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OPENSEQ.org
RSPA - Starvation-sensing protein RspA
UniProt: P38104 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12451
Length: 404 (370)
Sequences: 2927
Seq/Len: 7.91
RSPA
Paralog alert: 0.72 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: AEEP DGOD GUDD GUDX MENC RHMD RSPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
58_R 69_F 3.89 1.00
116_G 363_Y 3.888 1.00
253_R 282_D 3.794 1.00
98_A 105_L 3.561 1.00
28_I 96_I 3.483 1.00
226_G 237_M 2.909 1.00
90_D 295_T 2.891 1.00
21_K 378_E 2.883 1.00
136_A 202_K 2.822 1.00
24_T 96_I 2.792 1.00
276_I 309_V 2.677 1.00
31_L 376_F 2.671 1.00
250_R 254_Q 2.635 1.00
227_K 230_E 2.628 1.00
28_I 100_A 2.582 1.00
269_I 296_G 2.531 1.00
291_A 300_I 2.518 1.00
23_T 29_T 2.489 1.00
218_T 221_E 2.374 1.00
24_T 28_I 2.21 1.00
245_N 248_C 2.179 1.00
99_K 375_E 2.17 1.00
7_E 21_K 2.159 1.00
230_E 257_V 2.157 1.00
226_G 256_T 2.133 1.00
118_M 144_K 2.125 1.00
223_A 255_H 2.124 1.00
139_Q 207_E 2.103 1.00
51_L 70_F 2.024 1.00
250_R 278_E 2.018 1.00
149_Q 214_H 2.007 1.00
251_L 254_Q 1.958 1.00
241_T 252_I 1.956 1.00
273_K 277_E 1.95 1.00
228_S 231_D 1.941 1.00
21_K 29_T 1.939 1.00
247_E 278_E 1.931 1.00
6_A 22_I 1.909 1.00
132_L 202_K 1.89 1.00
360_D 365_H 1.878 1.00
105_L 372_L 1.854 1.00
225_F 229_I 1.843 1.00
136_A 140_E 1.832 1.00
197_D 201_N 1.818 1.00
219_P 252_I 1.816 1.00
44_A 48_Q 1.815 1.00
22_I 93_L 1.807 1.00
200_R 204_G 1.803 1.00
223_A 252_I 1.792 1.00
230_E 258_T 1.769 1.00
28_I 99_K 1.747 1.00
274_Q 278_E 1.727 1.00
19_T 381_A 1.695 1.00
128_I 132_L 1.649 1.00
261_A 285_R 1.642 1.00
66_I 70_F 1.635 1.00
116_G 365_H 1.627 1.00
1_M 25_E 1.607 1.00
59_D 62_R 1.601 1.00
90_D 94_W 1.598 1.00
146_I 207_E 1.597 1.00
239_D 285_R 1.591 1.00
7_E 23_T 1.578 1.00
203_F 209_L 1.564 1.00
45_S 49_D 1.562 1.00
288_L 297_M 1.56 1.00
302_D 305_S 1.546 1.00
234_M 258_T 1.546 1.00
6_A 20_L 1.527 1.00
287_T 314_H 1.522 1.00
26_D 100_A 1.521 1.00
61_H 100_A 1.515 1.00
297_M 330_F 1.505 1.00
332_L 366_P 1.504 1.00
275_L 281_I 1.499 1.00
2_K 25_E 1.485 0.99
62_R 65_D 1.484 0.99
22_I 55_L 1.449 0.99
197_D 231_D 1.447 0.99
299_R 305_S 1.44 0.99
64_E 299_R 1.414 0.99
199_V 203_F 1.412 0.99
24_T 100_A 1.408 0.99
251_L 255_H 1.404 0.99
276_I 303_F 1.402 0.99
272_C 300_I 1.391 0.99
139_Q 146_I 1.388 0.99
277_E 307_Y 1.387 0.99
5_K 23_T 1.386 0.99
276_I 307_Y 1.383 0.99
197_D 232_Y 1.381 0.99
58_R 66_I 1.376 0.99
112_A 115_E 1.373 0.99
98_A 108_L 1.371 0.99
210_L 235_F 1.366 0.99
291_A 297_M 1.365 0.99
103_M 107_Q 1.364 0.99
380_L 383_K 1.362 0.99
219_P 251_L 1.361 0.99
286_T 297_M 1.353 0.99
230_E 256_T 1.349 0.99
77_R 80_P 1.348 0.99
66_I 93_L 1.346 0.99
70_F 86_I 1.345 0.99
127_S 130_E 1.34 0.99
378_E 381_A 1.326 0.98
136_A 139_Q 1.307 0.98
223_A 251_L 1.3 0.98
93_L 97_K 1.291 0.98
194_K 197_D 1.29 0.98
29_T 375_E 1.285 0.98
58_R 62_R 1.282 0.98
105_L 294_I 1.279 0.98
376_F 381_A 1.272 0.98
262_V 275_L 1.266 0.98
61_H 101_A 1.26 0.98
196_F 211_H 1.254 0.98
135_Y 203_F 1.254 0.98
213_M 237_M 1.253 0.98
34_A 88_A 1.251 0.98
64_E 298_R 1.25 0.98
148_V 199_V 1.248 0.98
94_W 295_T 1.247 0.98
67_W 90_D 1.243 0.97
354_P 375_E 1.237 0.97
326_A 372_L 1.234 0.97
193_P 228_S 1.23 0.97
211_H 234_M 1.221 0.97
227_K 257_V 1.213 0.97
133_D 136_A 1.204 0.97
298_R 302_D 1.201 0.97
190_D 205_F 1.195 0.97
112_A 368_D 1.195 0.97
58_R 65_D 1.194 0.97
294_I 330_F 1.192 0.96
272_C 284_I 1.189 0.96
378_E 382_A 1.187 0.96
4_V 25_E 1.185 0.96
137_R 140_E 1.181 0.96
241_T 248_C 1.181 0.96
51_L 89_V 1.178 0.96
3_I 6_A 1.178 0.96
106_Y 329_H 1.173 0.96
266_F 271_D 1.172 0.96
97_K 101_A 1.169 0.96
20_L 88_A 1.167 0.96
274_Q 277_E 1.166 0.96
196_F 229_I 1.16 0.96
19_T 322_V 1.159 0.96
263_G 287_T 1.152 0.96
200_R 206_N 1.152 0.96
21_K 31_L 1.149 0.95
198_A 202_K 1.147 0.95
59_D 107_Q 1.138 0.95
54_Q 69_F 1.138 0.95
196_F 232_Y 1.126 0.95
296_G 299_R 1.126 0.95
130_E 133_D 1.119 0.94
217_L 237_M 1.116 0.94
380_L 384_Y 1.11 0.94
198_A 201_N 1.106 0.94
9_F 21_K 1.103 0.94
227_K 255_H 1.102 0.94
101_A 104_P 1.102 0.94
267_N 271_D 1.093 0.94
150_C 213_M 1.092 0.94
42_S 45_S 1.083 0.93
19_T 31_L 1.076 0.93
268_S 271_D 1.074 0.93
132_L 136_A 1.069 0.93
98_A 372_L 1.065 0.92
239_D 263_G 1.065 0.92
102_N 370_P 1.064 0.92
379_K 382_A 1.058 0.92
67_W 295_T 1.056 0.92
128_I 194_K 1.046 0.91
26_D 60_A 1.04 0.91
219_P 241_T 1.039 0.91
66_I 69_F 1.036 0.91
4_V 23_T 1.03 0.91
276_I 284_I 1.029 0.91
253_R 279_Q 1.026 0.90
132_L 203_F 1.022 0.90
118_M 363_Y 1.016 0.90
139_Q 203_F 1.013 0.90
263_G 285_R 1.012 0.90
241_T 249_F 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4il2A411000.186Contact Map0.825
4k8gA10.99261000.196Contact Map0.813
3rcyA80.93811000.199Contact Map0.793
3v3wA10.99261000.2Contact Map0.813
3t6cA20.99261000.201Contact Map0.768
3vcnA20.99261000.204Contact Map0.792
3tjiA40.97031000.209Contact Map0.773
4hnlA10.97281000.213Contact Map0.718
3sbfA40.96041000.214Contact Map0.794
3rr1A20.92331000.236Contact Map0.75
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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