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OPENSEQ.org
DGOD - D-galactonate dehydratase
UniProt: Q6BF17 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20050
Length: 382 (364)
Sequences: 3435
Seq/Len: 9.44
DGOD
Paralog alert: 0.74 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: AEEP DGOD GUDD GUDX MENC RHMD RSPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_Q 66_V 3.689 1.00
113_K 339_F 3.59 1.00
224_A 253_S 3.558 1.00
26_V 93_I 3.355 1.00
95_G 102_V 2.976 1.00
133_K 173_A 2.97 1.00
87_D 266_T 2.814 1.00
240_R 267_E 2.756 1.00
22_T 93_I 2.75 1.00
247_L 280_V 2.669 1.00
19_K 354_E 2.602 1.00
197_I 208_I 2.6 1.00
221_P 225_A 2.598 1.00
198_K 201_E 2.596 1.00
21_E 27_V 2.517 1.00
7_T 19_K 2.416 1.00
29_W 352_I 2.396 1.00
189_S 192_M 2.372 1.00
26_V 97_V 2.356 1.00
262_A 271_I 2.347 1.00
216_Q 219_Y 2.238 1.00
19_K 27_V 2.228 1.00
197_I 227_T 2.148 1.00
201_E 228_H 2.133 1.00
7_T 21_E 2.105 1.00
199_E 202_P 2.023 1.00
129_I 173_A 2.021 1.00
125_P 129_I 2.012 1.00
194_K 226_Q 2.004 1.00
196_L 200_L 1.974 1.00
133_K 137_E 1.966 1.00
22_T 26_V 1.965 1.00
102_V 348_L 1.917 1.00
221_P 249_A 1.902 1.00
218_E 249_A 1.901 1.00
96_K 351_E 1.888 1.00
222_K 225_A 1.878 1.00
136_R 178_I 1.876 1.00
168_A 172_E 1.874 1.00
115_K 141_D 1.871 1.00
6_I 20_I 1.853 1.00
20_I 90_L 1.842 1.00
146_N 185_H 1.834 1.00
244_K 248_E 1.82 1.00
212_V 223_L 1.818 1.00
168_A 202_P 1.782 1.00
336_V 341_K 1.772 1.00
245_R 249_A 1.733 1.00
5_K 49_G 1.728 1.00
201_E 229_I 1.716 1.00
59_R 62_D 1.713 1.00
124_R 127_D 1.697 1.00
164_V 199_E 1.686 1.00
5_K 21_E 1.679 1.00
2_K 23_D 1.651 1.00
248_E 278_Y 1.65 1.00
194_K 223_L 1.648 1.00
61_N 270_K 1.643 1.00
113_K 341_K 1.635 1.00
4_T 21_E 1.573 1.00
26_V 96_K 1.563 1.00
246_V 252_I 1.562 1.00
190_A 223_L 1.56 1.00
1_M 23_D 1.56 1.00
87_D 91_W 1.551 1.00
171_R 175_G 1.529 1.00
273_G 276_E 1.525 1.00
42_E 46_H 1.524 1.00
259_L 268_C 1.517 1.00
232_A 256_Q 1.513 1.00
165_N 168_A 1.511 1.00
258_D 285_H 1.487 1.00
100_A 104_Q 1.481 1.00
210_E 256_Q 1.469 1.00
168_A 203_Y 1.463 1.00
222_K 226_Q 1.459 1.00
56_D 59_R 1.45 1.00
182_L 205_P 1.45 1.00
4_T 23_D 1.443 1.00
24_E 97_V 1.43 1.00
301_F 342_P 1.425 0.99
46_H 49_G 1.412 0.99
239_S 242_D 1.409 0.99
109_L 112_D 1.406 0.99
247_L 274_M 1.406 0.99
174_F 180_F 1.405 0.99
20_I 52_L 1.401 0.99
17_F 357_V 1.399 0.99
247_L 278_Y 1.397 0.99
194_K 222_K 1.394 0.99
130_D 133_K 1.392 0.99
129_I 172_E 1.389 0.99
143_F 178_I 1.388 0.99
91_W 266_T 1.381 0.99
243_F 271_I 1.376 0.99
257_P 268_C 1.376 0.99
267_E 270_K 1.363 0.99
190_A 222_K 1.359 0.99
55_Q 63_L 1.354 0.99
167_V 203_Y 1.342 0.99
63_L 67_M 1.335 0.99
268_C 299_I 1.332 0.99
19_K 29_W 1.33 0.99
136_R 143_F 1.321 0.99
102_V 265_I 1.313 0.99
270_K 276_E 1.298 0.99
171_R 177_Q 1.293 0.99
92_D 96_K 1.29 0.99
58_S 97_V 1.288 0.99
205_P 229_I 1.283 0.99
48_L 67_M 1.279 0.99
233_A 246_V 1.276 0.99
181_G 206_L 1.271 0.99
95_G 105_L 1.27 0.99
63_L 90_L 1.268 0.99
164_V 203_Y 1.265 0.98
171_R 180_F 1.264 0.98
262_A 268_C 1.261 0.98
18_L 85_G 1.258 0.98
101_P 104_Q 1.257 0.98
356_K 359_E 1.25 0.98
123_D 127_D 1.243 0.98
243_F 255_L 1.239 0.98
22_T 97_V 1.236 0.98
55_Q 62_D 1.23 0.98
201_E 227_T 1.22 0.98
354_E 358_I 1.219 0.98
212_V 219_Y 1.216 0.98
218_E 245_R 1.211 0.98
133_K 136_R 1.211 0.98
354_E 357_V 1.208 0.98
169_Q 172_E 1.202 0.98
170_I 174_F 1.199 0.98
134_T 137_E 1.191 0.98
9_Y 19_K 1.188 0.97
9_Y 358_I 1.18 0.97
179_E 206_L 1.178 0.97
55_Q 59_R 1.171 0.97
103_W 298_H 1.17 0.97
352_I 357_V 1.168 0.97
269_Y 273_G 1.16 0.97
169_Q 173_A 1.16 0.97
164_V 168_A 1.152 0.97
184_F 208_I 1.152 0.97
6_I 18_L 1.148 0.97
265_I 299_I 1.147 0.97
297_L 340_F 1.139 0.97
94_K 98_L 1.136 0.96
224_A 250_G 1.129 0.96
167_V 200_L 1.125 0.96
234_G 258_D 1.124 0.96
164_V 202_P 1.122 0.96
132_I 174_F 1.111 0.96
67_M 83_I 1.105 0.96
90_L 94_K 1.097 0.95
17_F 291_I 1.096 0.95
129_I 133_K 1.091 0.95
61_N 269_Y 1.088 0.95
245_R 248_E 1.088 0.95
162_A 165_N 1.085 0.95
64_W 87_D 1.081 0.95
27_V 351_E 1.08 0.95
32_P 85_G 1.077 0.95
198_K 226_Q 1.072 0.95
57_P 90_L 1.071 0.95
3_I 6_I 1.069 0.95
88_Q 295_A 1.068 0.95
353_D 356_K 1.06 0.94
355_A 358_I 1.058 0.94
190_A 212_V 1.056 0.94
58_S 98_L 1.049 0.94
210_E 234_G 1.048 0.94
238_F 242_D 1.045 0.94
259_L 296_C 1.044 0.94
126_A 130_D 1.043 0.94
256_Q 285_H 1.043 0.94
125_P 165_N 1.038 0.93
131_G 134_T 1.037 0.93
212_V 220_Y 1.035 0.93
188_V 208_I 1.035 0.93
136_R 174_F 1.034 0.93
109_L 344_T 1.029 0.93
130_D 134_T 1.027 0.93
134_T 138_I 1.026 0.93
244_K 274_M 1.025 0.93
167_V 182_L 1.021 0.93
232_A 254_I 1.02 0.93
129_I 174_F 1.016 0.92
165_N 169_Q 1.004 0.92
184_F 188_V 1.003 0.92
145_L 170_I 1.002 0.92
142_T 181_G 1.002 0.92
115_K 339_F 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rr1A211000.163Contact Map0.75
3rcyA80.97911000.172Contact Map0.794
3t6cA20.97641000.187Contact Map0.782
4k8gA10.97641000.19Contact Map0.809
3v3wA10.97641000.195Contact Map0.813
3tjiA40.97381000.195Contact Map0.774
3vcnA20.97641000.197Contact Map0.794
4hnlA10.97381000.198Contact Map0.731
3sbfA40.97381000.201Contact Map0.789
4jn7A10.98431000.209Contact Map0.749
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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