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OPENSEQ.org
RHMD - L-rhamnonate dehydratase
UniProt: P77215 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14085
Length: 401 (341)
Sequences: 2557
Seq/Len: 7.50
RHMD
Paralog alert: 0.73 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: AEEP DGOD GUDD GUDX MENC RHMD RSPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
163_E 374_R 4.048 1.00
103_K 114_Q 4.011 1.00
263_K 293_D 3.883 1.00
145_G 152_V 3.674 1.00
76_Q 143_L 3.65 1.00
69_E 391_R 3.164 1.00
237_H 240_A 3.052 1.00
72_A 143_L 2.879 1.00
137_D 306_T 2.85 1.00
260_R 264_R 2.826 1.00
288_S 320_Q 2.821 1.00
302_C 311_I 2.807 1.00
79_F 389_L 2.806 1.00
236_A 247_I 2.778 1.00
281_L 307_T 2.682 1.00
76_Q 147_V 2.627 1.00
71_E 77_T 2.56 1.00
228_D 231_Y 2.434 1.00
285_R 289_E 2.238 1.00
236_A 266_A 2.199 1.00
165_Q 182_I 2.18 1.00
146_K 388_E 2.165 1.00
72_A 76_Q 2.126 1.00
257_E 290_T 2.121 1.00
96_L 115_M 2.095 1.00
69_E 77_T 2.091 1.00
260_R 290_T 2.071 1.00
89_C 93_E 2.066 1.00
371_V 376_H 1.98 1.00
286_T 290_T 1.965 1.00
233_T 265_N 1.96 1.00
152_V 385_F 1.957 1.00
255_Q 258_S 1.925 1.00
207_A 211_E 1.901 1.00
251_L 262_L 1.874 1.00
213_C 219_L 1.868 1.00
378_S 382_K 1.861 1.00
235_L 239_C 1.861 1.00
187_P 224_W 1.742 1.00
106_S 147_V 1.741 1.00
90_F 94_K 1.74 1.00
74_N 147_V 1.729 1.00
238_A 241_P 1.728 1.00
273_T 296_Q 1.724 1.00
67_V 394_N 1.691 1.00
70_V 140_L 1.686 1.00
111_I 115_M 1.678 1.00
210_R 214_G 1.672 1.00
229_V 262_L 1.66 1.00
240_A 267_P 1.644 1.00
299_V 308_L 1.634 1.00
233_T 262_L 1.632 1.00
207_A 242_Y 1.627 1.00
104_C 107_D 1.618 1.00
261_E 264_R 1.612 1.00
163_E 376_H 1.606 1.00
249_E 296_Q 1.59 1.00
298_D 325_H 1.587 1.00
310_E 316_K 1.581 1.00
76_Q 146_K 1.549 1.00
111_I 140_L 1.533 1.00
203_A 238_A 1.533 1.00
207_A 241_P 1.529 1.00
104_C 154_K 1.528 1.00
109_K 310_E 1.517 0.99
177_K 217_F 1.514 0.99
308_L 334_A 1.504 0.99
209_M 213_C 1.499 0.99
115_M 133_I 1.495 0.99
184_G 217_F 1.495 0.99
152_V 305_L 1.477 0.99
72_A 147_V 1.47 0.99
107_D 110_L 1.46 0.99
288_S 318_R 1.459 0.99
103_K 111_I 1.453 0.99
313_A 316_K 1.449 0.99
289_E 318_R 1.449 0.99
284_F 311_I 1.437 0.99
240_A 270_M 1.429 0.99
96_L 136_V 1.419 0.99
336_I 377_K 1.412 0.99
70_V 100_I 1.411 0.99
159_A 162_D 1.401 0.99
150_L 154_K 1.389 0.99
229_V 261_E 1.382 0.99
288_S 314_I 1.368 0.99
140_L 144_F 1.361 0.99
206_V 242_Y 1.35 0.99
274_S 287_L 1.338 0.98
261_E 265_N 1.336 0.98
137_D 141_W 1.336 0.98
99_F 114_Q 1.331 0.98
109_K 309_V 1.331 0.98
77_T 388_E 1.324 0.98
287_L 292_I 1.316 0.98
221_L 244_L 1.316 0.98
302_C 308_L 1.314 0.98
365_L 388_E 1.309 0.98
204_A 207_A 1.299 0.98
309_V 313_A 1.291 0.98
206_V 239_C 1.288 0.98
280_T 283_S 1.276 0.98
250_C 272_V 1.263 0.97
159_A 381_D 1.262 0.97
186_M 209_M 1.258 0.97
223_C 247_I 1.258 0.97
145_G 155_L 1.255 0.97
284_F 295_M 1.249 0.97
240_A 266_A 1.247 0.97
227_Q 235_L 1.243 0.97
145_G 385_F 1.234 0.97
206_V 221_L 1.228 0.97
244_L 270_M 1.225 0.97
305_L 334_A 1.224 0.97
390_N 393_C 1.223 0.97
204_A 208_D 1.218 0.97
106_S 148_V 1.218 0.97
257_E 286_T 1.21 0.97
92_V 97_N 1.2 0.96
203_A 242_Y 1.194 0.96
103_K 110_L 1.193 0.96
297_P 308_L 1.191 0.96
237_H 265_N 1.19 0.96
144_F 148_V 1.188 0.96
286_T 289_E 1.188 0.96
278_H 283_S 1.182 0.96
103_K 107_D 1.181 0.96
288_S 295_M 1.163 0.95
233_T 261_E 1.16 0.95
177_K 184_G 1.16 0.95
112_H 137_D 1.153 0.95
366_N 388_E 1.152 0.95
391_R 394_N 1.141 0.95
208_D 211_E 1.134 0.94
279_G 283_S 1.132 0.94
198_G 201_K 1.129 0.94
141_W 306_T 1.124 0.94
259_Y 274_S 1.121 0.94
365_L 368_P 1.116 0.94
251_L 258_S 1.108 0.94
220_M 245_K 1.104 0.93
67_V 79_F 1.102 0.93
210_R 216_D 1.102 0.93
208_D 212_K 1.091 0.93
73_E 105_V 1.089 0.93
69_E 79_F 1.085 0.93
227_Q 247_I 1.082 0.92
393_C 396_K 1.079 0.92
203_A 207_A 1.076 0.92
203_A 241_P 1.074 0.92
111_I 114_Q 1.071 0.92
187_P 202_D 1.07 0.92
149_G 383_P 1.064 0.92
82_S 135_C 1.062 0.92
307_T 310_E 1.054 0.91
249_E 275_G 1.053 0.91
200_R 238_A 1.052 0.91
275_G 298_D 1.052 0.91
299_V 331_S 1.044 0.91
210_R 219_L 1.044 0.91
68_V 135_C 1.043 0.91
200_R 215_E 1.042 0.90
112_H 116_L 1.039 0.90
234_K 238_A 1.036 0.90
124_G 127_G 1.033 0.90
376_H 381_D 1.031 0.90
151_P 333_H 1.021 0.89
74_N 105_V 1.013 0.89
213_C 217_F 1.007 0.88
223_C 227_Q 1.002 0.88
154_K 381_D 1.002 0.88
266_A 270_M 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ekgA20.97511000.166Contact Map0.687
2p3zA211000.177Contact Map0.738
3fxgA80.98251000.187Contact Map0.72
3stpA10.94761000.232Contact Map0.734
3cyjA40.87531000.251Contact Map0.724
3i4kA80.86281000.251Contact Map0.734
3dgbA10.86281000.256Contact Map0.7
4hpnA10.86781000.257Contact Map0.698
3toyA40.86031000.258Contact Map0.652
3ugvA80.86281000.258Contact Map0.676
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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