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GUDX - Glucarate dehydratase-related protein
UniProt: Q46915 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13168
Length: 446 (394)
Sequences: 2056
Seq/Len: 5.22
GUDX
Paralog alert: 0.67 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: AEEP DGOD GUDD GUDX MENC RHMD RSPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_Q 85_Q 4.174 1.00
278_R 307_D 3.929 1.00
48_H 122_L 3.839 1.00
143_A 388_K 3.826 1.00
124_G 131_V 3.545 1.00
192_E 225_R 3.291 1.00
13_K 41_V 3.274 1.00
41_V 403_W 2.781 1.00
51_I 401_L 2.765 1.00
44_D 122_L 2.756 1.00
301_V 333_L 2.678 1.00
12_M 42_L 2.608 1.00
275_A 279_R 2.587 1.00
248_C 258_A 2.484 1.00
116_E 319_S 2.435 1.00
13_K 43_T 2.428 1.00
240_L 243_E 2.417 1.00
294_W 320_G 2.412 1.00
43_T 49_T 2.375 1.00
11_D 43_T 2.372 1.00
192_E 196_D 2.315 1.00
248_C 281_T 2.269 1.00
125_K 400_E 2.26 1.00
249_K 252_N 2.228 1.00
245_I 280_A 2.215 1.00
206_K 236_N 2.206 1.00
315_F 324_V 2.198 1.00
10_T 45_N 2.17 1.00
39_I 406_V 2.155 1.00
8_V 45_N 2.126 1.00
252_N 282_G 2.1 1.00
48_H 126_A 2.088 1.00
44_D 48_H 1.995 1.00
67_A 86_V 1.97 1.00
145_T 201_K 1.962 1.00
61_Y 65_V 1.92 1.00
298_G 302_M 1.901 1.00
275_A 303_L 1.892 1.00
262_C 277_F 1.865 1.00
10_T 43_T 1.864 1.00
41_V 49_T 1.858 1.00
184_S 188_V 1.847 1.00
226_F 231_I 1.82 1.00
12_M 40_V 1.761 1.00
11_D 68_I 1.755 1.00
312_D 338_H 1.755 1.00
385_K 390_A 1.749 1.00
75_E 78_R 1.715 1.00
188_V 225_R 1.708 1.00
131_V 397_L 1.685 1.00
241_L 277_F 1.675 1.00
195_Q 229_A 1.675 1.00
82_V 86_V 1.669 0.99
379_Q 400_E 1.666 0.99
48_H 125_K 1.659 0.99
276_E 279_R 1.626 0.99
220_R 253_D 1.621 0.99
403_W 406_V 1.615 0.99
15_I 41_V 1.604 0.99
82_V 119_L 1.597 0.99
247_L 251_L 1.567 0.99
301_V 327_L 1.551 0.99
189_R 192_E 1.548 0.99
252_N 283_L 1.536 0.99
119_L 123_L 1.53 0.99
276_E 280_A 1.526 0.99
245_I 277_F 1.512 0.99
205_L 222_L 1.509 0.99
39_I 345_I 1.504 0.99
299_H 303_L 1.504 0.99
216_I 253_D 1.501 0.99
321_A 353_V 1.5 0.99
220_R 224_K 1.494 0.99
78_R 81_K 1.481 0.98
401_L 406_V 1.477 0.98
286_A 310_L 1.471 0.98
7_P 45_N 1.471 0.98
195_Q 203_F 1.466 0.98
250_G 253_D 1.458 0.98
323_R 329_D 1.44 0.98
78_R 133_E 1.415 0.98
65_V 68_I 1.413 0.98
183_N 186_A 1.413 0.98
42_L 119_L 1.412 0.98
128_N 395_P 1.402 0.98
203_F 229_A 1.398 0.98
77_A 127_L 1.398 0.98
116_E 120_L 1.385 0.97
80_N 323_R 1.372 0.97
405_Q 408_K 1.369 0.97
300_A 306_V 1.361 0.97
216_I 250_G 1.358 0.97
318_L 353_V 1.358 0.97
269_S 303_L 1.358 0.97
44_D 126_A 1.356 0.97
302_M 331_W 1.353 0.97
143_A 390_A 1.351 0.97
46_A 126_A 1.343 0.97
75_E 133_E 1.342 0.97
139_K 142_E 1.341 0.97
129_V 133_E 1.34 0.97
54_A 114_A 1.338 0.97
355_A 391_V 1.328 0.96
241_L 276_E 1.326 0.96
184_S 217_D 1.322 0.96
42_L 71_V 1.322 0.96
260_D 310_L 1.316 0.96
297_M 324_V 1.313 0.96
404_E 407_Q 1.312 0.96
211_P 214_Q 1.312 0.96
403_W 407_Q 1.31 0.96
255_L 283_L 1.31 0.96
219_V 233_V 1.308 0.96
77_A 126_A 1.305 0.96
188_V 226_F 1.305 0.96
222_L 226_F 1.303 0.96
215_E 236_N 1.3 0.96
185_E 189_R 1.299 0.96
74_Q 81_K 1.285 0.95
49_T 400_E 1.282 0.95
349_M 397_L 1.282 0.95
292_T 296_E 1.276 0.95
402_D 405_Q 1.267 0.95
191_A 226_F 1.26 0.95
220_R 254_V 1.259 0.95
12_M 71_V 1.254 0.95
191_A 222_L 1.252 0.95
131_V 318_L 1.245 0.94
287_T 300_A 1.244 0.94
82_V 85_Q 1.243 0.94
297_M 309_P 1.231 0.94
39_I 51_I 1.229 0.94
266_Q 270_G 1.228 0.94
301_V 331_W 1.225 0.94
213_E 246_S 1.216 0.93
14_V 64_L 1.202 0.93
301_V 309_P 1.199 0.93
86_V 112_V 1.198 0.93
239_W 258_A 1.196 0.93
124_G 134_L 1.188 0.92
67_A 115_L 1.181 0.92
322_V 326_Q 1.181 0.92
318_L 322_V 1.178 0.92
214_Q 217_D 1.177 0.92
74_Q 78_R 1.169 0.91
326_Q 329_D 1.168 0.91
245_I 276_E 1.165 0.91
206_K 215_E 1.163 0.91
12_M 68_I 1.161 0.91
99_G 102_A 1.16 0.91
390_A 393_D 1.155 0.91
380_N 394_A 1.154 0.91
207_G 235_P 1.147 0.90
219_V 254_V 1.147 0.90
74_Q 82_V 1.146 0.90
76_V 119_L 1.142 0.90
252_N 281_T 1.139 0.90
288_N 312_D 1.137 0.90
139_K 393_D 1.135 0.90
123_L 127_L 1.132 0.90
71_V 85_Q 1.131 0.90
310_L 337_C 1.129 0.89
217_D 220_R 1.115 0.89
45_N 76_V 1.114 0.89
10_T 44_D 1.113 0.89
223_K 228_D 1.111 0.88
310_L 338_H 1.11 0.88
262_C 270_G 1.104 0.88
260_D 288_N 1.103 0.88
171_H 174_Y 1.097 0.88
249_K 282_G 1.096 0.88
351_T 389_I 1.088 0.87
299_H 302_M 1.083 0.87
208_G 215_E 1.083 0.87
120_L 319_S 1.082 0.87
223_K 231_I 1.08 0.87
288_N 310_L 1.079 0.86
379_Q 402_D 1.079 0.86
15_I 407_Q 1.075 0.86
311_A 321_A 1.071 0.86
291_A 296_E 1.071 0.86
355_A 392_P 1.062 0.85
70_M 85_Q 1.061 0.85
345_I 348_A 1.059 0.85
274_M 287_T 1.058 0.85
128_N 394_A 1.057 0.85
188_V 192_E 1.054 0.85
42_L 115_L 1.049 0.84
226_F 229_A 1.047 0.84
15_I 410_H 1.047 0.84
293_N 296_E 1.042 0.84
41_V 51_I 1.041 0.84
145_T 388_K 1.04 0.84
64_L 68_I 1.04 0.84
9_I 12_M 1.032 0.83
26_N 31_H 1.031 0.83
62_Q 66_D 1.03 0.83
186_A 189_R 1.022 0.82
239_W 247_L 1.021 0.82
320_G 323_R 1.016 0.82
235_P 258_A 1.011 0.81
232_T 256_T 1.008 0.81
313_P 321_A 1 0.80
188_V 224_K 1 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pfrA40.99331000.249Contact Map0.705
4hyrA20.98431000.253Contact Map0.709
3mznA20.98211000.255Contact Map0.678
4g8tA40.98431000.266Contact Map0.716
3p0wA40.98431000.267Contact Map0.702
3vc5A10.93051000.309Contact Map0.711
3vdgA10.92831000.309Contact Map0.726
4it1A40.94171000.311Contact Map0.756
3va8A10.9261000.323Contact Map0.724
3i6eA80.82741000.36Contact Map0.702
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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