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OPENSEQ.org

FIME - Type 1 fimbriae regulatory protein FimE
UniProt: P0ADH7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10312
Length: 198 (188)
Sequences: 14216
Seq/Len: 75.62

FIME
Paralog alert: 0.88 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
143_G 160_L 3.976 1.00
71_T 161_G 2.772 1.00
50_Y 87_T 2.67 1.00
49_H 110_R 2.609 1.00
134_H 137_M 2.384 1.00
58_G 80_R 2.384 1.00
142_C 159_Y 2.313 1.00
35_A 45_L 2.104 1.00
39_G 142_C 2.072 1.00
61_N 72_V 2.044 1.00
54_D 57_E 2.027 1.00
49_H 101_A 1.975 1.00
147_A 156_I 1.927 1.00
35_A 135_P 1.924 1.00
49_H 100_D 1.849 1.00
154_R 157_Q 1.845 1.00
80_R 84_E 1.844 1.00
152_D 155_L 1.841 1.00
59_R 72_V 1.802 1.00
75_L 80_R 1.782 1.00
50_Y 102_I 1.74 1.00
8_T 11_E 1.725 1.00
140_H 173_A 1.719 1.00
37_R 76_R 1.713 1.00
40_M 45_L 1.631 1.00
69_F 163_R 1.631 1.00
42_I 46_L 1.536 1.00
31_L 116_A 1.51 1.00
146_L 156_I 1.508 1.00
42_I 136_H 1.498 1.00
30_C 86_W 1.493 1.00
162_H 168_T 1.49 1.00
29_Y 33_L 1.48 1.00
52_D 63_R 1.479 1.00
11_E 14_A 1.476 1.00
146_L 151_A 1.449 1.00
63_R 70_S 1.438 1.00
44_E 71_T 1.432 1.00
113_R 117_Y 1.419 1.00
124_G 133_T 1.418 1.00
142_C 146_L 1.401 0.99
49_H 52_D 1.393 0.99
167_H 170_R 1.391 0.99
148_E 178_R 1.379 0.99
54_D 59_R 1.364 0.99
40_M 62_I 1.358 0.99
31_L 45_L 1.358 0.99
36_Y 145_E 1.356 0.99
74_P 159_Y 1.356 0.99
43_S 47_D 1.332 0.99
154_R 158_D 1.314 0.99
48_L 60_I 1.299 0.99
12_V 36_Y 1.298 0.99
33_L 82_A 1.289 0.99
144_Y 173_A 1.288 0.99
7_L 133_T 1.286 0.99
9_G 149_R 1.285 0.99
61_N 70_S 1.285 0.99
160_L 168_T 1.284 0.99
7_L 11_E 1.263 0.99
42_I 113_R 1.263 0.99
166_R 169_V 1.262 0.99
55_L 84_E 1.256 0.99
147_A 172_T 1.253 0.99
58_G 77_F 1.244 0.98
11_E 131_T 1.244 0.98
55_L 80_R 1.242 0.98
101_A 110_R 1.24 0.98
157_Q 165_I 1.232 0.98
51_Q 100_D 1.192 0.98
114_Q 117_Y 1.186 0.98
112_S 115_Q 1.172 0.98
155_L 182_L 1.166 0.97
19_V 123_A 1.157 0.97
7_L 141_A 1.151 0.97
42_I 117_Y 1.149 0.97
14_A 18_A 1.147 0.97
30_C 82_A 1.144 0.97
36_Y 138_L 1.142 0.97
181_G 185_R 1.139 0.97
37_R 79_E 1.137 0.97
28_D 119_I 1.131 0.97
148_E 175_N 1.121 0.97
145_E 148_E 1.119 0.96
13_Q 17_Q 1.118 0.96
18_A 126_E 1.111 0.96
76_R 79_E 1.106 0.96
9_G 145_E 1.104 0.96
115_Q 118_R 1.101 0.96
42_I 116_A 1.098 0.96
143_G 156_I 1.094 0.96
46_L 116_A 1.083 0.96
6_Y 173_A 1.076 0.95
18_A 127_A 1.07 0.95
119_I 122_D 1.069 0.95
141_A 145_E 1.057 0.95
7_L 15_M 1.052 0.95
5_R 131_T 1.045 0.94
178_R 181_G 1.042 0.94
143_G 147_A 1.041 0.94
36_Y 141_A 1.04 0.94
122_D 126_E 1.031 0.94
121_R 132_Q 1.028 0.94
75_L 79_E 1.027 0.94
20_C 29_Y 1.027 0.94
12_V 145_E 1.01 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2a3vA40.92421000.175Contact Map0.867
4a8eA10.94441000.199Contact Map0.786
3nkhA20.96461000.205Contact Map0.801
1a0pA10.91921000.21Contact Map0.588
1z1bA20.89391000.248Contact Map0.563
1z19A20.9041000.261Contact Map0.568
1xo0A20.94441000.262Contact Map0.54
1ae9A20.87881000.271Contact Map0.61
4e0gA10.944499.90.329Contact Map0.395
1aihA40.848599.90.334Contact Map0.761

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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