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OPENSEQ.org
GPR - L-glyceraldehyde 3-phosphate reductase
UniProt: Q46851 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13010
Length: 346 (319)
Sequences: 9854
Seq/Len: 30.89
GPR
Paralog alert: 0.76 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_K 309_E 3.623 1.00
42_L 79_R 3.217 1.00
121_D 161_K 3.106 1.00
82_R 128_G 3.095 1.00
276_Q 327_Q 3.03 1.00
277_R 324_E 2.84 1.00
51_K 55_L 2.814 1.00
120_L 156_A 2.697 1.00
96_T 132_V 2.695 1.00
17_Y 24_R 2.66 1.00
117_L 159_S 2.495 1.00
321_S 324_E 2.362 1.00
154_A 158_Q 2.35 1.00
72_S 75_E 2.336 1.00
322_T 326_A 2.24 1.00
94_I 129_L 2.24 1.00
120_L 132_V 2.169 1.00
16_R 27_A 2.167 1.00
271_N 275_Q 2.137 1.00
117_L 155_H 2.096 1.00
136_Y 220_I 1.995 1.00
120_L 135_F 1.989 1.00
291_K 325_L 1.965 1.00
55_L 312_V 1.952 1.00
55_L 309_E 1.949 1.00
131_Y 163_L 1.932 1.00
136_Y 191_I 1.931 1.00
155_H 158_Q 1.931 1.00
29_S 59_H 1.911 1.00
113_R 155_H 1.876 1.00
276_Q 324_E 1.834 1.00
98_A 116_L 1.828 1.00
326_A 330_Q 1.826 1.00
176_Q 214_N 1.782 1.00
132_V 162_A 1.763 1.00
272_E 327_Q 1.759 1.00
280_S 310_E 1.743 1.00
96_T 123_S 1.742 1.00
155_H 159_S 1.731 1.00
46_R 80_L 1.725 1.00
41_A 44_S 1.705 1.00
287_S 318_L 1.705 1.00
162_A 165_V 1.696 1.00
113_R 117_L 1.694 1.00
52_A 57_I 1.689 1.00
88_Y 91_E 1.686 1.00
32_L 60_F 1.676 1.00
60_F 77_F 1.659 1.00
279_Q 318_L 1.647 1.00
64_N 119_S 1.638 1.00
269_L 272_E 1.633 1.00
49_L 80_L 1.63 1.00
305_A 309_E 1.621 1.00
211_T 215_N 1.609 1.00
95_S 136_Y 1.572 1.00
176_Q 180_E 1.565 1.00
279_Q 283_Q 1.563 1.00
207_G 210_D 1.562 1.00
273_M 284_M 1.55 1.00
51_K 305_A 1.542 1.00
15_Y 24_R 1.539 1.00
122_Q 125_K 1.536 1.00
118_A 122_Q 1.524 1.00
122_Q 126_R 1.522 1.00
75_E 126_R 1.51 1.00
213_Q 293_D 1.508 1.00
46_R 50_R 1.507 1.00
156_A 162_A 1.483 1.00
306_E 309_E 1.476 1.00
50_R 54_D 1.464 1.00
48_I 308_L 1.454 1.00
280_S 283_Q 1.446 1.00
117_L 152_A 1.422 1.00
46_R 79_R 1.414 1.00
327_Q 330_Q 1.407 0.99
153_L 165_V 1.406 0.99
44_S 47_A 1.403 0.99
75_E 125_K 1.401 0.99
152_A 155_H 1.395 0.99
51_K 54_D 1.392 0.99
117_L 121_D 1.392 0.99
308_L 312_V 1.383 0.99
121_D 159_S 1.382 0.99
171_S 174_R 1.372 0.99
89_R 129_L 1.361 0.99
42_L 46_R 1.354 0.99
137_S 153_L 1.346 0.99
212_L 219_C 1.344 0.99
198_L 328_I 1.343 0.99
98_A 135_F 1.34 0.99
309_E 313_Q 1.339 0.99
292_D 329_D 1.337 0.99
46_R 83_E 1.326 0.99
283_Q 313_Q 1.324 0.99
272_E 276_Q 1.323 0.99
14_Q 27_A 1.322 0.99
75_E 79_R 1.313 0.99
79_R 128_G 1.311 0.99
179_V 215_N 1.309 0.99
323_K 326_A 1.304 0.99
23_L 93_I 1.301 0.99
172_P 211_T 1.293 0.99
53_F 92_L 1.292 0.99
289_L 298_V 1.29 0.99
113_R 148_E 1.285 0.99
194_P 219_C 1.277 0.99
203_V 219_C 1.271 0.99
279_Q 284_M 1.264 0.99
49_L 60_F 1.263 0.99
272_E 275_Q 1.251 0.99
283_Q 310_E 1.25 0.99
64_N 115_Y 1.247 0.99
68_P 71_G 1.24 0.98
268_R 271_N 1.239 0.98
164_Y 190_L 1.236 0.98
58_T 93_I 1.236 0.98
213_Q 294_R 1.23 0.98
121_D 125_K 1.226 0.98
81_L 92_L 1.225 0.98
154_A 187_I 1.217 0.98
176_Q 211_T 1.212 0.98
270_L 281_M 1.207 0.98
268_R 272_E 1.204 0.98
26_P 57_I 1.197 0.98
23_L 164_Y 1.196 0.98
269_L 327_Q 1.187 0.98
93_I 134_I 1.178 0.98
292_D 325_L 1.173 0.98
271_N 281_M 1.173 0.98
140_V 174_R 1.171 0.98
89_R 131_Y 1.17 0.97
169_S 222_F 1.167 0.97
149_T 152_A 1.165 0.97
133_D 163_L 1.155 0.97
27_A 290_L 1.154 0.97
113_R 151_S 1.145 0.97
195_S 200_N 1.143 0.97
114_K 118_A 1.142 0.97
198_L 285_A 1.133 0.97
74_E 123_S 1.132 0.97
287_S 291_K 1.129 0.97
14_Q 319_T 1.122 0.97
47_A 305_A 1.12 0.96
32_L 77_F 1.115 0.96
302_A 308_L 1.11 0.96
134_I 191_I 1.103 0.96
270_L 328_I 1.102 0.96
156_A 161_K 1.1 0.96
43_E 47_A 1.098 0.96
218_G 297_S 1.093 0.96
78_G 128_G 1.092 0.96
29_S 300_I 1.086 0.96
47_A 51_K 1.084 0.96
50_R 80_L 1.083 0.96
147_E 177_K 1.083 0.96
313_Q 317_N 1.082 0.96
177_K 180_E 1.081 0.95
17_Y 22_G 1.078 0.95
151_S 155_H 1.068 0.95
218_G 296_T 1.068 0.95
209_L 219_C 1.064 0.95
176_Q 215_N 1.059 0.95
59_H 95_S 1.058 0.95
201_R 204_D 1.056 0.95
179_V 211_T 1.054 0.95
180_E 184_E 1.051 0.94
21_S 190_L 1.043 0.94
261_E 265_N 1.043 0.94
210_D 214_N 1.039 0.94
284_M 318_L 1.035 0.94
277_R 321_S 1.028 0.94
183_R 188_P 1.02 0.93
124_L 161_K 1.018 0.93
302_A 307_Q 1.016 0.93
175_T 217_V 1.015 0.93
146_M 149_T 1.013 0.93
191_I 220_I 1.01 0.93
117_L 156_A 1.006 0.93
26_P 58_T 1.003 0.93
55_L 313_Q 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3n6qA811000.108Contact Map0.789
3erpA20.95951000.138Contact Map0.783
3lutA10.96241000.169Contact Map0.764
3eauA10.92771000.175Contact Map0.772
1pz1A20.91331000.179Contact Map0.728
1pyfA10.87861000.182Contact Map0.739
1lqaA20.91911000.189Contact Map0.747
2bp1A40.9481000.191Contact Map0.706
3n2tA10.93351000.197Contact Map0.705
3v0sA10.91621000.199Contact Map0.802
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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