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OPENSEQ.org
YDHF - Oxidoreductase YdhF
UniProt: P76187 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13420
Length: 298 (292)
Sequences: 13989
Seq/Len: 47.91
YDHF
Paralog alert: 0.86 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: DKGA DKGB GPR TAS YAJO YDBC YDHF YDJG YEAE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_E 270_R 3.076 1.00
111_E 151_K 3.063 1.00
69_K 118_A 2.769 1.00
31_A 66_E 2.676 1.00
110_A 146_L 2.605 1.00
237_L 284_Q 2.577 1.00
6_T 13_E 2.526 1.00
236_E 287_R 2.483 1.00
40_E 44_L 2.397 1.00
107_I 149_S 2.37 1.00
80_I 119_T 2.369 1.00
281_T 284_Q 2.202 1.00
107_I 145_H 2.168 1.00
82_S 122_L 2.115 1.00
236_E 284_Q 2.107 1.00
282_R 286_F 2.016 1.00
231_A 235_E 1.991 1.00
145_H 149_S 1.985 1.00
35_V 70_L 1.964 1.00
252_R 285_W 1.95 1.00
112_Q 116_N 1.932 1.00
232_V 287_R 1.888 1.00
5_I 16_R 1.865 1.00
35_V 66_E 1.844 1.00
144_K 148_Q 1.815 1.00
266_I 270_R 1.787 1.00
145_H 148_Q 1.774 1.00
82_S 113_S 1.773 1.00
248_A 278_L 1.771 1.00
199_L 206_P 1.765 1.00
198_Q 202_L 1.762 1.00
110_A 125_L 1.759 1.00
240_G 271_A 1.746 1.00
44_L 273_V 1.72 1.00
122_L 152_V 1.708 1.00
166_A 170_S 1.695 1.00
121_H 153_R 1.694 1.00
59_Q 62_A 1.691 1.00
205_R 258_L 1.688 1.00
239_A 278_L 1.685 1.00
62_A 116_N 1.674 1.00
35_V 67_A 1.673 1.00
44_L 270_R 1.651 1.00
126_L 178_T 1.646 1.00
18_V 48_T 1.644 1.00
148_Q 173_P 1.628 1.00
253_L 289_R 1.601 1.00
40_E 43_D 1.595 1.00
74_L 77_R 1.591 1.00
4_R 13_E 1.581 1.00
40_E 266_I 1.57 1.00
103_R 107_I 1.559 1.00
53_D 109_S 1.556 1.00
126_L 207_M 1.543 1.00
270_R 274_E 1.539 1.00
103_R 145_H 1.532 1.00
49_V 64_F 1.518 1.00
166_A 198_Q 1.508 1.00
41_H 46_V 1.498 1.00
12_P 154_H 1.496 1.00
81_V 126_L 1.495 1.00
35_V 39_E 1.467 1.00
233_V 245_V 1.464 1.00
110_A 122_L 1.451 1.00
274_E 277_T 1.448 1.00
30_S 33_Q 1.441 1.00
21_Y 49_V 1.44 1.00
152_V 155_F 1.439 1.00
146_L 152_V 1.432 1.00
166_A 201_Q 1.429 1.00
286_F 290_K 1.426 1.00
42_L 78_M 1.416 1.00
84_C 106_I 1.41 1.00
229_E 232_V 1.405 0.99
107_I 111_E 1.388 0.99
39_E 43_D 1.384 0.99
239_A 244_Q 1.38 0.99
197_D 201_Q 1.376 0.99
38_I 67_A 1.369 0.99
33_Q 36_S 1.365 0.99
37_F 269_V 1.362 0.99
142_A 145_H 1.358 0.99
111_E 115_I 1.344 0.99
84_C 125_L 1.328 0.99
39_E 70_L 1.326 0.99
107_I 142_A 1.323 0.99
12_P 79_E 1.319 0.99
232_V 235_E 1.312 0.99
267_E 270_R 1.307 0.99
248_A 252_R 1.295 0.99
144_K 174_F 1.295 0.99
112_Q 115_I 1.29 0.99
263_S 269_V 1.285 0.99
269_V 273_V 1.277 0.99
161_T 164_Q 1.271 0.99
75_R 119_T 1.269 0.99
240_G 244_Q 1.268 0.99
108_K 112_Q 1.268 0.99
147_H 174_F 1.261 0.99
79_E 124_L 1.261 0.99
263_S 268_R 1.254 0.99
61_E 113_S 1.246 0.98
62_A 66_E 1.243 0.98
31_A 35_V 1.24 0.98
194_G 197_D 1.236 0.98
169_Q 202_L 1.234 0.98
143_F 155_F 1.224 0.98
185_P 288_I 1.223 0.98
181_V 206_P 1.223 0.98
228_D 232_V 1.221 0.98
66_E 118_A 1.212 0.98
162_P 198_Q 1.206 0.98
103_R 142_A 1.204 0.98
65_G 118_A 1.201 0.98
62_A 115_I 1.192 0.98
154_H 177_A 1.19 0.98
239_A 245_V 1.188 0.98
32_R 36_S 1.188 0.98
102_D 105_H 1.185 0.98
8_A 177_A 1.178 0.98
287_R 290_K 1.161 0.97
75_R 121_H 1.156 0.97
250_V 259_P 1.154 0.97
232_V 236_E 1.141 0.97
104_D 108_K 1.139 0.97
111_E 149_S 1.138 0.97
103_R 141_D 1.135 0.97
39_E 67_A 1.132 0.97
237_L 281_T 1.123 0.97
162_P 166_A 1.122 0.97
48_T 207_M 1.117 0.96
117_L 122_L 1.113 0.96
200_Q 254_P 1.109 0.96
229_E 287_R 1.108 0.96
283_Q 286_F 1.103 0.96
146_L 151_K 1.102 0.96
36_S 266_I 1.095 0.96
39_E 71_A 1.094 0.96
185_P 246_V 1.093 0.96
3_Q 16_R 1.093 0.96
267_E 271_A 1.091 0.96
230_L 241_S 1.087 0.96
103_R 138_E 1.08 0.95
230_L 288_I 1.08 0.95
166_A 202_L 1.077 0.95
197_D 200_Q 1.076 0.95
169_Q 198_Q 1.076 0.95
183_I 253_L 1.071 0.95
36_S 40_E 1.068 0.95
68_L 78_M 1.065 0.95
127_I 143_F 1.063 0.95
138_E 141_D 1.06 0.95
236_E 281_T 1.047 0.94
248_A 275_A 1.04 0.94
251_L 275_A 1.04 0.94
123_D 153_R 1.035 0.94
196_L 200_Q 1.035 0.94
286_F 289_R 1.032 0.94
137_D 171_R 1.031 0.94
48_T 81_V 1.03 0.94
124_L 178_T 1.022 0.93
182_E 187_H 1.017 0.93
146_L 149_S 1.005 0.93
139_V 142_A 1.002 0.92
105_H 108_K 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ur3M111000.043Contact Map0.721
3v0sA10.96641000.087Contact Map0.792
1pyfA10.9531000.088Contact Map0.723
1pz1A20.96641000.088Contact Map0.72
3lutA10.97321000.09Contact Map0.747
3eauA10.97651000.09Contact Map0.759
1lqaA20.98321000.095Contact Map0.751
3n2tA10.97321000.096Contact Map0.712
3n6qA80.97991000.101Contact Map0.767
3erpA20.96981000.107Contact Map0.774
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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