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YJHF - Uncharacterized permease YjhF
UniProt: P39357 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12548
Length: 449 (445)
Sequences: 1323
Seq/Len: 2.97
YJHF
Paralog alert: 0.66 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DSDX GNTP GNTT GNTU IDNT YGBN YJHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
237_L 282_F 3.505 1.00
15_L 20_I 3.477 1.00
49_S 328_D 3.139 1.00
228_F 232_F 2.954 1.00
9_G 35_V 2.91 1.00
167_Y 394_T 2.867 1.00
87_T 228_F 2.82 1.00
12_L 34_A 2.735 1.00
196_F 200_I 2.646 1.00
324_Q 328_D 2.644 1.00
99_W 191_P 2.595 1.00
115_E 407_A 2.593 1.00
419_T 422_E 2.394 1.00
80_G 231_S 2.389 1.00
163_I 368_A 2.238 1.00
444_L 448_V 2.233 1.00
77_D 301_S 2.164 1.00
440_I 444_L 2.164 1.00
351_W 435_S 2.14 1.00
188_L 437_S 2.035 1.00
396_A 438_G 2.017 1.00
115_E 316_I 1.988 1.00
355_A 400_I 1.965 1.00
359_I 401_C 1.939 0.99
436_I 440_I 1.921 0.99
348_L 439_L 1.85 0.99
227_G 230_I 1.848 0.99
114_F 408_S 1.843 0.99
9_G 322_F 1.827 0.99
50_V 321_A 1.805 0.99
401_C 428_T 1.795 0.99
333_Q 337_T 1.779 0.99
31_V 124_I 1.767 0.99
402_S 406_D 1.764 0.99
11_A 15_L 1.744 0.99
70_M 302_C 1.736 0.99
58_L 317_G 1.725 0.99
166_E 372_A 1.696 0.98
253_A 259_S 1.692 0.98
52_S 56_G 1.688 0.98
429_L 433_L 1.687 0.98
316_I 407_A 1.66 0.98
281_L 285_Y 1.647 0.98
152_G 399_C 1.598 0.97
90_N 199_R 1.596 0.97
261_L 265_V 1.573 0.97
229_G 233_L 1.572 0.97
35_V 322_F 1.56 0.97
193_L 429_L 1.544 0.96
359_I 400_I 1.537 0.96
285_Y 290_G 1.534 0.96
400_I 435_S 1.505 0.96
36_A 325_V 1.498 0.96
188_L 192_V 1.488 0.95
94_K 131_E 1.458 0.95
15_L 19_K 1.455 0.95
74_L 283_A 1.434 0.94
118_L 415_F 1.42 0.94
145_S 190_G 1.414 0.93
174_V 391_T 1.405 0.93
337_T 340_S 1.405 0.93
26_V 280_L 1.403 0.93
148_L 431_S 1.402 0.93
54_L 62_G 1.389 0.93
169_A 174_V 1.376 0.92
37_I 43_L 1.376 0.92
180_I 184_P 1.375 0.92
140_C 416_F 1.374 0.92
150_A 157_H 1.371 0.92
5_I 38_A 1.356 0.91
423_T 427_W 1.349 0.91
413_K 423_T 1.346 0.91
28_L 322_F 1.325 0.90
181_V 394_T 1.316 0.90
351_W 439_L 1.305 0.89
421_K 425_L 1.304 0.89
117_G 147_L 1.299 0.89
400_I 432_T 1.294 0.89
109_G 157_H 1.284 0.88
93_G 96_K 1.282 0.88
379_L 390_I 1.281 0.88
14_L 18_I 1.279 0.88
53_G 324_Q 1.277 0.88
181_V 445_A 1.274 0.88
358_R 406_D 1.262 0.87
335_I 360_C 1.256 0.87
105_A 117_G 1.255 0.86
143_M 146_G 1.254 0.86
73_R 77_D 1.248 0.86
376_I 380_A 1.244 0.86
45_K 48_T 1.241 0.86
23_N 26_V 1.24 0.86
63_L 273_T 1.239 0.86
51_E 60_H 1.229 0.85
19_K 107_I 1.228 0.85
148_L 399_C 1.224 0.85
193_L 197_C 1.217 0.84
70_M 280_L 1.215 0.84
261_L 448_V 1.209 0.84
42_D 45_K 1.207 0.83
445_A 448_V 1.205 0.83
230_I 286_T 1.201 0.83
114_F 412_I 1.201 0.83
22_L 27_S 1.2 0.83
392_L 442_I 1.193 0.82
196_F 199_R 1.193 0.82
34_A 38_A 1.192 0.82
177_Y 392_L 1.192 0.82
17_T 24_T 1.177 0.81
294_T 297_D 1.174 0.81
344_I 352_G 1.172 0.81
309_I 313_L 1.171 0.81
112_L 144_L 1.168 0.81
86_L 131_E 1.167 0.81
428_T 435_S 1.166 0.80
150_A 160_P 1.161 0.80
108_V 121_L 1.161 0.80
102_V 186_F 1.16 0.80
444_L 447_L 1.16 0.80
318_G 321_A 1.158 0.80
49_S 324_Q 1.156 0.80
148_L 364_A 1.156 0.80
9_G 34_A 1.153 0.79
241_L 278_I 1.151 0.79
193_L 196_F 1.15 0.79
63_L 67_F 1.15 0.79
151_H 157_H 1.15 0.79
282_F 286_T 1.142 0.78
169_A 391_T 1.137 0.78
159_G 319_G 1.132 0.78
249_Q 448_V 1.13 0.77
374_L 393_A 1.128 0.77
31_V 34_A 1.127 0.77
99_W 103_C 1.127 0.77
262_F 265_V 1.124 0.77
16_L 22_L 1.122 0.77
324_Q 327_I 1.121 0.77
323_K 327_I 1.118 0.76
22_L 281_L 1.112 0.76
244_V 253_A 1.11 0.76
66_G 314_L 1.11 0.76
9_G 39_S 1.108 0.76
49_S 326_L 1.108 0.76
12_L 16_L 1.104 0.75
442_I 446_S 1.091 0.74
197_C 200_I 1.09 0.74
260_G 264_N 1.09 0.74
406_D 410_W 1.088 0.74
163_I 169_A 1.077 0.73
172_G 326_L 1.074 0.72
71_L 280_L 1.072 0.72
149_V 434_L 1.071 0.72
46_V 444_L 1.067 0.72
14_L 31_V 1.066 0.71
226_P 231_S 1.06 0.71
151_H 365_T 1.057 0.71
401_C 424_L 1.055 0.70
145_S 430_M 1.055 0.70
160_P 438_G 1.054 0.70
93_G 100_A 1.054 0.70
87_T 91_Y 1.053 0.70
252_H 266_I 1.053 0.70
347_I 390_I 1.05 0.70
335_I 419_T 1.049 0.70
11_A 44_S 1.049 0.70
84_I 231_S 1.048 0.70
15_L 74_L 1.048 0.70
379_L 387_L 1.048 0.70
83_R 87_T 1.047 0.69
28_L 319_G 1.046 0.69
98_D 138_F 1.046 0.69
350_A 392_L 1.041 0.69
181_V 392_L 1.041 0.69
133_K 281_L 1.041 0.69
54_L 63_L 1.039 0.69
404_V 415_F 1.035 0.68
262_F 444_L 1.032 0.68
82_Q 223_S 1.031 0.68
176_I 179_I 1.03 0.68
33_I 274_I 1.03 0.68
181_V 441_F 1.026 0.67
151_H 155_P 1.025 0.67
383_P 387_L 1.021 0.67
331_V 398_S 1.021 0.67
36_A 46_V 1.019 0.66
424_L 428_T 1.018 0.66
260_G 263_Y 1.018 0.66
12_L 31_V 1.017 0.66
218_R 222_E 1.017 0.66
402_S 427_W 1.016 0.66
37_I 278_I 1.016 0.66
358_R 367_A 1.012 0.66
118_L 122_V 1.012 0.66
406_D 427_W 1.011 0.66
58_L 356_F 1.01 0.65
361_L 367_A 1.008 0.65
259_S 262_F 1.008 0.65
47_V 274_I 1.005 0.65
176_I 180_I 1.004 0.65
270_G 319_G 1.004 0.65
105_A 121_L 1.001 0.64
83_R 228_F 1 0.64
412_I 418_L 1 0.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.89531000.749Contact Map0.358
3qnqA40.443247.60.967Contact Map0.384
3giaA10.423218.40.973Contact Map0.229
4k0jA60.371913.20.975Contact Map0.358
4dx5A30.383110.20.976Contact Map0.353
3aqpA20.34088.90.977Contact Map0.363
3ne5A10.33635.50.979Contact Map0.226
4b19A10.066850.979Contact Map0.109
1q90G10.0783.60.981Contact Map0.832
3zuxA10.45213.60.981Contact Map0.391
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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