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OPENSEQ.org
YGBN - Inner membrane permease YgbN
UniProt: Q46892 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13108
Length: 454 (446)
Sequences: 1313
Seq/Len: 2.94
YGBN
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DSDX GNTP GNTT GNTU IDNT YGBN YJHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
19_L 24_A 3.563 1.00
246_I 287_L 3.44 1.00
53_V 333_E 3.078 1.00
91_Y 237_V 3.009 1.00
237_V 241_T 2.976 1.00
171_L 399_A 2.952 1.00
13_G 39_V 2.881 1.00
199_I 203_R 2.847 1.00
119_D 412_S 2.658 1.00
103_A 194_Y 2.574 1.00
329_K 333_E 2.529 1.00
16_M 38_L 2.468 1.00
84_G 240_V 2.443 1.00
424_S 427_D 2.313 1.00
445_L 449_C 2.241 1.00
449_C 453_V 2.24 1.00
81_H 306_I 2.209 1.00
167_A 373_I 2.19 1.00
356_F 440_G 2.133 1.00
192_V 442_T 2.072 1.00
119_D 321_T 2.011 1.00
360_L 405_G 1.98 1.00
401_F 443_G 1.978 1.00
441_F 445_L 1.942 0.99
364_A 406_A 1.912 0.99
13_G 327_F 1.87 0.99
338_K 342_N 1.835 0.99
353_P 444_F 1.819 0.99
236_G 239_L 1.814 0.99
321_T 412_S 1.784 0.99
74_M 307_M 1.767 0.99
434_V 438_I 1.765 0.99
170_L 377_G 1.756 0.99
56_A 60_G 1.754 0.99
406_A 433_T 1.751 0.99
62_L 322_G 1.751 0.99
118_F 413_G 1.748 0.99
35_V 128_I 1.739 0.99
54_M 326_V 1.736 0.99
407_S 411_D 1.722 0.98
15_I 19_L 1.717 0.98
266_P 270_T 1.694 0.98
156_V 404_L 1.655 0.98
40_A 330_V 1.636 0.98
286_V 290_W 1.593 0.97
19_L 23_K 1.57 0.97
196_A 434_V 1.566 0.97
39_V 327_F 1.538 0.96
364_A 405_G 1.532 0.96
238_A 242_S 1.504 0.96
78_M 288_A 1.498 0.95
178_L 396_T 1.486 0.95
405_G 440_G 1.459 0.95
30_V 285_L 1.452 0.94
122_F 420_Y 1.448 0.94
196_A 199_I 1.445 0.94
98_D 135_V 1.427 0.94
149_G 193_G 1.425 0.94
152_L 436_T 1.42 0.93
184_A 188_P 1.403 0.93
389_P 392_C 1.396 0.93
342_N 345_Q 1.396 0.93
185_I 450_V 1.395 0.93
26_V 31_A 1.394 0.93
41_L 47_A 1.391 0.93
173_A 178_L 1.391 0.93
356_F 444_F 1.383 0.92
418_T 428_G 1.382 0.92
154_V 161_H 1.362 0.91
192_V 195_F 1.353 0.91
428_G 432_W 1.351 0.91
426_A 430_K 1.347 0.91
287_L 291_L 1.344 0.91
144_G 421_L 1.34 0.91
121_G 151_M 1.339 0.91
290_W 295_R 1.333 0.90
58_M 66_T 1.33 0.90
383_A 389_P 1.329 0.90
185_I 399_A 1.315 0.89
9_I 42_A 1.306 0.89
147_V 150_I 1.303 0.89
118_F 417_V 1.289 0.88
363_R 411_D 1.289 0.88
340_L 365_S 1.289 0.88
49_E 52_K 1.288 0.88
57_G 329_K 1.284 0.88
46_P 49_E 1.282 0.88
113_G 161_H 1.282 0.88
32_L 327_F 1.281 0.88
77_R 81_H 1.279 0.88
20_L 26_V 1.278 0.88
405_G 437_T 1.277 0.88
13_G 38_L 1.273 0.87
90_N 135_V 1.267 0.87
181_I 397_L 1.267 0.87
18_L 22_I 1.261 0.87
97_G 100_R 1.25 0.86
109_A 121_G 1.235 0.85
67_I 71_L 1.232 0.85
299_S 302_H 1.228 0.85
27_Q 30_V 1.226 0.84
152_L 404_L 1.222 0.84
41_L 283_I 1.22 0.84
450_V 453_V 1.217 0.84
67_I 278_M 1.216 0.84
74_M 285_L 1.209 0.83
16_M 20_L 1.202 0.83
314_A 318_I 1.201 0.83
154_V 164_P 1.199 0.83
55_I 64_S 1.198 0.83
239_L 291_L 1.189 0.82
21_V 28_P 1.189 0.82
433_T 440_G 1.187 0.82
349_L 357_I 1.185 0.82
116_V 148_A 1.177 0.81
250_I 283_I 1.171 0.81
112_L 125_L 1.17 0.81
173_A 396_T 1.168 0.80
323_A 326_V 1.165 0.80
53_V 329_K 1.163 0.80
180_I 184_A 1.157 0.79
152_L 369_A 1.154 0.79
13_G 43_A 1.143 0.78
379_L 398_A 1.142 0.78
155_H 161_H 1.141 0.78
103_A 107_L 1.141 0.78
94_R 202_K 1.138 0.78
53_V 331_L 1.133 0.77
196_A 200_I 1.131 0.77
18_L 35_V 1.129 0.77
397_L 447_T 1.128 0.77
106_T 190_G 1.125 0.77
37_L 279_V 1.125 0.77
87_S 91_Y 1.121 0.76
95_K 203_R 1.12 0.76
191_V 195_F 1.114 0.76
41_L 452_A 1.111 0.76
267_L 449_C 1.104 0.75
15_I 207_M 1.103 0.75
163_G 324_G 1.102 0.75
70_G 319_L 1.102 0.75
355_A 397_L 1.101 0.75
38_L 42_A 1.101 0.75
265_H 269_G 1.095 0.74
235_P 240_V 1.091 0.74
329_K 332_V 1.091 0.74
328_G 332_V 1.091 0.74
447_T 451_W 1.089 0.73
145_L 196_A 1.088 0.73
95_K 99_K 1.086 0.73
35_V 38_L 1.084 0.73
155_H 370_T 1.079 0.72
266_P 453_V 1.074 0.72
149_G 435_L 1.073 0.72
40_A 50_V 1.072 0.72
364_A 433_T 1.07 0.72
409_I 420_Y 1.07 0.72
58_M 67_I 1.065 0.71
167_A 173_A 1.061 0.71
200_I 203_R 1.054 0.70
199_I 202_K 1.054 0.70
32_L 324_G 1.054 0.70
153_T 439_L 1.049 0.69
16_M 35_V 1.048 0.69
26_V 286_V 1.046 0.69
176_G 331_L 1.046 0.69
258_A 453_V 1.044 0.69
88_L 240_V 1.044 0.69
340_L 379_L 1.04 0.68
236_G 240_V 1.034 0.68
407_S 432_W 1.031 0.67
409_I 429_L 1.031 0.67
188_P 192_V 1.029 0.67
155_H 159_P 1.028 0.67
363_R 372_A 1.028 0.67
192_V 438_I 1.026 0.67
406_A 429_L 1.022 0.66
185_I 397_L 1.017 0.66
51_G 279_V 1.015 0.66
366_Q 372_A 1.014 0.66
340_L 424_S 1.014 0.66
97_G 104_A 1.013 0.65
252_M 327_F 1.011 0.65
24_A 300_L 1.01 0.65
157_A 443_G 1.008 0.65
59_G 63_G 1.008 0.65
91_Y 95_K 1.007 0.65
85_A 121_G 1.006 0.65
164_P 443_G 1.005 0.65
75_L 285_L 1.004 0.64
366_Q 419_K 1.003 0.64
122_F 126_A 1.002 0.64
71_L 281_L 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.89211000.757Contact Map0.367
3qnqA40.451578.20.961Contact Map0.4
3giaA10.4559110.977Contact Map0.262
4dx5A30.38555.50.979Contact Map0.356
2jlnA10.47143.70.981Contact Map0.231
2kncA10.11233.60.981Contact Map0.222
2ls4A10.05293.40.981Contact Map0.059
3ne5A10.35463.40.981Contact Map0.227
4apsA20.43613.30.982Contact Map0.072
2kv5A10.07273.20.982Contact Map0.501
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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