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OPENSEQ.org
INTB - Putative prophage P4 integrase
UniProt: P39347 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12364
Length: 396 (372)
Sequences: 5908
Seq/Len: 15.88
INTB
Paralog alert: 0.72 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
110_R 119_D 4.003 1.00
323_C 341_M 3.555 1.00
226_D 229_A 3.199 1.00
314_C 317_G 3.029 1.00
222_W 273_K 3.005 1.00
42_R 45_E 2.692 1.00
221_R 280_D 2.627 1.00
222_W 282_I 2.62 1.00
230_S 266_L 2.512 1.00
96_L 100_E 2.433 1.00
74_K 78_I 2.417 1.00
257_H 342_S 2.396 1.00
322_A 340_Q 2.384 1.00
77_A 146_I 2.362 1.00
116_K 119_D 2.34 1.00
115_L 147_M 2.324 1.00
16_Q 23_Q 2.296 1.00
127_V 139_L 2.258 1.00
320_T 355_H 2.204 1.00
230_S 263_T 2.201 1.00
76_V 112_I 2.182 1.00
327_V 337_V 2.146 1.00
76_V 150_A 2.139 1.00
74_K 109_E 2.133 1.00
211_F 322_A 2.118 1.00
45_E 49_L 2.099 1.00
231_I 258_L 2.083 1.00
77_A 99_L 2.045 1.00
224_E 235_P 2.032 1.00
207_T 217_L 2.008 1.00
207_T 315_G 1.972 1.00
233_T 258_L 1.97 1.00
35_T 38_D 1.951 1.00
36_L 40_R 1.948 1.00
78_I 104_F 1.94 1.00
261_L 265_A 1.935 1.00
202_W 272_I 1.933 1.00
227_F 266_L 1.932 1.00
322_A 326_L 1.895 1.00
120_L 161_A 1.889 1.00
18_R 23_Q 1.883 1.00
368_Q 372_D 1.871 1.00
16_Q 25_M 1.851 1.00
74_K 104_F 1.837 1.00
334_R 350_R 1.827 1.00
106_A 126_A 1.782 1.00
111_N 114_E 1.758 1.00
91_H 95_V 1.744 1.00
214_S 316_H 1.738 1.00
260_P 340_Q 1.731 1.00
220_A 225_I 1.704 1.00
110_R 114_E 1.702 1.00
152_Q 165_A 1.693 1.00
222_W 269_L 1.687 1.00
345_A 351_A 1.686 1.00
203_A 217_L 1.676 1.00
206_L 265_A 1.671 1.00
124_I 140_Q 1.67 1.00
148_R 162_Q 1.646 1.00
134_E 138_R 1.645 1.00
327_V 354_I 1.641 1.00
72_T 75_E 1.639 1.00
333_S 336_A 1.637 1.00
201_R 205_E 1.624 1.00
220_A 232_W 1.618 1.00
151_V 156_I 1.611 1.00
323_C 337_V 1.599 1.00
107_L 123_P 1.591 1.00
99_L 104_F 1.587 1.00
180_E 183_R 1.587 1.00
212_I 234_I 1.582 1.00
88_S 243_G 1.57 1.00
212_I 217_L 1.55 1.00
335_D 338_E 1.537 1.00
73_F 115_L 1.526 1.00
154_G 158_Y 1.512 1.00
226_D 231_I 1.508 1.00
266_L 270_K 1.483 1.00
149_Y 153_S 1.474 1.00
183_R 186_E 1.47 1.00
224_E 238_R 1.466 1.00
110_R 115_L 1.442 1.00
88_S 91_H 1.439 1.00
148_R 159_N 1.433 1.00
262_S 265_A 1.432 1.00
348_S 352_A 1.431 1.00
261_L 266_L 1.427 1.00
179_L 187_L 1.42 1.00
214_S 218_R 1.416 1.00
147_M 160_P 1.396 0.99
227_F 270_K 1.385 0.99
74_K 108_G 1.385 0.99
332_W 369_W 1.378 0.99
263_T 267_A 1.372 0.99
140_Q 144_T 1.365 0.99
76_V 149_Y 1.364 0.99
15_L 42_R 1.351 0.99
73_F 146_I 1.351 0.99
41_V 45_E 1.349 0.99
208_L 318_F 1.34 0.99
78_I 81_H 1.338 0.99
98_S 142_R 1.331 0.99
95_V 142_R 1.322 0.99
121_L 125_K 1.313 0.99
326_L 337_V 1.304 0.99
324_S 356_K 1.3 0.99
209_L 262_S 1.299 0.99
212_I 232_W 1.296 0.99
183_R 311_V 1.296 0.99
184_I 208_L 1.294 0.99
221_R 281_L 1.288 0.99
73_F 143_T 1.288 0.99
87_W 91_H 1.283 0.99
45_E 48_K 1.271 0.99
97_K 101_D 1.267 0.99
144_T 148_R 1.26 0.99
255_T 344_M 1.254 0.99
232_W 261_L 1.253 0.99
147_M 161_A 1.248 0.99
336_A 366_M 1.247 0.99
323_C 327_V 1.246 0.98
216_E 257_H 1.24 0.98
42_R 46_A 1.235 0.98
28_L 42_R 1.232 0.98
123_P 139_L 1.22 0.98
220_A 282_I 1.212 0.98
179_L 313_V 1.196 0.98
112_I 147_M 1.194 0.98
263_T 368_Q 1.19 0.98
202_W 268_I 1.189 0.98
12_Y 27_A 1.188 0.98
14_R 27_A 1.185 0.98
43_R 47_R 1.185 0.98
338_E 351_A 1.179 0.98
361_E 364_R 1.179 0.98
116_K 157_D 1.179 0.98
102_N 130_S 1.17 0.97
203_A 283_F 1.162 0.97
84_N 92_A 1.159 0.97
12_Y 30_V 1.156 0.97
326_L 332_W 1.153 0.97
209_L 265_A 1.153 0.97
347_N 351_A 1.143 0.97
206_L 283_F 1.142 0.97
49_L 54_V 1.131 0.97
186_E 190_K 1.127 0.97
227_F 261_L 1.123 0.97
73_F 77_A 1.123 0.97
224_E 236_P 1.12 0.96
221_R 224_E 1.119 0.96
48_K 52_N 1.118 0.96
238_R 245_K 1.117 0.96
219_F 238_R 1.116 0.96
223_S 280_D 1.116 0.96
78_I 100_E 1.115 0.96
270_K 273_K 1.113 0.96
103_L 143_T 1.11 0.96
102_N 105_A 1.11 0.96
215_S 219_F 1.103 0.96
81_H 84_N 1.096 0.96
79_E 82_G 1.096 0.96
227_F 282_I 1.095 0.96
343_H 349_V 1.091 0.96
80_W 145_A 1.086 0.96
146_I 150_A 1.084 0.96
77_A 104_F 1.083 0.96
117_T 152_Q 1.079 0.95
73_F 107_L 1.078 0.95
177_P 183_R 1.071 0.95
99_L 146_I 1.071 0.95
37_A 40_R 1.063 0.95
205_E 264_Q 1.057 0.95
262_S 371_A 1.047 0.94
202_W 271_Q 1.04 0.94
44_D 51_A 1.039 0.94
192_D 201_R 1.039 0.94
87_W 92_A 1.038 0.94
225_I 232_W 1.038 0.94
4_L 25_M 1.037 0.94
210_I 262_S 1.036 0.94
324_S 354_I 1.031 0.94
332_W 366_M 1.03 0.94
78_I 96_L 1.029 0.94
218_R 295_E 1.028 0.94
206_L 269_L 1.028 0.94
332_W 336_A 1.027 0.94
227_F 230_S 1.023 0.93
120_L 143_T 1.013 0.93
118_R 122_A 1.007 0.93
37_A 41_V 1.005 0.93
365_L 369_W 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z1bA20.82581000.39Contact Map0.609
1z19A20.68181000.464Contact Map0.596
1a0pA10.68691000.466Contact Map0.558
2a3vA40.68691000.476Contact Map0.725
1xo0A20.71721000.516Contact Map0.51
4a8eA10.71461000.52Contact Map0.675
4e0gA10.87371000.562Contact Map0.392
3nkhA20.53031000.596Contact Map0.795
1ae9A20.42171000.646Contact Map0.602
1aihA40.429399.90.66Contact Map0.746
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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