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OPENSEQ.org
INTE - Prophage lambda integrase
UniProt: P75969 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12370
Length: 375 (340)
Sequences: 5619
Seq/Len: 16.53
INTE
Paralog alert: 0.72 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
126_K 135_D 4.052 1.00
51_I 54_E 3.124 1.00
235_F 277_R 2.998 1.00
234_K 283_A 2.884 1.00
337_E 351_L 2.848 1.00
235_F 285_L 2.727 1.00
328_T 331_E 2.71 1.00
334_S 364_D 2.692 1.00
85_S 89_D 2.688 1.00
143_Y 155_V 2.596 1.00
113_A 117_S 2.579 1.00
88_L 162_V 2.464 1.00
131_V 163_F 2.457 1.00
132_D 135_D 2.448 1.00
29_R 38_F 2.435 1.00
241_D 270_R 2.409 1.00
85_S 125_M 2.4 1.00
87_W 128_I 2.36 1.00
44_N 47_E 2.356 1.00
88_L 116_V 2.312 1.00
45_E 49_I 2.274 1.00
89_D 120_R 2.24 1.00
220_A 329_F 2.163 1.00
136_I 179_A 2.112 1.00
241_D 267_W 2.105 1.00
87_W 166_A 2.07 1.00
168_H 183_K 2.039 1.00
85_S 120_R 2.021 1.00
235_F 273_V 1.978 1.00
220_A 230_I 1.95 1.00
215_N 276_C 1.936 1.00
336_S 350_L 1.93 1.00
237_D 246_I 1.829 1.00
54_E 58_R 1.815 1.00
108_T 112_K 1.792 1.00
224_G 336_S 1.775 1.00
270_R 274_A 1.766 1.00
127_L 130_A 1.76 1.00
126_K 130_A 1.709 1.00
115_P 158_V 1.709 1.00
122_R 142_E 1.708 1.00
233_M 238_I 1.705 1.00
353_H 359_T 1.699 1.00
140_L 156_R 1.685 1.00
225_Q 230_I 1.68 1.00
336_S 340_Y 1.672 1.00
335_L 338_R 1.67 1.00
84_T 131_V 1.668 1.00
337_E 341_K 1.655 1.00
227_L 330_H 1.653 1.00
358_Q 361_R 1.628 1.00
214_G 218_L 1.617 1.00
227_L 231_S 1.609 1.00
164_K 180_L 1.607 1.00
195_S 198_E 1.605 1.00
216_A 230_I 1.6 1.00
50_A 54_E 1.599 1.00
132_D 173_P 1.595 1.00
167_Q 172_V 1.587 1.00
123_A 139_L 1.584 1.00
165_E 169_Y 1.581 1.00
254_I 352_G 1.578 1.00
89_D 93_A 1.573 1.00
150_R 154_V 1.565 1.00
265_I 269_L 1.556 1.00
31_K 38_F 1.555 1.00
20_S 23_V 1.55 1.00
194_L 202_I 1.549 1.00
341_K 347_T 1.538 1.00
163_F 178_P 1.537 1.00
85_S 124_G 1.531 1.00
66_Q 72_D 1.514 1.00
83_T 86_T 1.498 1.00
219_L 269_L 1.473 1.00
198_E 201_K 1.455 1.00
242_H 255_A 1.451 1.00
335_L 339_L 1.438 1.00
92_Q 109_Y 1.438 1.00
156_R 160_I 1.421 1.00
126_K 131_V 1.414 1.00
164_K 177_N 1.412 1.00
139_L 155_V 1.411 1.00
84_T 159_L 1.401 0.99
105_R 108_T 1.4 0.99
112_K 158_V 1.399 0.99
87_W 165_E 1.391 0.99
233_M 243_L 1.39 0.99
199_W 221_L 1.388 0.99
221_L 332_Q 1.387 0.99
348_Q 359_T 1.372 0.99
137_A 141_D 1.37 0.99
170_G 174_P 1.37 0.99
92_Q 113_A 1.367 0.99
233_M 285_L 1.366 0.99
258_L 265_I 1.363 0.99
58_R 63_R 1.358 0.99
84_T 162_V 1.345 0.99
93_A 101_S 1.345 0.99
116_V 120_R 1.316 0.99
128_I 163_F 1.313 0.99
198_E 320_D 1.303 0.99
194_L 327_A 1.299 0.99
355_T 358_Q 1.289 0.99
116_V 162_V 1.286 0.99
51_I 55_A 1.286 0.99
216_A 306_L 1.284 0.99
52_A 56_N 1.283 0.99
202_I 310_F 1.279 0.99
91_Y 161_D 1.267 0.99
32_H 35_T 1.265 0.99
57_T 61_E 1.265 0.99
355_T 360_D 1.264 0.99
216_A 286_V 1.251 0.99
244_H 255_A 1.243 0.98
160_I 164_K 1.242 0.98
267_W 271_D 1.231 0.98
225_Q 245_V 1.231 0.98
90_R 94_I 1.23 0.98
111_Q 114_K 1.227 0.98
228_G 232_R 1.224 0.98
252_S 354_K 1.223 0.98
201_K 205_I 1.223 0.98
265_I 270_R 1.221 0.98
118_L 121_E 1.199 0.98
54_E 57_T 1.193 0.98
307_T 311_S 1.193 0.98
215_N 272_V 1.184 0.98
215_N 275_R 1.182 0.98
231_S 303_A 1.166 0.97
234_K 284_Y 1.157 0.97
134_R 138_Q 1.156 0.97
41_L 51_I 1.154 0.97
274_A 277_R 1.153 0.97
234_K 237_D 1.15 0.97
236_S 283_A 1.149 0.97
225_Q 233_M 1.146 0.97
202_I 217_M 1.135 0.97
141_D 169_Y 1.134 0.97
243_L 265_I 1.132 0.97
101_S 109_Y 1.123 0.97
84_T 88_L 1.122 0.97
218_L 268_S 1.121 0.97
53_T 60_A 1.118 0.96
340_Y 347_T 1.116 0.96
90_R 171_E 1.111 0.96
222_V 269_L 1.098 0.96
50_A 57_T 1.097 0.96
219_L 286_V 1.096 0.96
193_R 198_E 1.096 0.96
222_V 266_N 1.093 0.96
327_A 331_E 1.091 0.96
162_V 166_A 1.091 0.96
341_K 363_H 1.087 0.96
163_F 172_V 1.086 0.96
337_E 347_T 1.085 0.96
106_L 110_K 1.083 0.96
118_L 146_A 1.083 0.96
134_R 170_G 1.076 0.95
351_L 359_T 1.075 0.95
302_K 305_T 1.073 0.95
163_F 179_A 1.07 0.95
357_Q 360_D 1.056 0.95
117_S 120_R 1.055 0.95
136_I 159_L 1.054 0.95
207_D 218_L 1.054 0.95
225_Q 243_L 1.052 0.95
219_L 273_V 1.051 0.94
266_N 269_L 1.045 0.94
55_A 58_R 1.044 0.94
133_V 168_H 1.035 0.94
116_V 119_L 1.035 0.94
163_F 167_Q 1.034 0.94
288_F 297_R 1.029 0.94
203_F 218_L 1.029 0.94
119_L 159_L 1.026 0.94
205_I 316_L 1.025 0.93
46_A 50_A 1.024 0.93
153_Q 185_P 1.019 0.93
219_L 230_I 1.019 0.93
123_A 131_V 1.018 0.93
194_L 221_L 1.015 0.93
91_Y 112_K 1.014 0.93
227_L 303_A 1.013 0.93
348_Q 360_D 1.007 0.93
109_Y 113_A 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z1bA20.93331000.271Contact Map0.677
1z19A20.7441000.38Contact Map0.676
1a0pA10.71731000.44Contact Map0.588
2a3vA40.721000.449Contact Map0.757
1xo0A20.74131000.485Contact Map0.535
4a8eA10.70671000.494Contact Map0.672
4e0gA10.87471000.547Contact Map0.406
1ae9A20.46931000.589Contact Map0.676
3nkhA20.521000.602Contact Map0.788
1aihA40.418799.90.65Contact Map0.779
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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