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OPENSEQ.org
GUDD - Glucarate dehydratase
UniProt: P0AES2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13167
Length: 446 (388)
Sequences: 2293
Seq/Len: 5.91
GUDD
Paralog alert: 0.71 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: AEEP DGOD GUDD GUDX MENC RHMD RSPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
49_H 123_L 3.946 1.00
144_E 389_L 3.916 1.00
125_G 132_V 3.824 1.00
279_R 308_D 3.725 1.00
75_K 86_L 3.578 1.00
193_E 226_R 3.333 1.00
14_Q 42_I 3.037 1.00
45_D 123_L 2.755 1.00
14_Q 44_K 2.639 1.00
42_I 404_M 2.614 1.00
49_H 127_H 2.595 1.00
249_G 259_A 2.587 1.00
117_E 320_Q 2.54 1.00
13_M 43_I 2.52 1.00
316_F 325_V 2.476 1.00
276_A 280_R 2.446 1.00
52_V 402_I 2.438 1.00
44_K 50_T 2.423 1.00
295_W 321_G 2.411 1.00
302_L 334_L 2.38 1.00
250_K 253_K 2.375 1.00
126_Q 401_E 2.279 1.00
9_V 46_N 2.264 1.00
241_S 244_E 2.252 1.00
12_E 44_K 2.213 1.00
193_E 197_E 2.128 1.00
11_T 44_K 2.127 1.00
45_D 49_H 2.121 1.00
249_G 282_T 2.112 1.00
62_R 66_E 2.108 1.00
299_G 303_S 2.1 1.00
276_A 304_L 2.084 1.00
11_T 46_N 2.057 1.00
12_E 69_I 2.046 1.00
68_A 87_V 2.01 1.00
146_E 202_N 2.001 1.00
189_V 226_R 1.978 1.00
8_P 46_N 1.976 1.00
246_I 281_A 1.959 1.00
13_M 41_V 1.921 1.00
196_Y 230_A 1.915 1.00
253_K 283_G 1.912 1.00
83_V 87_V 1.898 1.00
263_C 278_F 1.868 1.00
227_F 232_I 1.852 1.00
207_K 237_N 1.831 1.00
40_I 407_V 1.814 1.00
42_I 50_T 1.785 1.00
380_K 401_E 1.776 1.00
386_K 391_Q 1.745 1.00
300_H 304_L 1.739 1.00
277_E 280_R 1.712 1.00
253_K 284_L 1.704 1.00
221_V 225_Q 1.691 1.00
251_Y 254_G 1.689 1.00
221_V 254_G 1.684 1.00
185_P 189_V 1.651 1.00
49_H 126_Q 1.646 1.00
248_I 252_L 1.642 1.00
16_I 42_I 1.621 1.00
76_T 79_E 1.613 0.99
256_L 284_L 1.612 0.99
132_V 398_L 1.608 0.99
204_F 230_A 1.593 0.99
313_D 339_H 1.591 0.99
327_Q 330_H 1.589 0.99
78_G 127_H 1.574 0.99
184_T 187_A 1.566 0.99
79_E 82_N 1.566 0.99
324_R 330_H 1.51 0.99
40_I 346_I 1.497 0.99
270_S 304_L 1.496 0.99
287_A 311_L 1.491 0.99
206_L 223_L 1.468 0.99
314_P 322_S 1.467 0.99
406_Q 409_K 1.459 0.99
47_S 127_H 1.458 0.99
404_M 407_V 1.45 0.99
144_E 391_Q 1.447 0.99
13_M 69_I 1.445 0.99
267_Q 271_G 1.433 0.98
81_K 324_R 1.423 0.98
16_I 408_M 1.422 0.98
189_V 227_F 1.405 0.98
261_D 311_L 1.4 0.98
45_D 127_H 1.395 0.98
132_V 319_M 1.393 0.98
63_K 67_D 1.391 0.98
402_I 407_V 1.391 0.98
196_Y 204_F 1.388 0.98
190_R 193_E 1.388 0.98
50_T 401_E 1.388 0.98
43_I 72_V 1.386 0.98
277_E 281_A 1.384 0.98
223_L 227_F 1.382 0.98
87_V 113_V 1.374 0.98
356_A 392_V 1.37 0.98
288_T 301_T 1.365 0.98
120_M 124_L 1.355 0.98
66_E 69_I 1.349 0.98
302_L 328_M 1.348 0.98
298_M 310_P 1.348 0.98
220_I 255_S 1.342 0.97
43_I 120_M 1.336 0.97
242_L 278_F 1.335 0.97
303_S 332_F 1.316 0.97
242_L 277_E 1.308 0.97
76_T 134_S 1.308 0.97
68_A 116_I 1.302 0.97
212_A 215_E 1.289 0.96
83_V 86_L 1.284 0.96
117_E 121_L 1.277 0.96
405_D 408_M 1.274 0.96
404_M 408_M 1.273 0.96
75_K 83_V 1.267 0.96
11_T 45_D 1.26 0.96
220_I 234_L 1.258 0.96
218_E 221_V 1.255 0.96
350_M 398_L 1.254 0.96
125_G 135_L 1.248 0.96
298_M 325_V 1.243 0.95
125_G 398_L 1.238 0.95
75_K 82_N 1.235 0.95
262_P 286_T 1.234 0.95
130_V 134_S 1.231 0.95
78_G 128_L 1.225 0.95
15_V 65_L 1.215 0.95
356_A 393_P 1.213 0.95
246_I 278_F 1.211 0.95
391_Q 394_E 1.202 0.94
75_K 79_E 1.195 0.94
217_A 221_V 1.191 0.94
316_F 322_S 1.19 0.94
185_P 218_E 1.186 0.94
129_G 396_P 1.184 0.94
13_M 72_V 1.184 0.94
218_E 222_A 1.183 0.94
46_N 77_L 1.182 0.94
189_V 193_E 1.181 0.94
322_S 354_V 1.173 0.93
323_V 327_Q 1.168 0.93
221_V 255_S 1.165 0.93
302_L 332_F 1.162 0.93
406_Q 410_A 1.161 0.93
16_I 402_I 1.156 0.93
186_D 190_R 1.153 0.92
217_A 251_Y 1.151 0.92
253_K 282_T 1.137 0.92
293_T 297_Q 1.136 0.92
301_T 307_V 1.132 0.92
140_Q 394_E 1.125 0.91
207_K 216_E 1.125 0.91
41_V 115_G 1.124 0.91
140_Q 143_S 1.122 0.91
216_E 237_N 1.109 0.90
236_P 259_A 1.103 0.90
81_K 323_V 1.103 0.90
403_D 406_Q 1.096 0.90
144_E 387_G 1.093 0.90
187_A 190_R 1.091 0.89
224_A 229_Q 1.091 0.89
77_L 120_M 1.09 0.89
124_L 128_L 1.085 0.89
27_N 32_H 1.082 0.89
319_M 323_V 1.08 0.89
83_V 120_M 1.079 0.89
194_A 197_E 1.078 0.89
311_L 338_S 1.078 0.89
13_M 116_I 1.077 0.89
405_D 409_K 1.077 0.89
227_F 230_A 1.076 0.89
217_A 254_G 1.073 0.88
294_D 297_Q 1.072 0.88
193_E 196_Y 1.071 0.88
263_C 271_G 1.07 0.88
192_A 227_F 1.069 0.88
202_N 387_G 1.069 0.88
307_V 310_P 1.065 0.88
55_I 115_G 1.064 0.88
65_L 69_I 1.063 0.88
16_I 411_H 1.061 0.88
275_M 288_T 1.06 0.88
300_H 303_S 1.052 0.87
183_M 187_A 1.051 0.87
189_V 225_Q 1.051 0.87
65_L 116_I 1.049 0.87
220_I 252_L 1.043 0.86
312_A 322_S 1.034 0.86
240_W 248_I 1.032 0.86
289_N 313_D 1.027 0.85
380_K 403_D 1.027 0.85
250_K 281_A 1.025 0.85
189_V 223_L 1.021 0.85
215_E 218_E 1.017 0.84
209_G 216_E 1.016 0.84
47_S 77_L 1.015 0.84
270_S 300_H 1.011 0.84
261_D 289_N 1.01 0.84
279_R 305_Q 1.008 0.84
275_M 286_T 1.007 0.84
234_L 256_L 1.004 0.83
214_E 228_P 1.003 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3mznA20.98431000.215Contact Map0.659
4hyrA20.98651000.217Contact Map0.689
3pfrA40.98651000.227Contact Map0.691
3p0wA40.9911000.23Contact Map0.676
4g8tA40.99331000.232Contact Map0.708
3vc5A10.93721000.295Contact Map0.678
4it1A40.94391000.299Contact Map0.741
3vdgA10.93721000.301Contact Map0.699
3va8A10.93721000.314Contact Map0.687
3i6eA80.83181000.351Contact Map0.695
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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