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OPENSEQ.org
GNTT - High-affinity gluconate transporter
UniProt: P39835 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12380
Length: 438 (437)
Sequences: 1312
Seq/Len: 3.00
GNTT
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DSDX GNTP GNTT GNTU IDNT YGBN YJHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
15_L 20_F 3.563 1.00
231_V 272_I 3.336 1.00
49_S 318_D 3.074 1.00
9_G 35_V 2.932 1.00
87_T 222_F 2.927 1.00
167_F 383_V 2.923 1.00
222_F 226_V 2.878 1.00
12_L 34_A 2.64 1.00
115_E 396_P 2.632 1.00
99_W 191_P 2.605 1.00
314_Q 318_D 2.525 1.00
408_T 411_E 2.446 1.00
433_L 437_V 2.427 1.00
80_G 225_S 2.367 1.00
163_I 358_A 2.234 1.00
196_V 200_I 2.199 1.00
77_D 291_T 2.156 1.00
341_W 424_S 2.113 1.00
429_V 433_L 2.044 1.00
188_L 426_C 1.957 1.00
345_A 389_I 1.957 1.00
115_E 306_I 1.954 1.00
385_S 427_G 1.953 1.00
349_I 390_F 1.903 0.99
9_G 312_F 1.882 0.99
425_V 429_V 1.847 0.99
306_I 396_P 1.841 0.99
323_K 327_S 1.838 0.99
338_L 428_L 1.833 0.99
31_V 124_L 1.808 0.99
418_M 422_I 1.777 0.99
50_I 311_A 1.773 0.99
58_L 307_G 1.762 0.99
221_S 224_V 1.758 0.99
390_F 417_S 1.745 0.99
166_I 362_G 1.739 0.99
114_Y 397_G 1.725 0.99
251_A 255_V 1.712 0.98
391_S 395_D 1.699 0.98
70_M 292_L 1.657 0.98
152_G 388_V 1.609 0.97
52_A 56_G 1.601 0.97
11_I 15_L 1.597 0.97
349_I 389_I 1.572 0.97
15_L 19_R 1.568 0.97
35_V 312_F 1.548 0.97
271_L 275_F 1.53 0.96
36_G 315_V 1.526 0.96
193_Y 418_M 1.52 0.96
275_F 280_N 1.519 0.96
74_M 273_A 1.482 0.95
223_G 227_W 1.473 0.95
26_I 270_V 1.472 0.95
174_T 380_V 1.459 0.95
389_I 424_S 1.432 0.94
180_I 184_P 1.43 0.94
327_S 330_H 1.425 0.94
373_G 376_P 1.421 0.94
118_F 404_Y 1.401 0.93
169_A 174_T 1.394 0.93
148_S 420_E 1.393 0.93
54_V 62_A 1.391 0.93
150_T 157_H 1.379 0.92
145_A 190_G 1.378 0.92
402_K 412_T 1.378 0.92
90_A 199_G 1.358 0.92
188_L 192_V 1.353 0.91
140_G 405_F 1.35 0.91
410_G 414_K 1.347 0.91
94_K 131_S 1.343 0.91
197_L 200_I 1.336 0.91
412_T 416_W 1.33 0.90
369_I 379_M 1.324 0.90
341_W 428_L 1.324 0.90
181_L 383_V 1.323 0.90
117_G 147_L 1.317 0.90
53_G 314_Q 1.315 0.90
109_G 157_H 1.311 0.90
181_L 434_L 1.301 0.89
37_L 43_L 1.285 0.88
93_G 96_H 1.284 0.88
366_A 370_A 1.284 0.88
28_L 312_F 1.281 0.88
45_K 48_G 1.278 0.88
348_R 395_D 1.276 0.88
73_K 77_D 1.27 0.88
14_L 18_I 1.257 0.87
389_I 421_T 1.253 0.87
434_L 437_V 1.249 0.86
381_I 431_C 1.249 0.86
143_M 146_A 1.248 0.86
23_N 26_I 1.246 0.86
105_G 117_G 1.243 0.86
22_M 27_A 1.242 0.86
51_K 60_S 1.241 0.86
325_I 350_A 1.237 0.86
114_Y 401_F 1.237 0.86
70_M 270_V 1.219 0.84
299_I 303_L 1.217 0.84
34_A 38_M 1.216 0.84
63_L 263_V 1.204 0.83
42_P 45_K 1.198 0.83
284_S 287_Q 1.192 0.83
37_L 268_I 1.192 0.83
433_L 436_M 1.191 0.83
148_S 388_V 1.189 0.82
334_I 342_S 1.187 0.82
102_V 186_V 1.181 0.82
86_T 131_S 1.177 0.82
417_S 424_S 1.176 0.81
192_V 199_G 1.176 0.81
112_L 144_A 1.175 0.81
63_L 67_F 1.161 0.80
150_T 160_P 1.158 0.80
220_P 225_S 1.156 0.80
17_M 24_G 1.156 0.80
33_L 264_M 1.154 0.80
272_I 276_T 1.151 0.79
308_G 311_A 1.151 0.79
151_H 157_H 1.151 0.79
9_G 34_A 1.15 0.79
251_A 437_V 1.147 0.79
216_E 219_M 1.146 0.79
177_Y 381_I 1.144 0.79
169_A 380_V 1.142 0.79
99_W 103_L 1.139 0.79
14_L 31_V 1.139 0.79
16_L 22_M 1.135 0.78
148_S 354_A 1.134 0.78
224_V 276_T 1.132 0.78
248_K 253_L 1.131 0.78
108_V 121_M 1.13 0.78
235_L 268_I 1.126 0.77
83_R 87_T 1.123 0.77
12_L 16_L 1.123 0.77
176_L 180_I 1.115 0.76
31_V 34_A 1.112 0.76
49_S 316_L 1.111 0.76
159_G 309_G 1.11 0.76
66_G 304_L 1.106 0.76
314_Q 317_V 1.102 0.75
218_E 281_R 1.094 0.74
163_I 169_A 1.093 0.74
12_L 31_V 1.092 0.74
9_G 39_Q 1.086 0.74
187_I 192_V 1.081 0.73
181_L 430_G 1.08 0.73
313_K 317_V 1.079 0.73
84_I 225_S 1.077 0.73
340_A 381_I 1.077 0.73
149_V 423_I 1.071 0.72
337_L 379_M 1.071 0.72
172_G 316_L 1.07 0.72
268_I 272_I 1.07 0.72
49_S 314_Q 1.069 0.72
364_I 382_A 1.069 0.72
22_M 271_L 1.065 0.72
145_A 419_L 1.064 0.72
431_C 435_N 1.063 0.71
87_T 91_K 1.062 0.71
413_I 417_S 1.06 0.71
36_G 46_V 1.06 0.71
98_Q 138_Y 1.056 0.71
193_Y 197_L 1.055 0.71
393_V 404_Y 1.053 0.70
19_R 107_T 1.051 0.70
390_F 413_I 1.048 0.70
28_L 309_G 1.043 0.69
391_S 416_W 1.042 0.69
83_R 222_F 1.041 0.69
48_G 91_K 1.038 0.69
15_L 74_M 1.037 0.69
151_H 355_T 1.035 0.69
325_I 408_T 1.034 0.68
151_H 155_P 1.033 0.68
93_G 100_A 1.03 0.68
141_V 193_Y 1.027 0.68
91_K 95_K 1.024 0.67
82_Q 217_E 1.019 0.67
351_L 357_A 1.018 0.67
243_E 437_V 1.017 0.67
60_S 396_P 1.012 0.66
176_L 179_T 1.009 0.66
274_M 304_L 1.009 0.66
71_L 270_V 1.007 0.65
183_I 410_G 1.003 0.65
160_P 427_G 1.001 0.65
5_I 38_M 1 0.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.91551000.746Contact Map0.36
3qnqA40.454361.70.964Contact Map0.265
3giaA10.433820.70.973Contact Map0.199
3aqpA20.3539100.976Contact Map0.374
4dx5A30.36766.10.978Contact Map0.325
2kluA10.14615.90.979Contact Map0.386
3ne5A10.34474.80.979Contact Map0.226
2kncA10.11873.60.981Contact Map0.273
4b19A10.06853.60.981Contact Map0.092
4k0jA60.36763.30.981Contact Map0.269
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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