| UniProt: | Q46857 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13015 | ||
| Length: | 275 (261) | ||
| Sequences: | 14091 | ||
| Seq/Len: | 53.99 |
| DKGA
Paralog alert: 0.86 [within 20: 0.29] - ratio of genomes with paralogs Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 90_L | 131_L | 3.007 | 1.00 | |
| 36_K | 239_A | 2.996 | 1.00 | |
| 62_K | 97_Q | 2.717 | 1.00 | |
| 209_Y | 253_E | 2.571 | 1.00 | |
| 89_L | 126_L | 2.517 | 1.00 | |
| 208_K | 256_E | 2.385 | 1.00 | |
| 8_K | 14_V | 2.335 | 1.00 | |
| 36_K | 40_V | 2.329 | 1.00 | |
| 86_R | 129_E | 2.255 | 1.00 | |
| 73_I | 98_L | 2.215 | 1.00 | |
| 250_D | 253_E | 2.137 | 1.00 | |
| 86_R | 125_E | 2.063 | 1.00 | |
| 208_K | 253_E | 2.032 | 1.00 | |
| 75_T | 101_I | 2.03 | 1.00 | |
| 125_E | 129_E | 1.982 | 1.00 | |
| 251_K | 255_G | 1.968 | 1.00 | |
| 203_R | 207_D | 1.963 | 1.00 | |
| 31_I | 63_N | 1.932 | 1.00 | |
| 91_D | 95_K | 1.925 | 1.00 | |
| 223_D | 254_L | 1.907 | 1.00 | |
| 204_D | 256_E | 1.875 | 1.00 | |
| 124_I | 128_K | 1.853 | 1.00 | |
| 31_I | 59_K | 1.807 | 1.00 | |
| 175_W | 179_H | 1.797 | 1.00 | |
| 75_T | 92_S | 1.787 | 1.00 | |
| 219_R | 247_F | 1.773 | 1.00 | |
| 235_P | 239_A | 1.763 | 1.00 | |
| 89_L | 104_Y | 1.741 | 1.00 | |
| 125_E | 128_K | 1.738 | 1.00 | |
| 176_N | 183_T | 1.718 | 1.00 | |
| 212_T | 240_E | 1.684 | 1.00 | |
| 7_I | 17_Q | 1.681 | 1.00 | |
| 19_G | 44_S | 1.676 | 1.00 | |
| 105_L | 158_I | 1.662 | 1.00 | |
| 100_Y | 133_K | 1.66 | 1.00 | |
| 55_E | 95_K | 1.65 | 1.00 | |
| 224_S | 258_A | 1.65 | 1.00 | |
| 211_K | 247_F | 1.648 | 1.00 | |
| 101_I | 132_I | 1.639 | 1.00 | |
| 40_V | 242_F | 1.636 | 1.00 | |
| 182_Q | 227_V | 1.631 | 1.00 | |
| 6_V | 14_V | 1.624 | 1.00 | |
| 40_V | 239_A | 1.608 | 1.00 | |
| 67_N | 70_E | 1.597 | 1.00 | |
| 36_K | 39_E | 1.589 | 1.00 | |
| 36_K | 235_P | 1.584 | 1.00 | |
| 31_I | 60_A | 1.573 | 1.00 | |
| 105_L | 184_E | 1.542 | 1.00 | |
| 146_Q | 175_W | 1.537 | 1.00 | |
| 49_A | 88_A | 1.533 | 1.00 | |
| 146_Q | 150_D | 1.527 | 1.00 | |
| 255_G | 259_K | 1.514 | 1.00 | |
| 74_T | 105_L | 1.501 | 1.00 | |
| 37_A | 42_Y | 1.5 | 1.00 | |
| 27_N | 59_K | 1.495 | 1.00 | |
| 132_I | 135_I | 1.455 | 1.00 | |
| 31_I | 35_Q | 1.453 | 1.00 | |
| 239_A | 243_D | 1.447 | 1.00 | |
| 13_N | 134_S | 1.43 | 1.00 | |
| 122_G | 125_E | 1.414 | 1.00 | |
| 22_V | 45_I | 1.41 | 1.00 | |
| 77_L | 85_P | 1.409 | 1.00 | |
| 45_I | 57_V | 1.405 | 0.99 | |
| 89_L | 101_I | 1.404 | 0.99 | |
| 201_V | 204_D | 1.403 | 0.99 | |
| 243_D | 246_D | 1.393 | 0.99 | |
| 126_L | 132_I | 1.39 | 0.99 | |
| 211_K | 215_Q | 1.38 | 0.99 | |
| 86_R | 90_L | 1.38 | 0.99 | |
| 128_K | 153_G | 1.371 | 0.99 | |
| 174_A | 178_T | 1.36 | 0.99 | |
| 146_Q | 178_T | 1.359 | 0.99 | |
| 205_L | 216_I | 1.359 | 0.99 | |
| 35_Q | 39_E | 1.353 | 0.99 | |
| 34_I | 60_A | 1.346 | 0.99 | |
| 38_L | 71_L | 1.338 | 0.99 | |
| 33_A | 238_I | 1.334 | 0.99 | |
| 90_L | 94_K | 1.33 | 0.99 | |
| 35_Q | 63_N | 1.319 | 0.99 | |
| 29_E | 32_T | 1.314 | 0.99 | |
| 219_R | 223_D | 1.301 | 0.99 | |
| 77_L | 104_Y | 1.294 | 0.99 | |
| 86_R | 122_G | 1.293 | 0.99 | |
| 91_D | 94_K | 1.285 | 0.99 | |
| 13_N | 72_F | 1.28 | 0.99 | |
| 87_E | 91_D | 1.276 | 0.99 | |
| 232_S | 237_R | 1.268 | 0.99 | |
| 232_S | 238_I | 1.261 | 0.99 | |
| 141_Q | 144_H | 1.258 | 0.99 | |
| 256_E | 259_K | 1.242 | 0.98 | |
| 238_I | 242_F | 1.241 | 0.98 | |
| 204_D | 207_D | 1.241 | 0.98 | |
| 161_I | 183_T | 1.241 | 0.98 | |
| 54_E | 92_S | 1.24 | 0.98 | |
| 212_T | 215_Q | 1.227 | 0.98 | |
| 236_S | 239_A | 1.225 | 0.98 | |
| 123_M | 135_I | 1.222 | 0.98 | |
| 59_K | 97_Q | 1.22 | 0.98 | |
| 211_K | 216_I | 1.21 | 0.98 | |
| 72_F | 103_L | 1.21 | 0.98 | |
| 68_R | 98_L | 1.207 | 0.98 | |
| 55_E | 59_K | 1.187 | 0.98 | |
| 149_I | 179_H | 1.184 | 0.98 | |
| 58_G | 97_Q | 1.183 | 0.98 | |
| 165_P | 257_I | 1.182 | 0.98 | |
| 142_I | 175_W | 1.175 | 0.98 | |
| 202_I | 213_P | 1.165 | 0.97 | |
| 134_S | 157_V | 1.163 | 0.97 | |
| 96_L | 101_I | 1.14 | 0.97 | |
| 68_R | 100_Y | 1.139 | 0.97 | |
| 171_Q | 174_A | 1.138 | 0.97 | |
| 83_K | 87_E | 1.133 | 0.97 | |
| 204_D | 208_K | 1.13 | 0.97 | |
| 35_Q | 60_A | 1.128 | 0.97 | |
| 221_H | 228_V | 1.128 | 0.97 | |
| 201_V | 256_E | 1.127 | 0.97 | |
| 55_E | 94_K | 1.108 | 0.96 | |
| 90_L | 129_E | 1.106 | 0.96 | |
| 44_S | 184_E | 1.103 | 0.96 | |
| 10_Q | 157_V | 1.101 | 0.96 | |
| 146_Q | 179_H | 1.101 | 0.96 | |
| 11_D | 134_S | 1.1 | 0.96 | |
| 142_I | 146_Q | 1.095 | 0.96 | |
| 252_D | 255_G | 1.084 | 0.96 | |
| 32_T | 36_K | 1.08 | 0.95 | |
| 177_A | 225_G | 1.077 | 0.95 | |
| 32_T | 235_P | 1.074 | 0.95 | |
| 5_T | 17_Q | 1.069 | 0.95 | |
| 162_E | 167_M | 1.06 | 0.95 | |
| 165_P | 217_V | 1.055 | 0.95 | |
| 163_L | 224_S | 1.055 | 0.95 | |
| 61_L | 71_L | 1.052 | 0.95 | |
| 126_L | 131_L | 1.049 | 0.94 | |
| 106_M | 123_M | 1.046 | 0.94 | |
| 174_A | 177_A | 1.045 | 0.94 | |
| 209_Y | 250_D | 1.041 | 0.94 | |
| 149_I | 175_W | 1.04 | 0.94 | |
| 203_R | 213_P | 1.039 | 0.94 | |
| 173_H | 177_A | 1.038 | 0.94 | |
| 16_P | 42_Y | 1.034 | 0.94 | |
| 222_L | 244_V | 1.031 | 0.94 | |
| 84_R | 87_E | 1.027 | 0.94 | |
| 118_E | 121_K | 1.025 | 0.93 | |
| 236_S | 240_E | 1.022 | 0.93 | |
| 22_V | 57_V | 1.021 | 0.93 | |
| 102_D | 133_K | 1.018 | 0.93 | |
| 49_A | 84_R | 1.008 | 0.93 | |
| 44_S | 74_T | 1.004 | 0.93 | |
| 219_R | 244_V | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2wzmA | 2 | 0.9927 | 100 | 0.047 | Contact Map | 0.705 |
| 1hw6A | 1 | 0.9927 | 100 | 0.055 | Contact Map | 0.66 |
| 1mzrA | 2 | 1 | 100 | 0.059 | Contact Map | 0.779 |
| 3f7jA | 2 | 0.9855 | 100 | 0.066 | Contact Map | 0.812 |
| 3b3eA | 2 | 0.9855 | 100 | 0.067 | Contact Map | 0.818 |
| 1vbjA | 2 | 0.9855 | 100 | 0.068 | Contact Map | 0.722 |
| 1mi3A | 4 | 0.9964 | 100 | 0.069 | Contact Map | 0.71 |
| 3up8A | 2 | 0.9818 | 100 | 0.071 | Contact Map | 0.755 |
| 4f40A | 2 | 0.9927 | 100 | 0.075 | Contact Map | 0.727 |
| 4mhbA | 6 | 0.9891 | 100 | 0.079 | Contact Map | 0.788 |
Sequence Conservation (Image Generated using WebLogo v3)