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OPENSEQ.org
XERD - Tyrosine recombinase XerD
UniProt: P0A8P8 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11071
Length: 298 (291)
Sequences: 15629
Seq/Len: 53.71
XERD
Paralog alert: 0.88 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
251_A 268_L 4.119 1.00
177_R 269_G 3.02 1.00
51_Q 54_D 2.992 1.00
157_M 193_L 2.82 1.00
156_T 217_Q 2.65 1.00
242_S 245_V 2.47 1.00
45_L 54_D 2.467 1.00
250_F 267_L 2.383 1.00
142_L 243_P 2.305 1.00
165_G 186_V 2.238 1.00
32_D 74_R 2.161 1.00
161_S 164_Q 2.151 1.00
62_R 75_L 2.124 1.00
142_L 152_L 2.124 1.00
149_V 244_H 2.102 1.00
156_T 208_V 2.09 1.00
114_S 117_Q 2.068 1.00
146_G 250_F 2.067 1.00
255_L 264_V 2.024 1.00
168_R 178_L 1.999 1.00
260_D 263_V 1.988 1.00
156_T 207_D 1.987 1.00
248_H 281_H 1.947 1.00
157_M 209_L 1.923 1.00
30_R 34_S 1.918 1.00
186_V 190_E 1.874 1.00
270_H 276_T 1.799 1.00
50_A 83_F 1.782 1.00
175_K 271_S 1.764 1.00
12_L 30_R 1.729 1.00
262_R 265_Q 1.725 1.00
181_L 186_V 1.724 1.00
166_V 178_L 1.709 1.00
25_T 29_Y 1.695 1.00
46_T 49_T 1.658 1.00
144_A 182_G 1.637 1.00
73_A 103_P 1.63 1.00
35_M 75_L 1.621 1.00
151_E 177_R 1.614 1.00
55_L 97_S 1.611 1.00
254_L 259_A 1.592 1.00
59_L 76_L 1.588 1.00
32_D 78_A 1.568 1.00
254_L 264_V 1.56 1.00
39_W 61_E 1.547 1.00
250_F 254_L 1.535 1.00
147_L 152_L 1.52 1.00
275_T 278_I 1.514 1.00
85_Y 89_E 1.505 1.00
117_Q 120_R 1.502 1.00
82_L 86_L 1.476 1.00
138_M 223_F 1.469 1.00
159_D 170_I 1.449 1.00
274_S 277_Q 1.446 1.00
143_Y 253_H 1.444 1.00
180_P 267_L 1.443 1.00
149_V 153_V 1.439 1.00
23_E 27_N 1.43 1.00
156_T 159_D 1.424 1.00
138_M 152_L 1.412 1.00
87_Y 92_R 1.401 0.99
58_L 75_L 1.398 0.99
255_L 280_T 1.394 0.99
137_A 192_Y 1.384 0.99
24_N 27_N 1.381 0.99
162_L 190_E 1.369 0.99
256_N 286_R 1.368 0.99
150_S 154_G 1.345 0.99
268_L 276_T 1.34 0.99
165_G 183_E 1.337 0.99
113_L 241_L 1.33 0.99
170_I 176_E 1.327 0.99
158_S 207_D 1.322 0.99
147_L 169_V 1.318 0.99
149_V 220_R 1.316 0.99
119_E 123_Q 1.315 0.99
161_S 166_V 1.311 0.99
113_L 117_Q 1.31 0.99
11_F 81_R 1.306 0.99
231_A 241_L 1.296 0.99
149_V 224_W 1.294 0.99
208_V 217_Q 1.293 0.99
136_K 140_E 1.286 0.99
88_R 101_A 1.285 0.99
115_E 253_H 1.281 0.99
84_Q 98_A 1.273 0.99
140_E 188_W 1.26 0.99
262_R 266_M 1.252 0.99
265_Q 276_T 1.245 0.98
286_R 289_Q 1.242 0.98
70_T 74_R 1.239 0.98
252_T 281_H 1.23 0.98
144_A 185_A 1.223 0.98
112_D 281_H 1.221 0.98
117_Q 238_S 1.212 0.98
113_L 249_A 1.211 0.98
125_P 230_Y 1.207 0.98
162_L 186_V 1.206 0.98
265_Q 273_L 1.193 0.98
181_L 185_A 1.189 0.98
220_R 224_W 1.182 0.98
219_T 222_T 1.173 0.98
124_A 234_A 1.17 0.97
256_N 283_A 1.166 0.97
71_S 75_L 1.164 0.97
39_W 57_A 1.16 0.97
285_E 289_Q 1.16 0.97
39_W 58_L 1.159 0.97
155_L 167_V 1.157 0.97
272_D 277_Q 1.155 0.97
115_E 257_H 1.155 0.97
182_G 185_A 1.153 0.97
137_A 188_W 1.149 0.97
27_N 31_R 1.149 0.97
8_I 33_L 1.144 0.97
153_V 223_F 1.141 0.97
249_A 253_H 1.132 0.97
253_H 256_N 1.131 0.97
76_L 80_R 1.13 0.97
153_V 220_R 1.13 0.97
183_E 187_Y 1.115 0.96
56_Q 60_A 1.114 0.96
83_F 97_S 1.112 0.96
168_R 176_E 1.107 0.96
83_F 96_P 1.105 0.96
226_R 229_H 1.098 0.96
143_Y 249_A 1.093 0.96
118_V 143_Y 1.089 0.96
250_F 268_L 1.084 0.96
124_A 233_L 1.069 0.95
8_I 82_L 1.066 0.95
58_L 62_R 1.064 0.95
251_A 255_L 1.062 0.95
272_D 275_T 1.049 0.94
227_I 231_A 1.049 0.94
141_V 167_V 1.048 0.94
221_Q 224_W 1.047 0.94
138_M 210_F 1.045 0.94
120_R 124_A 1.045 0.94
62_R 72_S 1.042 0.94
251_A 264_V 1.041 0.94
90_K 94_D 1.041 0.94
143_Y 246_L 1.033 0.94
135_D 226_R 1.029 0.94
158_S 206_I 1.027 0.94
289_Q 292_Q 1.022 0.93
21_L 26_L 1.022 0.93
86_L 91_F 1.014 0.93
84_Q 95_D 1.007 0.93
112_D 249_A 1.005 0.93
221_Q 228_K 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a0pA10.97321000.145Contact Map0.597
2a3vA40.9431000.212Contact Map0.814
1z19A20.93621000.213Contact Map0.6
1z1bA20.92951000.214Contact Map0.588
1xo0A20.96641000.236Contact Map0.582
4a8eA10.90941000.238Contact Map0.73
4e0gA10.9531000.374Contact Map0.398
3nkhA20.70471000.417Contact Map0.789
1ae9A20.57721000.478Contact Map0.583
1aihA40.54799.90.521Contact Map0.759
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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