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OPENSEQ.org
YDBC - Putative oxidoreductase YdbC
UniProt: P25906 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11309
Length: 286 (280)
Sequences: 14110
Seq/Len: 50.39
YDBC
Paralog alert: 0.86 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_E 262_R 3.151 1.00
109_H 155_L 3.11 1.00
35_R 70_E 2.787 1.00
230_L 276_V 2.638 1.00
108_V 150_M 2.61 1.00
229_S 279_T 2.516 1.00
73_Y 116_G 2.456 1.00
105_Q 153_Q 2.455 1.00
44_E 48_L 2.423 1.00
81_I 117_L 2.387 1.00
7_T 12_S 2.364 1.00
273_S 276_V 2.251 1.00
105_Q 149_E 2.2 1.00
83_T 120_L 2.136 1.00
229_S 276_V 2.119 1.00
274_E 278_S 2.048 1.00
149_E 153_Q 2.034 1.00
224_S 228_A 2.006 1.00
110_D 114_N 2 1.00
244_Q 277_L 1.996 1.00
39_I 70_E 1.929 1.00
225_D 279_T 1.92 1.00
148_A 152_Q 1.884 1.00
63_V 66_Q 1.857 1.00
258_V 262_R 1.855 1.00
149_E 152_Q 1.851 1.00
198_A 202_D 1.811 1.00
199_L 206_Y 1.802 1.00
108_V 123_V 1.801 1.00
83_T 111_N 1.778 1.00
120_L 156_V 1.769 1.00
240_A 270_L 1.744 1.00
170_A 174_K 1.741 1.00
205_A 250_L 1.731 1.00
233_T 263_E 1.729 1.00
124_N 180_C 1.727 1.00
17_G 52_H 1.719 1.00
245_R 281_D 1.713 1.00
119_V 157_K 1.702 1.00
232_A 270_L 1.7 1.00
48_L 265_M 1.688 1.00
48_L 262_R 1.678 1.00
101_P 105_Q 1.662 1.00
44_E 258_V 1.632 1.00
39_I 71_A 1.615 1.00
101_P 149_E 1.608 1.00
44_E 47_A 1.596 1.00
57_D 107_A 1.593 1.00
170_A 198_A 1.588 1.00
124_N 207_V 1.571 1.00
278_S 282_G 1.569 1.00
11_K 158_H 1.554 1.00
45_A 50_V 1.546 1.00
82_V 124_N 1.542 1.00
262_R 266_A 1.529 1.00
66_Q 114_N 1.52 1.00
39_I 43_R 1.5 1.00
226_V 237_V 1.492 1.00
266_A 269_K 1.482 1.00
170_A 201_H 1.464 1.00
34_D 37_V 1.463 1.00
20_A 53_I 1.462 1.00
150_M 156_V 1.458 1.00
46_L 79_L 1.44 1.00
53_I 68_I 1.431 1.00
156_V 159_I 1.429 1.00
108_V 120_L 1.429 1.00
197_D 201_H 1.424 1.00
105_Q 109_H 1.421 1.00
232_A 236_Q 1.399 0.99
222_T 225_D 1.39 0.99
37_V 40_T 1.372 0.99
43_R 47_A 1.37 0.99
41_V 261_L 1.363 0.99
39_I 74_P 1.352 0.99
240_A 244_Q 1.351 0.99
42_L 71_A 1.346 0.99
110_D 113_R 1.342 0.99
109_H 113_R 1.342 0.99
225_D 228_A 1.337 0.99
255_T 261_L 1.333 0.99
11_K 80_T 1.333 0.99
255_T 260_H 1.318 0.99
279_T 282_G 1.316 0.99
66_Q 70_E 1.311 0.99
259_A 262_R 1.301 0.99
85_I 104_L 1.3 0.99
173_R 202_D 1.299 0.99
147_L 159_I 1.296 0.99
233_T 236_Q 1.284 0.99
261_L 265_M 1.282 0.99
106_K 110_D 1.281 0.99
35_R 39_I 1.274 0.99
232_A 237_V 1.241 0.98
80_T 122_V 1.231 0.98
100_S 103_E 1.226 0.98
221_S 225_D 1.221 0.98
165_T 168_Q 1.22 0.98
152_Q 177_E 1.218 0.98
85_I 123_V 1.215 0.98
166_P 198_A 1.213 0.98
76_S 117_L 1.213 0.98
65_N 111_N 1.192 0.98
223_L 234_P 1.188 0.98
102_A 106_K 1.179 0.98
222_T 279_T 1.171 0.98
115_L 120_L 1.167 0.97
242_L 251_L 1.162 0.97
194_A 197_D 1.159 0.97
166_P 170_A 1.159 0.97
101_P 146_V 1.157 0.97
200_A 246_S 1.156 0.97
52_H 207_V 1.156 0.97
225_D 229_S 1.156 0.97
109_H 153_Q 1.141 0.97
170_A 202_D 1.14 0.97
173_R 198_A 1.139 0.97
36_H 40_T 1.135 0.97
69_R 116_G 1.135 0.97
275_E 278_S 1.135 0.97
43_R 71_A 1.132 0.97
66_Q 113_R 1.132 0.97
65_N 69_R 1.124 0.97
40_T 258_V 1.121 0.97
230_L 273_S 1.117 0.96
197_D 200_A 1.117 0.96
70_E 116_G 1.116 0.96
150_M 155_L 1.109 0.96
40_T 44_E 1.108 0.96
259_A 263_E 1.106 0.96
43_R 74_P 1.104 0.96
223_L 280_L 1.101 0.96
196_I 200_A 1.09 0.96
5_T 12_S 1.087 0.96
171_E 175_I 1.085 0.96
6_F 15_R 1.077 0.95
139_S 142_A 1.076 0.95
187_I 280_L 1.074 0.95
72_L 79_L 1.073 0.95
125_L 147_L 1.062 0.95
239_L 267_A 1.062 0.95
187_I 238_A 1.061 0.95
148_A 176_A 1.057 0.95
243_L 267_A 1.057 0.95
14_N 50_V 1.056 0.95
184_E 189_H 1.044 0.94
121_D 157_K 1.04 0.94
278_S 281_D 1.039 0.94
240_A 267_A 1.039 0.94
52_H 82_V 1.038 0.94
128_M 168_Q 1.037 0.94
229_S 273_S 1.035 0.94
224_S 234_P 1.032 0.94
103_E 106_K 1.032 0.94
150_M 153_Q 1.03 0.94
14_N 51_N 1.026 0.94
207_V 250_L 1.025 0.93
148_A 151_Q 1.024 0.93
122_V 180_C 1.014 0.93
236_Q 263_E 1.012 0.93
51_N 80_T 1.011 0.93
263_E 266_A 1.011 0.93
236_Q 266_A 1.009 0.93
159_I 178_I 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pyfA10.96151000.066Contact Map0.722
3n2tA10.96851000.069Contact Map0.704
3v0sA10.90911000.074Contact Map0.78
1pz1A20.96151000.081Contact Map0.707
3eauA10.95451000.092Contact Map0.763
1ynpA20.94061000.095Contact Map0.731
1ur3M10.95451000.1Contact Map0.705
3lutA10.94761000.105Contact Map0.753
3n6qA80.94761000.106Contact Map0.767
3erpA20.94761000.107Contact Map0.766
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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