May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org

UVRY - Response regulator UvrY
UniProt: P0AED5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11140
Length: 218 (210)
Sequences: 30431
Seq/Len: 144.91

UVRY
Paralog alert: 0.94 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
14_R 32_E 3.64 1.00
14_R 34_S 2.925 1.00
18_R 32_E 2.665 1.00
37_E 59_G 2.644 1.00
7_V 39_A 2.481 1.00
35_C 59_G 2.461 1.00
167_V 182_N 2.372 1.00
179_K 182_N 2.367 1.00
60_I 68_K 2.346 1.00
153_R 156_Q 2.344 1.00
87_N 107_A 2.299 1.00
18_R 22_E 2.262 1.00
90_P 110_E 2.25 1.00
36_G 60_I 2.232 1.00
154_E 191_K 2.156 1.00
30_V 48_V 2.095 1.00
35_C 38_D 2.08 1.00
20_I 108_P 2.059 1.00
44_R 72_S 2.052 1.00
40_V 68_K 2.018 1.00
3_N 28_K 1.954 1.00
61_G 64_E 1.896 1.00
184_Y 187_R 1.877 1.00
34_S 38_D 1.837 1.00
159_L 163_K 1.836 1.00
33_A 42_W 1.83 1.00
80_M 93_V 1.728 1.00
50_V 115_I 1.72 1.00
3_N 30_V 1.718 1.00
66_T 78_I 1.714 1.00
21_L 115_I 1.709 1.00
79_I 118_V 1.696 1.00
53_M 65_A 1.682 1.00
55_M 80_M 1.65 1.00
95_Q 116_R 1.641 1.00
56_S 84_H 1.622 1.00
160_M 170_I 1.603 1.00
99_A 121_G 1.584 1.00
160_M 173_Q 1.582 1.00
53_M 66_T 1.565 1.00
66_T 80_M 1.563 1.00
5_L 33_A 1.556 1.00
80_M 98_A 1.546 1.00
166_K 169_E 1.523 1.00
68_K 71_R 1.517 1.00
8_D 14_R 1.466 1.00
60_I 64_E 1.452 1.00
7_V 57_M 1.448 1.00
84_H 89_L 1.44 1.00
36_G 65_A 1.429 1.00
70_A 99_A 1.405 0.99
51_V 76_V 1.402 0.99
165_Q 173_Q 1.388 0.99
40_V 65_A 1.387 0.99
100_G 114_A 1.379 0.99
194_I 203_L 1.375 0.99
63_L 96_A 1.345 0.99
30_V 42_W 1.33 0.99
42_W 46_N 1.283 0.99
136_S 139_E 1.279 0.99
160_M 165_Q 1.278 0.99
64_E 67_R 1.272 0.99
37_E 60_I 1.267 0.99
68_K 72_S 1.264 0.99
55_M 63_L 1.263 0.99
42_W 45_T 1.249 0.99
41_K 45_T 1.247 0.99
86_E 89_L 1.218 0.98
180_T 184_Y 1.213 0.98
25_K 112_V 1.206 0.98
37_E 41_K 1.204 0.98
26_G 116_R 1.203 0.98
33_A 39_A 1.193 0.98
40_V 60_I 1.192 0.98
43_C 69_I 1.185 0.98
27_I 116_R 1.183 0.98
151_S 191_K 1.181 0.98
11_E 34_S 1.18 0.98
183_S 186_Y 1.165 0.97
67_R 92_K 1.155 0.97
168_N 178_P 1.155 0.97
185_R 189_F 1.13 0.97
9_D 54_D 1.125 0.97
168_N 172_E 1.113 0.96
50_V 119_Y 1.108 0.96
4_V 27_I 1.105 0.96
38_D 41_K 1.094 0.96
132_Q 144_E 1.088 0.96
39_A 43_C 1.088 0.96
88_P 92_K 1.087 0.96
132_Q 139_E 1.069 0.95
118_V 121_G 1.06 0.95
31_G 46_N 1.059 0.95
17_I 81_L 1.053 0.95
38_D 42_W 1.051 0.94
57_M 65_A 1.051 0.94
7_V 51_V 1.048 0.94
63_L 92_K 1.046 0.94
158_M 200_L 1.045 0.94
30_V 46_N 1.045 0.94
156_Q 159_L 1.036 0.94
5_L 39_A 1.035 0.94
165_Q 169_E 1.033 0.94
203_L 207_H 1.026 0.94
56_S 83_V 1.023 0.93
142_K 147_F 1.019 0.93
17_I 111_V 1.017 0.93
91_A 109_Q 1.016 0.93
51_V 69_I 1.015 0.93
87_N 91_A 1.012 0.93
8_D 57_M 1.007 0.93
135_L 162_T 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA211000.122Contact Map0.631
4gvpA40.95411000.135Contact Map0.805
4hyeA20.91741000.152Contact Map0.799
1a04A20.96331000.154Contact Map0.701
3kloA40.98621000.172Contact Map0.451
1yioA10.94041000.195Contact Map0.694
1ys7A20.97251000.201Contact Map0.764
1p2fA10.95871000.211Contact Map0.745
1kgsA10.97251000.218Contact Map0.697
3q9sA10.93121000.22Contact Map0.682

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.5762 seconds.