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OPENSEQ.org
GNTP - High-affinity gluconate transporter
UniProt: P0AC94 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12563
Length: 447 (440)
Sequences: 1313
Seq/Len: 2.98
GNTP
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DSDX GNTP GNTT GNTU IDNT YGBN YJHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_V 23_F 3.485 1.00
234_I 275_V 3.357 1.00
52_T 321_D 3.154 1.00
225_F 229_I 2.952 1.00
90_T 225_F 2.952 1.00
170_Y 392_T 2.93 1.00
12_G 38_V 2.88 1.00
15_L 37_S 2.683 1.00
118_E 405_A 2.676 1.00
317_Q 321_D 2.672 1.00
102_L 194_L 2.608 1.00
417_S 420_D 2.377 1.00
442_I 446_V 2.365 1.00
83_A 228_S 2.326 1.00
166_L 361_A 2.266 1.00
191_C 435_V 2.181 1.00
80_D 294_A 2.167 1.00
438_I 442_I 2.13 1.00
344_W 433_S 2.101 1.00
394_A 436_G 2.005 1.00
118_E 309_I 1.979 1.00
199_F 202_N 1.979 1.00
224_S 227_V 1.959 1.00
348_V 398_T 1.957 1.00
352_L 399_L 1.911 0.99
309_I 405_A 1.876 0.99
34_A 127_L 1.866 0.99
12_G 315_L 1.857 0.99
326_D 330_M 1.836 0.99
434_V 438_I 1.822 0.99
341_I 437_L 1.779 0.99
53_M 314_V 1.775 0.99
399_L 426_G 1.752 0.99
117_Y 406_S 1.744 0.99
61_L 310_G 1.737 0.99
400_T 404_D 1.727 0.99
169_A 365_A 1.721 0.98
73_V 295_F 1.679 0.98
55_A 59_N 1.661 0.98
254_P 258_V 1.644 0.98
14_G 18_V 1.637 0.98
427_L 431_V 1.632 0.98
155_S 397_N 1.602 0.97
226_G 230_L 1.552 0.97
39_G 318_T 1.548 0.97
38_V 315_L 1.546 0.96
196_L 427_L 1.545 0.96
77_L 276_A 1.539 0.96
196_L 199_F 1.508 0.96
278_V 283_A 1.5 0.96
352_L 398_T 1.481 0.95
40_M 46_L 1.47 0.95
398_T 433_S 1.465 0.95
382_G 385_P 1.457 0.95
18_V 22_K 1.448 0.94
177_V 389_V 1.443 0.94
330_M 333_S 1.442 0.94
97_L 134_E 1.438 0.94
29_V 273_M 1.437 0.94
274_V 278_V 1.433 0.94
151_T 429_E 1.427 0.94
121_F 413_Y 1.426 0.94
148_A 193_G 1.414 0.93
172_A 177_V 1.407 0.93
153_A 160_Q 1.401 0.93
183_L 187_P 1.398 0.93
419_K 423_K 1.395 0.93
57_F 65_A 1.391 0.93
411_K 421_T 1.378 0.92
143_A 414_F 1.365 0.92
191_C 195_I 1.354 0.91
421_T 425_W 1.348 0.91
184_V 392_T 1.343 0.91
344_W 437_L 1.335 0.91
372_I 388_L 1.311 0.89
184_V 443_I 1.302 0.89
56_G 317_Q 1.299 0.89
120_A 150_A 1.297 0.89
351_R 404_D 1.296 0.89
112_G 160_Q 1.293 0.89
398_T 430_L 1.288 0.88
108_G 120_A 1.284 0.88
66_I 266_P 1.282 0.88
255_A 442_I 1.281 0.88
17_L 21_L 1.271 0.87
146_A 149_A 1.27 0.87
117_Y 410_F 1.266 0.87
287_D 290_W 1.263 0.87
31_L 315_L 1.257 0.87
221_N 284_R 1.255 0.87
96_G 99_Y 1.251 0.86
26_N 29_V 1.247 0.86
76_K 80_D 1.243 0.86
328_I 353_A 1.219 0.84
151_T 397_N 1.218 0.84
73_V 273_M 1.218 0.84
45_D 48_S 1.214 0.84
390_L 440_V 1.213 0.84
302_I 306_I 1.206 0.83
442_I 445_M 1.203 0.83
311_A 314_V 1.198 0.83
54_K 63_E 1.197 0.83
36_L 267_I 1.191 0.82
48_S 51_H 1.189 0.82
25_I 30_A 1.184 0.82
20_N 27_S 1.181 0.82
115_M 147_V 1.181 0.82
238_I 271_I 1.181 0.82
105_I 189_V 1.179 0.82
426_G 433_S 1.176 0.81
443_I 446_V 1.176 0.81
223_P 228_S 1.175 0.81
19_L 25_I 1.172 0.81
337_I 345_L 1.171 0.81
89_H 134_E 1.168 0.81
275_V 279_L 1.167 0.81
180_Y 390_L 1.165 0.80
102_L 106_I 1.165 0.80
52_T 317_Q 1.161 0.80
153_A 163_P 1.159 0.80
15_L 19_L 1.155 0.80
151_T 357_G 1.154 0.80
172_A 389_V 1.152 0.79
12_G 37_S 1.151 0.79
154_H 160_Q 1.148 0.79
8_W 41_L 1.148 0.79
254_P 446_V 1.139 0.78
66_I 70_F 1.136 0.78
111_F 124_L 1.131 0.78
227_V 279_L 1.13 0.78
52_T 319_I 1.129 0.77
37_S 41_L 1.127 0.77
316_K 320_I 1.126 0.77
440_V 444_S 1.125 0.77
34_A 37_S 1.124 0.77
317_Q 320_I 1.12 0.77
17_L 34_A 1.119 0.77
144_I 196_L 1.117 0.76
25_I 274_V 1.117 0.76
15_L 34_A 1.116 0.76
162_G 312_G 1.116 0.76
69_V 307_L 1.115 0.76
40_M 271_I 1.114 0.76
340_Y 388_L 1.111 0.76
196_L 200_L 1.102 0.75
277_F 307_L 1.096 0.74
152_T 432_N 1.095 0.74
255_A 258_V 1.095 0.74
12_G 42_A 1.089 0.74
87_I 228_S 1.088 0.74
86_Q 90_T 1.087 0.74
367_I 391_A 1.087 0.74
22_K 110_I 1.083 0.73
343_A 390_L 1.082 0.73
200_L 203_L 1.08 0.73
18_V 77_L 1.078 0.73
101_Q 141_K 1.073 0.72
74_I 273_M 1.072 0.72
241_S 250_V 1.071 0.72
224_S 228_S 1.068 0.72
352_L 426_G 1.065 0.71
184_V 439_I 1.06 0.71
31_L 312_G 1.059 0.71
402_I 413_Y 1.058 0.71
246_N 446_V 1.057 0.71
399_L 422_L 1.055 0.70
96_G 103_S 1.054 0.70
148_A 428_L 1.054 0.70
166_L 172_A 1.053 0.70
400_T 425_W 1.048 0.70
175_G 319_I 1.048 0.70
86_Q 225_F 1.046 0.69
154_H 358_V 1.045 0.69
39_G 49_L 1.042 0.69
57_F 66_I 1.041 0.69
422_L 426_G 1.041 0.69
251_K 256_W 1.039 0.69
154_H 158_P 1.037 0.69
253_T 257_E 1.035 0.68
372_I 385_P 1.032 0.68
184_V 390_L 1.032 0.68
61_L 349_L 1.03 0.68
219_M 222_L 1.029 0.68
40_M 49_L 1.027 0.67
90_T 94_R 1.025 0.67
351_R 360_S 1.024 0.67
179_I 183_L 1.022 0.67
163_P 436_G 1.021 0.67
328_I 417_S 1.017 0.66
70_F 269_M 1.009 0.65
144_I 148_A 1.007 0.65
63_E 405_A 1.007 0.65
14_G 47_M 1.006 0.65
308_I 362_M 1.004 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.90831000.749Contact Map0.374
3qnqA40.451964.60.964Contact Map0.305
3giaA10.4609100.976Contact Map0.252
4b19A10.06714.10.98Contact Map0.134
3ne5A10.29753.70.981Contact Map0.192
2ls4A10.05373.70.981Contact Map0.059
4dx5A30.3873.60.981Contact Map0.297
1m56D20.10963.40.981Contact Map0.369
3arcD20.2642.90.982Contact Map0.111
2vdaB10.06262.90.982Contact Map0
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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