_I 116_A 1.657 1.00
54_D 82_K 1.616 1.00
93_D 114_E 1.595 1.00
154_Y 167_K 1.591 1.00
53_V 78_I 1.588 1.00
4_I 31_L 1.544 1.00
51_I 64_L 1.524 1.00
78_I 96_A 1.515 1.00
160_D 163_D 1.51 1.00
66_T 69_K 1.496 1.00
97_N 119_G 1.495 1.00
154_Y 164_I 1.492 1.00
64_L 78_I 1.491 1.00
58_V 62_Q 1.46 1.00
82_K 87_Y 1.459 1.00
7_D 13_I 1.43 1.00
49_V 74_G 1.421 1.00
68_R 97_N 1.419 1.00
188_C 197_F 1.413 1.00
98_G 112_A 1.399 0.99
34_G 63_V 1.389 0.99
159_K 167_K 1.388 0.99
6_I 55_I 1.381 0.99
38_V 63_V 1.365 0.99
28_L 40_R 1.328 0.99
40_R 44_L 1.315 0.99
35_G 58_V 1.297 0.99
61_I 94_A 1.288 0.99
66_T 70_R 1.259 0.99
53_V 61_I 1.257 0.99
62_Q 65_E 1.255 0.99
24_D 114_E 1.253 0.99
39_Q 43_T 1.251 0.99
40_R 43_T 1.24 0.98
23_N 110_I 1.233 0.98
25_I 114_E 1.228 0.98
154_Y 159_K 1.222 0.98
10_P 32_T 1.219 0.98
35_G 39_Q 1.219 0.98
84_D 87_Y 1.21 0.98
38_V 58_V 1.208 0.98
177_T 180_S 1.173 0.98
41_V 67_L 1.165 0.97
174_T 178_Y 1.158 0.97
31_L 37_A 1.156 0.97
162_N 172_N 1.156 0.97
65_E 90_H 1.15 0.97
179_K 183_M 1.147 0.97
8_D 52_D 1.138 0.97
197_F 201_N 1.13 0.97
36_S 39_Q 1.126 0.97
48_I 117_K 1.12 0.96
162_N 166_E 1.118 0.96
3_A 25_I 1.113 0.96
152_M 194_L 1.103 0.96
86_F 90_H 1.101 0.96
145_S 185_K 1.098 0.96
37_A 41_V 1.086 0.96
28_L 44_L 1.083 0.96
16_I 79_V 1.066 0.95
36_S 40_R 1.061 0.95
150_S 153_R 1.06 0.95
61_I 90_H 1.06 0.95
159_K 163_D 1.049 0.94
128_N 133_S 1.046 0.94
6_I 49_V 1.035 0.94
116_A 119_G 1.034 0.94
4_I 37_A 1.033 0.94
29_A 44_L 1.032 0.94
163_D 167_K 1.031 0.94
130_F 138_Q 1.022 0.93
89_K 107_N 1.012 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gvpA411000.062Contact Map0.797
3c3wA211000.067Contact Map0.647
4hyeA20.97061000.083Contact Map0.786
1a04A211000.089Contact Map0.703
1yioA10.97551000.116Contact Map0.692
3kloA40.99511000.124Contact Map0.428
1ys7A20.99511000.159Contact Map0.759
4b09A120.99021000.176Contact Map0.646
3q9sA10.97551000.177Contact Map0.676
1kgsA10.99511000.187Contact Map0.69

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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