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GNTU - Low-affinity gluconate transporter
UniProt: P0AC96 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12631
Length: 446 (438)
Sequences: 1316
Seq/Len: 3.00
GNTU
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DSDX GNTP GNTT GNTU IDNT YGBN YJHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
19_F 24_A 3.563 1.00
235_L 276_V 3.402 1.00
53_T 322_D 3.169 1.00
91_K 226_F 3.008 1.00
226_F 230_L 2.914 1.00
171_M 390_I 2.861 1.00
200_F 204_Y 2.846 1.00
13_S 39_A 2.824 1.00
318_Q 322_D 2.659 1.00
103_Y 195_P 2.623 1.00
119_E 403_A 2.587 1.00
16_L 38_G 2.558 1.00
84_A 229_S 2.39 1.00
415_T 418_E 2.386 1.00
167_L 362_C 2.239 1.00
81_E 295_I 2.138 1.00
345_F 431_G 2.122 1.00
436_I 440_I 2.093 1.00
440_I 444_L 2.006 1.00
353_I 397_V 1.983 1.00
119_E 310_I 1.966 1.00
349_A 396_V 1.953 1.00
13_S 316_F 1.889 0.99
392_G 434_G 1.858 0.99
225_S 228_F 1.854 0.99
432_T 436_I 1.834 0.99
397_V 424_T 1.803 0.99
342_I 435_A 1.796 0.99
118_F 404_G 1.786 0.99
310_I 403_A 1.779 0.99
54_M 315_V 1.766 0.99
40_G 319_V 1.761 0.99
62_L 311_G 1.759 0.99
35_V 128_V 1.741 0.99
327_P 331_E 1.729 0.99
398_S 402_D 1.726 0.99
170_Q 366_V 1.716 0.98
425_M 429_I 1.7 0.98
255_T 259_W 1.676 0.98
74_M 296_C 1.662 0.98
192_I 433_V 1.652 0.98
156_A 395_I 1.617 0.98
15_L 19_F 1.608 0.97
56_K 60_G 1.591 0.97
275_L 279_Y 1.567 0.97
121_A 151_V 1.522 0.96
197_W 200_F 1.514 0.96
39_A 316_F 1.512 0.96
30_L 274_C 1.504 0.96
197_W 425_M 1.503 0.96
396_V 431_G 1.481 0.95
379_S 382_Q 1.477 0.95
178_M 385_A 1.472 0.95
331_E 334_T 1.455 0.95
78_I 277_A 1.449 0.94
353_I 396_V 1.447 0.94
441_A 444_L 1.436 0.94
122_I 411_F 1.427 0.94
184_C 188_P 1.42 0.94
149_A 194_G 1.417 0.94
227_G 231_S 1.413 0.93
98_H 135_H 1.413 0.93
19_F 23_K 1.409 0.93
173_A 178_M 1.398 0.93
152_A 427_E 1.39 0.93
41_L 47_L 1.39 0.93
185_A 390_I 1.386 0.93
154_A 161_G 1.382 0.92
409_G 419_T 1.369 0.92
185_A 441_A 1.367 0.92
419_T 423_W 1.364 0.92
144_V 412_T 1.36 0.92
58_M 66_A 1.353 0.91
9_T 42_F 1.337 0.91
49_K 52_A 1.325 0.90
345_F 435_A 1.323 0.90
26_M 31_A 1.317 0.90
57_G 318_Q 1.307 0.89
370_M 374_E 1.29 0.89
32_L 316_F 1.29 0.89
329_L 354_I 1.287 0.88
77_K 81_E 1.28 0.88
147_L 150_G 1.272 0.88
109_G 121_A 1.27 0.88
18_L 22_M 1.27 0.88
279_Y 284_R 1.263 0.87
373_I 384_A 1.262 0.87
191_I 195_P 1.26 0.87
352_R 402_D 1.252 0.87
27_H 30_L 1.249 0.86
94_K 203_R 1.246 0.86
46_P 49_K 1.23 0.85
417_A 421_K 1.23 0.85
181_I 386_L 1.224 0.85
74_M 274_C 1.219 0.84
21_V 28_A 1.218 0.84
224_P 229_S 1.201 0.83
90_V 135_H 1.201 0.83
67_V 267_F 1.199 0.83
113_A 161_G 1.198 0.83
152_A 395_I 1.197 0.83
396_V 428_T 1.195 0.83
55_E 64_F 1.185 0.82
424_T 431_G 1.179 0.82
303_A 307_L 1.177 0.82
116_L 148_F 1.177 0.82
312_A 315_V 1.174 0.81
53_T 318_Q 1.17 0.81
112_C 125_L 1.169 0.81
255_T 444_L 1.164 0.81
386_L 438_G 1.16 0.80
201_I 205_V 1.158 0.80
67_V 71_L 1.157 0.80
154_A 164_P 1.153 0.80
23_K 111_V 1.152 0.80
26_M 275_L 1.15 0.79
180_L 184_C 1.149 0.79
288_P 291_K 1.148 0.79
180_L 183_L 1.144 0.79
228_F 280_G 1.143 0.79
239_L 272_V 1.142 0.79
16_L 20_L 1.134 0.78
18_L 35_V 1.128 0.78
13_S 38_G 1.127 0.77
155_A 161_G 1.126 0.77
13_S 43_S 1.123 0.77
152_A 358_A 1.119 0.77
103_Y 107_L 1.115 0.76
338_L 346_V 1.114 0.76
173_A 385_A 1.112 0.76
16_L 35_V 1.112 0.76
102_H 142_K 1.111 0.76
438_G 442_F 1.11 0.76
106_G 190_M 1.11 0.76
318_Q 321_V 1.109 0.76
20_L 26_M 1.109 0.76
163_A 313_G 1.109 0.76
167_L 173_A 1.108 0.76
40_G 50_I 1.106 0.76
276_V 280_G 1.104 0.75
377_N 381_A 1.103 0.75
368_L 387_S 1.1 0.75
35_V 38_G 1.098 0.75
70_A 308_L 1.097 0.75
19_F 78_I 1.096 0.75
317_K 321_V 1.096 0.75
15_L 48_D 1.094 0.74
95_S 204_Y 1.092 0.74
118_F 408_F 1.091 0.74
97_G 100_R 1.086 0.74
53_T 320_L 1.083 0.73
88_I 229_S 1.077 0.73
87_Q 91_K 1.074 0.73
254_S 258_E 1.072 0.72
38_G 42_F 1.068 0.72
344_C 386_L 1.066 0.72
197_W 201_I 1.065 0.72
149_A 426_M 1.063 0.71
41_L 443_Q 1.061 0.71
37_M 268_T 1.061 0.71
255_T 275_L 1.06 0.71
186_A 375_Q 1.054 0.71
397_V 420_L 1.053 0.70
86_D 221_G 1.052 0.70
341_A 384_A 1.047 0.70
400_V 411_F 1.045 0.70
185_A 437_V 1.04 0.69
155_A 359_T 1.036 0.69
26_M 34_V 1.035 0.69
32_L 313_G 1.032 0.68
398_S 423_W 1.028 0.68
97_G 104_A 1.028 0.68
58_M 67_V 1.027 0.68
220_E 223_M 1.025 0.67
12_G 48_D 1.024 0.67
153_A 430_L 1.023 0.67
278_I 308_L 1.019 0.67
402_D 423_W 1.019 0.67
91_K 95_S 1.019 0.67
275_L 278_I 1.017 0.67
420_L 424_T 1.014 0.66
176_G 320_L 1.014 0.66
225_S 229_S 1.014 0.66
325_V 394_S 1.013 0.66
155_A 159_V 1.012 0.66
329_L 415_T 1.011 0.66
71_L 270_I 1.01 0.66
352_R 361_A 1.009 0.66
85_V 121_A 1.009 0.66
241_G 316_F 1.008 0.66
50_I 440_I 1.008 0.66
157_F 434_G 1.006 0.65
79_L 84_A 1.003 0.65
376_L 381_A 1.002 0.65
11_V 201_I 1.001 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.91261000.749Contact Map0.369
3qnqA40.452952.10.967Contact Map0.457
3giaA10.464120.90.973Contact Map0.233
4k0jA60.37223.40.981Contact Map0.378
4b19A10.06733.40.981Contact Map0.354
3aqpA20.36553.10.982Contact Map0.372
1m56D20.11213.10.982Contact Map0.345
1b9uA10.076230.982Contact Map0.297
1qleD10.09642.90.982Contact Map0.348
2kr6A10.13682.80.982Contact Map0.059
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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